2025
Nexfin versus conventional oscillometric cuff for blood pressure monitoring during neuro-endovascular procedures
Chen H, Njonkou-Tchoquessi R, Colasurdo M, Cobb C, Payabvash S, Malhotra A, Gandhi D. Nexfin versus conventional oscillometric cuff for blood pressure monitoring during neuro-endovascular procedures. Brain Circulation 2025 DOI: 10.4103/bc.bc_146_24.Peer-Reviewed Original ResearchNeuro-endovascular proceduresBlood pressureSystolic BPArterial lineNeurological injurySingle-center retrospective studyPredictive valueNegative predictive valuePositive predictive valueAcute neurological injuryBlood pressure monitoringArterial line measurementsConsecutive patientsRelative hypotensionRetrospective studyNeuro-endovascular treatmentNeuroendovascular interventionsNeuroendovascular proceduresSBP dropNexfinClinical scenariosNoninvasive blood pressureBP monitoringPatientsConventional cuff
2024
Diverse NKT cells regulate early inflammation and neurological outcomes after cardiac arrest and resuscitation
Tamura T, Cheng C, Villaseñor-Altamirano A, Yamada K, Ikeda K, Hayashida K, Menon J, Chen X, Chung H, Varon J, Chen J, Choi J, Cullen A, Guo J, Lin X, Olenchock B, Pinilla-Vera M, Manandhar R, Sheikh M, Hou P, Lawler P, Oldham W, Seethala R, Baron R, Bohula E, Morrow D, Blumberg R, Chen F, Merriam L, Weissman A, Brenner M, Chen X, Ichinose F, Kim E, Sohn H, Rolland T, Weil B. Diverse NKT cells regulate early inflammation and neurological outcomes after cardiac arrest and resuscitation. Science Translational Medicine 2024, 16: eadq5796. PMID: 39630883, PMCID: PMC11792709, DOI: 10.1126/scitranslmed.adq5796.Peer-Reviewed Original ResearchConceptsOut-of-hospital cardiac arrestCohort of patientsNeurological outcomeT cellsImmune cellsCardiac arrestNatural killer (NK) cellsAssociated with good neurological outcomesDiverse T cell receptor repertoireNeurological injuryT cell receptor repertoireAssociated with poor neurological outcomeIncreased inflammatory chemokineInnate T cellsPoor neurological outcomeWild-type micePost-cardiac arrestAccumulation of macrophagesIncreased neuronal injuryBrains of miceNKT cellsTreated miceReceptor repertoireInflammatory chemokinesCytokine expressionStroke Care in the Intensive Care Unit
Robinson A, Al-Dulaimi M, Beekman R. Stroke Care in the Intensive Care Unit. 2024, 167-185. DOI: 10.1007/978-3-031-66289-8_16.Peer-Reviewed Original ResearchNeurological intensive care unitStroke careIntensive care unitCare unitCritical care specialistsHealthcare professionalsCare specialistsChance of recoveryExpertise of neurologistsCareNeurological conditionsManagement of patientsNeurological injurySpecial careLife-threatening neurological conditionHealthcareProfessionalsPatientsPrimary goalVariability in the Spectrum of Reporting on the Schenck KD I Classification in the Orthopaedic Literature: A Systematic Review and Meta-analysis
Green J, Marcel A, Li Z, Moran J, Schenck R, Alaia M, Medvecky M. Variability in the Spectrum of Reporting on the Schenck KD I Classification in the Orthopaedic Literature: A Systematic Review and Meta-analysis. Orthopaedic Journal Of Sports Medicine 2024, 12: 23259671241264214. PMID: 39291123, PMCID: PMC11406613, DOI: 10.1177/23259671241264214.Peer-Reviewed Original ResearchMultiligament kneeKnee dislocationOdds ratioNeurological injuryConcomitant neurologic injurySchenck Knee DislocationTear patternsSystematic literature search of PubMedLiterature search of PubMedConcomitant vascular injuryPooled odds ratioSearch of PubMedSystematic reviewLevel of evidenceMeta-analysesCollateral ligamentSystematic literature searchPublished clinical resultsClinical resultsPooled analysisNeurovascular injuryVascular injuryWeb of ScienceCochrane LibraryPatients
2023
Brain imaging after cardiac arrest
Beekman R, Hirsch K. Brain imaging after cardiac arrest. Current Opinion In Critical Care 2023, 29: 192-198. PMID: 37078612, DOI: 10.1097/mcc.0000000000001032.Peer-Reviewed Original ResearchConceptsCardiac arrestComputed tomographyLong-term neurological outcomeQuantitative analysis of CTPrediction of long-term neurologic outcomeInterpretation of CTAnalysis of CTInterpreting CTBrain imagingNovel imaging techniquesNeurological outcomePoor outcomeDisorders of consciousnessNeurological injuryLack of specificityMRIInter-rater reliabilityQuantitative image analysisArrestOutcomesImaging techniquesBrainMultimodal assessmentMethodological limitationsPatients
2021
Longitudinal imaging history in early identification of intimate partner violence
Park H, Gujrathi R, Gosangi B, Thomas R, Cai T, Chen I, Bay C, Hassan N, Boland G, Kohane I, Seltzer S, Rexrode K, Khurana B. Longitudinal imaging history in early identification of intimate partner violence. European Radiology 2021, 32: 2824-2836. PMID: 34797386, DOI: 10.1007/s00330-021-08362-2.Peer-Reviewed Original ResearchConceptsSelf-reported dateIPV-related injuriesGroup 1Neurological injuryMusculoskeletal injuriesGroup 2Early identificationGroup 2 patientsIntimate partner violencePhysical abuseTypes of abuseNeurologic injuryHigh suspicionCommon injuriesResultsA totalImaging reviewPartner violenceInjuryStudy datesLikelihood of IPVCommon typeRadiologistsPatientsSuspicionIPVPharmacotherapy for Nonconvulsive Seizures and Nonconvulsive Status Epilepticus
Bravo P, Vaddiparti A, Hirsch LJ. Pharmacotherapy for Nonconvulsive Seizures and Nonconvulsive Status Epilepticus. Drugs 2021, 81: 749-770. PMID: 33830480, DOI: 10.1007/s40265-021-01502-4.Peer-Reviewed Original ResearchConceptsNonconvulsive status epilepticusAntiseizure medicationsNonconvulsive seizuresStatus epilepticusIll patientsRefractory nonconvulsive status epilepticusFurther neurological injuryMultiple antiseizure medicationsAdverse neurological outcomesContinuous electroencephalogram monitoringLong-term outcomesHemodynamic labilityRecent neurosurgerySeizure burdenNeurological outcomePharmacological managementBrain infectionGlobal hypoxiaNeurological injuryEarly recognitionMost seizuresUnderlying conditionClinical trialsElectroencephalogram monitoringHepatic function
2020
Assessment of Brain Injury Using Portable, Low-Field Magnetic Resonance Imaging at the Bedside of Critically Ill Patients
Sheth KN, Mazurek MH, Yuen MM, Cahn BA, Shah JT, Ward A, Kim JA, Gilmore EJ, Falcone GJ, Petersen N, Gobeske KT, Kaddouh F, Hwang DY, Schindler J, Sansing L, Matouk C, Rothberg J, Sze G, Siner J, Rosen MS, Spudich S, Kimberly WT. Assessment of Brain Injury Using Portable, Low-Field Magnetic Resonance Imaging at the Bedside of Critically Ill Patients. JAMA Neurology 2020, 78: 41-47. PMID: 32897296, PMCID: PMC7489395, DOI: 10.1001/jamaneurol.2020.3263.Peer-Reviewed Original ResearchIntensive care unit roomsIntensive care settingBrain injuryCare settingsIll patientsNeurological injuryT2 fluid-attenuated inversion recoveryCOVID-19Intensive care unit admissionSingle-center cohort studyIntensive care unit settingUnit roomsYale-New Haven HospitalNasopharyngeal swab resultsCare unit admissionSingle-center seriesBrain imaging findingsIntensive care unitFluid-attenuated inversion recoveryDiffusion-weighted imaging sequencesTraumatic brain injuryClinical care settingsNew Haven HospitalMagnetic resonance imagingConventional magnetic resonance imaging (MRI) systemNeurological injuries in COVID-19 patients: direct viral invasion or a bystander injury after infection of epithelial/endothelial cells
Azizi S, Azizi S. Neurological injuries in COVID-19 patients: direct viral invasion or a bystander injury after infection of epithelial/endothelial cells. Journal Of NeuroVirology 2020, 26: 631-641. PMID: 32876900, PMCID: PMC7465881, DOI: 10.1007/s13365-020-00903-7.Peer-Reviewed Original ResearchMeSH KeywordsAngiotensin-Converting Enzyme 2BetacoronavirusBrainBrain DiseasesBystander EffectCoronavirus InfectionsCOVID-19Epithelial CellsGene Expression RegulationHost-Pathogen InteractionsHumansLungNeuronsOlfaction DisordersPandemicsPeptidyl-Dipeptidase APneumonia, ViralPulmonary EmbolismSARS-CoV-2Signal TransductionSpike Glycoprotein, CoronavirusStrokeConceptsCOVID-19 patientsBystander injuryNeurological complicationsSARS-CoV-2Cerebral vascular endothelial cellsSecondary to hypoxiaInitial symptoms of COVID-19Post-COVID-19 patientsInflammatory neuromuscular diseasesVascular endothelial cellsImmunological abnormalitiesHost cellsSymptoms of COVID-19Oral cavityMetabolic abnormalitiesThrombo-EmbolismEpithelial/endothelial cellsInitial symptomsNeurological injuryEpithelial cellsFunctional receptorsPatientsPeripheral nervesMolecular mimicryEndothelial cellsDifferential Contribution of Neuronal Uptake Transporters to Oxaliplatin Peripheral Neurotoxicity
Huang K, Leblanc A, Alberti P, Sprowl J, Wang J, Lustberg M, Cavaletti G, Hu S, Sparreboom A. Differential Contribution of Neuronal Uptake Transporters to Oxaliplatin Peripheral Neurotoxicity. The FASEB Journal 2020, 34: 1-1. DOI: 10.1096/fasebj.2020.34.s1.03083.Peer-Reviewed Original ResearchDorsal root gangliaPeripheral neurotoxicityColorectal cancerOxaliplatin-induced peripheral neurotoxicityVon Frey hair testChronic peripheral neurotoxicityOxaliplatin-induced neurotoxicityVivo cultureColorectal cancer cellsWild-type ratsEx vivo cultureOxaliplatin therapyAfford neuroprotectionObserved neuroprotectionNeurological injuryRoot gangliaOxaliplatin accumulationSystemic clearanceConventional chemotherapyGlial cellsPreclinical modelsSprague-DawleySensory neuronsMouse modelSide effects
2019
Minimally Invasive Delivery of Microbeads with Encapsulated, Viable and Quiescent Neural Stem Cells to the Adult Subventricular Zone
Matta R, Lee S, Genet N, Hirschi KK, Thomas JL, Gonzalez AL. Minimally Invasive Delivery of Microbeads with Encapsulated, Viable and Quiescent Neural Stem Cells to the Adult Subventricular Zone. Scientific Reports 2019, 9: 17798. PMID: 31780709, PMCID: PMC6882840, DOI: 10.1038/s41598-019-54167-1.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell DifferentiationCell EncapsulationCell LineCell ProliferationCell SurvivalEndothelial CellsLateral VentriclesMaleMatrix MetalloproteinasesMiceMice, Inbred C57BLMicrospheresNeural Stem CellsNeuronsPolyethylene GlycolsRecovery of FunctionStem Cell NicheStem Cell TransplantationConceptsEndothelial cellsSubventricular zoneNSC quiescenceNon-injury modelQuiescent neural stem cellsAdult subventricular zoneNeuronal stem cellsStem cellsNeural stem cellsFunctional recoveryNeurological injuryInflammatory responseNeural stem cell maintenanceNSC deliveryNeural tissue repairNeurological diseasesMouse brainCell therapyNSC viabilityBrainTissue repairInjuryCo-encapsulated cellsSurvivalDelivery
2017
Aneurysmal Subarachnoid Hemorrhage
White J, Matouk C. Aneurysmal Subarachnoid Hemorrhage. 2017, 55-74. DOI: 10.1007/978-3-319-48669-7_4.Peer-Reviewed Original ResearchAneurysmal subarachnoid hemorrhageSubarachnoid hemorrhageLong-term cognitive impairmentAdditional neurological injuryCerebral vasospasmHospital admissionOverall mortalityNeurological injurySurgical clippingAneurysmal ruptureEndovascular coilingVascular lesionsRuptured aneurysmsCognitive impairmentEarly identificationHemorrhageAneurysmsDevastating diseaseMortalityRequisite first stepRebleedingVasospasmHydrocephalusAdmissionSeizuresProposed Standardized Neurological Endpoints for Cardiovascular Clinical Trials
Lansky AJ, Messé SR, Brickman AM, Dwyer M, van der Worp H, Lazar RM, Pietras CG, Abrams KJ, McFadden E, Petersen NH, Browndyke J, Prendergast B, Ng VG, Cutlip DE, Kapadia S, Krucoff MW, Linke A, Moy C, Schofer J, van Es GA, Virmani R, Popma J, Parides MK, Kodali S, Bilello M, Zivadinov R, Akar J, Furie KL, Gress D, Voros S, Moses J, Greer D, Forrest JK, Holmes D, Kappetein AP, Mack M, Baumbach A. Proposed Standardized Neurological Endpoints for Cardiovascular Clinical Trials. European Heart Journal 2017, 39: 1687-1697. PMID: 28171522, PMCID: PMC6251670, DOI: 10.1093/eurheartj/ehx037.Peer-Reviewed Original ResearchConceptsCardiovascular proceduresClinical trialsNeurological endpointsAcademic Research ConsortiumBenefit-risk assessmentAdjunctive pharmacologyNeurological complicationsNeurological outcomePreventive therapyClinical effectsNeurovascular injuryNeurological injuryNeurological riskEndpoint definitionsCardiovascular interventionsAscertainment methodsTherapyInjuryResearch ConsortiumRiskTrialsEndpointInherent risksSuch proceduresComplicationsProposed Standardized Neurological Endpoints for Cardiovascular Clinical Trials An Academic Research Consortium Initiative
Lansky AJ, Messé SR, Brickman AM, Dwyer M, van der Worp HB, Lazar RM, Pietras CG, Abrams KJ, McFadden E, Petersen NH, Browndyke J, Prendergast B, Ng VG, Cutlip DE, Kapadia S, Krucoff MW, Linke A, Moy CS, Schofer J, van Es GA, Virmani R, Popma J, Parides MK, Kodali S, Bilello M, Zivadinov R, Akar J, Furie KL, Gress D, Voros S, Moses J, Greer D, Forrest JK, Holmes D, Kappetein AP, Mack M, Baumbach A. Proposed Standardized Neurological Endpoints for Cardiovascular Clinical Trials An Academic Research Consortium Initiative. Journal Of The American College Of Cardiology 2017, 69: 679-691. PMID: 28183511, DOI: 10.1016/j.jacc.2016.11.045.Peer-Reviewed Original ResearchConceptsCardiovascular proceduresClinical trialsNeurological endpointsAcademic Research ConsortiumBenefit-risk assessmentAdjunctive pharmacologyNeurological complicationsNeurological outcomePreventive therapyClinical effectsNeurovascular injuryNeurological injuryNeurological riskEndpoint definitionsCardiovascular interventionsAscertainment methodsTherapyInjuryResearch ConsortiumRiskTrialsEndpointInherent risksSuch proceduresComplicationsChapter 10 Sur1–Trpm4-Promising Target for Brain Edema Treatment in Brain Edema From Molecular Mechanisms to Clinical Practice
Urday S, Sheth K, Simard J. Chapter 10 Sur1–Trpm4-Promising Target for Brain Edema Treatment in Brain Edema From Molecular Mechanisms to Clinical Practice. 2017, 183-198. DOI: 10.1016/b978-0-12-803196-4.00010-2.Peer-Reviewed Original ResearchSUR1-TRPM4Brain edemaEdema formationDefinitive phase III studyBrain edema treatmentNeurocritical care conditionsPhase III studyAcute neurological injuryExtravasation of bloodType of edemaMicrovascular failureIII studySignificant morbidityNeurological functionNeurological injuryEdema treatmentSafe medicationSelective blockadeLesion volumeClinical studiesPetechial hemorrhagesCare conditionsEdemaClinical practiceSulfonylurea receptor
2016
Nationwide secondary overtriage in level 3 and level 4 trauma centers: are these transfers necessary?
Lynch K, Essig R, Long D, Wilson A, Con J. Nationwide secondary overtriage in level 3 and level 4 trauma centers: are these transfers necessary? Journal Of Surgical Research 2016, 204: 460-466. PMID: 27565083, PMCID: PMC5018990, DOI: 10.1016/j.jss.2016.05.035.Peer-Reviewed Original ResearchConceptsLevel 1 trauma centerSecondary overtriageTransfer of trauma patientsHead computed tomography scanSystolic blood pressure <Injury Severity Score >Multivariate logistic regression analysisInjury patternsBlood pressure <Injury Severity ScoreLogistic regression analysisMultivariate regression analysisNational Trauma Data BankRegression analysisTrauma Data BankPatient demographicsSurgical interventionTomography scanTrauma center resourcesSurgical proceduresTrauma patientsSeverity scoreInterfacility transferNeurological injuryPatient risk
2014
CCR2+ monocytes contribute to hematoma clearance and long-term functional recovery after experimental intracerebral hemorrhage (HUM1P.324)
Hammond M, Taylor R, Ai Y, Sansing L. CCR2+ monocytes contribute to hematoma clearance and long-term functional recovery after experimental intracerebral hemorrhage (HUM1P.324). The Journal Of Immunology 2014, 192: 52.24-52.24. DOI: 10.4049/jimmunol.192.supp.52.24.Peer-Reviewed Original ResearchIntracerebral hemorrhageHematoma clearanceFunctional recoveryBlood injection ICH modelLong-term functional recoveryExperimental intracerebral hemorrhageSevere motor deficitsEarly neurological injuryResident microgliaInflammatory monocytesMotor deficitsNeurological injuryICH modelMouse modelInjected bloodMotor coordinationCCR2Day 1Normal microgliaMinimal deficitsBrain regionsMonocytesBrainClearancePotential role
2009
Intracortical electroencephalography in acute brain injury
Waziri A, Claassen J, Stuart RM, Arif H, Schmidt JM, Mayer SA, Badjatia N, Kull LL, Connolly ES, Emerson RG, Hirsch LJ. Intracortical electroencephalography in acute brain injury. Annals Of Neurology 2009, 66: 366-377. PMID: 19798724, DOI: 10.1002/ana.21721.Peer-Reviewed Original ResearchConceptsSecondary neurological complicationsElectrographic seizuresIctal activityNeurological complicationsScalp electroencephalographyNeurological injuryBrain injuryIntracortical EEGIntensive care unit settingSecondary neurological injurySecondary neuronal injuryAcute brain injuryIll neurological patientsIntracortical electroencephalographyClinical deteriorationNeuronal injuryInvasive neuromonitoringUnderwent implantationNeuromonitoring modalitiesBedside placementIctal dischargesRhythmic deltaUnit settingAcute changesContinuous electroencephalographyUsing proteomics in perinatal and neonatal sepsis: hopes and challenges for the future
Buhimschi CS, Bhandari V, Han YW, Dulay AT, Baumbusch MA, Madri JA, Buhimschi IA. Using proteomics in perinatal and neonatal sepsis: hopes and challenges for the future. Current Opinion In Infectious Diseases 2009, 22: 235-243. PMID: 19395960, PMCID: PMC2763282, DOI: 10.1097/qco.0b013e32832a5963.Peer-Reviewed Original ResearchConceptsNeonatal sepsisEarly-onset neonatal sepsisInsulin-like growth factor-binding protein-1Growth factor-binding protein-1Proteomic biomarkersAdvanced glycation end productsAmniotic fluid biomarkersAmniotic fluid inflammationFetal immune responsePoor neurodevelopmental outcomesIntra-amniotic infectionRisk of sepsisGlycation end productsHistological chorioamnionitisPreterm birthInflammatory statusNeurodevelopmental outcomesNeuroprotection strategiesInflammatory stateNeurological injuryFluid biomarkersInflammatory processImmune responseAmniotic fluidDefensin 2
2008
Axonal growth therapeutics: regeneration or sprouting or plasticity?
Cafferty WB, McGee AW, Strittmatter SM. Axonal growth therapeutics: regeneration or sprouting or plasticity? Trends In Neurosciences 2008, 31: 215-220. PMID: 18395807, PMCID: PMC2678051, DOI: 10.1016/j.tins.2008.02.004.Peer-Reviewed Original ResearchConceptsAxonal growthAstroglial scarHigh clinical significanceFunctional recoveryNeurological injuryInciting eventFunctional deficitsSpinal cordClinical significanceAdult brainLoss of functionCell lossInhibitory factorAxonal connectivityAxonal anatomyAxonal extensionMolecular interventionsMyelinScarCordInjuryBrain
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