2025
Intensive Care After Cardiac Arrest
Hassager C, Meyer M, Perman S, Møller J, Kjaergaard J, Nielsen N, Beske R, Horn J, Lilja G, Skrifvars M. Intensive Care After Cardiac Arrest. European Heart Journal Acute Cardiovascular Care 2025, zuaf119. PMID: 40972086, DOI: 10.1093/ehjacc/zuaf119.Peer-Reviewed Original ResearchCardiac arrest patientsCardiac arrestArrest patientsPost-cardiac arrest syndromeHypoxic-ischemic brain injuryRecurrent cardiac arrestMulti-organ failureRisk of patientsBrain injurySystem ischemiaMyocardial dysfunctionComplex pattern of symptomsReperfusion responseGlobal ischemiaRegained consciousnessIntensive careCessation of circulationPattern of symptomsPatientsArrestIschemiaTherapeutic areasPathological processesInjuryEducational review
2024
Early vigabatrin to augment GABAergic pathways in post-anoxic status epilepticus
Maciel C, Ahmad B, Jose Bruzzone Giraldez M, Eisenschenk S, Ramsay E, Maranchick N, Peloquin C, Hirsch L, Busl K. Early vigabatrin to augment GABAergic pathways in post-anoxic status epilepticus. Epilepsy & Behavior 2024, 160: 110082. PMID: 39393141, DOI: 10.1016/j.yebeh.2024.110082.Peer-Reviewed Original ResearchStatus epilepticusGamma-aminobutyric acidGABAergic pathwayHypoxic-ischemic brain injuryPost-cardiac arrest periodHypoxic-ischemic insultOutcomes of patientsEffective adjunctive therapyInhibition of gamma-aminobutyric acidLondon-Innsbruck ColloquiumAdjunctive therapyAcute seizuresEffective therapyPoor outcomeEpilepticusExclusion criteriaEarly inhibitionSynergistic augmentationGamma-aminobutyric acid catabolismArrest periodTherapeutic nihilismSeizuresClinal trialsAllosteric modulatorsVigabatrinA practical magnetic-resonance imaging score for outcome prediction in comatose cardiac arrest survivors
Chan W, Nguyen C, Kim N, Tripodis Y, Gilmore E, Greer D, Beekman R. A practical magnetic-resonance imaging score for outcome prediction in comatose cardiac arrest survivors. Resuscitation 2024, 202: 110370. PMID: 39178939, DOI: 10.1016/j.resuscitation.2024.110370.Peer-Reviewed Original ResearchHypoxic-ischemic brain injuryDeep gray nucleiArea under the receiver operating curveMagnetic resonance imagingMagnetic Resonance Imaging ScorePoor neurological outcomeCerebral Performance CategoryIntra-class correlationNeurological outcomeMRI scoreCardiac arrestComatose CA survivorsCA survivorsComatose cardiac arrest survivorsPredicting neurologic outcomeCardiac arrest survivorsInter-rater reliabilityReceiver operating curveAcademic medical centerMedian timePoor outcomePrognostic toolGray nucleiArrest survivorsScore group
2023
Temperature Control in the Era of Personalized Medicine: Knowledge Gaps, Research Priorities, and Future Directions
Beekman R, Khosla A, Buckley R, Honiden S, Gilmore E. Temperature Control in the Era of Personalized Medicine: Knowledge Gaps, Research Priorities, and Future Directions. Journal Of Intensive Care Medicine 2023, 39: 611-622. PMID: 37787185, DOI: 10.1177/08850666231203596.Peer-Reviewed Original ResearchHypoxic-ischemic brain injuryCardiac arrestPopulation-based thresholdsDuration of therapyCardiac arrest survivorsCause of deathRobust preclinical evidencePatient-centered careCritical future stepNeurologic outcomeNeuroprotective therapiesPreclinical evidenceArrest survivorsClinical equipoiseBrain injuryCurrent guidelinesFever preventionIndividualized targetOnly interventionTherapeutic windowInsufficient evidenceResearch prioritiesPersonalized approachMetabolic demandsCore temperatureNeurophysiology State Dynamics Underlying Acute Neurologic Recovery After Cardiac Arrest
Amorim E, Zheng W, Jing J, Ghassemi M, Lee J, Wu O, Herman S, Pang T, Sivaraju A, Gaspard N, Hirsch L, Ruijter B, Tjepkema-Cloostermans M, Hofmeijer J, van Putten M, Westover M. Neurophysiology State Dynamics Underlying Acute Neurologic Recovery After Cardiac Arrest. Neurology 2023, 101: e940-e952. PMID: 37414565, PMCID: PMC10501085, DOI: 10.1212/wnl.0000000000207537.Peer-Reviewed Original Research
2022
Bedside monitoring of hypoxic ischemic brain injury using low-field, portable brain magnetic resonance imaging after cardiac arrest
Beekman R, Crawford A, Mazurek MH, Prabhat AM, Chavva IR, Parasuram N, Kim N, Kim JA, Petersen N, de Havenon A, Khosla A, Honiden S, Miller PE, Wira C, Daley J, Payabvash S, Greer DM, Gilmore EJ, Kimberly W, Sheth KN. Bedside monitoring of hypoxic ischemic brain injury using low-field, portable brain magnetic resonance imaging after cardiac arrest. Resuscitation 2022, 176: 150-158. PMID: 35562094, PMCID: PMC9746653, DOI: 10.1016/j.resuscitation.2022.05.002.Peer-Reviewed Original ResearchConceptsCardiac arrestBrain injuryHypoxic-ischemic brain injuryAdverse neurological outcomesIschemic brain injurySingle-center studyBrain magnetic resonanceBrain injury severityBoard-certified neuroradiologistsLow-field MRIFLAIR signal intensityNeurological outcomeCA patientsIll patientsMRI findingsCA survivorsCenter studyMRI examinationsClinical careHigh riskInjury severityPatientsSignal intensityBedside monitoringMR imagingArterial Carbon Dioxide and Acute Brain Injury in Venoarterial Extracorporeal Membrane Oxygenation
Shou BL, Ong CS, Zhou AL, Al-Kawaz MN, Etchill E, Giuliano K, Dong J, Bush E, Kim BS, Choi CW, Whitman G, Cho SM. Arterial Carbon Dioxide and Acute Brain Injury in Venoarterial Extracorporeal Membrane Oxygenation. ASAIO Journal 2022, 68: 1501-1507. PMID: 35671442, PMCID: PMC9477972, DOI: 10.1097/mat.0000000000001699.Peer-Reviewed Original ResearchConceptsAcute brain injuryVenoarterial extracorporeal membrane oxygenationExtracorporeal membrane oxygenationPaCO 2Blood gas dataIntracranial hemorrhageBrain injuryMembrane oxygenationHypoxic-ischemic brain injuryArterial blood gas dataUnivariable logistic regression analysisArterial carbon dioxide tensionTertiary care centerVA-ECMO patientsArterial carbon dioxidePaCO 2 valuesLogistic regression analysisCarbon dioxide tensionPrevalence of ICHVA-ECMOAdult patientsCerebral edemaIschemic strokeCare centerBrain death
2021
Preimplantation factor modulates oligodendrocytes by H19-induced demethylation of NCOR2
Spinelli M, Boucard C, Ornaghi S, Schoeberlein A, Irene K, Coman D, Hyder F, Zhang L, Haesler V, Bordey A, Barnea E, Paidas M, Surbek D, Mueller M. Preimplantation factor modulates oligodendrocytes by H19-induced demethylation of NCOR2. JCI Insight 2021, 6: e132335. PMID: 34676826, PMCID: PMC8564895, DOI: 10.1172/jci.insight.132335.Peer-Reviewed Original ResearchConceptsSynthetic preimplantation factorNuclear receptor corepressor 2PreImplantation FactorHypoxic-ischemic brain injuryDiffuse white matter injuryWhite matter injuryS-adenosylhomocysteine hydrolaseOligodendrocyte differentiation markersMyelin preservationPremature birthBrain recoveryBrain injuryMyelin protectionRNA H19Neurodegenerative diseasesOligodendrocyte fateDifferentiation markersInjuryH19Cellular componentsDiverse cellular componentsOligodendrocytesGliogenesisDiseaseNeurotransmittersNeuromonitoring After Cardiac Arrest Can Twenty-First Century Medicine Personalize Post Cardiac Arrest Care?
Beekman R, Maciel CB, Balu R, Greer DM, Gilmore EJ. Neuromonitoring After Cardiac Arrest Can Twenty-First Century Medicine Personalize Post Cardiac Arrest Care? Neurologic Clinics 2021, 39: 273-292. PMID: 33896519, DOI: 10.1016/j.ncl.2021.01.002.Peer-Reviewed Original ResearchConceptsSecondary brain injuryCardiac arrest careBrain injuryArrest carePost-cardiac arrest syndromeHypoxic-ischemic brain injuryPost-cardiac arrest careEtiology of arrestSecondary neurologic injuryCardiac arrest survivorsNeurologic comorbiditiesNeuromonitoring toolsNeurologic injuryArrest survivorsCardiac arrestNeuromonitoring techniquesCerebral physiologyPhysiologic variablesIndividualized approachRisk profileInjuryHeterogeneous populationCareArrestComorbidities
2020
Acute Brain Injury in Infant Venoarterial Extracorporeal Membrane Oxygenation: An Autopsy Study.
Caturegli G, Cho S, White B, Chen L. Acute Brain Injury in Infant Venoarterial Extracorporeal Membrane Oxygenation: An Autopsy Study. Pediatric Critical Care Medicine 2020, 22: 297-302. PMID: 33055528, DOI: 10.1097/pcc.0000000000002573.Peer-Reviewed Original ResearchConceptsExtracorporeal membrane oxygenationVenoarterial extracorporeal membrane oxygenationAcute brain injuryHypoxic-ischemic brain injuryMembrane oxygenationMedian ageIntracranial hemorrhageExtracorporeal membrane oxygenation support durationExtracorporeal membrane oxygenation durationExtracorporeal membrane oxygenation initiationExtracorporeal membrane oxygenation patientsBrain injuryElevated liver enzymesAssociated with acute brain injuryApgar scoreGestational ageOxygenation durationTiming of acute brain injuryHepatic impairmentAnticoagulant therapyPathology recordsBirth weightOxygenation patientsOxygenation initiationAutopsied patientsUnderstanding Characteristics of Acute Brain Injury in Adult Extracorporeal Membrane Oxygenation: An Autopsy Study.
Cho S, Geocadin R, Caturegli G, Chan V, White B, Dodd-O J, Kim B, Sussman M, Choi C, Whitman G, Chen L. Understanding Characteristics of Acute Brain Injury in Adult Extracorporeal Membrane Oxygenation: An Autopsy Study. Critical Care Medicine 2020, 48: e532-e536. PMID: 32102063, DOI: 10.1097/ccm.0000000000004289.Peer-Reviewed Original ResearchConceptsHypoxic-ischemic brain injuryExtracorporeal membrane oxygenationAcute brain injuryMembrane oxygenationIntracranial hemorrhageExtracorporeal membrane oxygenation nonsurvivorsExtracorporeal membrane oxygenation durationIschemic infarctionVenoarterial extracorporeal membrane oxygenationExtracorporeal membrane oxygenation cannulationExtracorporeal membrane oxygenation patientsRisk factorsCerebral cortexBrain injuryAssociated with acute brain injuryExtracorporeal membrane oxygenator support timeAdult extracorporeal membrane oxygenationOxygenation durationRenal impairmentHepatic impairmentTiming of acute brain injuryAntiplatelet useOxygenation patientsHemoglobin levelsIntracerebral hemorrhage
2018
Low b-value diffusion weighted imaging is promising in the diagnosis of brain death and hypoxic-ischemic injury secondary to cardiopulmonary arrest
Peckham ME, Anderson JS, Rassner UA, Shah LM, Hinckley PJ, de Havenon A, Kim SE, McNally JS. Low b-value diffusion weighted imaging is promising in the diagnosis of brain death and hypoxic-ischemic injury secondary to cardiopulmonary arrest. Critical Care 2018, 22: 165. PMID: 29925413, PMCID: PMC6011248, DOI: 10.1186/s13054-018-2087-9.Peer-Reviewed Original ResearchConceptsHypoxic-ischemic encephalopathyBrain deathGlobal hypoperfusionNormal subjectsDiagnosis of HIEHypoxic-ischemic brain injuryMatter regionsHypoxic-ischemic injuryIschemic brain injurySex-matched controlsLow b-value DWIApparent diffusion coefficient (ADC) valuesGray matter regionsWhite matter regionsWhite matter valuesIschemic encephalopathyDelayed DiagnosisArrest patientsCardiopulmonary arrestCardiorespiratory arrestBrain injuryInclusion criteriaBD subjectsOrgan donorsGray matterS96. EEG reactivity testing practices for cardiac arrest coma prognostication in North America
Amorim E, Gaspard N, Gilmore E, Hahn C, Abend N, Herman S, Hirsch L, Lee J, Cash S, Westover M. S96. EEG reactivity testing practices for cardiac arrest coma prognostication in North America. Clinical Neurophysiology 2018, 129: e178. DOI: 10.1016/j.clinph.2018.04.456.Peer-Reviewed Original ResearchEEG reactivityReactivity testingPractice patternsCritical Care EEG Monitoring Research ConsortiumHypoxic-ischemic brain injuryNorth American academic medical centersCardiac arrest prognosticationNail bed pressureEEG technologistsUnfavorable functional outcomeAcademic medical centerAmerican academic medical centersReactivity assessmentPediatric hospitalFunctional outcomeIctal dischargesBrain injuryMultiple-choice surveyMedical CenterInter-rater agreementStimulation protocolComa prognosticationAuditory stimulationStimulation modalitiesTesting protocol
2008
Clinically Tolerated Strategies for NMDA Receptor Antagonism
Vincent Chen H, Zhang D, Lipton S. Clinically Tolerated Strategies for NMDA Receptor Antagonism. The Receptors 2008, 327-361. DOI: 10.1007/978-1-59745-055-3_8.Peer-Reviewed Original ResearchExcessive NMDAR activityNMDAR activityClinical trialsGlutamate receptorsSide effectsNeurologic disordersNervous systemAcute hypoxic-ischemic brain injuryGeneralized inhibitionAlzheimer's diseaseSecond-generation memantine derivativesHypoxic-ischemic brain injuryPhase 3 clinical trialsExcessive NMDAR activationSevere neuropathic painExcitatory amino acidsGlutamate-mediated neurotoxicityGlutamate receptor subtypesChronic neurodegenerative diseasesSystemic side effectsMajor excitatory transmitterNormal functionNMDA receptor antagonismGreater neuroprotective propertiesCentral nervous system
1992
Open-channel block of N-methyl-D-aspartate (NMDA) responses by memantine: therapeutic advantage against NMDA receptor-mediated neurotoxicity
Chen H, Pellegrini J, Aggarwal S, Lei S, Warach S, Jensen F, Lipton. Open-channel block of N-methyl-D-aspartate (NMDA) responses by memantine: therapeutic advantage against NMDA receptor-mediated neurotoxicity. Journal Of Neuroscience 1992, 12: 4427-4436. PMID: 1432103, PMCID: PMC6576016, DOI: 10.1523/jneurosci.12-11-04427.1992.Peer-Reviewed Original ResearchConceptsNMDA receptor-mediated neurotoxicityMK-801Open channel blockTherapeutic advantageLow micromolar concentrationsNMDA open-channel blockersHypoxic-ischemic brain injuryN-methyl-D-aspartate (NMDA) responsesTherapeutic potentialRetinal ganglion cell neuronsRat stroke modelGanglion cell neuronsLevels of glutamateNMDA receptor stimulationCultures of ratConsiderable therapeutic potentialMechanism of actionOpen channel blockerMicromolar concentrationsClinical entityBrain injuryNMDA antagonistsNMDA receptorsExcessive activationStroke model
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply