2025
Incidence of Concurrent Cerebral Desaturation and Electroencephalographic Burst Suppression in Cardiac Surgery Patients
Ramachandran R, Behera A, Hussain Z, Peck J, Ananthakrishanan A, Mathur P, Banner-Goodspeed V, Muehlschlegel J, Pittet J, Bardia A, Schonberger R, Marcantonio E, Kveraga K, Subramaniam B. Incidence of Concurrent Cerebral Desaturation and Electroencephalographic Burst Suppression in Cardiac Surgery Patients. Anesthesia & Analgesia 2025, 140: 1086-1092. PMID: 39446661, PMCID: PMC11996613, DOI: 10.1213/ane.0000000000007209.Peer-Reviewed Original ResearchCerebral desaturationAortic cross-clampingCardiac surgeryPost-CPBBurst suppressionCross-clampingRemoval of aortic cross-clampCerebral oximetryAssociated with postoperative deliriumPhase of cardiac surgeryCardiac surgery patientsElectroencephalographic burst suppressionConfidence intervalsIntraoperative burst suppressionPostoperative cognitive functionPre-CPBPrecardiopulmonary bypassSurgery patientsEntire surgeryEEG monitoringPostoperative deliriumTargeted interventionsOdds ratioSurgerySurgical phaseRetrospective Visual and Quantitative Assessment of Burst Suppression With and Without Identical Bursts in Patients After Cardiac Arrest
Fong M, Pu K, Beekman R, Kim N, Nguyen C, Gilmore E, Hirsch L, Zaveri H. Retrospective Visual and Quantitative Assessment of Burst Suppression With and Without Identical Bursts in Patients After Cardiac Arrest. Neurocritical Care 2025, 1-11. PMID: 39900751, DOI: 10.1007/s12028-024-02208-7.Peer-Reviewed Original ResearchIdentical burstsBurst suppressionCardiac arrest survivorsInterburst intervalClinical featuresNeurological outcomeCardiac arrestArrest survivorsAssociated with poor neurological outcomeContinuous electroencephalogramCerebral Performance Category scoreAssociated with poor outcomesCardiac arrest patientsPoor neurological outcomePost-cardiac arrestPredictors of mortalityUS academic medical centersEEG backgroundPrognostic significanceArrest patientsClinical outcomesPoor outcomeRetrospective analysisAcademic medical centerUS cohort
2024
EEG for good outcome prediction after cardiac arrest: A multicentre cohort study
Turella S, Dankiewicz J, Ben-Hamouda N, Nilsen K, Düring J, Endisch C, Engstrøm M, Flügel D, Gaspard N, Grejs A, Haenggi M, Haffey S, Imbach L, Johnsen B, Kemlink D, Leithner C, Legriel S, Lindehammar H, Mazzon G, Nielsen N, Peyre A, Stanford B, Roman-Pognuz E, Rossetti A, Schrag C, Valeriánová A, Wendel-Garcia P, Zubler F, Cronberg T, Westhall E, investigators T. EEG for good outcome prediction after cardiac arrest: A multicentre cohort study. Resuscitation 2024, 202: 110319. PMID: 39029579, DOI: 10.1016/j.resuscitation.2024.110319.Peer-Reviewed Original ResearchConceptsMalignant EEG patternsEEG reactivityReactive EEGsCardiac arrestComatose patientsEEG patternsOut-of-hospital cardiac arrest trialModified Rankin Scale scoreMulticentre cohort studyRankin Scale scoreLong-term outcomesOut-of-hospitalCardiac arrest trialsSpecificity of EEGEEG assessmentHospital stayGood outcomeMultimodal prognosticationPrognostic performanceNon-highlyPrognostic abilityCohort studyMalignant patternArrest trialsBurst suppression
2023
The International Cardiac Arrest Research Consortium Electroencephalography Database
Amorim E, Zheng W, Ghassemi M, Aghaeeaval M, Kandhare P, Karukonda V, Lee J, Herman S, Sivaraju A, Gaspard N, Hofmeijer J, van Putten M, Sameni R, Reyna M, Clifford G, Westover M. The International Cardiac Arrest Research Consortium Electroencephalography Database. Critical Care Medicine 2023, 51: 1802-1811. PMID: 37855659, PMCID: PMC10841086, DOI: 10.1097/ccm.0000000000006074.Peer-Reviewed Original ResearchConceptsCardiac arrestNeurologic outcomeCerebral Performance Category scaleContinuous electroencephalography monitoringGood functional recoverySevere neurologic disabilityIctal-interictal continuumIndividuals 16 yearsBrain injury researchCardiac arrest researchMost patientsNeurologic disabilityMulticenter cohortSpontaneous circulationComatose patientsFunctional recoveryEpileptiform activityElectroencephalography monitoringTeaching hospitalBackground continuityClinical dataBurst suppressionPatientsEpileptiform patternsSpike frequency
2021
Processed intraoperative burst suppression and postoperative cognitive dysfunction in a cohort of older noncardiac surgery patients
Dustin Boone M, Lin H, Liu X, Kim J, Sano M, Baxter M, Sieber F, Deiner S. Processed intraoperative burst suppression and postoperative cognitive dysfunction in a cohort of older noncardiac surgery patients. Journal Of Clinical Monitoring And Computing 2021, 36: 1433-1440. PMID: 34862586, DOI: 10.1007/s10877-021-00783-0.Peer-Reviewed Original ResearchConceptsPostoperative cognitive dysfunctionIntraoperative burst suppressionNoncardiac surgery patientsSurgery patientsBurst suppressionEEG monitoringAssociated with postoperative cognitive dysfunctionCognitive dysfunctionZ-scoreBaseline z-scoresIntraoperative anesthetic managementReduced alpha-band powerPreventing postoperative cognitive dysfunctionProspective cohort studyClinical trial numberPeriods of electrical silenceElective surgery patientsYears of ageDetect burst suppressionProcessed EEG monitoringPreoperative baselineBurst suppression ratioHigh-voltage activityOlder age groupsComposite z-score
2016
A major miss in prognostication after cardiac arrest: Burst suppression and brain healing
Becker D, Schiff N, Becker L, Holmes M, Fins J, Horowitz J, Devinsky O. A major miss in prognostication after cardiac arrest: Burst suppression and brain healing. Epilepsy & Behavior Reports 2016, 7: 1-5. PMID: 28053858, PMCID: PMC5198796, DOI: 10.1016/j.ebcr.2016.09.004.Peer-Reviewed Original ResearchCardiac arrestBurst suppressionTherapeutic hypothermiaLoss of brainstem reflexesMechanisms of therapeutic hypothermiaOut-of-hospital cardiac arrestAbsent motor responseStatus epilepticusBrainstem reflexesNeuronal cell deathFunctional capacityStandard criteriaCell deathArrestNegative endpointsHypothermiaMotor responseEnd-of-life decisionsBrain healingEnd-of-lifeEpilepticusSuppressionEndpoint
2006
In Nonconvulsive Status Epilepticus (NCSE), Treat to Burst‐Suppression: Pro and Con
Jordan KG, Hirsch LJ. In Nonconvulsive Status Epilepticus (NCSE), Treat to Burst‐Suppression: Pro and Con. Epilepsia 2006, 47: 41-45. PMID: 17044825, DOI: 10.1111/j.1528-1167.2006.00659.x.Peer-Reviewed Original ResearchConceptsNonconvulsive status epilepticusNonconvulsive seizuresRefractory nonconvulsive status epilepticusPermanent neuronal injuryAcute brain injuryIntensive care interventionsHigh mortality rateNeuronal injuryStatus epilepticusIatrogenic complicationsBrain damageBrain injuryCare interventionsDr. HirschBurst suppressionMortality rateExpert managementSeizuresInjuryMost casesEpilepticusMedicationsComplicationsDr. Jordan
2003
Treatment of status epilepticus: a survey of neurologists
Claassen J, Hirsch LJ, Mayer SA. Treatment of status epilepticus: a survey of neurologists. Journal Of The Neurological Sciences 2003, 211: 37-41. PMID: 12767495, DOI: 10.1016/s0022-510x(03)00036-4.Peer-Reviewed Original ResearchConceptsAntiepileptic drugsStatus epilepticusCurrent treatment preferencesElimination of seizuresFourth-line treatmentTreatment of RSESecond-line therapyConvulsive status epilepticusFirst-line therapyNew antiepileptic drugsTraditional treatment paradigmSurvey of neurologistsIntravenous lorazepamSE refractoryTitration goalsMulticenter trialTreatment paradigmTreatment preferencesCritical careValproic acidBurst suppressionAmerican AcademyEpilepticusEpilepsy SectionTherapy
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