2025
Impact of Nimodipine-Induced Blood Pressure Reductions on Cerebral Autoregulation and Functional Outcome After Aneurysmal Subarachnoid Hemorrhage
Stoehr K, Bartolome D, Jayasundara S, Thinzar P, Vargas D, Kim J, Magid-Bernstein J, O’Keefe L, de Havenon A, Hebert R, Matouk C, Sheth K, Gilmore E, Ortega-Gutierrez S, Petersen N. Impact of Nimodipine-Induced Blood Pressure Reductions on Cerebral Autoregulation and Functional Outcome After Aneurysmal Subarachnoid Hemorrhage. Neurocritical Care 2025, 1-11. PMID: 40847251, DOI: 10.1007/s12028-025-02338-6.Peer-Reviewed Original ResearchAneurysmal subarachnoid hemorrhageMean arterial pressureAssociated with worse functional outcomeBP reductionFunctional outcomesNimodipine administrationSubarachnoid hemorrhageHunt & Hess scoreBlood pressureAssociated with BP reductionSevere aneurysmal subarachnoid hemorrhageModified Fisher gradeResponse to nimodipineSensitive to nimodipineCerebral autoregulationDelayed Cerebral IschemiaBlood pressure reductionRegional oxygen saturationObservational cohort studyModified Rankin ScaleLimits of autoregulationFisher gradeHess scoreAneurysm securementNeurological outcomeEarly CSF inflammatory markers after aneurysmal subarachnoid hemorrhage and their relationship to disease severity and shunt placement
Magid-Bernstein J, Yan J, Herman A, He Z, Johnson C, Beatty H, Choi R, Velazquez S, Sorensen G, Jayasundara S, Grychowski L, Amllay A, Falcone G, Kim J, Petersen N, O’Keefe L, Gilmore E, Matouk C, Sheth K, Sansing L. Early CSF inflammatory markers after aneurysmal subarachnoid hemorrhage and their relationship to disease severity and shunt placement. Journal Of Stroke And Cerebrovascular Diseases 2025, 34: 108395. PMID: 40639751, PMCID: PMC12333380, DOI: 10.1016/j.jstrokecerebrovasdis.2025.108395.Peer-Reviewed Original ResearchConceptsPermanent shunt placementAneurysmal subarachnoid hemorrhage patientsGranulocyte-colony stimulating factorAneurysmal subarachnoid hemorrhageVascular endothelial growth factorCC motif chemokine ligand 2Shunt placementCerebrospinal fluidCerebrospinal fluid samplesInterleukin-6Interleukin-8Disease severityPreclinical modelsSubarachnoid hemorrhageModified Fisher scale scoresModels of CNS inflammationShunt-dependent hydrocephalusAssociated with clinical severityConcentrations of interleukin-6Post-hemorrhagic hydrocephalusMotif chemokine ligand 2Panel of cytokinesCSF inflammatory markersEndothelial growth factorCerebrospinal fluid concentrations
2024
Intraparenchymal near-infrared spectroscopy for detection of delayed cerebral ischemia in poor-grade aneurysmal subarachnoid hemorrhage
Willms J, Boss J, Huo S, Wolf S, Westphal L, Bögli S, Inauen C, Baumann D, Fröhlich J, Keller E. Intraparenchymal near-infrared spectroscopy for detection of delayed cerebral ischemia in poor-grade aneurysmal subarachnoid hemorrhage. Journal Of Neuroscience Methods 2024, 406: 110113. PMID: 38537749, DOI: 10.1016/j.jneumeth.2024.110113.Peer-Reviewed Original ResearchDetection of delayed cerebral ischemiaAneurysmal subarachnoid hemorrhagePoor-grade aneurysmal subarachnoid hemorrhagePerfusion deficitsSubarachnoid hemorrhageIntracranial pressureCerebral ischemiaMedian valuePerfusion CT scansCerebral perfusion deficitsDetect perfusion deficitsBrain tissue oxygen pressureMeasurement of intracranial pressureCT scanTissue oxygen pressureComatose patientsCerebral infarctionPatientsNear-infrared spectroscopyMultimodal neuromonitoringPatient collectivesHbtotalPerfusionInfarctionPbtO2
2023
Practice Standards for the Use of Multimodality Neuromonitoring: A Delphi Consensus Process*
Foreman B, Kapinos G, Wainwright M, Ngwenya L, O'Phelan K, LaRovere K, Kirschen M, Appavu B, Lazaridis C, Alkhachroum A, Maciel C, Amorim E, Chang J, Gilmore E, Rosenthal E, Park S. Practice Standards for the Use of Multimodality Neuromonitoring: A Delphi Consensus Process*. Critical Care Medicine 2023, 51: 1740-1753. PMID: 37607072, PMCID: PMC11036878, DOI: 10.1097/ccm.0000000000006016.Peer-Reviewed Original ResearchGuidelines in Action: Management of Acute and Chronic Hydrocephalus Following Aneurysmal Subarachnoid Hemorrhage
Parasram M, Park J, Al-Dulaimi M, Magid-Bernstein J. Guidelines in Action: Management of Acute and Chronic Hydrocephalus Following Aneurysmal Subarachnoid Hemorrhage. Stroke 2023, 54: e508-e511. PMID: 37842781, DOI: 10.1161/strokeaha.123.044793.Peer-Reviewed Original ResearchGuidelines for the Neurocritical Care Management of Aneurysmal Subarachnoid Hemorrhage
Treggiari M, Rabinstein A, Busl K, Caylor M, Citerio G, Deem S, Diringer M, Fox E, Livesay S, Sheth K, Suarez J, Tjoumakaris S. Guidelines for the Neurocritical Care Management of Aneurysmal Subarachnoid Hemorrhage. Neurocritical Care 2023, 39: 1-28. PMID: 37202712, DOI: 10.1007/s12028-023-01713-5.Peer-Reviewed Original ResearchConceptsAneurysmal subarachnoid hemorrhagePICO questionMedical managementRecommendations AssessmentSubarachnoid hemorrhageObservational studyCare managementLong-term patient outcomesNeurocritical care managementNeurointensive care managementOutcomes of patientsRetrospective observational studyQuality of evidenceRisk of biasCase-control studyImportant clinical questionsMeeting inclusion criteriaFull-text reviewHuman study participantsAssessment of RCTConclusionsThese guidelinesBias toolCase seriesConditional recommendationNonrandomized study
2022
Automated EEG-based prediction of delayed cerebral ischemia after subarachnoid hemorrhage
Zheng WL, Kim JA, Elmer J, Zafar SF, Ghanta M, Moura V, Patel A, Rosenthal E, Westover M. Automated EEG-based prediction of delayed cerebral ischemia after subarachnoid hemorrhage. Clinical Neurophysiology 2022, 143: 97-106. PMID: 36182752, PMCID: PMC9847346, DOI: 10.1016/j.clinph.2022.08.023.Peer-Reviewed Original ResearchConceptsMultiple EEG featuresEEG featuresInformative featuresPrediction algorithmSubarachnoid hemorrhageBetter performanceNon-DCI patientsMachineCerebral ischemiaDCI riskAlpha-delta ratioAneurysmal subarachnoid hemorrhageUtility of electroencephalographyReceiver operator curveFeaturesDCI predictionAlgorithmDCI onsetSAH patientsShannon entropyDay 5Whole brainAlpha variabilityPatientsPrediction
2021
A Double-Blind, Randomized, Placebo-Controlled Trial of Soluble Epoxide Hydrolase Inhibition in Patients with Aneurysmal Subarachnoid Hemorrhage
Martini RP, Siler D, Cetas J, Alkayed NJ, Allen E, Treggiari MM. A Double-Blind, Randomized, Placebo-Controlled Trial of Soluble Epoxide Hydrolase Inhibition in Patients with Aneurysmal Subarachnoid Hemorrhage. Neurocritical Care 2021, 36: 905-915. PMID: 34873674, DOI: 10.1007/s12028-021-01398-8.Peer-Reviewed Original ResearchConceptsSoluble epoxide hydrolaseAneurysmal subarachnoid hemorrhageSubarachnoid hemorrhageDHET ratiosEnd pointDay 7Day 10Primary study end pointSoluble epoxide hydrolase inhibitionCSF inflammatory cytokinesEET/DHET ratiosIncidence of DCIPrevention of DCITertiary end pointSecondary end pointsStudy end pointCerebral blood flowLength of stayEndothelial injury biomarkersEpoxide hydrolase inhibitionNeurovascular inflammationResultsTen patientsStudy drugAdverse eventsCytokine levelsAntiseizure Medication Treatment and Outcomes in Patients with Subarachnoid Hemorrhage Undergoing Continuous EEG Monitoring
Zafar SF, Rosenthal ES, Postma EN, Sanches P, Ayub MA, Rajan S, Kim JA, Rubin DB, Lee H, Patel AB, Hsu J, Patorno E, Westover MB. Antiseizure Medication Treatment and Outcomes in Patients with Subarachnoid Hemorrhage Undergoing Continuous EEG Monitoring. Neurocritical Care 2021, 36: 857-867. PMID: 34843082, PMCID: PMC9117405, DOI: 10.1007/s12028-021-01387-x.Peer-Reviewed Original ResearchConceptsAneurysmal subarachnoid hemorrhageGood functional outcomeAntiseizure medicationsFunctional outcomeContinuous electroencephalographyEpileptiform activityLower likelihoodBetter outcomesAneurysm treatmentRetrospective single-center cohort studySingle-center cohort studyAntiseizure medication (ASM) treatmentElectroencephalographic epileptiform activityResultsNinety-four patientsDay of admissionContinuous EEG monitoringASM treatmentCEEG initiationCohort studyProspective trialHigh-intensity treatmentLow-intensity treatmentMedication treatmentSubarachnoid hemorrhageOutcome measures
2020
Posterior Reversible Encephalopathy Syndrome Caused by Induced Hypertension to Treat Cerebral Vasospasm Secondary to Aneurysmal Subarachnoid Hemorrhage
Elsamadicy AA, Koo AB, Reeves BC, Sujijantarat N, David WB, Malhotra A, Gilmore EJ, Matouk CC, Hebert R. Posterior Reversible Encephalopathy Syndrome Caused by Induced Hypertension to Treat Cerebral Vasospasm Secondary to Aneurysmal Subarachnoid Hemorrhage. World Neurosurgery 2020, 143: e309-e323. PMID: 32721559, DOI: 10.1016/j.wneu.2020.07.135.Peer-Reviewed Original ResearchConceptsPosterior reversible encephalopathy syndromeSystolic blood pressure goalBlood pressure goalsReversible encephalopathy syndromeAneurysmal subarachnoid hemorrhageSubarachnoid hemorrhageEncephalopathy syndromeCerebral vasospasmClinical statusFluid-attenuated inversion recovery hyperintensityMiddle cerebral artery syndromeAcute-onset headachePossible ischemic eventsClinical examination findingsInversion recovery hyperintensityPatient's clinical statusTransient clinical improvementArtery aneurysm ruptureMiddle cerebral arteryLevel of arousalMagnetic resonance imagingDigital subtraction angiographyInduced hypertensionClinical improvementIschemic eventsPterygopalatine Fossa Blockade: a novel, narcotic-sparing Treatment for Headache in Patients with Aneurysmal Subarachnoid Hemorrhage (4708)
Busl K, Maciel C, Babi M, Robinson C, Lobmeyer E, Pizzi M, Bursian A, Fox C, Smith C. Pterygopalatine Fossa Blockade: a novel, narcotic-sparing Treatment for Headache in Patients with Aneurysmal Subarachnoid Hemorrhage (4708). Neurology 2020, 94 DOI: 10.1212/wnl.94.15_supplement.4708.Peer-Reviewed Original ResearchAneurysmal subarachnoid hemorrhageSubarachnoid hemorrhage
2019
Direct electrophysiological evidence that spreading depolarization-induced spreading depression is the pathophysiological correlate of the migraine aura and a review of the spreading depolarization continuum of acute neuronal mass injury
Major S, Huo S, Lemale C, Siebert E, Milakara D, Woitzik J, Gertz K, Dreier J. Direct electrophysiological evidence that spreading depolarization-induced spreading depression is the pathophysiological correlate of the migraine aura and a review of the spreading depolarization continuum of acute neuronal mass injury. GeroScience 2019, 42: 57-80. PMID: 31820363, PMCID: PMC7031471, DOI: 10.1007/s11357-019-00142-7.Peer-Reviewed Original ResearchConceptsDepression of activityDirect electrophysiological evidenceMigraine auraNeurological deficitsPathophysiological correlatesGray matterMassive glutamate releaseMassive ion translocationTransient ischemic attackFocal neurological deficitsCerebral amyloid angiopathyAneurysmal subarachnoid hemorrhageElectrophysiological evidenceMass injuryBrain gray matterIschemic attackMigraine strokeDendritic beadingAmyloid angiopathyGlutamate releaseSubarachnoid hemorrhageDirect current potentialNeuronal somataClinical distinctionIschemic tissueDeviation From Personalized Blood Pressure Targets Is Associated With Worse Outcome After Subarachnoid Hemorrhage
Silverman A, Kodali S, Strander S, Gilmore EJ, Kimmel A, Wang A, Cord B, Falcone G, Hebert R, Matouk C, Sheth KN, Petersen NH. Deviation From Personalized Blood Pressure Targets Is Associated With Worse Outcome After Subarachnoid Hemorrhage. Stroke 2019, 50: 2729-2737. PMID: 31495332, PMCID: PMC6756936, DOI: 10.1161/strokeaha.119.026282.Peer-Reviewed Original ResearchConceptsLimits of autoregulationAneurysmal subarachnoid hemorrhageSubarachnoid hemorrhageFunctional outcomeArterial pressureIntracranial pressureBP targetsWorse outcomesPercent timeBlood pressure targetsBlood pressure managementMean arterial pressureModified Rankin ScalePotential neuroprotective strategiesWorse functional outcomePoor functional outcomeCerebral blood flowMultivariate logistic regressionTotal monitoring periodAutoregulatory indexPressure targetsCerebral ischemiaNeuroprotective strategiesRankin ScaleCerebral autoregulationDeviation from Dynamic and Personalized Optimal Blood Pressure Targets is Associated With Worse Functional Outcomes After Aneurysmal Subarachnoid Hemorrhage
Silverman A, Kodali S, Strander S, Gilmore E, Kimmel A, Wang A, Cord B, Falcone G, Hebert R, Matouk C, Sheth K, Petersen N. Deviation from Dynamic and Personalized Optimal Blood Pressure Targets is Associated With Worse Functional Outcomes After Aneurysmal Subarachnoid Hemorrhage. Neurosurgery 2019, 66: 310-186. DOI: 10.1093/neuros/nyz310_186.Peer-Reviewed Original ResearchOptimal blood pressure targetBlood pressure targetsWorse functional outcomeAneurysmal subarachnoid hemorrhagePressure targetsSubarachnoid hemorrhageFunctional outcomeChanges on Dynamic Cerebral Autoregulation Are Associated with Delayed Cerebral Ischemia in Patients with Aneurysmal Subarachnoid Hemorrhage
Ortega-Gutierrez S, Samaniego E, Reccius A, Huang A, Zheng-Lin B, Masukar A, Marshall R, Petersen N. Changes on Dynamic Cerebral Autoregulation Are Associated with Delayed Cerebral Ischemia in Patients with Aneurysmal Subarachnoid Hemorrhage. Acta Neurochirurgica Supplement 2019, 127: 149-153. PMID: 31407076, DOI: 10.1007/978-3-030-04615-6_22.Peer-Reviewed Original ResearchConceptsDynamic cerebral autoregulationAneurysmal subarachnoid hemorrhageCerebral blood flow velocityBlood pressureSymptomatic vasospasmCerebral ischemiaSAH patientsCerebral autoregulationSubarachnoid hemorrhageCerebral blood flow regulationGlasgow Coma ScoreSystemic blood pressureDelayed Cerebral IschemiaLarge cohort studyBlood flow regulationBlood flow velocityRecording periodDCA assessmentCohort studyComa ScoreEntire recording periodSymptom onsetMedian timeDay 3Early identificationDynamic Cerebral Autoregulation and Personalized Blood Pressure Monitoring in Patients with Aneurysmal Subarachnoid Hemorrhage (aSAH) (P5.3-025)
Silverman A, Wang A, Kodali S, Strander S, Cord B, Hebert R, Matouk C, Sheth K, Gilmore E, Petersen N. Dynamic Cerebral Autoregulation and Personalized Blood Pressure Monitoring in Patients with Aneurysmal Subarachnoid Hemorrhage (aSAH) (P5.3-025). Neurology 2019, 92 DOI: 10.1212/wnl.92.15_supplement.p5.3-025.Peer-Reviewed Original Research
2018
Cerebrospinal fluid untargeted metabolomic profiling of aneurysmal subarachnoid hemorrhage: an exploratory study
Lu AY, Damisah EC, Winkler EA, Grant RA, Eid T, Bulsara KR. Cerebrospinal fluid untargeted metabolomic profiling of aneurysmal subarachnoid hemorrhage: an exploratory study. British Journal Of Neurosurgery 2018, 32: 637-641. PMID: 30585503, DOI: 10.1080/02688697.2018.1519107.Peer-Reviewed Original ResearchConceptsAneurysmal subarachnoid hemorrhageGlasgow Outcome ScaleLong-term outcomesASAH patientsSubarachnoid hemorrhageTime pointsCSF samplesHigh-grade aSAH patientsFisher grade 4Cerebrospinal fluid samplesFalse discovery rate correctionSpecific metabolite changesLow disabilitySurgical therapyClinical outcomesCSF metabolitesUntargeted metabolomic profilingOutcome ScaleTissue hypoxiaGrade 3Year postPatientsClinical settingMetabolite predictorsMetabolic changesEffect of epileptiform abnormality burden on neurologic outcome and antiepileptic drug management after subarachnoid hemorrhage
Zafar SF, Postma EN, Biswal S, Boyle EJ, Bechek S, O'Connor K, Shenoy A, Kim J, Shafi MS, Patel AB, Rosenthal ES, Westover MB. Effect of epileptiform abnormality burden on neurologic outcome and antiepileptic drug management after subarachnoid hemorrhage. Clinical Neurophysiology 2018, 129: 2219-2227. PMID: 30212805, PMCID: PMC6478499, DOI: 10.1016/j.clinph.2018.08.015.Peer-Reviewed Original ResearchConceptsAnti-epileptic drugsAneurysmal subarachnoid hemorrhageEpileptiform abnormalitiesWorse outcomesSubarachnoid hemorrhageHigh-grade aSAH patientsEvidence-based treatment protocolsGlasgow Outcome ScoreAntiepileptic drug managementStandard prophylaxisNeurologic outcomeProphylactic protocolASAH patientsOutcome scoresDrug managementHigh burdenRetrospective analysisTreatment protocolOutcome measuresPatientsDaily burdenRhythmic activityFirst dayOutcomesBurden
2017
Electronic Health Data Predict Outcomes After Aneurysmal Subarachnoid Hemorrhage
Zafar SF, Postma EN, Biswal S, Fleuren L, Boyle EJ, Bechek S, O’Connor K, Shenoy A, Jonnalagadda D, Kim J, Shafi MS, Patel AB, Rosenthal ES, Westover MB. Electronic Health Data Predict Outcomes After Aneurysmal Subarachnoid Hemorrhage. Neurocritical Care 2017, 28: 184-193. PMID: 28983801, PMCID: PMC5886829, DOI: 10.1007/s12028-017-0466-8.Peer-Reviewed Original ResearchConceptsAneurysmal subarachnoid hemorrhageGlasgow Outcome ScaleWhite blood cellsIntracranial pressureAPACHE IIElectronic health dataSubarachnoid hemorrhageBetter outcomesSingle-center retrospective cohort studyDischarge Glasgow Outcome ScaleEarly goal-directed therapyAPACHE II scoreGoal-directed therapyRetrospective cohort studyMean arterial pressureRisk stratification scoresAdmission APACHE IIPredictors of outcomeMultivariate analysis predictorsLogistic regression modelsHealth dataAdmission dayII scoreNeurologic outcomeArterial pressureAneurysmal Subarachnoid Hemorrhage
White J, Matouk C. Aneurysmal Subarachnoid Hemorrhage. 2017, 55-74. DOI: 10.1007/978-3-319-48669-7_4.Peer-Reviewed Original ResearchAneurysmal subarachnoid hemorrhageSubarachnoid hemorrhageLong-term cognitive impairmentAdditional neurological injuryCerebral vasospasmHospital admissionOverall mortalityNeurological injurySurgical clippingAneurysmal ruptureEndovascular coilingVascular lesionsRuptured aneurysmsCognitive impairmentEarly identificationHemorrhageAneurysmsDevastating diseaseMortalityRequisite first stepRebleedingVasospasmHydrocephalusAdmissionSeizures
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