Treatment with Manganese Porphyrin, MnTnBuOE-2-PyP5+, Suppressed the Activation of Macrophages in a Mouse Intracerebral Hemorrhage
Zhang S, Cao J, Spasojevic I, Treggiari M, Sheng H. Treatment with Manganese Porphyrin, MnTnBuOE-2-PyP5+, Suppressed the Activation of Macrophages in a Mouse Intracerebral Hemorrhage. Pharmaceuticals 2025, 18: 547. PMID: 40283982, PMCID: PMC12030109, DOI: 10.3390/ph18040547.Peer-Reviewed Original ResearchMouse intracerebral hemorrhageIntracerebral hemorrhageActivation of macrophagesNeurological deficitsBMX-001Hemorrhage sizeBody weightSham surgery miceMnTnBuOE-2-PyP5+Neurological deficit scoreExperimental ischemic strokePrussian blue stainingAnti-inflammatory effectsStroke patientsPost-ICHNo significant differenceNeurological outcomeC57BL6 miceSurgery miceHemorrhagic transformationClinical trialsHemorrhageRotarod testDeficit scoresHistological evaluation
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