2025
Treatment with Manganese Porphyrin, MnTnBuOE-2-PyP5+, Suppressed the Activation of Macrophages in a Mouse Intracerebral Hemorrhage
Zhang S, Cao J, Spasojevic I, Treggiari M, Sheng H. Treatment with Manganese Porphyrin, MnTnBuOE-2-PyP5+, Suppressed the Activation of Macrophages in a Mouse Intracerebral Hemorrhage. Pharmaceuticals 2025, 18: 547. PMID: 40283982, PMCID: PMC12030109, DOI: 10.3390/ph18040547.Peer-Reviewed Original ResearchMouse intracerebral hemorrhageIntracerebral hemorrhageActivation of macrophagesNeurological deficitsBMX-001Hemorrhage sizeBody weightSham surgery miceMnTnBuOE-2-PyP5+Neurological deficit scoreExperimental ischemic strokePrussian blue stainingAnti-inflammatory effectsStroke patientsPost-ICHNo significant differenceNeurological outcomeC57BL6 miceSurgery miceHemorrhagic transformationClinical trialsHemorrhageRotarod testDeficit scoresHistological evaluation
2019
Measurement of executive functioning with the National Institute of Health Toolbox and the association to anxiety/depressive symptomatology in childhood/adolescence
Kavanaugh BC, Cancilliere MK, Fryc A, Tirrell E, Oliveira J, Oberman LM, Wexler BE, Carpenter LL, Spirito A. Measurement of executive functioning with the National Institute of Health Toolbox and the association to anxiety/depressive symptomatology in childhood/adolescence. Child Neuropsychology 2019, 26: 754-769. PMID: 31876232, PMCID: PMC10629577, DOI: 10.1080/09297049.2019.1708295.Peer-Reviewed Original ResearchConceptsAnxiety/depressive symptomatologyGlobal deficit scoreDepressive symptomatologyDetection of impairmentHealth ToolboxDepressive symptom varianceNational InstituteChildhood/adolescenceSelf-reported depressionComparable psychometric propertiesSymptom varianceEF symptomsDeficit scoresDepression diagnosisDepressive symptomsClinical diagnosisChild-reported anxietyClinical neuropsychological measuresImpairmentMeasures of EFSymptomatologyDepressionNeuropsychological measuresSymptomsParent report
2018
Imaging the Effects of &bgr;-Hydroxybutyrate on Peri-Infarct Neurovascular Function and Metabolism
Bazzigaluppi P, Lake EM, Beckett TL, Koletar MM, Weisspapir I, Heinen S, Mester J, Lai A, Janik R, Dorr A, McLaurin J, Stanisz GJ, Carlen PL, Stefanovic B. Imaging the Effects of &bgr;-Hydroxybutyrate on Peri-Infarct Neurovascular Function and Metabolism. Stroke 2018, 49: 2173-2181. PMID: 30354983, DOI: 10.1161/strokeaha.118.020586.Peer-Reviewed Original ResearchMeSH Keywords3-Hydroxybutyric AcidAcetoacetatesAnimalsAstrocytesBlood GlucoseBrainBrain IschemiaCell DeathCerebrovascular CirculationDisease Models, AnimalElectrophysiological PhenomenaEndothelin-1HemodynamicsMagnetic Resonance ImagingMagnetic Resonance SpectroscopyMicroinjectionsNeuronsRatsReactive Oxygen SpeciesSensorimotor CortexConceptsBody β-hydroxybutyrateFunctional recoveryMagnetic resonance imagingIschemic insultNeuronal deathResonance imagingFocal cortical strokeVehicle-administered animalsNeurological deficit scoresKetone body β-hydroxybutyrateNeuronal glucose uptakeContinuous arterial spinReduced oxidative stressPurpose Recent evidenceReactive oxygen species productionCortical microinjectionsCortical strokePostischemic hyperglycemiaDeficit scoresNeurovascular functionAcute phaseCerebrovascular reactivitySensorimotor cortexCerebral hemodynamicsEndothelin-1
2016
The Veterans Aging Cohort Study (VACS) Index and Neurocognitive Change: A Longitudinal Study
Marquine M, Montoya J, Umlauf A, Fazeli P, Gouaux B, Heaton R, Ellis R, Letendre S, Grant I, Moore D, Group F, Heaton R, Grant I, Atkinson J, Ellis R, Letendre S, Marcotte T, Marquie-Beck J, Sherman M, Ellis R, Letendre S, McCutchan J, Best B, Schrier R, Rosario D, Heaton R, Atkinson J, Woods S, Marcotte T, Cherner M, Moore D, Dawson M, Fennema-Notestine C, Buchsbaum M, Hesselink J, Archibald S, Brown G, Buxton R, Dale A, Liu T, Masliah E, Achim C, Smith D, Richman D, McCutchan J, Cherner M, Achim C, Lipton S, Atkinson J, Marquie-Beck J, Gamst A, Cushman C, Abramson I, Vaida F, Deutsch R, Umlauf A. The Veterans Aging Cohort Study (VACS) Index and Neurocognitive Change: A Longitudinal Study. Clinical Infectious Diseases 2016, 63: 694-702. PMID: 27199461, PMCID: PMC4981756, DOI: 10.1093/cid/ciw328.Peer-Reviewed Original ResearchConceptsVACS Index scoreVeterans Aging Cohort Study (VACS) IndexHigher VACS Index scoresVACS IndexNeurocognitive impairmentIndex scoreT-scoreNeurocognitive changesHIV Neurobehavioral Research ProgramStudy indicesIncident neurocognitive impairmentHuman immunodeficiency virusGlobal deficit scoreSubgroup of personsUpper quartile groupGlobal T-scoresLongitudinal neurocognitive changesCohort studyDeficit scoresImmunodeficiency virusLowest quartileNeurocognitive statusNeurocognitive functionDisease severityComprehensive neurocognitive battery
2000
Isoflurane Pretreatment Ameliorates Postischemic Neurologic Dysfunction and Preserves Hippocampal Ca2+/Calmodulin-dependent Protein Kinase in a Canine Cardiac Arrest Model
Blanck T, Haile M, Xu F, Zhang J, Heerdt P, Veselis R, Beckman J, Kang R, Adamo A, Hemmings H. Isoflurane Pretreatment Ameliorates Postischemic Neurologic Dysfunction and Preserves Hippocampal Ca2+/Calmodulin-dependent Protein Kinase in a Canine Cardiac Arrest Model. Anesthesiology 2000, 93: 1285-1293. PMID: 11046218, DOI: 10.1097/00000542-200011000-00023.Peer-Reviewed Original ResearchMeSH KeywordsAnesthetics, InhalationAnimalsBlood PressureBlotting, WesternBrain DiseasesCalciumCalcium-Calmodulin-Dependent Protein Kinase Type 2Calcium-Calmodulin-Dependent Protein KinasesDogsFemaleHeart Arrest, InducedHeart RateHippocampusIschemic Attack, TransientIschemic PreconditioningIsofluraneNeuroprotective AgentsSynaptosomesConceptsNeurologic deficit scoreCanine cardiac arrest modelCardiac arrest modelDeficit scoresIschemic animalsCardiac arrestGlobal ischemiaStriatum of animalsEffective neuroprotective drugsIsoflurane pretreatmentNeurologic dysfunctionNeurologic functionHippocampal contentNeuroprotective effectsIsoflurane exposureHippocampal levelsIntensive careNeuroprotective drugsRat modelVentricular fibrillationInhalational anestheticsTreatment groupsBlinded evaluatorsCanine modelIschemia
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