2025
A Case of Persistent, Delayed Multisystem Toxicities After Anti-PD-1 Therapy
Goodman R, Burnette H, Johnson D. A Case of Persistent, Delayed Multisystem Toxicities After Anti-PD-1 Therapy. 2025, 449-454. DOI: 10.1007/978-3-031-83533-9_56.Peer-Reviewed Original Research4-Anilinoquinolinylchalcone derivatives mediate antifibrotic effects through ERK/MRTF—a signaling pathway crosstalk
Selvam P, Tseng C, Wang C, Sun Y, Chen Y, Kao Y, Dahms H, Cheng C. 4-Anilinoquinolinylchalcone derivatives mediate antifibrotic effects through ERK/MRTF—a signaling pathway crosstalk. Environmental Science And Pollution Research 2025, 32: 11685-11696. PMID: 40234319, DOI: 10.1007/s11356-025-36382-8.Peer-Reviewed Original ResearchConceptsSide effectsAbnormal liver functionAnti-fibrosisSevere side effectsGroup of drugsAnti-inflammatory responseHuman immune systemSkin rashGenitourinary cancersMechanism of actionAntifibrotic effectsBreast cancerScreened 6Immunomodulatory qualitiesLiver functionPharmacological profileImmune systemSignaling pathwaySignaling pathway crosstalkQuinolone analoguesCancerAnti-cancerDerivativesBleedingRash
2022
Clinical Reasoning: A 60-Year-Old Man With Asymmetric Weakness and Persistent Fever
Zheng Y, Xiang J, Zhang X, Zhang S, Ding M, Huang J. Clinical Reasoning: A 60-Year-Old Man With Asymmetric Weakness and Persistent Fever. Neurology 2022, 100: 530-536. PMID: 36914272, PMCID: PMC10074466, DOI: 10.1212/wnl.0000000000201697.Peer-Reviewed Original ResearchConceptsPeripheral neuropathyPersistent feverAsymmetric weaknessDevelopment of rashElevated inflammatory markersAcute-onset weaknessClinical pattern recognitionDiagnostic challengeInflammatory markersDifferential diagnosisAtypical featuresElectrophysiological studiesAncillary testsTargeted treatmentNeuropathyRight legFeverLeft legDiagnosisRashPatientsChikungunya Arthritis
Amaral J, Pal T, Schoen R. Chikungunya Arthritis. Rare Diseases Of The Immune System 2022, 179-190. DOI: 10.1007/978-3-031-05002-2_14.Peer-Reviewed Original ResearchDisease-modifying anti-rheumatic drugsAnti-rheumatic drugsInflammatory rheumatic diseasesChikungunya arthritisChronic arthritisSupportive careBiphasic illnessRheumatic diseasesRheumatoid arthritisInflammatory processViral infectionArthritisAlphavirus infectionMillions of peopleIllnessInfectionDiseaseChikungunyaSubtropical worldArthralgiaRashPatientsFeverMethotrexateCarePI3K Inhibitor Eruptions: an Overview of Diagnostic and Management Strategies for the Inpatient Dermatologist
Belzer A, Bhullar S, Leventhal J. PI3K Inhibitor Eruptions: an Overview of Diagnostic and Management Strategies for the Inpatient Dermatologist. Current Dermatology Reports 2022, 11: 158-167. DOI: 10.1007/s13671-022-00365-6.Peer-Reviewed Original ResearchDermatologic adverse eventsBody surface areaClinical trialsAdverse eventsCommon dermatologic adverse eventsMucositis/stomatitisFrequent adverse eventsAddition of prednisoneMajority of malignanciesPI3K inhibitorsMaculopapular rashProphylactic therapyPsoriasiform eruptionTopical corticosteroidsSun avoidanceSummaryThis reviewPI3KiK inhibitorsInpatient DermatologistTrialsCancer therapyRashTherapyDermatologistsOverview of diagnosticsUveitis associated with tattoo granulomas
Abdel-Aty A, Apostolopoulos N, Kombo N. Uveitis associated with tattoo granulomas. BMJ Case Reports 2022, 15: e244196. PMID: 35131770, PMCID: PMC8823039, DOI: 10.1136/bcr-2021-244196.Peer-Reviewed Original ResearchConceptsOcular symptomsEmergency departmentSystemic diseaseDays of feverNon-caseating granulomasPrimary care physiciansDesquamative rashSore throatCare physiciansBlurry visionPhysical examinationCommon reasonEarly manifestationFurther evaluationGranulomasPatientsSymptomsUveitisRashDiseaseDepartmentCorticosteroidsLymphadenopathyPhotophobiaTonsillar
2021
Tylenol or acetaminophen: a recurrent fixed drug eruption perpetuated through the use of inconsistent drug terminology
Federman D, Gruen JA, Merchant N. Tylenol or acetaminophen: a recurrent fixed drug eruption perpetuated through the use of inconsistent drug terminology. BMJ Case Reports 2021, 14: e241908. PMID: 34344644, PMCID: PMC8336122, DOI: 10.1136/bcr-2021-241908.Peer-Reviewed Case Reports and Technical Notes
2020
Progressive Dyspnea and Hypoxemia With Diffuse Pulmonary Infiltrates in a Previously Healthy Woman
Mainardi AS, Siddon AJ, Bader AS, Hilbert J. Progressive Dyspnea and Hypoxemia With Diffuse Pulmonary Infiltrates in a Previously Healthy Woman. CHEST Journal 2020, 158: e327-e334. PMID: 33280778, DOI: 10.1016/j.chest.2020.07.009.Peer-Reviewed Case Reports and Technical NotesConceptsAdmission laboratory test resultsMonths of coughMild respiratory distressViolaceous maculesAcneiform rashProgressive dyspneaAxillary adenopathyNight sweatsHealthy womenNew feverRespiratory distressDiffuse pulmonaryPhysical examinationWBC countPlatelet levelsConjunctival edemaFurther managementOxygen saturationPulmonary cracklesLaboratory test resultsDyspneaRashWomenAdenopathyHypoxemiaA 62-Year-Old Woman With Lung Cancer, Ulcerating Rash, and Rapidly Progressive Hypoxemia
Kunitomo Y, Young G, Datta R, Korn LL, Tanoue L, Gautam S. A 62-Year-Old Woman With Lung Cancer, Ulcerating Rash, and Rapidly Progressive Hypoxemia. CHEST Journal 2020, 158: e191-e196. PMID: 33036118, PMCID: PMC7533682, DOI: 10.1016/j.chest.2020.06.020.Peer-Reviewed Case Reports and Technical NotesA Novel Treatment for a Rare Cause of Cardiogenic Shock
Chowdhury M, Azari BM, Desai NR, Ahmad T. A Novel Treatment for a Rare Cause of Cardiogenic Shock. JACC Case Reports 2020, 2: 1461-1465. PMID: 34316997, PMCID: PMC8302098, DOI: 10.1016/j.jaccas.2020.02.004.Peer-Reviewed Original Research
2019
The rash in life-threatening metabolic and endocrine disorders
Mirza FN, Leventhal JS. The rash in life-threatening metabolic and endocrine disorders. Clinics In Dermatology 2019, 38: 79-85. PMID: 32197751, DOI: 10.1016/j.clindermatol.2019.10.018.Peer-Reviewed Original ResearchConceptsEndocrine disordersCutaneous manifestationsLethal complicationSkin manifestationsSystemic disordersEarly diagnosisNutritional diseasesDisordersInternal healthRashManifestationsMorbidityComplicationsAdrenalsParathyroidNeuroendocrineThyroidMortalityPancreasCliniciansDermatologistsDiseaseDiagnosisBlood
2018
A Young Man With Hemoptysis and Cavitary Lung Lesions
Brady VA, Zinchuk AV, Siegel MD, Possick JD. A Young Man With Hemoptysis and Cavitary Lung Lesions. CHEST Journal 2018, 153: e85-e88. PMID: 29626974, PMCID: PMC6026285, DOI: 10.1016/j.chest.2017.09.018.Peer-Reviewed Case Reports and Technical NotesConceptsBacillus Calmette-Guérin (BCG) vaccineCavitary lung lesionsPrior cigarette smokingCalmette-Guérin vaccineHistory of alcoholIntermittent hemoptysisNight sweatsCigarette smokingMusculoskeletal symptomsLung lesionsMild fatigueDrug useWeight lossHemoptysisYoung menMenDyspneaRashMedicationsSmokingFeverVaccineLesionsSymptomsMonthsResponse to the BRAF/MEK inhibitors dabrafenib/trametinib in an adolescent with a BRAF V600E mutated anaplastic ganglioglioma intolerant to vemurafenib
Marks AM, Bindra RS, DiLuna ML, Huttner A, Jairam V, Kahle KT, Kieran MW. Response to the BRAF/MEK inhibitors dabrafenib/trametinib in an adolescent with a BRAF V600E mutated anaplastic ganglioglioma intolerant to vemurafenib. Pediatric Blood & Cancer 2018, 65: e26969. PMID: 29380516, DOI: 10.1002/pbc.26969.Peer-Reviewed Original ResearchConceptsAnaplastic gangliogliomaBRAF/MEK inhibitor combinationsBRAF V600ESubsequent tumor responseDabrafenib/trametinibLarge clinical trialsSquamous cell carcinomaMEK inhibitor combinationsSignificant side effectsSignificant skin reactionsCell carcinomaCase reportSkin reactionsTumor responseClinical trialsBrain tumorsInhibitor combinationsSide effectsAdolescent femalesGangliogliomaTrametinibPrevious reactionsV600EMonotherapyRash
2016
Disseminated Histoplasmosis with Skin Lesions and Osteomyelitis in a Patient from the Philippines.
Azar MM, Malinis MF. Disseminated Histoplasmosis with Skin Lesions and Osteomyelitis in a Patient from the Philippines. American Journal Of Tropical Medicine And Hygiene 2016, 95: 70-4. PMID: 26976880, PMCID: PMC4944712, DOI: 10.4269/ajtmh.16-0063.Peer-Reviewed Case Reports and Technical NotesConceptsBone involvementDisseminated histoplasmosisFoot woundsPapular rashProtean manifestationsFinal diagnosisUnusual manifestationSkin lesionsDimorphic fungus Histoplasma capsulatumHistoplasmosisFungus Histoplasma capsulatumHistoplasma capsulatumDiseaseManifestationsRashOsteomyelitisPatientsLesionsDiagnosis
2013
Novel PI3Kγ Mutation in a 44-Year-Old Man with Chronic Infections and Chronic Pelvic Pain
Bojarski E, Strauss A, Fagin A, Plantinga T, Hoischen A, Veltman J, Allsop S, Granadillo V, William A, Netea M, Dimitrakoff J. Novel PI3Kγ Mutation in a 44-Year-Old Man with Chronic Infections and Chronic Pelvic Pain. PLOS ONE 2013, 8: e68118. PMID: 23861857, PMCID: PMC3704649, DOI: 10.1371/journal.pone.0068118.Peer-Reviewed Original ResearchMeSH KeywordsAdultAmphotericin BAntifungal AgentsBase SequenceChronic DiseaseClass Ib Phosphatidylinositol 3-KinaseDNA Mutational AnalysisExomeFlow CytometryGranulocyte-Macrophage Colony-Stimulating FactorHumansImmunoglobulins, IntravenousLeukocyte CountMaleMolecular Sequence DataMutationPelvic PainReproducibility of ResultsConceptsChronic pelvic painPelvic painChronic infectionChronic purulent sinusitisLong-term treatment regimensCellular immune responsesAntifungal therapyPurulent sinusitisCandida speciesTreatment regimensProstatic fluidWork-upImmune responseSymptom improvementMissense mutationsLeukocyte functionRas-binding domainPainDebilitating symptomsInfectionMutationsSymptomsSignaling elementsRegimensRash
2009
Fat Embolism
Akhtar S. Fat Embolism. Anesthesiology Clinics 2009, 27: 533-550. PMID: 19825491, DOI: 10.1016/j.anclin.2009.07.018.Peer-Reviewed Original ResearchConceptsFat embolism syndromeFat embolismProgressive respiratory insufficiencyHours of injuryPetechial rashClinical sequelaeRespiratory insufficiencyClinical presentationSerious manifestationsMental statusOrthopedic injuriesClinical signsLung microcirculationEmbolismPathologic consequencesInjuryFat dropletsRashSequelaePrognosisPathophysiologySyndromeEtiologyInsufficiencyMicrocirculation
2008
Cross-sensitivity of skin rashes with antiepileptic drug use
Hirsch LJ, Arif H, Nahm EA, Buchsbaum R, Resor SR, Bazil CW. Cross-sensitivity of skin rashes with antiepileptic drug use. Neurology 2008, 71: 1527-1534. PMID: 18981374, DOI: 10.1212/01.wnl.0000334295.50403.4c.Peer-Reviewed Original ResearchConceptsRate of rashAntiepileptic drugsValproic acidSpecific antiepileptic drugsAntiepileptic drug useMore antiepileptic drugsCertain antiepileptic drugsAED selectionSkin rashIndividual patientsRashPatientsLamotrigineOxcarbazepineDrug usePhenytoinCarbamazepineLevetiracetamZonisamideGabapentinTiagabineVigabatrinClobazamDrugsMedicationsPerformance of an Algorithm for Assessing Smallpox Risk among Patients with Rashes That May Be Confused with Smallpox
Hutchins S, Sulemana I, Heilpern K, Schaffner W, Wax G, Lerner E, Watson B, Baltimore R, Waltenburg R, Aronsky D, Coffin S, Ng G, Craig A, Behrman A, Meek J, Sherman E, Chavez S, Harpaz R, Schmid S. Performance of an Algorithm for Assessing Smallpox Risk among Patients with Rashes That May Be Confused with Smallpox. Clinical Infectious Diseases 2008, 46: s195-s203. PMID: 18284359, DOI: 10.1086/524383.Peer-Reviewed Original Research
2007
Development of a functional assessment of side-effects to therapy (FAST) questionnaire to assess dermatology-related quality of life in patients treated with EGFR inhibitors (EGFRI): The FAST-EGFRI
Wagner L, Lai S, Aneja M, Lorusso P, Perez-Soler R, O’Brien B, Patel J, Lacouture M. Development of a functional assessment of side-effects to therapy (FAST) questionnaire to assess dermatology-related quality of life in patients treated with EGFR inhibitors (EGFRI): The FAST-EGFRI. Journal Of Clinical Oncology 2007, 25: 19532-19532. DOI: 10.1200/jco.2007.25.18_suppl.19532.Peer-Reviewed Original ResearchDisease-specific HRQL questionnairePatient self-report questionnairesHealth-related qualityBeneficial antitumor effectsEGFRI therapyDermatological toxicitiesHRQL questionnairesSkindex-29Self-report questionnairesAntitumor effectsBothersome aspectHRQLPatientsExpert cliniciansLife factorsHair alterationsQuestionnaireEGFRIsPruritusRashParonychiaTherapySymptomsCliniciansExpert input
2006
Reinfection and relapse in early Lyme disease.
KRAUSE PJ, FOLEY DT, BURKE GS, Christianson D, Closter L, Spielman A, _ _. Reinfection and relapse in early Lyme disease. American Journal Of Tropical Medicine And Hygiene 2006, 75: 1090-4. PMID: 17172372, DOI: 10.4269/ajtmh.2006.75.1090.Peer-Reviewed Original ResearchConceptsEarly Lyme diseaseRecurrent episodesLyme diseaseErythema migransStandard antibiotic therapyInitial rashPrompt administrationAntibiotic therapyClinical manifestationsPrevent relapsePersistent infectionBody sitesDiseaseSequential episodesSpecific antibodiesEndemic sitesEpisodesReinfectionRelapseDetectable levelsFrequent contactVector ticksYearsRashSerology
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