Impact of Nimodipine-Induced Blood Pressure Reductions on Cerebral Autoregulation and Functional Outcome After Aneurysmal Subarachnoid Hemorrhage
Stoehr K, Bartolome D, Jayasundara S, Thinzar P, Vargas D, Kim J, Magid-Bernstein J, O’Keefe L, de Havenon A, Hebert R, Matouk C, Sheth K, Gilmore E, Ortega-Gutierrez S, Petersen N. Impact of Nimodipine-Induced Blood Pressure Reductions on Cerebral Autoregulation and Functional Outcome After Aneurysmal Subarachnoid Hemorrhage. Neurocritical Care 2025, 1-11. PMID: 40847251, DOI: 10.1007/s12028-025-02338-6.Peer-Reviewed Original ResearchAneurysmal subarachnoid hemorrhageMean arterial pressureAssociated with worse functional outcomeBP reductionFunctional outcomesNimodipine administrationSubarachnoid hemorrhageHunt & Hess scoreBlood pressureAssociated with BP reductionSevere aneurysmal subarachnoid hemorrhageModified Fisher gradeResponse to nimodipineSensitive to nimodipineCerebral autoregulationDelayed Cerebral IschemiaBlood pressure reductionRegional oxygen saturationObservational cohort studyModified Rankin ScaleLimits of autoregulationFisher gradeHess scoreAneurysm securementNeurological outcome
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