2025
Race Comparisons in Patients With Cardiac Sarcoidosis: Insights From the Cardiac Sarcoidosis Consortium.
Trongtorsak A, De La Rosa Martinez J, Crawford T, Bogun F, Gu X, Purroll E, Ellenbogen K, Chicos A, Roukoz H, Zimetbaum P, Kalbfleisch S, Murgatroyd F, Steckman D, Rosenfeld L, Soejima K, Bhan A, Vedantham V, Dickfeld T, De Lurgio D, Platonov P, Zipse M, Nishiuchi S, Ortman M, Narasimhan C, Patton K, Rosenthal D, Mukerji S, Hoogendoorn J, Zeppenfeld K, Torosoff M, Judson M, Martin K, Madias C, Hermel M, Nour K, Torbey E, Sauer W, Kron J. Race Comparisons in Patients With Cardiac Sarcoidosis: Insights From the Cardiac Sarcoidosis Consortium. Circulation Arrhythmia And Electrophysiology 2025, e013670. PMID: 40557494, DOI: 10.1161/circep.124.013670.Peer-Reviewed Original ResearchLeft ventricular ejection fractionCardiac sarcoidosisVentricular ejection fractionBlack patientsEjection fractionNo significant differenceClinical outcomesPrimary outcomeWhite patientsImplantable cardioverter defibrillator therapyLeft ventricular assist device implantationSignificant differenceVentricular assist device implantationComposite end pointChronic kidney diseaseChronic obstructive pulmonary diseaseAll-Cause MortalityAssist device implantationRates of lungRates of hypertensionObstructive pulmonary diseaseImplantable cardioverter defibrillatorExtracardiac involvementEye involvementHeart transplantationB-cell immune repertoire sequencing in tobacco cigarette smoking, vaping, and chronic obstructive pulmonary disease in the COPDGene cohort
Moll M, Xu Z, Boueiz A, Ryu M, Silverman E, Cho M, Hersh C, Sauler M, Polverino F, Kinney G, Curtis J, Crotty-Alexander L, Vollmers C, Castaldi P. B-cell immune repertoire sequencing in tobacco cigarette smoking, vaping, and chronic obstructive pulmonary disease in the COPDGene cohort. Frontiers In Immunology 2025, 16: 1508786. PMID: 40386772, PMCID: PMC12082042, DOI: 10.3389/fimmu.2025.1508786.Peer-Reviewed Original ResearchConceptsB cell activationB cell functionB cellsCigarette smokingClonal expansionClass switchingB cell clonal expansionImpaired B-cell functionIncreased B cell activationImpact of e-cigarette useSecretory IgA productionB cell receptor sequencesTobacco cigarette smokingChronic obstructive pulmonary diseaseE-cigarette useImmune repertoire sequencingIncreased infection riskObstructive pulmonary diseaseBCR-seqResponse to infectionBlood RNA samplesAssessed multivariable associationsBenjamini-Hochberg methodDual usersMultiple alterationsLung Marginal Zone-like B Cells: A Novel Pathogenic Immune Cell Population in Chronic Obstructive Pulmonary Disease
Zhao A, Rojas-Quintero J, Cong C, Zhang Y, Semenova A, Schiller H, San Jose Estepar R, Bhattacharya D, Sauler M, Polverino F. Lung Marginal Zone-like B Cells: A Novel Pathogenic Immune Cell Population in Chronic Obstructive Pulmonary Disease. American Journal Of Respiratory And Critical Care Medicine 2025, 211: a5246-a5246. DOI: 10.1164/ajrccm.2025.211.abstracts.a5246.Peer-Reviewed Original ResearchImmune cell populationsChronic obstructive pulmonary diseaseObstructive pulmonary diseasePulmonary diseaseCell populationsHealthcare Expenditure on Atrial Fibrillation in the United States The Medical Expenditure Panel Survey 2016 to 2021
See C, Grubman S, Shah N, Hu J, Nanna M, Freeman J, Murugiah K. Healthcare Expenditure on Atrial Fibrillation in the United States The Medical Expenditure Panel Survey 2016 to 2021. JACC Advances 2025, 4: 101716. PMID: 40286372, PMCID: PMC12103078, DOI: 10.1016/j.jacadv.2025.101716.Peer-Reviewed Original ResearchMedical Expenditure Panel SurveyHealthcare expendituresInternational Classification of Disease-10 codesNationally representative assessmentTotal healthcare expendituresPoor income levelsPanel SurveyHigher expendituresIncreased healthcare expendituresAssociated with higher expendituresChronic obstructive pulmonary diseaseModified Charlson Comorbidity IndexObstructive pulmonary diseaseInpatient visitsInternational ClassificationType 2 diabetes mellitusSurvey yearCharlson Comorbidity IndexAtherosclerotic cardiovascular diseaseUnited StatesIdentifying individualsCardiovascular diseaseGamma regression modelRegression modelsRepresentative assessmentTemporal trends, setting and timing of palliative and hospice care in chronic obstructive pulmonary disease in the Veterans Health Administration 2010-2020
Smirnova N, Cross S, Kempker J, Sullivan D, Reinke L, Smallwood N, Plumley R, Duan K, Feder S, Ma Y, Vaughan C, Au D, Kavalieratos D. Temporal trends, setting and timing of palliative and hospice care in chronic obstructive pulmonary disease in the Veterans Health Administration 2010-2020. CHEST Pulmonary 2025, 100171. DOI: 10.1016/j.chpulm.2025.100171.Peer-Reviewed Original ResearchPalliative care useReceipt of palliative careChronic obstructive pulmonary diseasePalliative careCare useObstructive pulmonary diseaseTiming of palliative careSpecialist palliative carePalliative care encountersVeterans Health AdministrationNational retrospective cohort studyYear of deathPulmonary diseaseQuality of lifeInpatient hospiceHospice careCare encountersRural facilitiesRetrospective cohort studyHealth AdministrationBackground PeopleHousing instabilityCareMixed-effects multivariable regressionCohort study649 National Estimates and Outcomes for Oxygen Therapy Injuries—a BCQP Analysis
Sheckter C, Phillips B, Klas K, Coffey R, Savetamal A, Wibbenmeyer L. 649 National Estimates and Outcomes for Oxygen Therapy Injuries—a BCQP Analysis. Journal Of Burn Care & Research 2025, 46: s214-s214. PMCID: PMC11958026, DOI: 10.1093/jbcr/iraf019.278.Peer-Reviewed Original ResearchInjury descriptionIncidence rateWhite raceSmoke inhalation injuryBurn centerInhalation injuryFree-text fieldsChronic obstructive pulmonary diseaseChronic respiratory illnessText fieldsObstructive pulmonary diseasePoisson regressionAmerican Burn AssociationInjury characteristicsNational estimatesPrevention effortsInpatient mortalityResponder cohortInpatient outcomesLogistic regressionPrimary payerNational averageWhite patientsYears median ageNational databasePost-Transcatheter Aortic Valve Replacement Antithrombotic Treatment in Nonindicated Patients Updated Systematic Review and Network Meta-Analysis
Siami S, Kazemian S, Maleki S, Ebrahimi E, Jodeiri F, Ebrahimzade M, Hajiqasemi M, Ebrahimi S, Mehdizadeh M, Aghaei M, Bastan M, Sabet M, Nazari R, Ebrahimi P, Rana J, Nanna M, Giri J, Kolte D, Biering-Sørensen T, Alkhouli M, Hosseini K. Post-Transcatheter Aortic Valve Replacement Antithrombotic Treatment in Nonindicated Patients Updated Systematic Review and Network Meta-Analysis. JACC Advances 2025, 4: 101719. PMID: 40286375, PMCID: PMC12049831, DOI: 10.1016/j.jacadv.2025.101719.Peer-Reviewed Original ResearchTranscatheter aortic valve replacementDual antiplatelet therapyOral anticoagulantsAntithrombotic regimensNetwork Meta-AnalysisAntiplatelet therapyCardiovascular mortalityMyocardial infarctionRisk of all-cause mortalityChronic oral anticoagulationAortic valve replacementMeta-analysisOptimal antithrombotic strategyIncreased risk of mortalityFrequentist network meta-analysisRisk of cardiovascular mortalityChronic obstructive pulmonary diseaseAll-Cause MortalityRisk of mortalityObstructive pulmonary diseaseBleeding riskValve replacementAntithrombotic treatmentNo significant differenceAntithrombotic strategiesLong‐Term Outcomes of Peripheral Artery Disease in Veterans: Analysis of the Peripheral Artery Disease Long‐Term Survival Study (PEARLS)
Girotra S, Li Q, Vaughan‐Sarrazin M, Lund B, Al‐Garadi M, Beckman J, Nathani R, Hoffman R, Chan P, Banerjee S, Tsai S, Kumbhani D, Minniefield‐Young N, Smolderen K, Arya S, Nguyen C, Matheny M, Gobbel G. Long‐Term Outcomes of Peripheral Artery Disease in Veterans: Analysis of the Peripheral Artery Disease Long‐Term Survival Study (PEARLS). Journal Of The American Heart Association 2025, 14: e038403. PMID: 40118806, PMCID: PMC12132885, DOI: 10.1161/jaha.124.038403.Peer-Reviewed Original ResearchConceptsVeterans Health AdministrationPeripheral arterial diseaseHealth AdministrationIntegrated health systemOutcomes of peripheral artery diseaseDiagnosis of peripheral arterial diseaseToe-brachial index valuesPrevalence of hypertensionLimb eventsChronic obstructive pulmonary diseaseAnkle-brachial indexImprove careHealth systemObstructive pulmonary diseaseCardiovascular eventsHigh-risk groupNational registryArtery diseaseVeteransIncidence of cardiovascular eventsRegistryIncidence of deathPulmonary diseasePatient yearsStudy end pointThe Implications of Oxygen-Dependent Chronic Obstructive Pulmonary Disease on Sac Growth and Mortality Following Endovascular Aneurysm Repair
Bellamkonda K, Suckow B, Columbo J, Upchurch G, Jacobs B, Ochoa Chaar C, Scully R, Goodney P, Scali S, Stone D. The Implications of Oxygen-Dependent Chronic Obstructive Pulmonary Disease on Sac Growth and Mortality Following Endovascular Aneurysm Repair. Annals Of Vascular Surgery 2025, 115: 98-106. PMID: 40081526, PMCID: PMC12047741, DOI: 10.1016/j.avsg.2025.02.019.Peer-Reviewed Original ResearchChronic obstructive pulmonary diseaseEndovascular AAA repairObstructive pulmonary diseaseSac growthImpact of chronic obstructive pulmonary diseaseOxygen-dependent chronic obstructive pulmonary diseaseEffect of COPD severityCox proportional hazards regressionElective endovascular AAA repairAAA-related mortalityPulmonary diseaseChronic obstructive pulmonary disease severityChronic obstructive pulmonary disease patientsLimited life expectancyIncreased reintervention rateAbdominal aortic aneurysm (AAAEndovascular aneurysm repairElevated mortality ratesPredictors of mortalityPrimary exposureHazards regressionInclusion criteriaIncreased reinterventionsLogistic regressionPost-EVARRisk of Atherosclerotic Cardiovascular Disease After Chronic Obstructive Pulmonary Disease Hospitalization among Primary and Secondary Prevention Older Adults
Mosher C, Osazuwa‐Peters O, Nanna M, MacIntyre N, Que L, Palmer S, Jones W, O'Brien E. Risk of Atherosclerotic Cardiovascular Disease After Chronic Obstructive Pulmonary Disease Hospitalization among Primary and Secondary Prevention Older Adults. Journal Of The American Heart Association 2025, 14: e035010. PMID: 39791395, PMCID: PMC12054414, DOI: 10.1161/jaha.124.035010.Peer-Reviewed Original ResearchConceptsChronic obstructive pulmonary disease hospitalizationsChronic obstructive pulmonary diseaseAtherosclerotic cardiovascular diseaseSecondary prevention cohortPrevention cohortASCVD hospitalizationRisk of atherosclerotic cardiovascular diseaseHazard ratioHospital outcomesHigh riskRisk factorsCardiovascular disease eventsCardiovascular diseasePrimary prevention cohortIdentified multiple risk factorsRisk of cardiovascular disease eventsMultiple risk factorsPulmonary disease hospitalizationsObstructive pulmonary diseaseOlder adultsHigh-risk patient cohortASCVD eventsDisease eventsHigh-risk patientsMeta-analysesUsing Quantitative Bias Analysis to Adjust for Misclassification of COVID‐19 Outcomes: An Applied Example of Inhaled Corticosteroids and COVID‐19 Outcomes
Bokern M, Rentsch C, Quint J, Hunnicutt J, Douglas I, Schultze A. Using Quantitative Bias Analysis to Adjust for Misclassification of COVID‐19 Outcomes: An Applied Example of Inhaled Corticosteroids and COVID‐19 Outcomes. Pharmacoepidemiology And Drug Safety 2025, 34: e70086. PMID: 39776023, PMCID: PMC11706700, DOI: 10.1002/pds.70086.Peer-Reviewed Original ResearchConceptsProbabilistic bias analysisRisk of COVID-19 hospitalisationCOVID-19 hospitalisationChronic obstructive pulmonary diseaseOutcome misclassificationInhaled corticosteroid usersCOVID-19 outcomesIncreased risk of COVID-19 hospitalisationClinical Practice Research Datalink AurumInhaled CorticosteroidsLogistic regressionQuantitative bias analysisBias analysisTriple therapySummary-levelObstructive pulmonary diseaseImpact treatment effect estimates
2024
HEALTH PROMOTION BEHAVIORS AMONG SPOUSAL CAREGIVERS WITH HIGH DAILY MANAGEMENT CHRONIC CONDITIONS
Cho J, Horstman M, Stevens A, Sands L, Allore H. HEALTH PROMOTION BEHAVIORS AMONG SPOUSAL CAREGIVERS WITH HIGH DAILY MANAGEMENT CHRONIC CONDITIONS. Innovation In Aging 2024, 8: 1060-1060. PMCID: PMC11693161, DOI: 10.1093/geroni/igae098.3409.Peer-Reviewed Original ResearchIntensity of caregivingHealth-promoting behaviorsSpousal caregiversPhysical activityChronic conditionsPromoting behaviorsManaging chronic conditionsDaily self-managementICD-10 codesFamily caregiversChronic obstructive pulmonary diseaseCaregiver distressCaregiving intensityCaregiving roleHealth behaviorsSelf-ManagementObstructive pulmonary diseaseDisease trajectoryCaregiversHealth responseStress managementIschemic heart diseaseICD-10Reduce burdenHealthOccurrence of Opioid-Related Neurocognitive Symptoms Associated With Long-term Opioid Therapy
León C, Sung M, Reisman J, Liu W, Kerns R, Gordon K, Mitra A, Kwon S, Yu H, Becker W, Li W. Occurrence of Opioid-Related Neurocognitive Symptoms Associated With Long-term Opioid Therapy. The Clinical Journal Of Pain 2024, 41: e1266. PMID: 39682036, PMCID: PMC11729567, DOI: 10.1097/ajp.0000000000001266.Peer-Reviewed Original ResearchLong-term opioid therapyElectronic health recordsIncidence rate ratiosOpioid-related harmsSubstance use disordersNeurocognitive symptomsHazard ratioPatients prescribed long-term opioid therapyVeterans Health AdministrationCalculated incidence ratesAssociated with increased likelihoodChronic obstructive pulmonary diseasePost-traumatic stress disorderHealth recordsProportional hazards modelRetrospective cohort studyObstructive pulmonary diseaseHealth AdministrationRate ratiosIncidence rateCohort studyTraumatic brain injuryClinical notesExtract dataHazards modelProtein as a preoperative predictor – Impact of hypoalbuminemia on 30-day outcomes of breast reduction surgery
Knoedler S, Klimitz F, Diatta F, Perozzo F, Sofo G, Alfertshofer M, Cherubino M, Mayer H, Panayi A, Kim B, Pomahac B, Kauke-Navarro M. Protein as a preoperative predictor – Impact of hypoalbuminemia on 30-day outcomes of breast reduction surgery. Journal Of Plastic Reconstructive & Aesthetic Surgery 2024, 100: 144-152. PMID: 39615141, DOI: 10.1016/j.bjps.2024.11.011.Peer-Reviewed Original ResearchBreast reduction surgeryImpact of hypoalbuminemiaReduction surgeryBody mass indexPostoperative complicationsSurgical outcomesMass indexAmerican College of Surgeons National Surgical Quality Improvement Program databaseSurgeons National Surgical Quality Improvement Program databaseNational Surgical Quality Improvement Program databaseAssociated with adverse surgical outcomesPredictor of postoperative complicationsIncreased risk of complicationsQuality Improvement Program databasePreoperative nutritional assessmentSuperficial incisional infectionNormal albumin levelsBiomarkers of malnutritionHigher Body Mass IndexAdverse surgical outcomesRisk of complicationsImprove surgical outcomesChronic obstructive pulmonary diseaseMultivariate logistic regressionObstructive pulmonary diseaseRisk of Atherosclerotic Cardiovascular Disease Hospitalizations after Chronic Obstructive Pulmonary Disease Hospitalization among Older Adults.
Mosher C, Osazuwa-Peters O, Nanna M, MacIntyre N, Que L, Jones W, Palmer S, O'Brien E. Risk of Atherosclerotic Cardiovascular Disease Hospitalizations after Chronic Obstructive Pulmonary Disease Hospitalization among Older Adults. Annals Of The American Thoracic Society 2024, 21: 1516-1523. PMID: 39018486, PMCID: PMC11568506, DOI: 10.1513/annalsats.202401-017oc.Peer-Reviewed Original ResearchConceptsChronic obstructive pulmonary disease hospitalizationsChronic obstructive pulmonary diseaseAtherosclerotic cardiovascular diseaseASCVD hospitalizationHospital outcomesMedicare beneficiariesCardiovascular diseaseHospitalization severityCardiovascular disease hospitalizationCardiovascular disease eventsRisk of cardiovascular diseaseAssociated with higher riskCox proportional hazards modelsPopulation of chronic obstructive pulmonary diseasePulmonary disease hospitalizationsHazard ratio estimatesRisk of atherosclerotic cardiovascular diseaseProportional hazards modelHospital 1 yearRetrospective cohort studyObstructive pulmonary diseaseOlder adultsClaims dataHospitalization riskHigh-risk subgroupsRandomized study of temporary diaphragm pacing for enhanced recovery after surgery in cardiac surgery patients at risk of prolonged mechanical ventilation
Hungate J, Onders R, Diasty M, Abu-Omar Y, Arora R, Baeza C, Elgudin Y, Gray K, Markowitz A, Pelletier M, Ribeiro I, Vega P, Rushing G, Sabik J. Randomized study of temporary diaphragm pacing for enhanced recovery after surgery in cardiac surgery patients at risk of prolonged mechanical ventilation. JTCVS Open 2024, 22: 76-84. PMID: 39780786, PMCID: PMC11704535, DOI: 10.1016/j.xjon.2024.09.031.Peer-Reviewed Original ResearchProlonged mechanical ventilationStandard of care groupRisk of prolonged mechanical ventilationMechanical ventilationCardiac surgeryDiaphragmatic pacingDiaphragm pacingTreatment groupsRandomized trialsHistory of chronic obstructive pulmonary diseaseLeft ventricular ejection fractionIntra-aortic balloon pumpDecrease mechanical ventilationCardiac surgery patientsVentricular ejection fractionHigh-risk patientsMulticenter randomized trialCare groupEnhanced recoveryChronic obstructive pulmonary diseaseRelative risk reductionIntensive care unitStandard of carePredictive enrichment strategiesObstructive pulmonary diseaseSevere Clinical Outcomes Due to Human Adenoviral Respiratory Infections in Hospitalized Immunocompetent Adults
Legakis L, Nguyen D, Bandaranayake T. Severe Clinical Outcomes Due to Human Adenoviral Respiratory Infections in Hospitalized Immunocompetent Adults. Infectious Diseases In Clinical Practice 2024, 32: e1412. DOI: 10.1097/ipc.0000000000001412.Peer-Reviewed Original ResearchSevere adenoviral infectionAdenoviral infectionImmunocompetent patientsClinical outcomesSmoking historyPulmonary diseaseRisk factorsSevere diseaseAdenoviral respiratory infectionUpper respiratory tract infectionRespiratory viral panelAbsence of feverAdult immunocompetent patientsExtracorporeal membrane oxygenationRespiratory tract infectionsSevere clinical outcomesChronic obstructive pulmonary diseasePresence of coinfectionObstructive pulmonary diseasePotential risk factorsCritical careImmunocompetent adultsImmunocompromised patientsImmunocompetent hostsTract infectionsThe impact of diabetes mellitus on the outcomes of revascularization for chronic limb-threatening ischemia in the BEST-CLI trial
Ochoa Chaar C, Malas M, Doros G, Schermerhorn M, Conte M, Alameddine D, Siracuse J, Yadavalli S, Dake M, Creager M, Tan T, Rosenfield K, Menard M, Farber A, Hamdan A. The impact of diabetes mellitus on the outcomes of revascularization for chronic limb-threatening ischemia in the BEST-CLI trial. Journal Of Vascular Surgery 2024, 81: 376-385.e3. PMID: 39332785, DOI: 10.1016/j.jvs.2024.09.026.Peer-Reviewed Original ResearchChronic limb-threatening ischemiaAnkle amputationLower extremity revascularizationBEST-CLI trialBEST-CLILimb-threatening ischemiaAll-cause deathDiabetes mellitusChronic obstructive pulmonary diseaseImpact of diabetes mellitusImpact of DMObstructive pulmonary diseasePotential confoundersBest Surgical TherapyAnkleAdverse limb eventsToe pressureBest EndovascularAnkle pressureRenal diseaseAmputationObservational studyOptimal medical therapyOutcomes of patientsCompared to patientsChitinase 3-like-1 Inhibits Innate Antitumor and Tissue Remodeling Immune Responses by Regulating CD47-SIRPα- and CD24-Siglec10-Mediated Phagocytosis.
Ma B, Kamle S, Sadanaga T, Lee C, Lee J, Yee D, Zhu Z, Silverman E, DeMeo D, Choi A, Lee C, Elias J. Chitinase 3-like-1 Inhibits Innate Antitumor and Tissue Remodeling Immune Responses by Regulating CD47-SIRPα- and CD24-Siglec10-Mediated Phagocytosis. The Journal Of Immunology 2024, 213: 1279-1291. PMID: 39291933, DOI: 10.4049/jimmunol.2400035.Peer-Reviewed Original ResearchImmune checkpoint moleculesChronic obstructive pulmonary diseaseInhibit adaptive immune responsesAdaptive immune responsesInnate immune responseImmune responseInhibition of innate immune responsesInhibits T cell costimulationGeneration of adaptive immune responsesMacrophage phagocytosisInhibit innate immune responsesChitinase 3-like 1T cell costimulationEpithelial cell deathObstructive pulmonary diseaseCheckpoint moleculesPoor prognosisLung injuryInhibit macrophagesPulmonary diseaseCHI3L1Inflammation pathwaysCancerSHP-2 phosphataseCell deathLongitudinal multicompartment characterization of host-microbiota interactions in patients with acute respiratory failure
Kitsios G, Sayed K, Fitch A, Yang H, Britton N, Shah F, Bain W, Evankovich J, Qin S, Wang X, Li K, Patel A, Zhang Y, Radder J, Dela Cruz C, Okin D, Huang C, Van Tyne D, Benos P, Methé B, Lai P, Morris A, McVerry B. Longitudinal multicompartment characterization of host-microbiota interactions in patients with acute respiratory failure. Nature Communications 2024, 15: 4708. PMID: 38830853, PMCID: PMC11148165, DOI: 10.1038/s41467-024-48819-8.Peer-Reviewed Original ResearchConceptsAcute respiratory failureRespiratory failureCohort of COVID-19 patientsLung microbiotaMechanically Ventilated PatientsChronic obstructive pulmonary diseaseIllumina amplicon sequencingDNA sequencing technologiesHost-microbiota interactionsObstructive pulmonary diseaseCOVID-19 patientsAssociated with specific patternsAntibiotic exposureClinical factorsNanopore metagenomicsPredicting SurvivalPrecision medicine interventionsPrognostic biomarkerSequencing technologiesAmplicon sequencingPulmonary diseaseGut microbiotaCritical illnessMicrobial diversityHuman microbiome
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