2025
Treatment outcomes of successful M1 versus M2 thrombectomy for low-ASPECTS stroke patients.
Chen H, Colasurdo M, Matsukawa H, Cunningham C, Maier I, Jabbour P, Kim J, Wolfe S, Rai A, Starke R, Psychogios M, Shaban A, Goyal N, Yoshimura S, Cuellar H, Howard B, Alawieh A, Alaraj A, Ezzeldin M, Romano D, Tanweer O, Mascitelli J, Fragata I, Polifka A, Siddiqui F, Osbun J, Crosa R, Grandhi R, Matouk C, Park M, Levitt M, Brinjikji W, Moss M, Daglioglu E, Williamson R, Navia P, Chowdhry S, Altschul D, Spiotta A, Kan P. Treatment outcomes of successful M1 versus M2 thrombectomy for low-ASPECTS stroke patients. Interventional Neuroradiology 2025, 15910199251343283. PMID: 40530425, PMCID: PMC12176791, DOI: 10.1177/15910199251343283.Peer-Reviewed Original ResearchLow Alberta Stroke Program Early CT ScoreAlberta Stroke Program Early CT ScoreEffect of endovascular thrombectomyM2 occlusionsIntracranial hemorrhageM2 patientsAssociated with intracranial hemorrhageOdds of all-cause mortalityMulticenter retrospective studyOdds of poor outcomeMultivariate logistic regression modelAll-Cause MortalityMiddle cerebral arteryStroke patientsM1 patientsM1 occlusionCT scoreRetrospective studyLogistic regression modelsPoor outcomeMultivariable adjustmentPrimary outcomeCerebral arteryTreatment outcomesEndovascular thrombectomyStroke risk prediction in symptomatic anterior circulation ICAD: Analysis of regional QMRA flow from the MYRIAD study
Amin-Hanjani S, Elder T, Du X, Romano J, Liebeskind D, De Havenon A, Chatterjee A, Prabhakaran S. Stroke risk prediction in symptomatic anterior circulation ICAD: Analysis of regional QMRA flow from the MYRIAD study. Journal Of Stroke And Cerebrovascular Diseases 2025, 34: 108322. PMID: 40246039, PMCID: PMC12101060, DOI: 10.1016/j.jstrokecerebrovasdis.2025.108322.Peer-Reviewed Original ResearchMeSH KeywordsAgedAlgorithmsBlood Flow VelocityCerebral AngiographyCerebrovascular CirculationCollateral CirculationFemaleHumansIntracranial ArteriosclerosisIschemic StrokeMagnetic Resonance AngiographyMaleMiddle AgedMiddle Cerebral ArteryPerfusion ImagingPredictive Value of TestsPrognosisProspective StudiesRecurrenceRisk AssessmentRisk FactorsStrokeTime FactorsConceptsMiddle cerebral arteryIntracranial atherosclerotic diseaseQuantitative MRAStroke riskRecurrent strokeFlow patientsIdentification of high-risk patientsIntracranial arteriesLow-flow patientsProximal intracranial arteriesHigh-risk patientsStroke risk predictionInvestigation of therapeutic interventionsRecurrent stroke riskRisk predictionRecurrence riskZ-score thresholdRegional hypoperfusionArtery territoryPrimary outcomeCerebral arteryLow flowsPatientsZ-scoreAtherosclerotic diseaseLater midline shift is associated with better post-hospitalization discharge status after large middle cerebral artery stroke
Song J, Stafford R, Pohlmann J, Kim I, Cheekati M, Dennison S, Brush B, Chatzidakis S, Huang Q, Smirnakis S, Gilmore E, Mohammed S, Abdalkader M, Benjamin E, Dupuis J, Greer D, Ong C. Later midline shift is associated with better post-hospitalization discharge status after large middle cerebral artery stroke. Scientific Reports 2025, 15: 11738. PMID: 40188256, PMCID: PMC11972405, DOI: 10.1038/s41598-025-95954-3.Peer-Reviewed Original ResearchConceptsMiddle cerebral arteryPeak edemaMiddle cerebral artery strokeMidline shiftCerebral edemaDecompressive hemicraniectomyRetrospective study of patientsMiddle cerebral artery territory infarctionStudy of patientsDischarge statusFavorable discharge statusAssociated with higher oddsRetrospective studyTerritory infarctionCerebral arteryEdemaTreatment decisionsPatientsIschemic strokeHigher oddsMultivariate modelArtery strokeUnfavorable dischargeTwo-center371 Endovascular Thrombectomy for Posterior Cerebral Artery Occlusions: 30- and 90-Day Unplanned Readmissions in the United States
Koo A, Amllay A, Kanzler M, Stogniy S, Renedo D, Sujijantarat N, Antonios J, Hebert R, Matouk C. 371 Endovascular Thrombectomy for Posterior Cerebral Artery Occlusions: 30- and 90-Day Unplanned Readmissions in the United States. Neurosurgery 2025, 71: 89-89. DOI: 10.1227/neu.0000000000003360_371.Peer-Reviewed Original ResearchEfficacy of endovascular thrombectomyPosterior cerebral artery occlusionPosterior cerebral arteryReadmitted cohortArtery occlusionEndovascular thrombectomyAcute basilar artery occlusionNationwide Readmissions Database yearsBasilar artery occlusionProportion of adverse eventsNon-readmitted cohortsNon-routine dischargeCerebral artery occlusionInpatient mortality rateAdult patientsRisk-stratifiedAdverse eventsShort-term readmissionNIHSS scorePrimary outcomeCardiac diagnosisCerebral arteryDatabase yearsPatientsIndex admissionA positron emission tomography tracer for the imaging of oxidative stress in the central nervous system
Wilde J, Sun Y, Simpson S, Hill E, Fu Z, Bian E, Kinkaid M, Villanueva P, Weybright A, Terrell W, Qureshi Z, Perera S, Sheppard H, Stone J, Kundu B, Kuan C, Neumann K. A positron emission tomography tracer for the imaging of oxidative stress in the central nervous system. Nature Biomedical Engineering 2025, 9: 716-729. PMID: 40044816, PMCID: PMC12092265, DOI: 10.1038/s41551-025-01362-3.Peer-Reviewed Original ResearchCentral nervous systemPositron emission tomographyInjection of sodium nitroprussideOxidative stressNervous systemClinical trials of antioxidantsMiddle cerebral arteryBlood-brain barrierTrials of antioxidantsPositron emission tomography tracersIntrastriatal injectionParametric mappingSodium nitroprussideCerebral arteryLongitudinally in vivoIn vivo quantificationQuantification of oxidative stressEmission tomographyPET imagingAntioxidant edaravoneDynamic PET imagesHuman plasmaQuantitative Pupillometry Predicts Neurologic Deterioration in Patients with Large Middle Cerebral Artery Stroke
Du Y, Pohlmann J, Chatzidakis S, Brush B, Malinger L, Stafford R, Cervantes‐Arslanian A, Benjamin E, Gilmore E, Dupuis J, Greer D, Smirnakis S, Mohammed S, Ong C. Quantitative Pupillometry Predicts Neurologic Deterioration in Patients with Large Middle Cerebral Artery Stroke. Annals Of Neurology 2025, 97: 930-941. PMID: 39825740, PMCID: PMC12011534, DOI: 10.1002/ana.27178.Peer-Reviewed Original ResearchNeurological Pupil indexMiddle cerebral arteryQuantitative pupillometryNeurological deteriorationMiddle cerebral artery strokeDilation velocitySingle-center observational cohort studyAlberta Stroke Program Early CT ScoreCox proportional hazards modelsObservational cohort studyIntensive care unitProportional hazards modelCT scoreCohort studyYouden indexCerebral arteryCare unitHazards modelTukey testLinear mixed-effects modelsPatientsArtery strokeDilatationOptimal thresholdMixed-effects models
2024
Postdural puncture headache: Beyond the evidence
Berg A, Lucas D, Leffert L. Postdural puncture headache: Beyond the evidence. Best Practice & Research Clinical Anaesthesiology 2024, 38: 267-277. PMID: 39764816, DOI: 10.1016/j.bpa.2024.11.004.Peer-Reviewed Original ResearchPostdural puncture headacheCalcitonin gene-related peptideAccidental dural punctureCerebrospinal fluidRelease of calcitonin gene-related peptideManagement of postdural puncture headacheTreat postdural puncture headacheLabor epidural analgesiaGene-related peptideAutonomic nervous systemCerebrospinal fluid dynamicsEvidence-based recommendationsEpidural analgesiaPuncture headacheDural punctureIntrathecal catheterNeuraxial proceduresCSF lossSphenopalatine ganglionAssociated with activationCerebral arteryCerebral vasodilationChronic manifestationsTherapeutic strategiesRoutine useClinical and radiographic outcomes after mechanical thrombectomy in medium-vessel posterior cerebral artery occlusions: Subgroup analysis from STAR.
Almallouhi E, Findlay M, Maier I, Jabbour P, Kim J, Wolfe S, Rai A, Starke R, Psychogios M, Shaban A, Goyal N, Yoshimura S, Cuellar H, Howard B, Alawieh A, Alaraj A, Ezzeldin M, Romano D, Tanweer O, Mascitelli J, Fragata I, Polifka A, Siddiqui F, Osbun J, Crosa R, Matouk C, Park M, Levitt M, Brinjikji W, Moss M, Daglioglu E, Williamson R, Navia P, Kan P, De Leacy R, Chowdhry S, Altschul D, Spiotta A, Grandhi R. Clinical and radiographic outcomes after mechanical thrombectomy in medium-vessel posterior cerebral artery occlusions: Subgroup analysis from STAR. Interventional Neuroradiology 2024, 15910199241273839. PMID: 39140967, PMCID: PMC11569802, DOI: 10.1177/15910199241273839.Peer-Reviewed Original ResearchPosterior cerebral arteryMiddle cerebral arteryMedium vessel occlusionsFirst-pass recanalizationMechanical thrombectomyCerebral arteryPosterior cerebral artery occlusionStandard-of-care treatmentPatients' median ageFirst-pass success rateIntra-arterial thrombolysisLarge-vessel occlusionCerebral artery occlusionSalvageable brain tissuePrimary occlusionMedian ageClinical outcomesRadiographic outcomesRecanalization rateFollow-upSubgroup analysisArtery occlusionRecanalizationStroke thrombectomyPatientsEndovascular thrombectomy versus medical management for moderate-to-severe anterior cerebral artery occlusion stroke
Chen H, Khunte M, Malhotra A, Gandhi D, Colasurdo M. Endovascular thrombectomy versus medical management for moderate-to-severe anterior cerebral artery occlusion stroke. Journal Of Neurology 2024, 271: 6247-6254. PMID: 39085619, DOI: 10.1007/s00415-024-12582-z.Peer-Reviewed Original ResearchAssociated with higher oddsAnterior cerebral arteryAssociated with higher ratesIntracranial hemorrhageEndovascular thrombectomyMedical managementHigher oddsEfficacy of endovascular thrombectomyFavorable short-term outcomesRetrospective cohort studyPatient selection criteriaShort-term outcomesEndovascular thrombectomy patientsIn-Hospital MortalityMultivariate logistic regressionHome dischargeArtery occlusion strokeNational Inpatient SampleHigher RatesNeurological outcomeCohort studyPrimary outcomeCerebral arterySecondary outcomesOcclusion strokeTenecteplase for Stroke at 4.5 to 24 Hours with Perfusion-Imaging Selection
Albers G, Jumaa M, Purdon B, Zaidi S, Streib C, Shuaib A, Sangha N, Kim M, Froehler M, Schwartz N, Clark W, Kircher C, Yang M, Massaro L, Lu X, Rippon G, Broderick J, Butcher K, Lansberg M, Liebeskind D, Nouh A, Schwamm L, Campbell B. Tenecteplase for Stroke at 4.5 to 24 Hours with Perfusion-Imaging Selection. New England Journal Of Medicine 2024, 390: 701-711. PMID: 38329148, DOI: 10.1056/nejmoa2310392.Peer-Reviewed Original ResearchConceptsModified Rankin ScaleSymptomatic intracranial hemorrhageInternal carotid arteryMiddle cerebral arteryRankin ScalePlacebo groupTenecteplase groupIntracranial hemorrhageIncidence of symptomatic intracranial hemorrhageCerebral arteryIncidence of symptomatic intracerebral hemorrhageCarotid arteryPlacebo-controlled trialSymptomatic intracerebral hemorrhageEvidence of occlusionSafety populationDouble-blindPerfusion-imagingMedian timeClinical outcomesIntracerebral hemorrhagePlaceboPerfusion imagingPrimary outcomeOdds ratioThrombectomy in Stroke Patients With Low Alberta Stroke Program Early Computed Tomography Score: Is Modified Thrombolysis in Cerebral Infarction (mTICI) 2c/3 Superior to mTICI 2b?
Elawady S, Saway B, Matsukawa H, Uchida K, Lin S, Maier I, Jabbour P, Kim J, Wolfe S, Rai A, Starke R, Psychogios M, Samaniego E, Arthur A, Yoshimura S, Cuellar H, Grossberg J, Alawieh A, Romano D, Tanweer O, Mascitelli J, Fragata I, Polifka A, Osbun J, Crosa R, Matouk C, Park M, Levitt M, Brinjikji W, Moss M, Dumont T, Williamson R, Navia P, Kan P, De Leacy R, Chowdhry S, Ezzeldin M, Spiotta A, Al Kasab S, Collaborators O. Thrombectomy in Stroke Patients With Low Alberta Stroke Program Early Computed Tomography Score: Is Modified Thrombolysis in Cerebral Infarction (mTICI) 2c/3 Superior to mTICI 2b? Journal Of Stroke 2024, 26: 95-103. PMID: 38326708, PMCID: PMC10850454, DOI: 10.5853/jos.2023.02292.Peer-Reviewed Original ResearchLower Alberta Stroke Program Early Computed Tomography ScoreAlberta Stroke Program Early Computed Tomography ScoreFavorable 90-day outcomeComputed tomography scoreMTICI 2bMechanical thrombectomyModified thrombolysisCerebral infarctionOutcomes of patientsRetrospective cohort studyInternal carotid arteryMiddle cerebral arteryAssociated with higher oddsBaseline characteristicsFavorable outcomeMTICI 2c/3MTICICohort studyCerebral arteryCarotid arteryStroke thrombectomyPatientsThrombectomy-capable stroke centersInclusion criteriaAneurysm Registry
2023
Successful mechanical thrombectomy for terminal ICA bullet embolism: A case report.
Clouse J, Thaci B, Clark A, Baggett M, Raslan O, Matouk C, Waldau B, Cord B. Successful mechanical thrombectomy for terminal ICA bullet embolism: A case report. Interventional Neuroradiology 2023, 15910199231219021. PMID: 38073079, DOI: 10.1177/15910199231219021.Peer-Reviewed Original ResearchMechanical thrombectomyBullet embolismBullet fragmentsMiddle cerebral arterySuccessful mechanical thrombectomyLeft-sided hemiparesisRight M1 segmentMultiple gunshot woundsProper resuscitationIschemic eventsCerebral arteryCase reportHead injuryTomography angiographyM1 segmentLower extremitiesForeign bodyGunshot woundsThrombectomyBlood vesselsEmbolismInjuryDistalRare eventVesselsMechanical thrombectomy for the treatment of primary and secondary anterior cerebral artery occlusions: insights from STAR
Dabhi N, Kumar J, Ironside N, Kellogg R, Sowlat M, Uchida K, Maier I, Al Kasab S, Jabbour P, Kim J, Wolfe S, Rai A, Starke R, Psychogios M, Samaniego E, Arthur A, Yoshimura S, Cuellar H, Howard B, Alawieh A, Romano D, Tanweer O, Mascitelli J, Fragata I, Polifka A, Osbun J, Crosa R, Matouk C, Levitt M, Brinjikji W, Moss M, Dumont T, Williamson R, Navia P, Kan P, De Leacy R, Chowdhry S, Ezzeldin M, Spiotta A, Park M. Mechanical thrombectomy for the treatment of primary and secondary anterior cerebral artery occlusions: insights from STAR. Journal Of NeuroInterventional Surgery 2023, 16: 1282-1287. PMID: 37968114, DOI: 10.1136/jnis-2023-020997.Peer-Reviewed Original ResearchConceptsMechanical thrombectomyProcedural outcomesCerebral arteryAnterior cerebral artery occlusionEfficacy of mechanical thrombectomyAnterior cerebral arteryMann-Whitney U testMT-treatedCerebral artery occlusionRetrospective reviewBaseline characteristicsClinical outcomesOcclusion groupStudy cohortArtery occlusionFunctional outcomesBaseline variablesIdeal patientStroke thrombectomyMann-WhitneyPatientsU testCategorical variablesThrombectomyOcclusionComparison of balloon guide catheter versus non-balloon guide catheter for mechanical thrombectomy in patients with distal medium vessel occlusion
Orscelik A, Kallmes D, Bilgin C, Musmar B, Senol Y, Kobeissi H, Elawady S, Cunningham C, Matsukawa H, Zandpazandi S, Sowlat M, Maier I, Al Kasab S, Jabbour P, Kim J, Wolfe S, Rai A, Starke R, Psychogios M, Samaniego E, Arthur A, Yoshimura S, Cuellar H, Howard B, Alawieh A, Romano D, Tanweer O, Mascitelli J, Fragata I, Polifka A, Osbun J, Crosa R, Matouk C, Park M, Levitt M, Moss M, Dumont T, Williamson R, Navia P, Kan P, De Leacy R, Chowdhry S, Ezzeldin M, Spiotta A, Brinjikji W. Comparison of balloon guide catheter versus non-balloon guide catheter for mechanical thrombectomy in patients with distal medium vessel occlusion. Journal Of NeuroInterventional Surgery 2023, 16: 587-594. PMID: 37918906, DOI: 10.1136/jnis-2023-020925.Peer-Reviewed Original ResearchConceptsDistal medium vessel occlusionBGC groupBalloon guide catheterMedium vessel occlusionsMechanical thrombectomyVessel occlusionProcedure timeCerebral arteryDistal embolizationNon-BGC groupGuide catheterRate of distal embolizationAnterior cerebral arteryPosterior cerebral arteryLarge vessel occlusionFPE rateReduce distal embolizationNeurological outcomeRetrospective studyAdult patientsClinical outcomesIntracranial accessFinal recanalizationMTICI scoreSubgroup analysisOperative Strategies for Aplastic Circle of Willis Arteries on CTA in Meningioma Surgery: A Case Report
Tabor J, Pappajohn A, Lei H, O'Brien J, Fulbright R, Morales-Valero S, Moliterno J. Operative Strategies for Aplastic Circle of Willis Arteries on CTA in Meningioma Surgery: A Case Report. Neurosurgery Practice 2023, 4: e00058. PMID: 39959393, PMCID: PMC11809949, DOI: 10.1227/neuprac.0000000000000058.Peer-Reviewed Original ResearchComputed tomography angiographyInternal carotid arteryA1 arteriesPreoperative computed tomography angiographyCarotid arteryNeurovascular structuresRemnants of tumorsNear-total resectionSupraclinoid internal carotid arteryRelationship of tumorSphenoid wing meningiomaAnterior cerebral arteryAssociated with tumorsCircle of Willis arteriesCircle of WillisTumor involvementPreoperative imagingSurgical strategyMeningioma surgeryInvasive modalitiesCase reportMicrovascular DopplerCerebral arteryTumorPreoperative planningAcute and subacute neurovascular impact of cryptogenic air emboli
Gummerson C, Parasram M, Peng T, Picard J, Kahn P, Angelus E, Bhatt S, de Havenon A, Jasne A, Magid-Bernstein J. Acute and subacute neurovascular impact of cryptogenic air emboli. Surgical Neurology International 2023, 14: 285. PMID: 37680929, PMCID: PMC10481802, DOI: 10.25259/sni_382_2023.Peer-Reviewed Case Reports and Technical NotesMagnetic resonance imagingCortical diffusion restrictionAir emboliMiddle cerebral artery territoryRight anterior cerebral arterySubsequent magnetic resonance imagingDiffusion restrictionClose neurologic monitoringNeurocritical care managementCerebral air embolismAcute ischemic strokeAnterior cerebral arteryInitial radiographic findingsCerebral air emboliType of injuryComputerized tomography scanCourse of careArtery territoryCerebral edemaIschemic strokeNeurologic monitoringCerebral arteryCortical veinsInitial imagingMechanical ventilation
2022
Delayed, Progressive Multivessel Occlusion After Resection of a Recurrent Glioma
Tanglay O, Dadario N, Young I, Yeung J, Teo C, Sughrue M, Yeung J. Delayed, Progressive Multivessel Occlusion After Resection of a Recurrent Glioma. Cureus 2022, 14: e33019. PMID: 36721529, PMCID: PMC9879796, DOI: 10.7759/cureus.33019.Peer-Reviewed Original ResearchMagnetic resonance imagingCerebral artery infarctionArtery infarctionGlioma resectionGlioblastoma multiformeMiddle cerebral artery infarctionPreoperative magnetic resonance imagingCommon primary brain tumorPosterior cerebral artery infarctionAggressive cytoreductive surgeryAggressive natural historyMiddle cerebral arteryPrimary brain tumorsMost clinical researchMultivessel occlusionCytoreductive surgeryAdjuvant radiochemotherapyMedian survivalNeurologic declineOverall survivalTotal resectionVascular etiologyCerebral arteryPatient outcomesClinical guidanceComparative anatomy of the middle cerebral artery, rhinal and endorhinal sulci, piriform lobe, entorhinal cortex, olfactory tubercule, anterior perforate substance, and hippocampus: A dissection study
Kier E, Conlogue G. Comparative anatomy of the middle cerebral artery, rhinal and endorhinal sulci, piriform lobe, entorhinal cortex, olfactory tubercule, anterior perforate substance, and hippocampus: A dissection study. The Anatomical Record 2022, 306: 2030-2043. PMID: 36371781, DOI: 10.1002/ar.25124.Peer-Reviewed Original ResearchConceptsMiddle cerebral arteryRecurrent arteryPiriform lobeHuman fetal specimensOlfactory tuberculeLenticulostriate arteriesRhinal sulcusEndorhinal sulcusCerebral arteryTemporal lobeFetal specimensAnatomic modificationsHuman temporal lobeStriate nucleusMCA branchesArteryInferomedial regionHeubnerHippocampusComplex anatomyDissection studiesBrain dissectionCerebrumSulcusLobe
2021
Stellate ganglion block used to treat reversible cerebral vasoconstriction syndrome
Davis J, Ozcan MS, Kamdar JK, Shoaib M. Stellate ganglion block used to treat reversible cerebral vasoconstriction syndrome. Regional Anesthesia & Pain Medicine 2021, 46: 732-734. PMID: 33875578, DOI: 10.1136/rapm-2021-102675.Peer-Reviewed Original ResearchConceptsReversible cerebral vasoconstriction syndromeStellate ganglion blockCerebral vasoconstriction syndromeTranscranial Doppler ultrasoundGanglion blockRescue therapyNeurological symptomsSevere reversible cerebral vasoconstriction syndromeAcute neurological symptomsPossible rescue therapySupportive critical careTranscranial Doppler measurementsTypical treatmentPermissive hypertensionSegmental narrowingSympathetic blockadeBlock successSevere vasospasmSupportive careCerebral arteryIntravenous fluidsSevere ischemiaCase reportUltrasound guidanceCritical care
2020
Hypoperfusion Distal to Anterior Circulation Intracranial Atherosclerosis is Associated with Recurrent Stroke
de Havenon A, Khatri P, Prabhakaran S, Yeatts S, Peterson C, Sacchetti D, Alexander M, Cutting S, Mac Grory B, Furie K, Liebeskind D, Yaghi S. Hypoperfusion Distal to Anterior Circulation Intracranial Atherosclerosis is Associated with Recurrent Stroke. Journal Of Neuroimaging 2020, 30: 468-470. PMID: 32579278, PMCID: PMC8010594, DOI: 10.1111/jon.12710.Peer-Reviewed Original ResearchConceptsIntracranial atherosclerotic diseaseSymptomatic intracranial atherosclerotic diseaseDistal hypoperfusionRecurrent strokeComputed tomographyRetrospective study of patientsImpaired distal flowIntracranial atherosclerotic disease patientsSymptomatic ischemic strokeStudy of patientsAssociated with recurrent strokeMiddle cerebral arteryAssociated with stroke recurrenceIntracranial carotidSecondary stroke preventionRetrospective studySymptomatic arteryPerfusion statusHazard ratioPrimary outcomeCerebral arteryStroke preventionHypoperfusionPatientsInclusion criteria
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