2025
Treatment with Manganese Porphyrin, MnTnBuOE-2-PyP5+, Suppressed the Activation of Macrophages in a Mouse Intracerebral Hemorrhage
Zhang S, Cao J, Spasojevic I, Treggiari M, Sheng H. Treatment with Manganese Porphyrin, MnTnBuOE-2-PyP5+, Suppressed the Activation of Macrophages in a Mouse Intracerebral Hemorrhage. Pharmaceuticals 2025, 18: 547. PMID: 40283982, PMCID: PMC12030109, DOI: 10.3390/ph18040547.Peer-Reviewed Original ResearchMouse intracerebral hemorrhageIntracerebral hemorrhageActivation of macrophagesNeurological deficitsBMX-001Hemorrhage sizeBody weightSham surgery miceMnTnBuOE-2-PyP5+Neurological deficit scoreExperimental ischemic strokePrussian blue stainingAnti-inflammatory effectsStroke patientsPost-ICHNo significant differenceNeurological outcomeC57BL6 miceSurgery miceHemorrhagic transformationClinical trialsHemorrhageRotarod testDeficit scoresHistological evaluation
2022
MR Imaging–Based In Vivo Macrophage Imaging to Monitor Immune Response after Radiofrequency Ablation of the Liver
Santana J, Petukhova-Greenstein A, Gross M, Hyder F, Pekurovsky V, Gottwald L, Boustani A, Walsh J, Kucukkaya A, Malpani R, Madoff D, Goldberg S, Ahmed M, Joshi N, Coman D, Chapiro J. MR Imaging–Based In Vivo Macrophage Imaging to Monitor Immune Response after Radiofrequency Ablation of the Liver. Journal Of Vascular And Interventional Radiology 2022, 34: 395-403.e5. PMID: 36423815, PMCID: PMC11042914, DOI: 10.1016/j.jvir.2022.11.013.Peer-Reviewed Original ResearchConceptsImmune responseT1-weighted MRPrussian blue stainingRadiofrequency ablationRF ablationC57BL/6 wild-type miceMR imagingDose-escalation studyLocal immune responseMass cytometryWild-type miceRadiological-pathological correlationBlue stainingT1-weighted MR imagingHepatic radiofrequency ablationCD68 antibodyUntreated lobeVivo doseHepatic RF ablationVivo macrophagesMacrophagesMiceMR imaging scannerCoagulation areaCD68
2011
Determining the fate of seeded cells in venous tissue‐engineered vascular grafts using serial MRI
Harrington JK, Chahboune H, Criscione JM, Li AY, Hibino N, Yi T, Villalona GA, Kobsa S, Meijas D, Duncan DR, Devine L, Papademetri X, Shin'oka T, Fahmy TM, Breuer CK. Determining the fate of seeded cells in venous tissue‐engineered vascular grafts using serial MRI. The FASEB Journal 2011, 25: 4150-4161. PMID: 21846838, PMCID: PMC3236630, DOI: 10.1096/fj.11-185140.Peer-Reviewed Original ResearchConceptsTissue-engineered vascular graftsTissue engineering researchSeeded cellsTissue-engineered constructsVascular graftsTissue engineeringImplanted scaffoldIron oxide nanoparticlesOxide nanoparticlesMonitoring techniquesSuperparamagnetic iron oxide nanoparticlesEngineering researchScaffoldsFirst successful applicationSuccessful applicationUltrasmall superparamagnetic iron oxide nanoparticlesRelaxation timeCellular magnetic resonance imagingTransverse relaxation timeVitro OptimizationPrussian blue stainingEngineeringSCID/bg miceNanoparticles
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