2000
Predictors of inactivation and reasons for participant inactivation during a skin cancer chemoprevention study.
Cartmel B, Moon T, Levine N, Rodney S, Alberts D. Predictors of inactivation and reasons for participant inactivation during a skin cancer chemoprevention study. Cancer Epidemiology Biomarkers & Prevention 2000, 9: 999-1002. PMID: 11008922.Peer-Reviewed Original ResearchConceptsCancer chemoprevention trialsChemoprevention trialsSkin cancer chemoprevention studiesFuture chemoprevention trialsIU of retinolCancer chemoprevention studiesLow education levelSkin cancer chemoprevention trialOnly significant predictorPlacebo groupChemoprevention studiesClinical symptomsUnmarried statusCommon reasonStudy capsulesTreatment groupsInactive participantsVitamin AGood complianceFirst monthTrialsSignificant predictorsNumber of participantsSignificant differencesSymptoms
1999
Predictors of participant retention in two chemoprevention feasibility trials
Bowen D, Cartmel B, Barnett M, Goodman G, Omenn G. Predictors of participant retention in two chemoprevention feasibility trials. Annals Of Behavioral Medicine 1999, 21: 210-215. PMID: 10626026, DOI: 10.1007/bf02884835.Peer-Reviewed Original ResearchConceptsPilot study participantsPilot studyClinical trialsEfficacy trialsStudy participantsLong-term clinical trialsAsbestos-exposed participantsRetinol Efficacy TrialAsbestos-exposed workersHigh blood pressureCancer chemoprevention trialsGeneral health issuesFull-scale efficacy trialHigher baseline levelsMental health measuresRetention of participantsOnly significant predictorCurrent smokersBlood pressureChemoprevention trialsFeasibility trialPredictors of retentionPrevention StudyBaseline predictorsBaseline levelsEffect of long-term beta-carotene and vitamin A on serum cholesterol and triglyceride levels among participants in the Carotene and Retinol Efficacy Trial (CARET)
Redlich C, Chung J, Cullen M, Blaner W, Van Bennekum A, Berglund L. Effect of long-term beta-carotene and vitamin A on serum cholesterol and triglyceride levels among participants in the Carotene and Retinol Efficacy Trial (CARET). Atherosclerosis 1999, 145: 425-432. PMID: 10488974, DOI: 10.1016/s0021-9150(99)00266-x.Peer-Reviewed Original ResearchConceptsSerum triglyceride levelsHigh-density lipoproteinActive treatment groupLDL cholesterol levelsTriglyceride levelsCancer chemoprevention trialsCholesterol levelsSmall nonsignificant increaseCARET participantsCardiovascular mortalityTreatment groupsNonsignificant increaseLow-density lipoprotein cholesterol levelsLung cancer chemoprevention trialsRetinol Efficacy TrialActive treatment armsLipoprotein cholesterol levelsLung cancer mortalityLong-term supplementationActive intervention groupTreatment-induced changesSerum lipidsChemoprevention trialsHDL cholesterolActive treatmentEffects of long-term intake of retinol on selected clinical and laboratory indexes
Cartmel B, Moon T, Levine N. Effects of long-term intake of retinol on selected clinical and laboratory indexes. American Journal Of Clinical Nutrition 1999, 69: 937-943. PMID: 10232634, DOI: 10.1093/ajcn/69.5.937.Peer-Reviewed Original ResearchConceptsRetinol intakeAdverse effectsLaboratory indicesVitamin A/dCoronary artery disease riskCancer chemoprevention trialsLong-term ingestionMinimal adverse effectsLong-term intakeSkin cancer chemoprevention trialAlkaline phosphataseMedian followPlacebo groupChemoprevention trialsClinical symptomsRetinol groupChemopreventive agentsCholesterol concentrationsHealthy populationSkin cancerModerate riskDisease riskIntakeFurther studiesSignificant differencesEffect of long-term beta-carotene and vitamin A on serum cholesterol and triglyceride levels among participants in the Carotene and Retinol Efficacy Trial (CARET)
Redlich C, Chung J, Cullen M, Blaner W, Van Bennekum A, Berglund L. Effect of long-term beta-carotene and vitamin A on serum cholesterol and triglyceride levels among participants in the Carotene and Retinol Efficacy Trial (CARET). Atherosclerosis 1999, 143: 427-434. PMID: 10217373, DOI: 10.1016/s0021-9150(98)00303-7.Peer-Reviewed Original ResearchConceptsSerum triglyceride levelsHigh-density lipoproteinActive treatment groupLDL cholesterol levelsTriglyceride levelsCancer chemoprevention trialsCholesterol levelsSmall nonsignificant increaseCARET participantsCardiovascular mortalityTreatment groupsNonsignificant increaseLow-density lipoprotein cholesterol levelsLung cancer chemoprevention trialsRetinol Efficacy TrialActive treatment armsLipoprotein cholesterol levelsLung cancer mortalityLong-term supplementationActive intervention groupTreatment-induced changesSerum lipidsChemoprevention trialsHDL cholesterolActive treatment
1998
Effect of supplementation with beta-carotene and vitamin A on lung nutrient levels.
Redlich CA, Blaner WS, Van Bennekum AM, Chung JS, Clever SL, Holm CT, Cullen MR. Effect of supplementation with beta-carotene and vitamin A on lung nutrient levels. Cancer Epidemiology Biomarkers & Prevention 1998, 7: 211-4. PMID: 9521435.Peer-Reviewed Original ResearchConceptsActive armRetinol levelsLung tissueExcess lung cancer mortalityLung cancer chemoprevention trialsLung retinol levelsRetinol Efficacy TrialLung tissue levelsLung cancer mortalityCancer chemoprevention trialsEffect of supplementationLung retinolChemoprevention trialsCancer mortalitySurgical controlEfficacy trialsCell levelVitamin ARetinyl palmitateSame interventionTissue levelsBiomarker studiesSupplementationInterventionTrials
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