2025
Preoperative smoking cessation impacts presentation and neurologic outcomes of carotid endarterectomy
Schwartz A, Carter W, Tonnessen B, Arhuidese I, Cardella J, Dardik A, Ochoa Chaar C. Preoperative smoking cessation impacts presentation and neurologic outcomes of carotid endarterectomy. Journal Of Vascular Surgery 2025 PMID: 40992521, DOI: 10.1016/j.jvs.2025.09.032.Peer-Reviewed Original ResearchVascular Quality InitiativeTransient ischemic attackSmoking cessation durationLong-term outcomesChronic obstructive pulmonary diseaseCessation durationCarotid endarterectomyNeurological outcomeNeurological eventsFollow-upFormer smokersCurrent smokersGroup of former smokersStatistically significant risk reductionDuration of smoking cessationSmoking cessationKaplan-Meier analysisOutcomes of carotid endarterectomyIpsilateral neurologic eventsSignificant risk reductionChronic kidney diseaseDuration of quittingAssociated with outcomeObstructive pulmonary diseasePerioperative mortalityCarotid Revascularization in the Modern Era: A Comparative Review of Carotid Endarterectomy, Carotid Angioplasty and Stenting, and Transcarotid Artery Revascularization
Amllay A, Koo A, Renedo D, Padmanaban V, Teasdale B, Hebert R, Arat A, Duda T, Schindler J, Stapleton C, Rabinov J, Patel A, Matouk C, Sujijantarat N. Carotid Revascularization in the Modern Era: A Comparative Review of Carotid Endarterectomy, Carotid Angioplasty and Stenting, and Transcarotid Artery Revascularization. Seminars In Neurology 2025 PMID: 40889763, DOI: 10.1055/a-2685-3141.Peer-Reviewed Original ResearchTranscarotid artery revascularizationCarotid endarterectomyArtery revascularizationCarotid angioplastyRevascularization strategyIndividual risk-benefit assessmentTF-CASOptimal medical therapyGold standard procedureCarotid artery stenosisCompared to carotid endarterectomyAcute ischemic strokeRisk-benefit assessmentAsymptomatic patientsSymptomatic patientsSurgical riskCarotid revascularization strategiesMedical therapySurgical interventionSurgical techniqueCarotid revascularizationClinical indicationsArtery stenosisRevascularizationPatients
2024
Carotid artery stenting versus carotid endarterectomy for symptomatic or asymptomatic extracranial carotid stenosis: A national cohort study
Krittanawong C, Ang S, Tangsrivimol J, Qadeer Y, Wang Z, Virk H, Khalid U, Sharma S, Dardik A. Carotid artery stenting versus carotid endarterectomy for symptomatic or asymptomatic extracranial carotid stenosis: A national cohort study. Journal Of Stroke And Cerebrovascular Diseases 2024, 33: 108094. PMID: 39424210, DOI: 10.1016/j.jstrokecerebrovasdis.2024.108094.Peer-Reviewed Original ResearchAsymptomatic carotid stenosisCarotid artery stenosisCarotid stenosisArtery stenosisAdverse eventsCohort studyAsymptomatic extracranial carotid stenosisNational population-based cohort studyPopulation-based cohort studyAssociated with lower adverse eventsAssociated with high mortalityAlternative to CEAExtracranial carotid stenosisSymptomatic carotid stenosisMortality of patientsCarotid artery stentingLower adverse eventsNational cohort studyAsymptomatic patientsClinical characteristicsArtery stentingPatient populationCarotid endarterectomyStenosisPatientsAn International, Expert-Based Delphi Consensus Document on Controversial Issues about TransCarotid Artery Revascularization (TCAR)
Paraskevas K, AbuRahma A, Abularrage C, Clair D, Eldrup-Jorgensen J, Kashyap V, Dardik A, de Borst G, Dermody M, Faggioli G, Hicks C, Kwolek C, Lyden S, Mansilha A, Van Herzeele I, Myrcha P, Leal Lorenzo J, Jim J, Pini R, Secemsky E, Spinelli F, Capoccia L, Stone D, Stoner M, Zeebregts C, Lal B, Schneider P, Malas M, Schermerhorn M. An International, Expert-Based Delphi Consensus Document on Controversial Issues about TransCarotid Artery Revascularization (TCAR). Annals Of Vascular Surgery 2024, 110: 42-53. PMID: 39413993, PMCID: PMC12439454, DOI: 10.1016/j.avsg.2024.09.048.Peer-Reviewed Original ResearchTransfemoral carotid artery stentingTranscarotid artery revascularizationRandomized Controlled TrialsCarotid endarterectomyConsensus documentArtery revascularizationAlternative therapeutic modalityManagement of patientsCarotid artery stentingCarotid artery stenosisTreatment of restenosisCarotid stenosis patientsSymptomatic patientsStenosis patientsTherapeutic modalitiesCerebrovascular eventsArtery stenosisArtery stentingControlled TrialsDelphi consensus processPatientsContraindicationsRevascularizationTranscarotidTrialsTranscarotid Arterial Revascularization of Symptomatic Internal Carotid Artery Disease: A Systematic Review and Study-Level Meta-Analysis
Ghannam M, AlMajali M, Khasiyev F, Dibas M, Al Qudah A, AlMajali F, Ghazaleh D, Shah A, Fayad F, Joudi K, Zaidat B, Childs C, Levy B, Abouainain Y, Brunschot D, Shu L, Goldstein E, Baig A, Roeder H, Henninger N, de Havenon A, Levy E, Matouk C, Derdeyn C, Leira E, Chaturvedi S, Yaghi S. Transcarotid Arterial Revascularization of Symptomatic Internal Carotid Artery Disease: A Systematic Review and Study-Level Meta-Analysis. Stroke 2024, 55: 921-930. PMID: 38299350, DOI: 10.1161/strokeaha.123.044246.Peer-Reviewed Original ResearchSymptomatic internal carotid artery diseaseCarotid artery stentingInternal carotid artery diseaseTranscarotid artery revascularizationTransient ischemic attackCarotid artery diseaseCarotid endarterectomyRate of strokeArtery diseaseIschemic attackMyocardial infarctionOdds ratioStudy-level meta-analysisProspective randomized trialsCranial nerve injurySystematic reviewRates of myocardial infarctionPooled odds ratioSymptomatic carotid stenosisDegree of stenosisNerve injuryPatient cohortArtery revascularizationInterventional therapySubgroup analysis
2023
Recent advances and controversial issues in the optimal management of asymptomatic carotid stenosis
Paraskevas K, Brown M, Lal B, Myrcha P, Lyden S, Schneider P, Poredos P, Mikhailidis D, Secemsky E, Musialek P, Mansilha A, Parikh S, Silvestrini M, Lavie C, Dardik A, Blecha M, Liapis C, Zeebregts C, Nederkoorn P, Poredos P, Gurevich V, Jawien A, Lanza G, Gray W, Gupta A, Svetlikov A, Fernandes E Fernandes J, Nicolaides A, White C, Meschia J, Cronenwett J, Schermerhorn M, AbuRahma A. Recent advances and controversial issues in the optimal management of asymptomatic carotid stenosis. Journal Of Vascular Surgery 2023, 79: 695-703. PMID: 37939746, DOI: 10.1016/j.jvs.2023.11.004.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsBest medical treatmentTranscarotid artery revascularizationAsymptomatic carotid stenosisCarotid revascularization proceduresRevascularization proceduresCarotid endarterectomyCarotid stenosisPatient subgroupsRisk prediction modelCognitive dysfunctionOptimal managementStroke risk prediction modelManagement of patientsSpecific patient subgroupsDuplex ultrasound examinationTreatment of patientsIndividual patient preferencesPubMed/PubMed CentralIndividual patient needsCarotid plaque ulcerationMagnetic resonance angiography scansArtery revascularizationSilent infarctsStroke riskCerebrovascular reserveCarotid Artery Operation Delay During the Covid-19 Pandemic: Results of a Multicenter International Study
Kabeil M, Wohlauer M, D'Oria M, Khetarpaul V, Gillette R, Moore E, Colborn K, Cuff R, O'Banion L, Koleilat I, Aziz F, Mouawad N, Kabeil M, Wohlauer M, D’Oria M, Khetarpaul V, Gillette R, Moore E, Colborn K, Cuff R, O’Banion L, Ali A, Lucero L, Costanza M, Hammond E, Motaganahalli R, Samra H, Westin G, Allen K, Sachdev U, Andraska E, Sharafuddin M, Pena-Quevedo J, Koleilat I, Carnevale M, Batarseh P, Tonnessen B, Harroun N, Sataviciute A, Aziz F, Tinelli G, Chuen J, Bath J, Mills J, Afifi R, Coscas R, Shalhub S, Nkansah R, Beck A, St. John R, Malekpour F, Siah M, Kim S, Davies M, Todd G, Busby C, Nelson P, Wyatt S, Ahmed S, Cosentino A, Ghosh A, Miranda J, Torres I, Fakhradiyev I, Kota A, Mier y Teran-Ellis S, Lopez G, Hinojosa C, Gunawansa N, Mouawad N, Singh K. Carotid Artery Operation Delay During the Covid-19 Pandemic: Results of a Multicenter International Study. Annals Of Vascular Surgery 2023, 96: 44-56. PMID: 37355018, DOI: 10.1016/j.avsg.2023.05.041.Peer-Reviewed Original ResearchConceptsCarotid artery stenosisArtery stenosisCarotid stenosisCOVID-19 pandemicCohort of patientsManagement of patientsSignificant carotid stenosisCarotid artery operationsMulticenter international studyCarotid operationsEmergency surgeryMost patientsNeurological deteriorationSurgical delayUrgent operationCarotid endarterectomyMedian lengthOperative delayMedian delayVascular operationsPatientsHospital policiesStenosisCOVID-19International studiesSafety of Carotid Endarterectomy for Symptomatic Stenosis by Age: Meta-Analysis With Individual Patient Data
Leung Y, Bera K, Rodriguez D, Dardik A, Mas J, Simonte G, Rerkasem K, Howard D. Safety of Carotid Endarterectomy for Symptomatic Stenosis by Age: Meta-Analysis With Individual Patient Data. Stroke 2023, 54: 457-467. PMID: 36647921, PMCID: PMC9855737, DOI: 10.1161/strokeaha.122.040819.Peer-Reviewed Original ResearchConceptsIndividual patient dataSymptomatic elderly patientsSymptomatic carotid stenosisCarotid endarterectomyPerioperative strokeElderly patientsStroke riskMedical therapyCarotid stenosisMyocardial infarctionPatient dataStroke risk increasesRecurrent stroke riskSymptomatic stenosisInterventional armPerioperative deathsPerioperative riskAdverse eventsProspective cohortSymptomatic patientsRandomized trialsOutcome ratesObservational studyOctogenariansEndarterectomy
2022
Antiplatelet regimens following carotid artery revascularization
Lee M, Ahmed ZV, Huang J, Brice A, Arham A, Castro-Dominguez Y, Aboian E, Nagpal S, Smolderen KG, Mena-Hurtado C. Antiplatelet regimens following carotid artery revascularization. American Heart Journal 2022, 253: 48-52. PMID: 35863439, DOI: 10.1016/j.ahj.2022.07.004.Peer-Reviewed Original ResearchConceptsDual antiplatelet therapySingle antiplatelet therapyCarotid artery stentingCarotid endarterectomyAntiplatelet therapyReal-world clinical practiceCarotid artery revascularizationLow adherence ratesArtery revascularizationArtery stentingAdherence ratesClinical practicePatientsTherapyEngland dataHigh percentageRevascularizationAntiplateletEndarterectomyStenting
2021
Transcarotid artery revascularization (TCAR): a technical video
Sujijantarat N, Antonios J, Koo A, Renedo D, Cord BJ, Zetchi A, Hebert R, Matouk C. Transcarotid artery revascularization (TCAR): a technical video. Journal Of NeuroInterventional Surgery 2021, 14: neurintsurg-2021-018024. PMID: 34475250, DOI: 10.1136/neurintsurg-2021-018024.Peer-Reviewed Original Research
2020
Regional Anesthesia is Underutilized for Carotid Endarterectomy Despite Improved Perioperative Outcomes Compared with General Anesthesia
Lumas S, Hsiang W, Akhtar S, Ochoa Chaar CI. Regional Anesthesia is Underutilized for Carotid Endarterectomy Despite Improved Perioperative Outcomes Compared with General Anesthesia. Annals Of Vascular Surgery 2020, 73: 336-343. PMID: 33373769, DOI: 10.1016/j.avsg.2020.11.035.Peer-Reviewed Original ResearchConceptsNational Surgical Quality Improvement ProgramCarotid endarterectomyGeneral anesthesiaRegional anesthesiaImproved outcomesSurgeons National Surgical Quality Improvement ProgramChronic obstructive pulmonary diseaseOutcomes of CEASurgical Quality Improvement ProgramCombined end pointObstructive pulmonary diseaseChoice of anestheticQuality Improvement ProgramAnesthesia typeHospital lengthPerioperative outcomesBaseline characteristicsPatient characteristicsCarotid surgeryHeart failurePropensity matchingPulmonary diseaseGA patientsMyocardial infarctionAmerican CollegeSafety of carotid artery revascularization procedures in patients with atrial fibrillation
Nejim B, Mathlouthi A, Weaver L, Faateh M, Arhuidese I, Malas M. Safety of carotid artery revascularization procedures in patients with atrial fibrillation. Journal Of Vascular Surgery 2020, 72: 2069-2078.e4. PMID: 32471737, DOI: 10.1016/j.jvs.2020.01.074.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAtrial FibrillationCarotid Artery DiseasesCerebral HemorrhageCross-Sectional StudiesDatabases, FactualEndarterectomy, CarotidEndovascular ProceduresFemaleHospital MortalityHumansMaleMiddle AgedRetrospective StudiesRisk AssessmentRisk FactorsStentsStrokeTime FactorsTreatment OutcomeUnited StatesConceptsCarotid artery stentingInternational Classification of DiseasesClinical Modification codesClassification of diseasesOdds of intracerebral hemorrhagePredictors of ischemic strokeIntracerebral hemorrhageMultivariate logistic modelIn-Hospital StrokeCarotid artery diseaseCarotid endarterectomyHospital sizeAFib patientsInternational ClassificationModification codesHealthcare databasesMedication useStatistically significant predictorsAdjusted analysesAtrial fibrillationRandomized clinical trialsArtery diseasePremier Healthcare DatabaseAssociated with worse postoperative outcomesCarotid artery revascularization proceduresPresentation and outcomes of carotid endarterectomy in active smokers
Kim TI, Zhang Y, Amin HP, Ochoa Chaar CI. Presentation and outcomes of carotid endarterectomy in active smokers. Journal Of Vascular Surgery 2020, 72: 1720-1727.e1. PMID: 32249043, DOI: 10.1016/j.jvs.2020.02.014.Peer-Reviewed Original ResearchConceptsCarotid endarterectomyRisk factorsWorse outcomesSurgeons National Surgical Quality Improvement ProgramNational Surgical Quality Improvement ProgramChronic obstructive pulmonary diseaseSignificant modifiable risk factorSurgical Quality Improvement ProgramHigh anatomic riskOutcomes of patientsModifiable risk factorsObstructive pulmonary diseaseCarotid artery diseaseImportant risk factorLarge national databaseQuality Improvement ProgramActive smokingEmergent surgeryPreoperative characteristicsActive smokersArtery diseasePropensity matchingPulmonary diseaseSymptomatic presentationSmoking statusInvestigation of Pupillary Changes After Carotid Endarterectomy and Carotid Stent Placement Using Automated Pupillometry
Weerakoon S, Stutzman S, Atem F, Kuchenbecker K, Olson D, Aiyagari V. Investigation of Pupillary Changes After Carotid Endarterectomy and Carotid Stent Placement Using Automated Pupillometry. Journal Of Stroke And Cerebrovascular Diseases 2020, 29: 104693. PMID: 32107154, DOI: 10.1016/j.jstrokecerebrovasdis.2020.104693.Peer-Reviewed Original ResearchConceptsCarotid artery stentingCarotid artery endarterectomyLeft eyeHorner's syndromeDilation velocityAutomated PupillometryConstriction velocityDecreased sympathetic responsePupillary changesPupillary light reflex measurementsCarotid stent placementLeft sided procedureMean pupil sizeCS patientsNo significant differenceStent placementIpsilateral pupilRetrospective analysisContralateral sideSide procedureArtery stentingCarotid endarterectomySympathetic responseReflex measurementsArterial plexus
2019
Carotid Endarterectomy and Carotid Artery Stenting for Patients With Crescendo Transient Ischemic Attacks
Fereydooni A, Gorecka J, Xu J, Schindler J, Dardik A. Carotid Endarterectomy and Carotid Artery Stenting for Patients With Crescendo Transient Ischemic Attacks. JAMA Surgery 2019, 154: 1055-1063. PMID: 31483458, DOI: 10.1001/jamasurg.2019.2952.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsCrescendo transient ischemic attacksTransient ischemic attackIschemic attackUrgent carotid endarterectomyCarotid endarterectomyTiming of interventionMedical managementSingle transient ischemic attackIntravenous heparin therapyPreoperative medical managementTiming of revascularizationDual antiplatelet therapyAcute neurological eventsOptimal medical managementProhibitive surgical riskCarotid artery stentingHours of presentationMultiple recurrent episodesRandomized clinical trialsAnalysis of patientsCarotid artery plaquesDays of presentationEnglish-language articlesEvidence-based medicineAntiplatelet therapyIschaemic stroke
Campbell B, De Silva D, Macleod M, Coutts S, Schwamm L, Davis S, Donnan G. Ischaemic stroke. Nature Reviews Disease Primers 2019, 5: 70. PMID: 31601801, DOI: 10.1038/s41572-019-0118-8.Peer-Reviewed Original ResearchConceptsIschemic strokeIntravenous thrombolysisEndovascular thrombectomyStroke onsetSevere symptomatic carotid artery stenosisSymptomatic carotid artery stenosisSalvageable brain tissueBlood pressure controlCardiovascular risk managementLarge vessel occlusionMajority of strokesMechanism of strokeOnset of strokeCarotid artery stenosisCause of disabilitySecond highest causeSystems of careAntithrombotic medicationRapid reperfusionReperfusion therapySecondary preventionStroke symptomsArterial occlusionArtery stenosisCarotid endarterectomyPerioperative Stroke in Carotid Artery Stenting as a Surrogate Marker and Predictor for 30-day Postprocedural Mortality - A Pooled Analysis of 156,000 Patients with Carotid Artery Disease.
Altibi A, Saca E, Dhillon H, Thirumala P. Perioperative Stroke in Carotid Artery Stenting as a Surrogate Marker and Predictor for 30-day Postprocedural Mortality - A Pooled Analysis of 156,000 Patients with Carotid Artery Disease. Neurology India 2019, 67: 1423-1428. PMID: 31857527, DOI: 10.4103/0028-3886.273642.Peer-Reviewed Original ResearchConceptsPredicting 30-day mortalityCarotid artery stenosisTransient ischemic attackPerioperative strokeCarotid endarterectomyOdds ratioOccurrence of perioperative strokeHigh-risk surgical patientsRelative riskPerioperative transient ischemic attackIncreased risk of strokeBilateral carotid diseasePooled odds ratioDetect intraoperative cerebral ischemiaSevere carotid stenosisCarotid artery stentingIntraoperative cerebral ischemiaCarotid artery diseaseCarotid stenosis patientsRisk of strokePatient ageStenosis patientsNeurophysiological monitoringPooled ORNeurological status
2018
Outcomes after carotid endarterectomy among elderly dual Medicare-Medicaid-eligible patients.
Leifheit EC, Wang Y, Howard G, Howard VJ, Goldstein LB, Brott TG, Lichtman JH. Outcomes after carotid endarterectomy among elderly dual Medicare-Medicaid-eligible patients. Neurology 2018, 91: e1553-e1558. PMID: 30266891, PMCID: PMC6205687, DOI: 10.1212/wnl.0000000000006380.Peer-Reviewed Original ResearchConceptsCarotid endarterectomyDual-eligible patientsRelative annual reductionService Medicare beneficiariesDual-eligible statusYears of ageDual-eligible beneficiariesEligible patientsCause mortalityCause readmissionClinical characteristicsIschemic strokeAdjusted analysisStudy cohortWorse outcomesMedicaid coverageMedicare beneficiariesDual eligiblesPatientsMedicaid benefitsMedicare-MedicaidMedicareOutcomesEndarterectomyHigh rateRisks Associated With Primary and Redo Carotid Endarterectomy in the Endovascular Era
Arhuidese I, Faateh M, Nejim B, Locham S, Abularrage C, Malas M. Risks Associated With Primary and Redo Carotid Endarterectomy in the Endovascular Era. JAMA Surgery 2018, 153: 252-259. PMID: 29117272, PMCID: PMC5885921, DOI: 10.1001/jamasurg.2017.4477.Peer-Reviewed Original ResearchConceptsPrimary carotid endarterectomyRedo carotid endarterectomyAsymptomatic patientsSymptomatic patientsCarotid endarterectomyMyocardial infarctionProspective cohort of patientsPoint of careCohort of patientsPerioperative myocardial infarctionRisk of deathAsymptomatic carotid stenosisVascular Quality InitiativeRisk of strokeExcess riskMain OutcomesSociety for Vascular SurgeryClinicians' expectationsCommunity hospitalProfessional guidelinesConsecutive patientsProspective cohortNo significant differenceEndovascular therapyQuality Initiative
2017
Outcomes of Primary and Secondary Carotid Artery Stenting
Arhuidese I, Rizwan M, Nejim B, Malas M. Outcomes of Primary and Secondary Carotid Artery Stenting. Stroke 2017, 48: 3086-3092. PMID: 28974632, DOI: 10.1161/strokeaha.117.016963.Peer-Reviewed Original ResearchConceptsAssociated with significantly lower oddsSymptomatic patientsSignificantly lower oddsLower oddsIpsilateral carotid endarterectomyCox regression analysisOdds of hypotensionCarotid artery stentingVascular Quality InitiativeAsymptomatic patientsOdds of hypertensionKaplan-MeierPeriprocedural stroke/deathCAS proceduresPeriprocedural hypotensionArtery stentingCarotid angioplastyCarotid endarterectomyPatientsStroke/deathEvaluate outcomesOddsHypotensionBradycardiaStent
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