2025
The implementation of artificial intelligence in serial monitoring of post gamma knife vestibular schwannomas: A pilot study
Singh M, Jester N, Lorr S, Briano A, Schwartz N, Mahajan A, Chiang V, Tommasini S, Wiznia D, Buono F. The implementation of artificial intelligence in serial monitoring of post gamma knife vestibular schwannomas: A pilot study. Clinical Imaging 2025, 123: 110495. PMID: 40388858, DOI: 10.1016/j.clinimag.2025.110495.Peer-Reviewed Original ResearchConceptsGamma knife radiosurgeryVestibular schwannomaPost-GKSTumor growthVS volumeHalting tumor growthRetrospective cohort studyAssess treatment efficacyManual segmentationHearing lossBenign tumorsPaired t-testT1-weighted MRI scansAssess statistical significanceCohort studyDice similarity coefficientNeurological functionTreatment efficacyClinical monitoringMRI scansStatistical significancePercentage changeSchwannomaSpatial overlapTumor
2024
RADT-45. INTEGRATION OF FUNCTIONAL MAGNETIC RESONANCE IMAGING INTO STEREOTACTIC RADIOSURGERY PLANNING TO REDUCE SYMPTOMATIC RADIATION NECROSIS
Gui C, Jenabi M, Daly J, Gillick C, Bradley T, Sze E, Maldonado R, Tiwari A, Stember J, Mankuzhy N, Yamada Y, Pike L, Pasquini L, Peck K, Ballangrud-Popovic Å, Holodny A, Imber B. RADT-45. INTEGRATION OF FUNCTIONAL MAGNETIC RESONANCE IMAGING INTO STEREOTACTIC RADIOSURGERY PLANNING TO REDUCE SYMPTOMATIC RADIATION NECROSIS. Neuro-Oncology 2024, 26: viii83-viii83. PMCID: PMC11554023, DOI: 10.1093/neuonc/noae165.0329.Peer-Reviewed Original ResearchStereotactic radiosurgerySymptomatic RNRadiation necrosisBrain metastasesNeurological symptomsDosimetric analysisTarget coverageComplications of stereotactic radiosurgeryMonths of SRSSacrificing target coverageSymptomatic radiation necrosisUnresectable brain metastasesMonths post-SRSEloquent cortical areasFunctional magnetic resonance imagingFocal neurological symptomsMagnetic resonance imagingRadiosurgery planningPost-SRSSRS plansPrimary motorEloquent areasNeurological functionPatientsResonance imagingSex Differences in the Blood Metabolome During Acute Response to Ischemic Stroke
Dylla L, Higgins H, Stephenson D, Reisz J, Vu T, Poisson S, Herson P, Monte A. Sex Differences in the Blood Metabolome During Acute Response to Ischemic Stroke. Journal Of Women's Health 2024, 33: 1378-1384. PMID: 38946610, PMCID: PMC11564668, DOI: 10.1089/jwh.2023.1133.Peer-Reviewed Original ResearchIschemic strokeLinear regression modelsMass spectrometry-based metabolomicsLifetime risk of strokeAssociated with neurological outcomeDifferentially expressed metabolitesRegression modelsAcute ischemic strokeRisk of strokeComprehensive stroke centerBlood metabolomeNeurological outcomeAcute treatmentMetabolomic profilesLifetime riskNeurological functionIndividual metabolitesTherapeutic potentialStroke centersAcute responseResults:</i></b>Study objectiveMetabolomicsStrokeNIHSSIntravenous infusion of auto-serum-expanded autologous mesenchymal stem cells into chronic severe brain injury patients
Yamaki T, Oka S, Iyama S, Sasaki M, Onodera R, Kataoka-Sasaki Y, Namioka T, Namioka A, Nakazaki M, Takemura M, Ukai R, Yokoyama T, Sasaki Y, Yamashita T, Kobayashi M, Yamaguchi M, Fukino M, Takazawa T, Hayasaka M, Owaku T, Funakura M, Onodera S, Ito Y, Kobune M, Kato J, Ishiai S, Kocsis J, Odaki M, Iwadate Y, Kobayashi S, Honmou O. Intravenous infusion of auto-serum-expanded autologous mesenchymal stem cells into chronic severe brain injury patients. Interdisciplinary Neurosurgery 2024, 36: 101927. DOI: 10.1016/j.inat.2023.101927.Peer-Reviewed Original ResearchSevere brain injury patientsAutologous mesenchymal stem cellsBrain injury patientsIntravenous infusionMesenchymal stem cellsAdverse eventsInjury patientsInfused mesenchymal stem cellsHealth Stroke ScaleSerious adverse eventsFugl-Meyer AssessmentInitial case seriesBrain metabolic activityStem cellsMSC infusionStroke ScaleNeurological deteriorationBarthel IndexCase seriesCNS tumorsNeurological functionFunctional statusFunctional improvementChronic patientsPlacebo effectComa Prognostication After Acute Brain Injury
Fischer D, Edlow B. Coma Prognostication After Acute Brain Injury. JAMA Neurology 2024, 81: 405-415. PMID: 38436946, DOI: 10.1001/jamaneurol.2023.5634.Peer-Reviewed Original ResearchMagnetic resonance imagingPrognostic markerAcute brain injuryLife-sustaining treatmentBrain injury etiologyPatient's current levelPrediction of neurological recoveryHealth care costsBrain injuryPatient valuesInjury etiologyCare costsPrognostic utilityComa prognosticationSerological markersClinical guidelinesComputed tomographyNeurological recoveryNeurological examinationDisorders of consciousnessNeurological assessmentNeurological functionPredictive valueResonance imagingNeuroprognosticationA Prospective Cohort Study of Antimony Exposure and Cognitive Impairment in Older Adults — China, 2017–2021
Qiu Y, Ji S, Chen C, Zhou J, Wang J, Wu B, Wei Y, Li F, Zheng X, Xu L, Zhang Z, Zhao F, Chen G, Ji J, Lyu Y, Tong S, Shi X. A Prospective Cohort Study of Antimony Exposure and Cognitive Impairment in Older Adults — China, 2017–2021. China CDC Weekly 2024, 6: 537-541. PMID: 38933661, PMCID: PMC11196874, DOI: 10.46234/ccdcw2024.104.Peer-Reviewed Original Research
2023
Therapeutic efficacy of intravenous infusion of mesenchymal stem cells in rat perinatal brain injury
Terada K, Sasaki M, Nagahama H, Kataoka-Sasaki Y, Oka S, Ukai R, Yokoyama T, Iizuka Y, Sakai T, Fukumura S, Tsugawa T, Kocsis J, Honmou O. Therapeutic efficacy of intravenous infusion of mesenchymal stem cells in rat perinatal brain injury. Pediatric Research 2023, 94: 1921-1928. PMID: 37422495, DOI: 10.1038/s41390-023-02717-9.Peer-Reviewed Original ResearchConceptsPerinatal brain injuryBrain injuryMesenchymal stem cellsIntravenous infusionVehicle groupBrain volumeTherapeutic efficacyInfused mesenchymal stem cellsLeft common carotid arteryHistological analysisNon-ischemic hemispherePostnatal day 7Common carotid arteryEmbryonic day 18Stem cellsHypoxia-ischemiaMSC infusionPreterm infantsGABAergic cellsNeurological functionSignificant complicationsCortical synapsesFunctional improvementCarotid arteryIntravenous administration
2022
Basic principles of neuroimmunology
Yoshida TM, Wang A, Hafler DA. Basic principles of neuroimmunology. Seminars In Immunopathology 2022, 44: 685-695. PMID: 35732977, DOI: 10.1007/s00281-022-00951-7.Peer-Reviewed Original ResearchConceptsNeuro-immune interactionsCentral nervous systemImmune privilegeCerebrospinal fluidCNS-resident immune cellsImmune-derived cytokinesResident T cellsImmune cell infiltrationImmune-privileged organMeningeal lymphatic systemIntroduction of antigenImmune compartmentNeuroinflammatory diseasesNeurological functionCNS homeostasisCell infiltrationHarmful inflammationImmune cellsPeripheral organsT cellsImmune responseLeukocyte traffickingNervous systemImmune systemLymphatic system
2021
Clinical presentation of new onset refractory status epilepticus in children (the pSERG cohort)
Sculier C, Aguilar C, Gaspard N, Gaínza‐Lein M, Fernández I, Amengual‐Gual M, Anderson A, Arya R, Burrows B, Brenton J, Carpenter J, Chapman K, Clark J, Gaillard W, Glauser T, Goldstein J, Goodkin H, Gorman M, Lai Y, McDonough T, Mikati M, Nayak A, Peariso K, Riviello J, Rusie A, Sperberg K, Stredny C, Tasker R, Tchapyjnikov D, Vasquez A, Wainwright M, Wilfong A, Williams K, Loddenkemper T, pSERG. Clinical presentation of new onset refractory status epilepticus in children (the pSERG cohort). Epilepsia 2021, 62: 1629-1642. PMID: 34091885, PMCID: PMC8362203, DOI: 10.1111/epi.16950.Peer-Reviewed Original ResearchConceptsOnset refractory status epilepticusRefractory status epilepticusRefractory SEFebrile SEStatus epilepticusUnknown etiologyBaseline neurological functionSE onsetMedian ageProlonged SESE episodesClinical presentationPediatric patientsClinical characteristicsFever onsetClinical profileSubgroup analysisNeurological functionEpilepsy syndromesPatientsFeverDiagnostic criteriaEpilepticusEtiologyBaseline functionDuration of Hyperoxia and Neurologic Outcomes in Patients Undergoing Extracorporeal Membrane Oxygenation
Al-Kawaz M, Canner J, Caturegli G, Kannapadi N, Balucani C, Shelley L, Kim B, Choi C, Geocadin R, Whitman G, Cho S. Duration of Hyperoxia and Neurologic Outcomes in Patients Undergoing Extracorporeal Membrane Oxygenation. Critical Care Medicine 2021, 49: e968-e977. PMID: 33935164, DOI: 10.1097/ccm.0000000000005069.Peer-Reviewed Original ResearchConceptsVenoarterial extracorporeal membrane oxygenationExtracorporeal membrane oxygenationPoor neurological outcomeNeurological outcomeMembrane oxygenationDuration of hyperoxiaSevere hyperoxiaExtracorporeal membrane oxygenation patientsAssociated with poor neurological outcomeVenoarterial extracorporeal membrane oxygenation patientsMultivariate logistic regression analysisArea under the curveModified Rankin ScaleAssociated with inhospital mortalityLogistic regression analysisJohns Hopkins HospitalOxygenation patientsRetrospective analysisInhospital mortalityMultivariate analysisPrimary outcomeRankin ScaleNeurological functionPatientsPaO2 values
2020
Tissue plasminogen activator mobilizes neutrophils and T cells that exacerbate hemorrhagic transformation in stroke
Shi K, Liu Q, Jia D, Yang X, Zou M, Shi S, Dong J, Sheth K, Wang X, Shi F. Tissue plasminogen activator mobilizes neutrophils and T cells that exacerbate hemorrhagic transformation in stroke. The Journal Of Immunology 2020, 204: 64.21-64.21. DOI: 10.4049/jimmunol.204.supp.64.21.Peer-Reviewed Original ResearchTissue plasminogen activatorT cellsEmbolic strokeHemorrhagic transformationNeurovascular unitThrombolytic therapyBrain hemorrhageEffects of tPAPlasminogen activatorFocal embolic strokeIschemic stroke patientsMyeloid cell recruitmentMigration of neutrophilsTPA thrombolysisHemorrhagic complicationsIschemic strokeLymphocyte egressEndothelial injuryNeurological functionStroke patientsImmune modulationRat modelCell recruitmentImmune invasionNeutrophils
2019
Standards for Studies of Neurological Prognostication in Comatose Survivors of Cardiac Arrest: A Scientific Statement From the American Heart Association
Geocadin RG, Callaway CW, Fink EL, Golan E, Greer DM, Ko NU, Lang E, Licht DJ, Marino BS, McNair ND, Peberdy MA, Perman SM, Sims DB, Soar J, Sandroni C, Committee O. Standards for Studies of Neurological Prognostication in Comatose Survivors of Cardiac Arrest: A Scientific Statement From the American Heart Association. Circulation 2019, 140: e517-e542. PMID: 31291775, DOI: 10.1161/cir.0000000000000702.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsLife-sustaining treatmentCardiac arrest survivorsNeurological prognosticationPrognostication studiesPoor outcomeArrest survivorsBrain injuryMeaningful neurological recoveryWidespread brain injuryAmerican Heart AssociationCardiac arrest resuscitationIntensive care medicineQuality of lifeWriting groupComatose survivorsNeurological recoveryNeurological functionCardiac arrestFunctional outcomeHeart AssociationResuscitation careComatose statePediatric expertsAccurate prognosticationClinical studiesTargeted temperature management for cardiac arrest
Mody P, Kulkarni N, Khera R, Link MS. Targeted temperature management for cardiac arrest. Progress In Cardiovascular Diseases 2019, 62: 272-278. PMID: 31078561, DOI: 10.1016/j.pcad.2019.05.007.Peer-Reviewed Original ResearchConceptsHospital sudden cardiac arrestSudden cardiac arrestTemperature managementCardiac arrestSurvivors of SCAInitial shockable rhythmTargeted temperature managementInitial clinical trialsNon-shockable rhythmCore body temperatureTherapeutic hypothermiaDuration of coolingNeurological functionShockable rhythmPatient populationClinical trialsCurrent guidelinesNeurological damageCurrent evidenceSevere hypoxiaSurvivorsBody temperatureReview articleArrestSignificant improvement
2018
Intraosseous versus intravenous access in patients with out-of-hospital cardiac arrest: Insights from the resuscitation outcomes consortium continuous chest compression trial
Mody P, Brown SP, Kudenchuk PJ, Chan PS, Khera R, Ayers C, Pandey A, Kern K, de Lemos JA, Link MS, Idris AH. Intraosseous versus intravenous access in patients with out-of-hospital cardiac arrest: Insights from the resuscitation outcomes consortium continuous chest compression trial. Resuscitation 2018, 134: 69-75. PMID: 30391366, DOI: 10.1016/j.resuscitation.2018.10.031.Peer-Reviewed Original ResearchConceptsFavorable neurological functionIntravenous accessNeurological functionIntraosseous accessCompression trialHospital cardiac arrest resuscitationInitial drug administrationHospital cardiac arrestCardiac arrest resuscitationOptimal access routeDelivery of medicationsBystander cardiopulmonary resuscitationRate of survivalSustained ROSCHospital survivalInitial rhythmHospital dischargeOHCA patientsROSC rateSpontaneous circulationUnadjusted outcomesSustained returnCardiac arrestCardiopulmonary resuscitationPatientsBrain Biomarker Interpretation in ASD Using Deep Learning and fMRI
Li X, Dvornek NC, Zhuang J, Ventola P, Duncan JS. Brain Biomarker Interpretation in ASD Using Deep Learning and fMRI. Lecture Notes In Computer Science 2018, 11072: 206-214. PMID: 32984865, PMCID: PMC7519581, DOI: 10.1007/978-3-030-00931-1_24.Peer-Reviewed Original ResearchDeep neural networksFunctional magnetic resonance imagingBrain functional magnetic resonance imagingAutism spectrum disorderComputer visionDeep learningDNN classifierMagnetic resonance imagingCorrupt imagesNeural networkSaliency featuresClassification scenariosNeurological functionControl subjectsComplex neurodevelopmental disorderEarly diagnosisComputational decisionReliable biomarkersResonance imagingBiomarker interpretationBiomarkersDetected biomarkersNeurodevelopmental disordersBrain featuresClassifier
2017
Chapter 10 Sur1–Trpm4-Promising Target for Brain Edema Treatment in Brain Edema From Molecular Mechanisms to Clinical Practice
Urday S, Sheth K, Simard J. Chapter 10 Sur1–Trpm4-Promising Target for Brain Edema Treatment in Brain Edema From Molecular Mechanisms to Clinical Practice. 2017, 183-198. DOI: 10.1016/b978-0-12-803196-4.00010-2.Peer-Reviewed Original ResearchSUR1-TRPM4Brain edemaEdema formationDefinitive phase III studyBrain edema treatmentNeurocritical care conditionsPhase III studyAcute neurological injuryExtravasation of bloodType of edemaMicrovascular failureIII studySignificant morbidityNeurological functionNeurological injuryEdema treatmentSafe medicationSelective blockadeLesion volumeClinical studiesPetechial hemorrhagesCare conditionsEdemaClinical practiceSulfonylurea receptor
2014
NGLY1 mutation causes neuromotor impairment, intellectual disability, and neuropathy
Caglayan AO, Comu S, Baranoski JF, Parman Y, Kaymakçalan H, Akgumus GT, Caglar C, Dolen D, Erson-Omay EZ, Harmanci AS, Mishra-Gorur K, Freeze HH, Yasuno K, Bilguvar K, Gunel M. NGLY1 mutation causes neuromotor impairment, intellectual disability, and neuropathy. European Journal Of Medical Genetics 2014, 58: 39-43. PMID: 25220016, PMCID: PMC4804755, DOI: 10.1016/j.ejmg.2014.08.008.Peer-Reviewed Original ResearchConceptsN-glycanase 1Proteasome-mediated degradationConserved enzymeFrame-shift mutationApparent intellectual disabilityBase pair deletionNeuromotor impairmentNovel homozygous frame-shift mutationHomozygous frame-shift mutationNeuronal cellsPair deletionAmyotrophic lateral sclerosisIntellectual disabilityMutationsProteinNeurological functionCorneal opacityNeurologic diseaseLateral sclerosisParkinson's diseaseProgressive lossDiseaseCytoplasmImpairmentDeletionStereotactic radiosurgery of petroclival meningiomas: a multicenter study
Starke R, Kano H, Ding D, Nakaji P, Barnett GH, Mathieu D, Chiang V, Yu JB, Hess J, McBride HL, Honea N, Lee JY, Rahmathulla G, Evanoff WA, Alonso-Basanta M, Lunsford LD, Sheehan JP. Stereotactic radiosurgery of petroclival meningiomas: a multicenter study. Journal Of Neuro-Oncology 2014, 119: 169-176. PMID: 24821284, DOI: 10.1007/s11060-014-1470-x.Peer-Reviewed Original ResearchConceptsGamma knife radiosurgeryPetroclival meningiomasMulticenter studyFavorable outcomeTumor volumeActuarial progression-free survival ratesNorth American Gamma Knife ConsortiumProgression-free survival ratesFree survival ratePrimary treatment modalityProgression of symptomsSmaller tumor volumeComplete microsurgical resectionNeurological preservationUpfront radiosurgeryPrior radiotherapyMost patientsMicrosurgical resectionSignificant morbidityNeurological functionMaximal doseTumor controlTreatment modalitiesKnife radiosurgeryFemale gender
2013
Therapeutic Potential of Human Induced Pluripotent Stem Cells in Experimental Stroke
Chang DJ, Lee N, Park IH, Choi C, Jeon I, Kwon J, Oh SH, Shin DA, Tae J, Lee DR, Lee H, Hong K, Daley G, Song J, Moon H. Therapeutic Potential of Human Induced Pluripotent Stem Cells in Experimental Stroke. Cell Transplantation 2013, 22: 1427-1440. PMID: 23044029, DOI: 10.3727/096368912x657314.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisBehavior, AnimalCell DifferentiationCell LineCell TrackingDisease Models, AnimalGliosisHumansInduced Pluripotent Stem CellsInfarction, Middle Cerebral ArteryInflammationMagnetic Resonance ImagingMaleMiceNeural Stem CellsNeurogenesisNeuronsRatsRats, Sprague-DawleyStem Cell TransplantationStrokeConceptsMiddle cerebral artery occlusionNeural precursor cellsNeural stem cellsStroke-induced inflammatory responseTherapeutic potentialMCAO stroke modelCerebral artery occlusionPeri-infarct areaTreatment of strokeLimited therapeutic optionsStem cellsAutologous cell therapyEndogenous neurogenesisExperimental strokePluripotent stem cellsArtery occlusionIschemic strokeBehavioral recoveryTherapeutic optionsNeurological functionInflammatory responseRobust therapeutic potentialStroke modelMRI resultsAnimal models
2012
Myelin-derived ephrinB3 restricts axonal regeneration and recovery after adult CNS injury
Duffy P, Wang X, Siegel CS, Tu N, Henkemeyer M, Cafferty WB, Strittmatter SM. Myelin-derived ephrinB3 restricts axonal regeneration and recovery after adult CNS injury. Proceedings Of The National Academy Of Sciences Of The United States Of America 2012, 109: 5063-5068. PMID: 22411787, PMCID: PMC3323955, DOI: 10.1073/pnas.1113953109.Peer-Reviewed Original ResearchConceptsAxonal regenerationAxonal growthAdult mammalian central nervous systemAdult CNS injuryDorsal hemisection injurySpinal cord injuryMammalian central nervous systemWild-type miceCentral nervous systemCaudal spinal cordAxonal guidance cuesAxonal growth inhibitionLater time pointsGreater spasticityCNS traumaHemisection injuryCrush siteOptic nerveNeurological functionCNS injuryCord injuryTransection modelGrowth restrictionSpinal cordTraumatic injury
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