2024
Licensed H5N1 vaccines generate cross-neutralizing antibodies against highly pathogenic H5N1 clade 2.3.4.4b influenza virus
Khurana S, King L, Manischewitz J, Posadas O, Mishra A, Liu D, Beigel J, Rappuoli R, Tsang J, Golding H. Licensed H5N1 vaccines generate cross-neutralizing antibodies against highly pathogenic H5N1 clade 2.3.4.4b influenza virus. Nature Medicine 2024, 30: 2771-2776. PMID: 39013430, DOI: 10.1038/s41591-024-03189-y.Peer-Reviewed Original ResearchCross-neutralizing antibodiesH5N1 vaccineNeutralizing antibody responsesVaccination of adultsDevelopment of effective vaccinesGlobal public health threatHPAI H5N1Influenza virusSeroconversion ratesH5N1Neutralizing antibodiesCross-reactive bindingPublic health threatLicensed vaccinesHemagglutination inhibitionPublic health priorityAntibody responseEffective vaccineHPAIVaccineAntibodiesDoseHealth priorityVirusHealth threatA humanized mouse that mounts mature class-switched, hypermutated and neutralizing antibody responses
Chupp D, Rivera C, Zhou Y, Xu Y, Ramsey P, Xu Z, Zan H, Casali P. A humanized mouse that mounts mature class-switched, hypermutated and neutralizing antibody responses. Nature Immunology 2024, 25: 1489-1506. PMID: 38918608, PMCID: PMC11291283, DOI: 10.1038/s41590-024-01880-3.Peer-Reviewed Original ResearchConceptsB cellsImmune cell differentiationAntibody responseHumanized micePfizer-BioNTech coronavirus disease 2019T cell antigen receptor repertoireFollicular helper T cellsGerminal center B cellsHuman cord blood CD34Human thymic epithelial cellsT cell-independent antibody responsesImmune systemMarginal zone B cellsMaturation of antibody responsesMemory B cell differentiationCD34+ cellsCord blood CD34Helper T cellsT cell-dependentThymic epithelial cellsNeutralizing antibody responsesB cell differentiationHuman B cellsAntigen receptor repertoireCell differentiation
2023
Intrinsic B cell TLR-BCR linked coengagement induces class-switched, hypermutated, neutralizing antibody responses in absence of T cells
Rivera C, Zhou Y, Chupp D, Yan H, Fisher A, Simon R, Zan H, Xu Z, Casali P. Intrinsic B cell TLR-BCR linked coengagement induces class-switched, hypermutated, neutralizing antibody responses in absence of T cells. The Journal Of Immunology 2023, 210: 60.08-60.08. DOI: 10.4049/jimmunol.210.supp.60.08.Peer-Reviewed Original ResearchClass switch DNA recombinationGeneration of memory B cellsAbsence of T cellsMemory B cellsT cell helpNeutralizing antibody responsesPlasma cell differentiationAntibody responseT cellsB cellsCell differentiationAnti-microbial responsesSomatic hypermutationT cell compartmentT cell functionAntibodies to E. coliDeclining T cell functionAffinity maturation processS. typhimuriumDNA recombinationMature antibody responseAnamnestic antibody responseLate-stage responsesSalmonella flagellinPhysical linkageIntrinsic B cell TLR-BCR linked coengagement induces class-switched, hypermutated, neutralizing antibody responses in absence of T cells
Rivera C, Zhou Y, Chupp D, Yan H, Fisher A, Simon R, Zan H, Xu Z, Casali P. Intrinsic B cell TLR-BCR linked coengagement induces class-switched, hypermutated, neutralizing antibody responses in absence of T cells. Science Advances 2023, 9: eade8928. PMID: 37115935, PMCID: PMC10146914, DOI: 10.1126/sciadv.ade8928.Peer-Reviewed Original ResearchConceptsClass switch DNA recombinationT cell helpPlasma cell differentiationAntibody responseCell differentiationSomatic hypermutationGeneration of memory B cellsInduce neutralizing antibody responsesAbsence of T cellsMaturation of antibody responsesMemory B cellsNeutralizing antibody responsesResponse to NPDNA recombinationAnamnestic antibody responseMicrobial pathogensFlagellinT cellsB cellsClonal expansionClass switchingProtective antibodiesCoengagementCell receptorsDifferentiation
2022
Efficacy, Immunogenicity, and Safety of COVID-19 Vaccines in Randomized Control Trials in the Pre-Delta Era: A Systematic Review and Network Meta-Analysis
Oh S, Purja S, Shin H, Kim M, Park S, Kronbichler A, Smith L, Eisenhut M, Shin J, Kim E. Efficacy, Immunogenicity, and Safety of COVID-19 Vaccines in Randomized Control Trials in the Pre-Delta Era: A Systematic Review and Network Meta-Analysis. Vaccines 2022, 10: 1572. PMID: 36298440, PMCID: PMC9608197, DOI: 10.3390/vaccines10101572.Peer-Reviewed Original ResearchNetwork Meta-AnalysisSafety of COVID-19 vaccinesMeta-analysisAdverse reactionsCOVID-19 vaccineSystemic adverse reactionsMRNA-1273 vaccineNeutralizing antibody responsesModerate risk of biasPre-Delta eraLive SARS-CoV-2Systematic reviewRandomized Controlled TrialsRisk of biasPlatform vaccinesMRNA-1273Comparative efficacyLow incidenceMedRxiv databasesCoronaVac vaccineAntibody responseVaccine efficacyControlled TrialsModerate riskSARS-CoV-2
2021
Serum and Cervicovaginal Fluid Antibody Profiling in Herpes Simplex Virus–Seronegative Recipients of the HSV529 Vaccine
Wang K, Dropulic L, Bozekowski J, Pietz H, Jegaskanda S, Dowdell K, Vogel J, Garabedian D, Oestreich M, Nguyen H, Ali M, Lumbard K, Hunsberger S, Reifert J, Haynes W, Sawyer J, Shon J, Daugherty P, Cohen J. Serum and Cervicovaginal Fluid Antibody Profiling in Herpes Simplex Virus–Seronegative Recipients of the HSV529 Vaccine. The Journal Of Infectious Diseases 2021, 224: 1509-1519. PMID: 33718970, PMCID: PMC8599754, DOI: 10.1093/infdis/jiab139.Peer-Reviewed Original ResearchConceptsVaccine recipientsHSV-2Genital tractNatural killer (NK) cell activityCell activationHerpes simplex virus type 2Replication-defective vaccinesNK cell activitySerum neutralizing antibody responsesNeutralizing antibody responsesAntibodies to epitopesCervicovaginal fluidGenital infectionGenital herpesAntibody profilesNeutralization titersHSV529Antibody responseSerum antibodiesHerpesType 2GD antibodiesAntibodiesSerumVaccine
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply