2025
Perirectal spacers in radiotherapy for prostate cancer – a systematic review and meta-analysis
Miszczyk M, Stando R, Francolini G, Zamboglou C, Cadenar A, Suleja A, Fazekas T, Matsukawa A, Tsuboi I, Przydacz M, Leapman M, Rajwa P, Supiot S, Shariat S. Perirectal spacers in radiotherapy for prostate cancer – a systematic review and meta-analysis. Współczesna Onkologia 2025, 29: 36-44. PMID: 40330445, PMCID: PMC12051878, DOI: 10.5114/wo.2025.148388.Peer-Reviewed Original ResearchProstate cancerAdverse eventsRisk of biasNon-randomised trialsClinically localised PCaOdds ratioAcute rectal toxicityLocalised PCaAssociated with decreased incidenceMeta-analysisSevere adverse eventsModerate risk of biasRandomised clinical trialsSystematic reviewROBINS-I toolModern RTRectal toxicityTreatment toxicityConcealment of allocationClinical outcomesPerirectal spaceClinical trialsRadiotherapyROBINS-IModerate riskSex-Specific Clinical and Genetic Factors Associated With Adverse Outcomes in Hypertrophic Cardiomyopathy
Butters A, Arnott C, Sweeting J, Claggett B, Cuomo A, Abrams D, Ashley E, Day S, Helms A, Lampert R, Lin K, Michels M, Miller E, Olivotto I, Owens A, Parikh V, Pereira A, Rossano J, Ryan T, Saberi S, Stendahl J, Ware J, Atherton J, Semsarian C, Lakdawala N, Ho C, Ingles J. Sex-Specific Clinical and Genetic Factors Associated With Adverse Outcomes in Hypertrophic Cardiomyopathy. Circulation Genomic And Precision Medicine 2025, 18: e004641. PMID: 39851041, DOI: 10.1161/circgen.124.004641.Peer-Reviewed Original ResearchConceptsRisk of heart failureSex-specific hazard ratiosHazard ratioHypertrophic cardiomyopathyAdverse outcomesHeart failureSex interaction termsFactors associated with adverse outcomesRisk of atrial fibrillationVentricular arrhythmiasCox proportional hazards modelsSarcomeric Human Cardiomyopathy RegistryManagement of hypertrophic cardiomyopathyProportional hazards modelInvestigate sex-related differencesSex differencesHeart failure riskRisk scoreHigher heart failureModerate riskHazards modelRisk factorsCardiomyopathy RegistryDeath riskImprove outcomes
2024
Long-Term Use of Muscle Relaxant Medications for Chronic Pain
Oldfield B, Gleeson B, Morford K, Adams Z, Funaro M, Becker W, Merlin J. Long-Term Use of Muscle Relaxant Medications for Chronic Pain. JAMA Network Open 2024, 7: e2434835. PMID: 39298168, PMCID: PMC11413720, DOI: 10.1001/jamanetworkopen.2024.34835.Peer-Reviewed Original ResearchConceptsLow back painBack painSkeletal muscle relaxantsChronic painRandomized clinical trialsNeck painCohort studyEfficacy of long-term useLong-term useSystematically searched Ovid MEDLINEMuscle relaxant medicationsModerate risk of biasOpioid prescribing guidelinesRisk of biasQuality of cohort studiesWeb of SciencePainful crampsRelaxant medicationsChronic pain syndromesPainful spasmsOvid MEDLINEPrescribing guidelinesSystematic reviewIncreased prescriptionModerate riskA multisite study to develop and validate first trimester, circulating microparticle biomarkers for tiered risk stratification of spontaneous preterm birth in nulliparas
Rosenblatt K, Zhang Z, Doss R, Gurnani P, Grobman W, Silver R, Parry S, Reddy U, Cao S, Haas D. A multisite study to develop and validate first trimester, circulating microparticle biomarkers for tiered risk stratification of spontaneous preterm birth in nulliparas. American Journal Of Obstetrics And Gynecology 2024, 232: 319.e1-319.e21. PMID: 38789072, PMCID: PMC11584339, DOI: 10.1016/j.ajog.2024.05.032.Peer-Reviewed Original ResearchIn vitro diagnostic multivariate index assaySpontaneous preterm birthGestational agePreterm birthLow riskModerate riskPrediction of spontaneous preterm birthHR groupRisk ratioHigh riskMonitoring Mothers-to-BeNulliparous Pregnancy Outcomes StudyTrimester of pregnancyMultivariate index assayPregnancy Outcomes StudyNested case-control designStatistically significant differencePregnant patientsWeeks gestationMass spectrometry assayCase-control designRisk stratificationStratify riskMothers-to-beStratification toolEffectiveness of glucose-lowering medications on cardiovascular outcomes in patients with type 2 diabetes at moderate cardiovascular risk
McCoy R, Herrin J, Swarna K, Deng Y, Kent D, Ross J, Umpierrez G, Galindo R, Crown W, Borah B, Montori V, Brito J, Neumiller J, Mickelson M, Polley E. Effectiveness of glucose-lowering medications on cardiovascular outcomes in patients with type 2 diabetes at moderate cardiovascular risk. Nature Cardiovascular Research 2024, 3: 431-440. PMID: 38846711, PMCID: PMC11156225, DOI: 10.1038/s44161-024-00453-9.Peer-Reviewed Original ResearchAdverse cardiovascular eventsGlucose-lowering medicationsType 2 diabetesCardiovascular diseaseGLP-1RACardiovascular eventsGlucagon-like peptide-1 receptor agonistsSodium-glucose cotransporter 2 inhibitorsPeptide-1 receptor agonistsDipeptidyl peptidase-4 inhibitorsPeptidase-4 inhibitorsRetrospective cohort studyCardiovascular disease risk reductionGlucose-lowering agentsModerate cardiovascular riskCardiovascular risk reductionReceptor agonistsEffects of glucose-lowering medicationsRisk reductionCardiovascular riskCohort studyCardiovascular outcomesHigh riskBaseline riskModerate risk
2023
Effects of Physical Exercise on Cerebral Blood Velocity in Older Adults: A Systematic Review and Meta−Analysis
Prudente T, Oliva H, Oliva I, Mezaiko E, Monteiro-Junior R. Effects of Physical Exercise on Cerebral Blood Velocity in Older Adults: A Systematic Review and Meta−Analysis. Behavioral Sciences 2023, 13: 847. PMID: 37887497, PMCID: PMC10604216, DOI: 10.3390/bs13100847.Peer-Reviewed Original ResearchEffects of physical exercisePhysical exerciseOlder peopleOlder adultsSystematic reviewCochrane risk-of-bias toolBenefits of exerciseRisk-of-bias toolEffectiveness of training programsMeta-analysisModerate risk of biasRisk of biasWeb of ScienceCerebral blood velocityGeneral healthOlder populationTraining programNon-randomized clinical trialExerciseModerate riskResults of randomized trialsStatistically significant increaseCerebral healthRandomized trialsBlood velocity
2022
Efficacy, Immunogenicity, and Safety of COVID-19 Vaccines in Randomized Control Trials in the Pre-Delta Era: A Systematic Review and Network Meta-Analysis
Oh S, Purja S, Shin H, Kim M, Park S, Kronbichler A, Smith L, Eisenhut M, Shin J, Kim E. Efficacy, Immunogenicity, and Safety of COVID-19 Vaccines in Randomized Control Trials in the Pre-Delta Era: A Systematic Review and Network Meta-Analysis. Vaccines 2022, 10: 1572. PMID: 36298440, PMCID: PMC9608197, DOI: 10.3390/vaccines10101572.Peer-Reviewed Original ResearchNetwork Meta-AnalysisSafety of COVID-19 vaccinesMeta-analysisAdverse reactionsCOVID-19 vaccineSystemic adverse reactionsMRNA-1273 vaccineNeutralizing antibody responsesModerate risk of biasPre-Delta eraLive SARS-CoV-2Systematic reviewRandomized Controlled TrialsRisk of biasPlatform vaccinesMRNA-1273Comparative efficacyLow incidenceMedRxiv databasesCoronaVac vaccineAntibody responseVaccine efficacyControlled TrialsModerate riskSARS-CoV-2
2021
Medical Sciences’ Students Responses During the Late Phase of the COVID-19 Pandemic in Iran: A Comprehensive Investigation of the Risk Perception and Information Exposure
Shafie M, Mayeli M, Hosseini H, Ashoorkhani M. Medical Sciences’ Students Responses During the Late Phase of the COVID-19 Pandemic in Iran: A Comprehensive Investigation of the Risk Perception and Information Exposure. Acta Medica Iranica 2021 DOI: 10.18502/acta.v59i12.8058.Peer-Reviewed Original ResearchRisk perceptionMedical sciences studentsCOVID-19 pandemicCOVID-19 exposureHealth professionalsHigh-risk patientsPreventive perceptionsCOVID-19Medical conditionsModerate riskFamily membersInformation exposureOnline questionnaireHigh riskBehavior modificationNo significant differenceMedical historyDemographic contributorsPerceived RiskSource of informationRiskSignificant differenceLate phasePerceptionTriatoScore: an entomological-risk score for Chagas disease vector control-surveillance
Ribeiro-Jr G, Abad-Franch F, de Sousa O, dos Santos C, Fonseca E, dos Santos R, Cunha G, de Carvalho C, Reis R, Gurgel-Gonçalves R, Reis M. TriatoScore: an entomological-risk score for Chagas disease vector control-surveillance. Parasites & Vectors 2021, 14: 492. PMID: 34563255, PMCID: PMC8465766, DOI: 10.1186/s13071-021-04954-5.Peer-Reviewed Original ResearchConceptsNon-native speciesTriatomine bug speciesBug speciesEntomological riskVector-borne Chagas diseaseSemiarid ecoregionsEcoregionsRelevant scalesBahia StateSpeciesMunicipal territoryDisease vectorsNative vectorsDomestic populationsRun systemModerate riskMunicipalitiesFaunaChagas disease vectorsOfficial classificationBahiaStrataTrypanosoma cruzi transmissionAmericaBrazilClosing the Compliance Loop on Follow-Up Imaging Recommendations: Comparing Radiologists’ and Administrators’ Attitudes
Kadom N, Fredericks N, Moore CL, Seidenwurm D, Shugarman S, Venkatesh A. Closing the Compliance Loop on Follow-Up Imaging Recommendations: Comparing Radiologists’ and Administrators’ Attitudes. Current Problems In Diagnostic Radiology 2021, 51: 486-490. PMID: 34565635, DOI: 10.1067/j.cpradiol.2021.08.003.Peer-Reviewed Original ResearchConceptsActionable incidental findingsTechnical expert panelNon-physician healthcare professionalsPrimary care providersIncidental findingImaging recommendationsAmerican CollegeCare providersOrdering providerMedical professional organizationsModerate riskHealthcare professionalsFollowExpert panelRespondent groupsTransition communicationHealthcare systemRadiologists
2019
Integration of care for HIV and opioid use disorder
Oldfield B, Muñoz N, McGovern M, Funaro M, Villanueva M, Tetrault J, Edelman E. Integration of care for HIV and opioid use disorder. AIDS 2019, Publish Ahead of Print: &na;. PMID: 30882491, PMCID: PMC6588508, DOI: 10.1097/qad.0000000000002125.Peer-Reviewed Original ResearchConceptsHIV care settingsCare settingsClinical benefitTreatment settingsSystematic reviewBuprenorphine/naloxoneOpioid use disorderProvision of medicationsIntegration of careAntiretroviral therapyOpioid useMedication adherencePROSPERO databaseOvid MEDLINETreatment strategiesObservational studyHIVUse disordersModerate riskBehavioral interventionsScreening strategyOUDRisk reductionTreatmentUnique studies
2017
Long-term alcohol use patterns and HIV disease severity
Marshall BDL, Tate JP, McGinnis KA, Bryant KJ, Cook RL, Edelman EJ, Gaither JR, Kahler CW, Operario D, Fiellin DA, Justice AC. Long-term alcohol use patterns and HIV disease severity. AIDS 2017, 31: 1313-1321. PMID: 28492393, PMCID: PMC5596310, DOI: 10.1097/qad.0000000000001473.Peer-Reviewed Original ResearchConceptsHIV disease severityVeterans Aging Cohort StudyHigh-risk drinkersDisease severityAlcohol useRisk drinkersLower riskAlcohol use trajectoriesIndex groupModerate riskIndex trajectoriesVeterans Health Administration sitesAging Cohort StudyHigh-risk groupMeasures of morbidityAlcohol Use Disorders IdentificationLow index groupAlcohol consumption trajectoriesUse trajectoriesSubset of participantsAlcohol use patternsVACS IndexCause mortalityCohort studyProspective cohort
2013
Long‐Term Risk Perceptions of Women With Ductal Carcinoma In Situ
Ruddy KJ, Meyer ME, Giobbie‐Hurder A, Emmons KM, Weeks JC, Winer EP, Partridge AH. Long‐Term Risk Perceptions of Women With Ductal Carcinoma In Situ. The Oncologist 2013, 18: 362-368. PMID: 23568001, PMCID: PMC3639521, DOI: 10.1634/theoncologist.2012-0376.Peer-Reviewed Original ResearchConceptsInvasive breast cancerBreast cancerDuctal carcinomaLifetime riskFuture breast cancer eventsHistory of DCISBreast cancer eventsTime of diagnosisLong-term followLongitudinal cohort studyFuture breast cancerWorse financial statusCohort studyMedian timeCancer eventsDCISOnly predictorModerate riskMultivariate modelCancerWomenDiagnosisRisk perceptionCarcinomaRecurrencePrescription of Second-Generation Antipsychotics: Responding to Treatment Risk in Real-World Practice
Hermes ED, Sernyak MJ, Rosenheck RA. Prescription of Second-Generation Antipsychotics: Responding to Treatment Risk in Real-World Practice. Psychiatric Services 2013, 64: 238-244. PMID: 23241613, DOI: 10.1176/appi.ps.201200183.Peer-Reviewed Original ResearchConceptsSecond-generation antipsychoticsProportion of patientsCardiometabolic riskCardiometabolic disordersCardiovascular diseaseSociodemographic dataSingle Veterans Affairs medical centerVeterans Affairs Medical CenterChoice of antipsychoticHigh cardiometabolic riskPatients' sociodemographic dataQuality of careAntipsychotic prescribedReal-world practicePsychiatric providersTreatment decisionsMedical CenterTreatment risksComorbid diagnosesPatientsAntipsychoticsSignificant associationModerate riskNew prescriptionsProvider sensitivity
2008
Performance of an Algorithm for Assessing Smallpox Risk among Patients with Rashes That May Be Confused with Smallpox
Hutchins S, Sulemana I, Heilpern K, Schaffner W, Wax G, Lerner E, Watson B, Baltimore R, Waltenburg R, Aronsky D, Coffin S, Ng G, Craig A, Behrman A, Meek J, Sherman E, Chavez S, Harpaz R, Schmid S. Performance of an Algorithm for Assessing Smallpox Risk among Patients with Rashes That May Be Confused with Smallpox. Clinical Infectious Diseases 2008, 46: s195-s203. PMID: 18284359, DOI: 10.1086/524383.Peer-Reviewed Original ResearchRisk Perceptions and Psychosocial Outcomes of Women With Ductal Carcinoma In Situ: Longitudinal Results From a Cohort Study
Partridge A, Adloff K, Blood E, Dees EC, Kaelin C, Golshan M, Ligibel J, de Moor JS, Weeks J, Emmons K, Winer E. Risk Perceptions and Psychosocial Outcomes of Women With Ductal Carcinoma In Situ: Longitudinal Results From a Cohort Study. Journal Of The National Cancer Institute 2008, 100: 243-251. PMID: 18270338, DOI: 10.1093/jnci/djn010.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAnxietyBreast NeoplasmsCarcinoma, Intraductal, NoninfiltratingCohort StudiesDepressionFemaleHumansLogistic ModelsLongitudinal StudiesMammographyMass ScreeningMassachusettsMiddle AgedNeoplasm Recurrence, LocalOdds RatioPredictive Value of TestsPrognosisQuality of LifeRisk AssessmentRisk FactorsConceptsLocal recurrence rateRecurrence ratePsychosocial outcomesDuctal carcinomaModerate riskCancer-related risksFavorable overall prognosisSystemic recurrence ratesBreast-conserving treatmentBreast cancer riskDCIS diagnosisCohort studyDCIS recurrenceOverall prognosisDisease recurrenceInvasive cancerDCISCancer riskPsychosocial concernsHealth behaviorsEnrollment surveySubstantial anxietyWomenInaccurate perceptionsModerate likelihood
2006
Brain-Derived Neurotrophic Factor–5-HTTLPR Gene Interactions and Environmental Modifiers of Depression in Children
Kaufman J, Yang BZ, Douglas-Palumberi H, Grasso D, Lipschitz D, Houshyar S, Krystal JH, Gelernter J. Brain-Derived Neurotrophic Factor–5-HTTLPR Gene Interactions and Environmental Modifiers of Depression in Children. Biological Psychiatry 2006, 59: 673-680. PMID: 16458264, DOI: 10.1016/j.biopsych.2005.10.026.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentBrain-Derived Neurotrophic FactorCase-Control StudiesChi-Square DistributionChildChild AbuseChild, PreschoolDepressionDNA Mutational AnalysisEnvironmentFemaleGene FrequencyGenetic VariationGenotypeHumansMaleMethioninePredictive Value of TestsPsychiatric Status Rating ScalesRisk FactorsSerotonin Plasma Membrane Transport ProteinsSeverity of Illness IndexSocial SupportSurveys and QuestionnairesValineConceptsBrain-derived neurotrophic factor (BDNF) genotypeNeurotrophic factor genotypeSocial supportHigher depression scoresBDNF genotypeProportion scoreBDNF geneProtective effectDepression scoresComparison subjectsPsychiatric symptomatologyModerate riskEnvironmental modifiersDepressionFactor genotypeChildrenDNA specimensStandard research instrumentsShort alleleRiskMaltreatment historyCurrent dataScoresAncestry informative markersChild abuse
2004
Social supports and serotonin transporter gene moderate depression in maltreated children
Kaufman J, Yang BZ, Douglas-Palumberi H, Houshyar S, Lipschitz D, Krystal JH, Gelernter J. Social supports and serotonin transporter gene moderate depression in maltreated children. Proceedings Of The National Academy Of Sciences Of The United States Of America 2004, 101: 17316-17321. PMID: 15563601, PMCID: PMC534414, DOI: 10.1073/pnas.0404376101.Peer-Reviewed Original ResearchConceptsSocial supportDevelopment of depressionGene promoter polymorphismTransporter gene promoter polymorphismSerotonin transporter gene promoter polymorphismHigher depression ratingsDepression ratingsClinical dataModerate depressionPsychiatric disordersDepression scoresPromoter polymorphismNegative sequelaeModerate riskDepressionEarly stressChildrenS genotypeHistory of maltreatmentRiskShort allele
1999
Effects of long-term intake of retinol on selected clinical and laboratory indexes
Cartmel B, Moon T, Levine N. Effects of long-term intake of retinol on selected clinical and laboratory indexes. American Journal Of Clinical Nutrition 1999, 69: 937-943. PMID: 10232634, DOI: 10.1093/ajcn/69.5.937.Peer-Reviewed Original ResearchConceptsRetinol intakeAdverse effectsLaboratory indicesVitamin A/dCoronary artery disease riskCancer chemoprevention trialsLong-term ingestionMinimal adverse effectsLong-term intakeSkin cancer chemoprevention trialAlkaline phosphataseMedian followPlacebo groupChemoprevention trialsClinical symptomsRetinol groupChemopreventive agentsCholesterol concentrationsHealthy populationSkin cancerModerate riskDisease riskIntakeFurther studiesSignificant differences
1983
Major surgery in infants weighing less than 1,500 grams
Seashore J, Touloukian R, Kopf G. Major surgery in infants weighing less than 1,500 grams. The American Journal Of Surgery 1983, 145: 483-487. PMID: 6404191, DOI: 10.1016/0002-9610(83)90044-2.Peer-Reviewed Original ResearchConceptsMajor surgeryPremature infantsSurvival rateShort duration anesthesiaPostoperative mechanical ventilationLow birth weightPatent ductus arteriosusNeuromuscular blocking agentsOnly moderate riskParenteral nutritionDuctus arteriosusIntraoperative managementMechanical ventilationBirth weightBlocking agentInfantsModerate riskVital signsOxygen toxicityAppropriate timingMajor operationsJudicious useSurgeryRiskCommon operation
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply