2025
Preoperative smoking cessation impacts presentation and neurologic outcomes of carotid endarterectomy
Schwartz A, Carter W, Tonnessen B, Arhuidese I, Cardella J, Dardik A, Ochoa Chaar C. Preoperative smoking cessation impacts presentation and neurologic outcomes of carotid endarterectomy. Journal Of Vascular Surgery 2025 PMID: 40992521, DOI: 10.1016/j.jvs.2025.09.032.Peer-Reviewed Original ResearchVascular Quality InitiativeTransient ischemic attackSmoking cessation durationLong-term outcomesChronic obstructive pulmonary diseaseCessation durationCarotid endarterectomyNeurological outcomeNeurological eventsFollow-upFormer smokersCurrent smokersGroup of former smokersStatistically significant risk reductionDuration of smoking cessationSmoking cessationKaplan-Meier analysisOutcomes of carotid endarterectomyIpsilateral neurologic eventsSignificant risk reductionChronic kidney diseaseDuration of quittingAssociated with outcomeObstructive pulmonary diseasePerioperative mortalityImpact of Nimodipine-Induced Blood Pressure Reductions on Cerebral Autoregulation and Functional Outcome After Aneurysmal Subarachnoid Hemorrhage
Stoehr K, Bartolome D, Jayasundara S, Thinzar P, Vargas D, Kim J, Magid-Bernstein J, O’Keefe L, de Havenon A, Hebert R, Matouk C, Sheth K, Gilmore E, Ortega-Gutierrez S, Petersen N. Impact of Nimodipine-Induced Blood Pressure Reductions on Cerebral Autoregulation and Functional Outcome After Aneurysmal Subarachnoid Hemorrhage. Neurocritical Care 2025, 1-11. PMID: 40847251, DOI: 10.1007/s12028-025-02338-6.Peer-Reviewed Original ResearchAneurysmal subarachnoid hemorrhageMean arterial pressureAssociated with worse functional outcomeBP reductionFunctional outcomesNimodipine administrationSubarachnoid hemorrhageHunt & Hess scoreBlood pressureAssociated with BP reductionSevere aneurysmal subarachnoid hemorrhageModified Fisher gradeResponse to nimodipineSensitive to nimodipineCerebral autoregulationDelayed Cerebral IschemiaBlood pressure reductionRegional oxygen saturationObservational cohort studyModified Rankin ScaleLimits of autoregulationFisher gradeHess scoreAneurysm securementNeurological outcomeNot All Temperature Control Is Equal: High-Quality Temperature Control Is Associated With Improved Outcomes Following Out-of-Hospital Cardiac Arrest
Beekman R, Nguyen C, Deng Y, Chakravartty A, Perman S, Wira C, Khosla A, Miller P, Sheth K, Greer D, Gilmore E. Not All Temperature Control Is Equal: High-Quality Temperature Control Is Associated With Improved Outcomes Following Out-of-Hospital Cardiac Arrest. Annals Of Emergency Medicine 2025 PMID: 40817896, DOI: 10.1016/j.annemergmed.2025.06.622.Peer-Reviewed Original ResearchSingle-center studyInverse probability treatment weightsNeurological outcomeCardiac arrestOut-of-hospital cardiac arrestOut-of-hospital cardiac arrest patientsHospital dischargeSecondary outcomesTreatment weightingCerebral Performance Category scoreAssociated with improved outcomesNeuroprotective benefitsProspective multicenter studyFavorable neurologic outcomeSmall effect sizesSurvivors of cardiac arrestCardiac arrest patientsAdjunctive pharmacologic treatmentStandardized mean differenceAchievement of target temperatureHigh-quality groupHospital arrivalArrest patientsMulticenter studyClinical outcomesThe impact of pupil diameter on assessing illness severity and outcome after out-of-hospital cardiac arrest in patients with unreactive pupils
Beekman R, Chakravartty A, Nguyen C, Perman S, Wira C, Buckley R, Khosla A, Miller P, Greer D, Gilmore E. The impact of pupil diameter on assessing illness severity and outcome after out-of-hospital cardiac arrest in patients with unreactive pupils. Resuscitation 2025, 215: 110699. PMID: 40582484, DOI: 10.1016/j.resuscitation.2025.110699.Peer-Reviewed Original ResearchConceptsOut-of-hospital cardiac arrestAbsent pupillary light reflexPupillary light reflexDilated pupilsPremorbid medical conditionsCardiac arrestPost-ROSCIllness severityClinical outcomesPupil sizeOut-of-hospital cardiac arrest patientsIndicator of poor prognosisHigher incidenceAssociated with poor outcomesMedical conditionsSingle-center studyPoor neurological outcomePrediction of brain deathIllness severity scoresBrain deathHigher illness severityIncidence of brain deathSpontaneous circulationQuantitative pupillometryNeurological outcomeRepolarisation abnormalities and outcomes among patients with cardiac arrest
Schenck C, Banna S, Kim N, Nguyen C, Gilmore E, Greer D, Beekman R, Miller P. Repolarisation abnormalities and outcomes among patients with cardiac arrest. European Heart Journal Acute Cardiovascular Care 2025, zuaf077. PMID: 40424593, DOI: 10.1093/ehjacc/zuaf077.Peer-Reviewed Original ResearchReturn of spontaneous circulationIn-Hospital MortalityAssociated with in-hospital mortalityQTc prolongationCardiac arrestInterval prolongationShockable rhythmNeurological outcomeClinical outcomesAssociated with increased in-hospital mortalityAssociated with adverse clinical outcomesTpTe intervalT-peak to T-endSusceptibility to ventricular arrhythmiasQTc interval prolongationIn-hospital cardiac arrestAdverse clinical outcomesT-end (TpTeOut-of-hospitalT-endSpontaneous circulationVentricular arrhythmiasVentricular repolarizationQTcRepolarisation abnormalitiesDeterminants of Outcome After Endovascular Middle Cerebral Artery Occlusion in Rats in the SPAN Trial.
Jin X, Morais A, Imai T, Lamb J, Nagarkatti K, Boisserand L, Beatty H, Sansing L, Khan M, Dhandapani K, Kamat P, Hess D, Patel R, Kumskova M, Chauhan A, McCullough L, Aronowski J, Leira E, Shi Y, Avery B, Koehler R, Lyden P, Ayata C. Determinants of Outcome After Endovascular Middle Cerebral Artery Occlusion in Rats in the SPAN Trial. Stroke 2025 PMID: 40396268, DOI: 10.1161/strokeaha.125.051235.Peer-Reviewed Original ResearchMiddle cerebral artery occlusionSpontaneously Hypertensive RatsCerebral artery occlusionProcedural predictorsNeurological outcomeHypertensive ratsArtery occlusionTransient middle cerebral artery occlusionActive treatment armsEndovascular middle cerebral artery occlusionSprague-Dawley ratsDeterminants of outcomeDependent outcome variablesOcclusal outcomesIndependent predictorsTreatment armsHippocampal infarctionInfarct volumeMultivariate analysisPreclinical trialsAnesthesia exposureImpact stroke outcomesMulticenter approachProcedural variablesRatsTreatment with Manganese Porphyrin, MnTnBuOE-2-PyP5+, Suppressed the Activation of Macrophages in a Mouse Intracerebral Hemorrhage
Zhang S, Cao J, Spasojevic I, Treggiari M, Sheng H. Treatment with Manganese Porphyrin, MnTnBuOE-2-PyP5+, Suppressed the Activation of Macrophages in a Mouse Intracerebral Hemorrhage. Pharmaceuticals 2025, 18: 547. PMID: 40283982, PMCID: PMC12030109, DOI: 10.3390/ph18040547.Peer-Reviewed Original ResearchMouse intracerebral hemorrhageIntracerebral hemorrhageActivation of macrophagesNeurological deficitsBMX-001Hemorrhage sizeBody weightSham surgery miceMnTnBuOE-2-PyP5+Neurological deficit scoreExperimental ischemic strokePrussian blue stainingAnti-inflammatory effectsStroke patientsPost-ICHNo significant differenceNeurological outcomeC57BL6 miceSurgery miceHemorrhagic transformationClinical trialsHemorrhageRotarod testDeficit scoresHistological evaluationEvolution of EEG Findings in Patients with Acute Brain Injury
Narrett J, Byrnes M, Gilmore E, Hirsch L, Punia V, Sivaraju A. Evolution of EEG Findings in Patients with Acute Brain Injury. Neurocritical Care 2025, 1-8. PMID: 40038178, DOI: 10.1007/s12028-025-02227-y.Peer-Reviewed Original ResearchAcute brain injuryLateralized rhythmic delta activityLateralized periodic dischargesRhythmic delta activityEEG findingsContinuous electroencephalographyPeriodic dischargesDelta activityEEG patternsRetrospective chart review of patientsChart review of patientsSporadic epileptiform dischargesFollow-up EEGReview of patientsBrain injuryGeneralized periodic dischargesRetrospective chart reviewAcute symptomatic seizuresAntiseizure medication treatmentEvolution of EEG patternsConclusionsIn patientsElectrographic seizuresNeurological outcomeBackgroundIncreasing useElectroclinical seizuresRetrospective Visual and Quantitative Assessment of Burst Suppression With and Without Identical Bursts in Patients After Cardiac Arrest
Fong M, Pu K, Beekman R, Kim N, Nguyen C, Gilmore E, Hirsch L, Zaveri H. Retrospective Visual and Quantitative Assessment of Burst Suppression With and Without Identical Bursts in Patients After Cardiac Arrest. Neurocritical Care 2025, 43: 157-167. PMID: 39900751, DOI: 10.1007/s12028-024-02208-7.Peer-Reviewed Original ResearchIdentical burstsBurst suppressionCardiac arrest survivorsInterburst intervalClinical featuresNeurological outcomeCardiac arrestArrest survivorsAssociated with poor neurological outcomeContinuous electroencephalogramCerebral Performance Category scoreAssociated with poor outcomesCardiac arrest patientsPoor neurological outcomePost-cardiac arrestPredictors of mortalityUS academic medical centersEEG backgroundPrognostic significanceArrest patientsClinical outcomesPoor outcomeRetrospective analysisAcademic medical centerUS cohortPrevalence and prognostic impact of ST-segment elevation in lead aVR among patients with cardiac arrest
Banna S, Schenck C, Kim N, Ali T, Gilmore E, Greer D, Beekman R, Miller P. Prevalence and prognostic impact of ST-segment elevation in lead aVR among patients with cardiac arrest. European Heart Journal Acute Cardiovascular Care 2025, 14: 232-236. PMID: 39873390, DOI: 10.1093/ehjacc/zuaf018.Peer-Reviewed Original ResearchOut-of-hospital cardiac arrestAssociated with higher in-hospital mortalityHigher In-Hospital MortalityST-segment elevationIn-Hospital MortalityReturn of spontaneous circulationCardiac arrestShockable rhythmLead aVRPoor neurological outcomeAcute coronary syndromeMultivariate logistic regressionPrognostic impactPost-ROSCPrognostic significanceSpontaneous circulationCA patientsNeurological outcomeCoronary syndromeIdentified patientsMultivariable adjustmentMain diseasePatientsCA survivorsArrest characteristics
2024
Diverse NKT cells regulate early inflammation and neurological outcomes after cardiac arrest and resuscitation
Tamura T, Cheng C, Villaseñor-Altamirano A, Yamada K, Ikeda K, Hayashida K, Menon J, Chen X, Chung H, Varon J, Chen J, Choi J, Cullen A, Guo J, Lin X, Olenchock B, Pinilla-Vera M, Manandhar R, Sheikh M, Hou P, Lawler P, Oldham W, Seethala R, Baron R, Bohula E, Morrow D, Blumberg R, Chen F, Merriam L, Weissman A, Brenner M, Chen X, Ichinose F, Kim E, Sohn H, Rolland T, Weil B. Diverse NKT cells regulate early inflammation and neurological outcomes after cardiac arrest and resuscitation. Science Translational Medicine 2024, 16: eadq5796. PMID: 39630883, PMCID: PMC11792709, DOI: 10.1126/scitranslmed.adq5796.Peer-Reviewed Original ResearchConceptsOut-of-hospital cardiac arrestCohort of patientsNeurological outcomeT cellsImmune cellsCardiac arrestNatural killer (NK) cellsAssociated with good neurological outcomesDiverse T cell receptor repertoireNeurological injuryT cell receptor repertoireAssociated with poor neurological outcomeIncreased inflammatory chemokineInnate T cellsPoor neurological outcomeWild-type micePost-cardiac arrestAccumulation of macrophagesIncreased neuronal injuryBrains of miceNKT cellsTreated miceReceptor repertoireInflammatory chemokinesCytokine expressionA practical magnetic-resonance imaging score for outcome prediction in comatose cardiac arrest survivors
Chan W, Nguyen C, Kim N, Tripodis Y, Gilmore E, Greer D, Beekman R. A practical magnetic-resonance imaging score for outcome prediction in comatose cardiac arrest survivors. Resuscitation 2024, 202: 110370. PMID: 39178939, DOI: 10.1016/j.resuscitation.2024.110370.Peer-Reviewed Original ResearchHypoxic-ischemic brain injuryDeep gray nucleiArea under the receiver operating curveMagnetic resonance imagingMagnetic Resonance Imaging ScorePoor neurological outcomeCerebral Performance CategoryIntra-class correlationNeurological outcomeMRI scoreCardiac arrestComatose CA survivorsCA survivorsComatose cardiac arrest survivorsPredicting neurologic outcomeCardiac arrest survivorsInter-rater reliabilityReceiver operating curveAcademic medical centerMedian timePoor outcomePrognostic toolGray nucleiArrest survivorsScore groupEndovascular thrombectomy versus medical management for moderate-to-severe anterior cerebral artery occlusion stroke
Chen H, Khunte M, Malhotra A, Gandhi D, Colasurdo M. Endovascular thrombectomy versus medical management for moderate-to-severe anterior cerebral artery occlusion stroke. Journal Of Neurology 2024, 271: 6247-6254. PMID: 39085619, DOI: 10.1007/s00415-024-12582-z.Peer-Reviewed Original ResearchAssociated with higher oddsAnterior cerebral arteryAssociated with higher ratesIntracranial hemorrhageEndovascular thrombectomyMedical managementHigher oddsEfficacy of endovascular thrombectomyFavorable short-term outcomesRetrospective cohort studyPatient selection criteriaShort-term outcomesEndovascular thrombectomy patientsIn-Hospital MortalityMultivariate logistic regressionHome dischargeArtery occlusion strokeNational Inpatient SampleHigher RatesNeurological outcomeCohort studyPrimary outcomeCerebral arterySecondary outcomesOcclusion strokeTemperature Control Parameters Are Important: Earlier Preinduction Is Associated With Improved Outcomes Following Out-of-Hospital Cardiac Arrest
Beekman R, Kim N, Nguyen C, McGinniss G, Deng Y, Kitlen E, Garcia G, Wira C, Khosla A, Johnson J, Miller P, Perman S, Sheth K, Greer D, Gilmore E. Temperature Control Parameters Are Important: Earlier Preinduction Is Associated With Improved Outcomes Following Out-of-Hospital Cardiac Arrest. Annals Of Emergency Medicine 2024, 84: 549-559. PMID: 39033449, DOI: 10.1016/j.annemergmed.2024.06.007.Peer-Reviewed Original ResearchOut-of-hospital cardiac arrestNeurological outcomeDevice cohortCardiac arrestOut-of-hospital cardiac arrest patientsConsecutive out-of-hospital cardiac arrestPreinduction timeInterquartile rangeAssociated with improved outcomesCardiac arrest patientsProportion of patientsMultivariate logistic regression modelInverse probability of treatmentDevice timeInverse probability treatment weightsProbability of treatmentProspective trialsOHCA patientsArrest patientsClinical outcomesLogistic regression modelsCenter studyEarly initiationSecondary outcomesTreatment weightingQuantitative Characterization of Rhythmic and Periodic EEG Patterns in Patients in a Coma After Cardiac Arrest and Association With Outcome
van Putten M, Ruijter B, Horn J, van Rootselaar A, Tromp S, van Kranen-Mastenbroek V, Gaspard N, Hofmeijer J, Investigators F. Quantitative Characterization of Rhythmic and Periodic EEG Patterns in Patients in a Coma After Cardiac Arrest and Association With Outcome. Neurology 2024, 103: e209608. PMID: 38991197, DOI: 10.1212/wnl.0000000000209608.Peer-Reviewed Original ResearchSex Differences in the Blood Metabolome During Acute Response to Ischemic Stroke
Dylla L, Higgins H, Stephenson D, Reisz J, Vu T, Poisson S, Herson P, Monte A. Sex Differences in the Blood Metabolome During Acute Response to Ischemic Stroke. Journal Of Women's Health 2024, 33: 1378-1384. PMID: 38946610, PMCID: PMC11564668, DOI: 10.1089/jwh.2023.1133.Peer-Reviewed Original ResearchIschemic strokeLinear regression modelsMass spectrometry-based metabolomicsLifetime risk of strokeAssociated with neurological outcomeDifferentially expressed metabolitesRegression modelsAcute ischemic strokeRisk of strokeComprehensive stroke centerBlood metabolomeNeurological outcomeAcute treatmentMetabolomic profilesLifetime riskNeurological functionIndividual metabolitesTherapeutic potentialStroke centersAcute responseResults:</i></b>Study objectiveMetabolomicsStrokeNIHSSDiagnostic accuracy of intraoperative neuromonitoring in transcarotid artery revascularization
Diogo C, Na D, Sujijantarat N, Matouk C, Callahan B. Diagnostic accuracy of intraoperative neuromonitoring in transcarotid artery revascularization. Journal Of NeuroInterventional Surgery 2024, 17: 81-87. PMID: 38378240, DOI: 10.1136/jnis-2023-021282.Peer-Reviewed Original ResearchSomatosensory Evoked PotentialsIntraoperative neuromonitoring alertsTranscarotid artery revascularizationNegative predictive valueIntraoperative neuromonitoringPredictive valueNeurological outcomeNeurological deficitsArtery revascularizationDiagnostic accuracyAccuracy of intraoperative neuromonitoringNew neurological deficitsPostoperative neurological outcomePredicting postoperative outcomesPositive predictive valueTranscarotid artery revascularization procedureCarotid artery stentingPostoperative outcomesSurgeon interventionArtery stentingHemodynamic interventionsRevascularizationNeuromonitoringOutcomesElectroencephalogramImpact of the COVID-19 Pandemic on the Personal Networks and Neurological Outcomes of People With Multiple Sclerosis: Cross-Sectional and Longitudinal Case-Control Study
Riley C, Venkatesh S, Dhand A, Doshi N, Kavak K, Levit E, Perrone C, Weinstock-Guttman B, Longbrake E, De Jager P, Xia Z. Impact of the COVID-19 Pandemic on the Personal Networks and Neurological Outcomes of People With Multiple Sclerosis: Cross-Sectional and Longitudinal Case-Control Study. JMIR Public Health And Surveillance 2024, 10: e45429. PMID: 38319703, PMCID: PMC10879979, DOI: 10.2196/45429.Peer-Reviewed Original ResearchControversies in the Indications for Surgery
Yang J, Sasson D, Smetona J, Persing J. Controversies in the Indications for Surgery. 2024, 175-187. DOI: 10.1007/978-3-031-69386-1_14.Peer-Reviewed Original Research
2023
Code ICH: A Call to Action
Li Q, Yakhkind A, Alexandrov A, Alexandrov A, Anderson C, Dowlatshahi D, Frontera J, Hemphill J, Ganti L, Kellner C, May C, Morotti A, Parry-Jones A, Sheth K, Steiner T, Ziai W, Goldstein J, Mayer S. Code ICH: A Call to Action. Stroke 2023, 55: 494-505. PMID: 38099439, DOI: 10.1161/strokeaha.123.043033.Peer-Reviewed Original ResearchIntracerebral hemorrhageHematoma expansionNeurological outcomeEarly aggressive careAcute ischemic strokeBlood pressure controlPoor functional outcomeMultiple simultaneous interventionsBundled careAggressive careIschemic strokeIndependent predictorsPrimary outcomeAcute phaseEmergency reversalFunctional recoveryRandomized trialsFunctional outcomeWorse outcomesConsensus statementCurrent evidenceTreatment opportunitiesSingle interventionEarly interventionPressure control
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