2025
Retrospective Visual and Quantitative Assessment of Burst Suppression With and Without Identical Bursts in Patients After Cardiac Arrest
Fong M, Pu K, Beekman R, Kim N, Nguyen C, Gilmore E, Hirsch L, Zaveri H. Retrospective Visual and Quantitative Assessment of Burst Suppression With and Without Identical Bursts in Patients After Cardiac Arrest. Neurocritical Care 2025, 1-11. PMID: 39900751, DOI: 10.1007/s12028-024-02208-7.Peer-Reviewed Original ResearchIdentical burstsBurst suppressionCardiac arrest survivorsInterburst intervalClinical featuresNeurological outcomeCardiac arrestArrest survivorsAssociated with poor neurological outcomeContinuous electroencephalogramCerebral Performance Category scoreAssociated with poor outcomesCardiac arrest patientsPoor neurological outcomePost-cardiac arrestPredictors of mortalityUS academic medical centersEEG backgroundPrognostic significanceArrest patientsClinical outcomesPoor outcomeRetrospective analysisAcademic medical centerUS cohort
2024
Advances in Enrolling Pregnant Persons Into Acute Care Clinical Trials, A Discussion With the Influence of Cooling Duration on Efficacy in Cardiac Arrest Patients (ICECAP) Trial Principal Investigators
Perman S, Meurer W, Silbergleit R, Jarman A. Advances in Enrolling Pregnant Persons Into Acute Care Clinical Trials, A Discussion With the Influence of Cooling Duration on Efficacy in Cardiac Arrest Patients (ICECAP) Trial Principal Investigators. Clinical Therapeutics 2024, 46: 945-948. PMID: 39613696, DOI: 10.1016/j.clinthera.2024.11.006.Peer-Reviewed Original ResearchVariability in temperature control practices amongst the Influence of Cooling duration on Efficacy in Cardiac Arrest Patients (ICECAP) trial
Beekman R, Perman S, Nguyen C, Kline P, Clevenger R, Yeatts S, Ramakrishnan R, Geocadin R, Silbergleit R, Meurer W, Gilmore E. Variability in temperature control practices amongst the Influence of Cooling duration on Efficacy in Cardiac Arrest Patients (ICECAP) trial. Resuscitation 2024, 203: 110397. PMID: 39278393, PMCID: PMC11466710, DOI: 10.1016/j.resuscitation.2024.110397.Peer-Reviewed Original ResearchTemperature Control Parameters Are Important: Earlier Preinduction Is Associated With Improved Outcomes Following Out-of-Hospital Cardiac Arrest
Beekman R, Kim N, Nguyen C, McGinniss G, Deng Y, Kitlen E, Garcia G, Wira C, Khosla A, Johnson J, Miller P, Perman S, Sheth K, Greer D, Gilmore E. Temperature Control Parameters Are Important: Earlier Preinduction Is Associated With Improved Outcomes Following Out-of-Hospital Cardiac Arrest. Annals Of Emergency Medicine 2024, 84: 549-559. PMID: 39033449, DOI: 10.1016/j.annemergmed.2024.06.007.Peer-Reviewed Original ResearchOut-of-hospital cardiac arrestNeurological outcomeDevice cohortCardiac arrestOut-of-hospital cardiac arrest patientsConsecutive out-of-hospital cardiac arrestPreinduction timeInterquartile rangeAssociated with improved outcomesCardiac arrest patientsProportion of patientsMultivariate logistic regression modelInverse probability of treatmentDevice timeInverse probability treatment weightsProbability of treatmentProspective trialsOHCA patientsArrest patientsClinical outcomesLogistic regression modelsCenter studyEarly initiationSecondary outcomesTreatment weighting
2023
Abstract 145: Deploying Early Cooling at ICECAP Sites: A Barrier Assessment
Beekman R, Kline P, Yeatts S, Geocadin R, Silbergleit R, Meurer W. Abstract 145: Deploying Early Cooling at ICECAP Sites: A Barrier Assessment. Circulation 2023, 148: a145-a145. DOI: 10.1161/circ.148.suppl_1.145.Peer-Reviewed Original ResearchBarriers to early initiationIntensive care unit transferCardiac arrest patientsNurse availabilityProvider educationControl practicesIdentified barriersElectronic surveyBarrier assessmentQuality improvementArrest patientsEducational initiativesInstitutional protocolUnit transferPrincipal investigatorCardiac arrestSurvivors of cardiac arrestBoarding timeStandard sedationBest practicesAverage boarding timeEarly initiationComatose survivors of cardiac arrestEarly coolingDevelopment of sedativesDiscrepancies Between Neuroprognostication Assessments and End-of-Life Decision-Making in Post-Cardiac Arrest Patients (S4.002)
Rubenstein A, Stafford R, Scott A, Maciel C, Silva G, Beekman R, Gilmore E, Greer D. Discrepancies Between Neuroprognostication Assessments and End-of-Life Decision-Making in Post-Cardiac Arrest Patients (S4.002). Neurology 2023, 100 DOI: 10.1212/wnl.0000000000203933.Peer-Reviewed Original Research
2022
Variation in coronary angiography use in Out-of-Hospital cardiac arrest
Agusala V, Dale P, Khera R, Brown S, Idris A, Link M, Mody P. Variation in coronary angiography use in Out-of-Hospital cardiac arrest. Resuscitation 2022, 181: 79-85. PMID: 36332772, DOI: 10.1016/j.resuscitation.2022.10.020.Peer-Reviewed Original ResearchConceptsRates of CAGEarly coronary angiographyCoronary angiographyST elevationNon-shockable rhythmTrial clustersOHCA patientsShockable rhythmInitial non-shockable rhythmHospital cardiac arrest patientsUse of CAGCoronary angiography useInitial arrest rhythmInitial shockable rhythmPost-resuscitation electrocardiogramProportion of patientsOverall study populationCardiac arrest patientsHospital cardiac arrestArrest rhythmAngiography useHospital admissionArrest patientsCardiac arrestNational cohortMyoclonic status epilepticus after severe hyperthermia in a patient with coronavirus disease 2019
Hill K, Peters J, Schaefer S. Myoclonic status epilepticus after severe hyperthermia in a patient with coronavirus disease 2019. Acute And Critical Care 2022, 38: 509-512. PMID: 35545241, PMCID: PMC10718496, DOI: 10.4266/acc.2021.01452.Peer-Reviewed Original ResearchMyoclonic status epilepticusCoronavirus disease 2019Status epilepticusDisease 2019Severe hyperthermiaAcute respiratory distress syndromeSevere neurologic injuryCommunity-acquired pneumoniaRespiratory distress syndromeCardiac arrest patientsSustained feverCortical injuryFever resolutionNeurologic injuryDistress syndromeHypovolemic shockArrest patientsIntubated patientsMultifocal myoclonusGastric lavageAggressive measuresPatient's armPatientsEpilepticusHyperpyrexia
2021
Early head CT in post-cardiac arrest patients: A helpful tool or contributor to self-fulfilling prophecy?
Beekman R, Maciel CB, Ormseth CH, Zhou SE, Galluzzo D, Miyares LC, Torres-Lopez VM, Payabvash S, Mak A, Greer DM, Gilmore EJ. Early head CT in post-cardiac arrest patients: A helpful tool or contributor to self-fulfilling prophecy? Resuscitation 2021, 165: 68-76. PMID: 34147572, DOI: 10.1016/j.resuscitation.2021.06.004.Peer-Reviewed Original ResearchConceptsGray-white matter ratioHCT findingsArrest patientsInter-rater reliabilityPost-cardiac arrest patientsTertiary care academic medical centerEarly head CTPost-CA carePost-CA patientsCardiac arrest patientsHalf of casesAcademic medical centerElectronic medical recordsWithdrawal of lifeNeurophysiologic testingSpontaneous circulationInjury burdenMedical recordsHead CTTherapeutic decisionsMedical CenterPatientsNeurointensivistsHctTemperature management
2019
Guiding Cardiopulmonary Resuscitation with Focused Echocardiography: A Report of Five Cases
Liu R, Bogucki S, Marcolini EG, Yu CY, Wira CR, Kalam S, Daley J, Moore CL, Cone D. Guiding Cardiopulmonary Resuscitation with Focused Echocardiography: A Report of Five Cases. Prehospital Emergency Care 2019, 24: 297-302. PMID: 31150302, DOI: 10.1080/10903127.2019.1626955.Peer-Reviewed Original ResearchConceptsCardiopulmonary resuscitationCardiac arrestEchocardiography studyFocused echocardiographyAdvanced cardiac life support algorithmLeft ventricular compressionCardiac arrest patientsEnd-tidal carbon dioxide valuesHospital cardiac arrestTransthoracic echocardiography studyFocused transthoracic echocardiographyTidal carbon dioxide valuesTransthoracic echocardiographyVentricular compressionArrest patientsPatient outcomesHemodynamic parametersPulse checksEchocardiographyInadequate compressionResuscitationCarbon dioxide valuesUltrasound timingPhysical performanceUltrasound performanceDistinct predictive values of current neuroprognostic guidelines in post-cardiac arrest patients
Zhou SE, Maciel CB, Ormseth CH, Beekman R, Gilmore EJ, Greer DM. Distinct predictive values of current neuroprognostic guidelines in post-cardiac arrest patients. Resuscitation 2019, 139: 343-350. PMID: 30951843, PMCID: PMC6589093, DOI: 10.1016/j.resuscitation.2019.03.035.Peer-Reviewed Original ResearchConceptsPost-cardiac arrest patientsAmerican Heart AssociationArrest patientsPredictive valueDiffuse hypoxic-ischemic injurySingle tertiary care centerDistinct predictive valuesHypoxic-ischemic injuryOutcomes of patientsTertiary care centerLife-sustaining therapyIntensive care medicineFalse positive rateAAN guidelinesAHA guidelinesHospital recordsCardiac arrestHeart AssociationCare centerCurrent guidelinesCare medicineBetter outcomesBiochemical findingsPatientsAmerican Academy
2018
Hospital Variation in the Utilization and Implementation of Targeted Temperature Management in Out-of-Hospital Cardiac Arrest
Khera R, Humbert A, Leroux B, Nichol G, Kudenchuk P, Scales D, Baker A, Austin M, Newgard CD, Radecki R, Vilke GM, Sawyer KN, Sopko G, Idris AH, Wang H, Chan PS, Kurz MC. Hospital Variation in the Utilization and Implementation of Targeted Temperature Management in Out-of-Hospital Cardiac Arrest. Circulation Cardiovascular Quality And Outcomes 2018, 11: e004829. PMID: 30571336, DOI: 10.1161/circoutcomes.118.004829.Peer-Reviewed Original ResearchConceptsTargeted temperature managementHospital cardiac arrestCardiac arrestMedian rateResuscitation Outcomes Consortium sitesHospital cardiac arrest patientsImproved functional survivalMedian hospital rateClass I recommendationPotential survival benefitResuscitation Outcomes ConsortiumNon-traumatic outCardiac arrest patientsTemperature managementPatterns of utilizationConsecutive adultsHospital arrivalProspective cohortSurvival benefitArrest patientsHospital variationI recommendationMean ageOutcomes ConsortiumResuscitation guidelinesLow b-value diffusion weighted imaging is promising in the diagnosis of brain death and hypoxic-ischemic injury secondary to cardiopulmonary arrest
Peckham ME, Anderson JS, Rassner UA, Shah LM, Hinckley PJ, de Havenon A, Kim SE, McNally JS. Low b-value diffusion weighted imaging is promising in the diagnosis of brain death and hypoxic-ischemic injury secondary to cardiopulmonary arrest. Critical Care 2018, 22: 165. PMID: 29925413, PMCID: PMC6011248, DOI: 10.1186/s13054-018-2087-9.Peer-Reviewed Original ResearchConceptsHypoxic-ischemic encephalopathyBrain deathGlobal hypoperfusionNormal subjectsDiagnosis of HIEHypoxic-ischemic brain injuryMatter regionsHypoxic-ischemic injuryIschemic brain injurySex-matched controlsLow b-value DWIApparent diffusion coefficient (ADC) valuesGray matter regionsWhite matter regionsWhite matter valuesIschemic encephalopathyDelayed DiagnosisArrest patientsCardiopulmonary arrestCardiorespiratory arrestBrain injuryInclusion criteriaBD subjectsOrgan donorsGray matter
2017
Prognostic Value of the Neurological Examination in Cardiac Arrest Patients After Therapeutic Hypothermia
Matthews EA, Magid-Bernstein J, Sobczak E, Velazquez A, Falo CM, Park S, Claassen J, Agarwal S. Prognostic Value of the Neurological Examination in Cardiac Arrest Patients After Therapeutic Hypothermia. The Neurohospitalist 2017, 8: 66-73. PMID: 29623156, PMCID: PMC5882011, DOI: 10.1177/1941874417733217.Peer-Reviewed Original ResearchPositive predictive valuePupillary light responseTherapeutic hypothermiaNeurological examinationCorneal reflexPredictive valueDay 3Poor outcomePrognostic valueDay 5Cerebral Performance Category scoreUniversity intensive care unitTime pointsCardiac arrest patientsCardiac arrest survivorsIntensive care unitLife-sustaining therapyNegative predictive valueLeast day 5False positive rateHospital dischargeArrest patientsArrest survivorsCare unitIdeal timingCategorization of survival and death after cardiac arrest
Matthews EA, Magid-Bernstein J, Presciutti A, Rodriguez A, Roh D, Park S, Claassen J, Agarwal S. Categorization of survival and death after cardiac arrest. Resuscitation 2017, 114: 79-82. PMID: 28279695, PMCID: PMC5548414, DOI: 10.1016/j.resuscitation.2017.03.005.Peer-Reviewed Original ResearchConceptsCerebral Performance CategoryPoor neurological prognosisNeurological prognosisFamily's wishesPoor outcomeMost cardiac arrest patientsFavorable recoveryOne-yearEarly recovery groupUnfavorable neurological prognosisCardiac arrest patientsLife-sustaining therapyHemodynamic instabilityFavorable prognosisArrest patientsCardiac arrestGOC discussionsWorse outcomesPatient outcomesBrain deathCommon causeEarly recoveryCare conversationsRecovery groupMost survivors
2016
Effect of stimulus type and temperature on EEG reactivity in cardiac arrest
Fantaneanu T, Tolchin B, Alvarez V, Friolet R, Avery K, Scirica B, O’Brien M, Henderson G, Lee J. Effect of stimulus type and temperature on EEG reactivity in cardiac arrest. Clinical Neurophysiology 2016, 127: 3412-3417. PMID: 27693940, DOI: 10.1016/j.clinph.2016.09.002.Peer-Reviewed Original ResearchConceptsCardiac arrest patientsNipple pressureTherapeutic hypothermiaArrest patientsDifferent stimulus modalitiesTesting modalitiesModerate agreement ratesReliable outcome predictorsAgreement rateStimulus modalityInterrater agreementCardiac arrestOutcome predictorsEEG reactivityPressure reactivityReactive backgroundBetter outcomesHypothermiaPatientsOutcome determinationNormothermiaModalitiesBackground reactivityStimulus typePrior studies
2013
Association Between a Hospital’s Quality Performance for In-Hospital Cardiac Arrest and Common Medical Conditions
Chen LM, Nallamothu BK, Krumholz HM, Spertus JA, Tang F, Chan PS. Association Between a Hospital’s Quality Performance for In-Hospital Cardiac Arrest and Common Medical Conditions. Circulation Cardiovascular Quality And Outcomes 2013, 6: 700-707. PMID: 24221831, PMCID: PMC4465597, DOI: 10.1161/circoutcomes.113.000377.Peer-Reviewed Original ResearchConceptsCommon medical conditionsHospital survival rateAcute myocardial infarctionCardiac arrestMedical conditionsSurvival rateInpatient survivalHeart failureMyocardial infarctionMortality rateHospital cardiac arrest registryHospital qualityIn-hospital cardiac arrestRisk-standardized mortality ratesCardiac Arrest RegistryCardiac arrest outcomesCardiac arrest patientsHospital cardiac arrestCardiac arrest survival ratesPublic reportingHospital outcomesArrest patientsHospital CompareArrest outcomesHospital
2012
Generalized periodic discharges in the critically ill
Foreman B, Claassen J, Abou Khaled K, Jirsch J, Alschuler DM, Wittman J, Emerson RG, Hirsch LJ. Generalized periodic discharges in the critically ill. Neurology 2012, 79: 1951-1960. PMID: 23035068, PMCID: PMC3484988, DOI: 10.1212/wnl.0b013e3182735cd7.Peer-Reviewed Original ResearchConceptsNonconvulsive status epilepticusStatus epilepticusLevel of consciousnessPeriodic dischargesNonconvulsive seizuresCardiac arrestWorse outcomesAcute systemic illnessAcute brain injuryCardiac arrest patientsContinuous EEG monitoringHospital staySystemic illnessConvulsive seizuresArrest patientsMean ageUnivariate analysisBrain injuryMultivariate predictorsEpilepticusEEG monitoringPatientsSeizuresSevere disabilityVegetative state
2011
Neurologic Prognosis in Cardiac Arrest Patients Treated With Therapeutic Hypothermia
Blondin NA, Greer DM. Neurologic Prognosis in Cardiac Arrest Patients Treated With Therapeutic Hypothermia. The Neurologist 2011, 17: 241-248. PMID: 21881465, DOI: 10.1097/nrl.0b013e318224ee0e.Peer-Reviewed Original ResearchConceptsTherapeutic hypothermiaCardiac arrestNeurologic prognosisNeurologic outcomeGood neurologic outcomeCardiac arrest patientsNeurology practice parameterNeuromuscular blocking agentsCerebrospinal fluid biomarkersEligible patientsNeurologic prognosticationNeurophysiologic testingArrest patientsNeurophysiologic findingsPoor prognosisClinical examinationFluid biomarkersPharmacologic effectsBlocking agentPhysiologic effectsPractice parametersClinical examBetter outcomesPatientsPrognosis
2007
Effective lactate clearance is associated with improved outcome in post-cardiac arrest patients
Donnino MW, Miller J, Goyal N, Loomba M, Sankey SS, Dolcourt B, Sherwin R, Otero R, Wira C. Effective lactate clearance is associated with improved outcome in post-cardiac arrest patients. Resuscitation 2007, 75: 229-234. PMID: 17583412, DOI: 10.1016/j.resuscitation.2007.03.021.Peer-Reviewed Original ResearchConceptsPost-cardiac arrest patientsHigher lactate clearanceArrest patientsLactate clearanceAPACHE II scoreCardiac arrest patientsInitial lactate levelUrban emergency departmentPre-hospital providersEmergency medical servicesHospital mortalityTraumatic arrestHospital courseHospital survivalII scorePrimary endpointHospital dischargeImproved mortalityOverall mortalityMean lactateMultivariable analysisSuccessful resuscitationCardiac arrestEmergency departmentMean age
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