2023
When Climate Change Shows Up in the Exam Room
Katzman J, Wheat S, Christiano A. When Climate Change Shows Up in the Exam Room. The Journal Of The American Board Of Family Medicine 2023, 37: 15-18. PMID: 38092434, DOI: 10.3122/jabfm.2023.230200r1.Peer-Reviewed Original ResearchConceptsHealth effects of climate changeMental health effectsMeeting patientsEffective communication strategiesHealth-related effectsPublic health emergencyPatient educationExam roomHealth issuesGlobal public health emergencyTrusted sourcesHealth emergencyEffects of climate changeCommunication strategiesCliniciansClimate changePatientsDegraded air qualityMillions of peopleSARS-CoV-2 reservoir in post-acute sequelae of COVID-19 (PASC)
Proal A, VanElzakker M, Aleman S, Bach K, Boribong B, Buggert M, Cherry S, Chertow D, Davies H, Dupont C, Deeks S, Eimer W, Ely E, Fasano A, Freire M, Geng L, Griffin D, Henrich T, Iwasaki A, Izquierdo-Garcia D, Locci M, Mehandru S, Painter M, Peluso M, Pretorius E, Price D, Putrino D, Scheuermann R, Tan G, Tanzi R, VanBrocklin H, Yonker L, Wherry E. SARS-CoV-2 reservoir in post-acute sequelae of COVID-19 (PASC). Nature Immunology 2023, 24: 1616-1627. PMID: 37667052, DOI: 10.1038/s41590-023-01601-2.Peer-Reviewed Original ResearchConceptsSARS-CoV-2 reservoirPost-acute sequelaeImmune responseHost immune responseCoronavirus SARS-CoV-2COVID-19SARS-CoV-2Neuroimmune abnormalitiesAcute infectionLong COVIDClinical trialsViral RNAMillions of peopleSequelaeFurther studiesViral proteinsPathologyResearch prioritiesRNA/proteinBiological factorsPASCAntiviralsInfectionAbnormalitiesTrials
2022
Dendritic Spines and Pain Memory
Benson C, King J, Reimer M, Kauer S, Waxman S, Tan A. Dendritic Spines and Pain Memory. The Neuroscientist 2022, 30: 294-314. PMID: 36461773, DOI: 10.1177/10738584221138251.Peer-Reviewed Original ResearchNeuropathic painDendritic spinesSynaptic transmissionSpinal cord dorsal hornForm of painNew therapeutic approachesSurface of neuronsDorsal hornIntractable painDeep laminaePain memoryTherapeutic approachesPainNervous systemNew therapeuticsSpineMillions of peopleInjuryDiseaseRecent studiesReview articlePrevalenceNeuronsImportant roleChikungunya Arthritis
Amaral J, Pal T, Schoen R. Chikungunya Arthritis. Rare Diseases Of The Immune System 2022, 179-190. DOI: 10.1007/978-3-031-05002-2_14.Peer-Reviewed Original ResearchDisease-modifying anti-rheumatic drugsAnti-rheumatic drugsInflammatory rheumatic diseasesChikungunya arthritisChronic arthritisSupportive careBiphasic illnessRheumatic diseasesRheumatoid arthritisInflammatory processViral infectionArthritisAlphavirus infectionMillions of peopleIllnessInfectionDiseaseChikungunyaSubtropical worldArthralgiaRashPatientsFeverMethotrexateCare
2021
Emerging hiPSC Models for Drug Discovery in Neurodegenerative Diseases
Trudler D, Ghatak S, Lipton S. Emerging hiPSC Models for Drug Discovery in Neurodegenerative Diseases. International Journal Of Molecular Sciences 2021, 22: 8196. PMID: 34360966, PMCID: PMC8347370, DOI: 10.3390/ijms22158196.Peer-Reviewed Original ResearchConceptsAmyotrophic lateral sclerosisNeurodegenerative diseasesParkinson's diseaseAnimal modelsAlzheimer's diseaseEffective disease-modifying therapiesHuntington's diseaseDisease-modifying therapiesSeverity of symptomsHuman samplesHiPSC-derived neural cellsHealthy donorsEffective treatmentLateral sclerosisEconomic burdenHuman-induced pluripotent stem cell (hiPSC) technologyProgressive deteriorationNeural functionDiseaseHiPSC modelsNeural cellsPluripotent stem cell (iPSC) technologyDisease mechanismsPoor accessMillions of people
2020
Identification of Potent and Safe Antiviral Therapeutic Candidates Against SARS-CoV-2
Xiao X, Wang C, Chang D, Wang Y, Dong X, Jiao T, Zhao Z, Ren L, Dela Cruz CS, Sharma L, Lei X, Wang J. Identification of Potent and Safe Antiviral Therapeutic Candidates Against SARS-CoV-2. Frontiers In Immunology 2020, 11: 586572. PMID: 33324406, PMCID: PMC7723961, DOI: 10.3389/fimmu.2020.586572.Peer-Reviewed Original ResearchConceptsSARS-CoV-2Therapeutic agentsAnti-coronaviral activitySARS-CoV-2 drugsWide therapeutic windowCOVID-19 infectionNovel therapeutic agentsEffective compoundsTherapeutic optionsReplication of coronavirusesSafe drugSevere diseaseTherapeutic windowHuman coronavirusesTherapeutic candidateUS FDAArbidol hydrochlorideIdentification of PotentTwo-step screenMillions of peopleSafety indexDrugsCOVID-19 pandemicFDACoronavirusSensory Discrimination of Blood and Floral Nectar by Aedes aegypti Mosquitoes
Jové V, Gong Z, Hol F, Zhao Z, Sorrells T, Carroll T, Prakash M, McBride C, Vosshall L. Sensory Discrimination of Blood and Floral Nectar by Aedes aegypti Mosquitoes. Neuron 2020, 108: 1163-1180.e12. PMID: 33049200, PMCID: PMC9831381, DOI: 10.1016/j.neuron.2020.09.019.Peer-Reviewed Original ResearchConceptsBlood componentsSpecific blood componentsBlood-feeding mosquitoesAdditional blood componentsAedes aegypti mosquitoesAedes aegypti femalesCalcium imagingNeuron classesBloodMeal sizeSpecialized neuronsAegypti mosquitoesMetabolic fateMillions of peopleAegypti femalesBlood mealSensory discriminationDisease transmissionFeeding programsNeuronsSensory detectionMosquitoesTaste qualityVector-borne disease transmissionMealRationale and study design: A randomized controlled trial of early palliative care in newly diagnosed cancer patients in Addis Ababa, Ethiopia
Reid E, Abathun E, Diribi J, Mamo Y, Hall P, Fallon M, Wondemagegnhu T, Grant L. Rationale and study design: A randomized controlled trial of early palliative care in newly diagnosed cancer patients in Addis Ababa, Ethiopia. Contemporary Clinical Trials Communications 2020, 18: 100564. PMID: 32309673, PMCID: PMC7154993, DOI: 10.1016/j.conctc.2020.100564.Peer-Reviewed Original ResearchStandard oncology carePatient-reported outcomesHealthcare utilizationLow-income countriesOncology careCancer patientsEarly palliative carePalliative care provisionTime of enrollmentCost-consequence analysisAddis AbabaQuality of lifeHealth care policyOncology clinicOncology visitsOutcome scoresPalliative carePC providersHome-based PCStudy designCare provisionPoor accessMillions of peopleCarePocket payments
2017
Classifying clinical notes with pain assessment using machine learning
Fodeh SJ, Finch D, Bouayad L, Luther SL, Ling H, Kerns RD, Brandt C. Classifying clinical notes with pain assessment using machine learning. Medical & Biological Engineering & Computing 2017, 56: 1285-1292. PMID: 29280092, PMCID: PMC6014866, DOI: 10.1007/s11517-017-1772-1.Peer-Reviewed Original ResearchConceptsPain care qualityPain assessmentClinical notesChronic painMusculoskeletal diagnosesSignificant public health problemCharacteristics of patientsIntensity of painType of painPublic health problemPain sitesPain complaintsPatient reportsPainPatientsHealth problemsCare qualityFiscal year 2011Health recordsMillions of peopleComplete dataClinical applicationDiagnosisDemographic variablesWide spectrumNeurodevelopmental disease-associated de novo mutations and rare sequence variants affect TRIO GDP/GTP exchange factor activity
Katrancha SM, Wu Y, Zhu M, Eipper BA, Koleske AJ, Mains RE. Neurodevelopmental disease-associated de novo mutations and rare sequence variants affect TRIO GDP/GTP exchange factor activity. Human Molecular Genetics 2017, 26: 4728-4740. PMID: 28973398, PMCID: PMC5886096, DOI: 10.1093/hmg/ddx355.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsDatabases, Nucleic AcidGuanine Nucleotide Exchange FactorsGuanosine DiphosphateGuanosine TriphosphateHEK293 CellsHumansMiceMice, KnockoutMutationNeurodevelopmental DisordersProtein DomainsProtein Serine-Threonine Kinasesrac1 GTP-Binding Proteinrho GTP-Binding ProteinsrhoA GTP-Binding ProteinConceptsDe novo mutationsNeurodevelopmental disordersRare sequence variantsTriple functional domain proteinNovo mutationsComplex neurodevelopmental disorderBipolar disorderTherapeutic progressSequence variantsImpaired inhibitionProtein levelsDisordersMolecular pathwaysMillions of peopleIntellectual disabilityRare variantsNeurite outgrowthGenetic damageFactor activityMutationsExchange factor activityDistinct specificitiesPoor understandingRac1Activity
2015
Synaptic lipids in cortical function and psychiatric disorders
Stutz B, Horvath TL. Synaptic lipids in cortical function and psychiatric disorders. EMBO Molecular Medicine 2015, 8: 3-5. PMID: 26671988, PMCID: PMC4718156, DOI: 10.15252/emmm.201505749.Peer-Reviewed Original ResearchConceptsPsychiatric disordersClinical therapeutic strategiesPathophysiologic mechanismsCortical circuitryCortical functionExcitatory neuronsTherapeutic strategiesAnimal modelsReliable biomarkersPsychiatric diseasesPsychiatric consequencesEMBO Molecular MedicinePsychiatric conditionsMillions of peopleHuman subjectsCircuit functionDisordersLipidsMolecular medicinePatientsPathophysiologyEtiologyDiseaseMiceNeuronsNatriuretic Peptides for Diagnosis, Prognosis, and Management of Heart Failure
Gandhi P, Januzzi Jr. J. Natriuretic Peptides for Diagnosis, Prognosis, and Management of Heart Failure. Biomarkers In Disease: Methods, Discoveries And Applications 2015, 731-756. DOI: 10.1007/978-94-007-7696-8_12.ChaptersB-type natriuretic peptideHeart failureNatriuretic peptideEjection fractionAmino-terminal pro-B-type natriuretic peptidePro-B-type natriuretic peptideHeart failure screeningReduced ejection fractionNatriuretic peptide releaseUse of biomarkersComplicated patientsRoutine carePressure overloadClinical assessmentMyocyte stretchCardiovascular homeostasisFluid balanceCardiac conditionsComplex syndromePatientsPersonalized carePeptide releaseMultiple studiesMillions of peopleCare
2014
Natriuretic Peptides for Diagnosis, Prognosis, and Management of Heart Failure
Gandhi P, Januzzi Jr. J. Natriuretic Peptides for Diagnosis, Prognosis, and Management of Heart Failure. 2014, 1-21. DOI: 10.1007/978-94-007-7740-8_12-1.ChaptersB-type natriuretic peptideHeart failureNatriuretic peptideEjection fractionAmino-terminal pro-B-type natriuretic peptidePro-B-type natriuretic peptideHeart failure screeningReduced ejection fractionNatriuretic peptide releaseUse of biomarkersComplicated patientsRoutine carePressure overloadClinical assessmentMyocyte stretchCardiovascular homeostasisFluid balanceCardiac conditionsComplex syndromePatientsPersonalized carePeptide releaseMultiple studiesMillions of peopleCare
2013
Generating protective immunity against genital herpes
Shin H, Iwasaki A. Generating protective immunity against genital herpes. Trends In Immunology 2013, 34: 487-494. PMID: 24012144, PMCID: PMC3819030, DOI: 10.1016/j.it.2013.08.001.Peer-Reviewed Original ResearchConceptsGenital herpesHerpes simplex virus infectionSimplex virus infectionSignificant risk factorsClinical vaccine trialsRecurrent symptomsHSV infectionProtective immunityViral sheddingVaccine trialsRisk factorsChronic diseasesVirus infectionHIV-1Clear infectionAntiviral drugsHost responseHerpesVaccine designInfectionMillions of peopleSpread of diseaseDiseaseRecent studiesVaccine
2012
Interstitial lung disease
Murray LA, Rubinowitz A, Herzog EL. Interstitial lung disease. Current Opinion In Rheumatology 2012, 24: 656-662. PMID: 22955020, DOI: 10.1097/bor.0b013e3283588de4.Peer-Reviewed Original ResearchConceptsIdiopathic pulmonary fibrosisInterstitial lung diseaseSSc-ILDClinical presentationPulmonary fibrosisLung diseaseRecent clinical trialsConcepts of pathogenesisLymphocyte subsetsOrigin of fibroblastsEpithelial injuryLung fibrosisPathologic criteriaPredictive biomarkersPathogenic roleClinical trialsDisease progressionCell injuryPutative biomarkersDiseaseFibrosisDeadly diseaseCommon formMillions of peopleDevastating diseaseMemory for Patient Information as a Function of Experience in Mental Health
Marsh J, Ahn W. Memory for Patient Information as a Function of Experience in Mental Health. Applied Cognitive Psychology 2012, 26: 462-474. PMID: 23105171, PMCID: PMC3481845, DOI: 10.1002/acp.2832.Peer-Reviewed Original ResearchMental health cliniciansHealth cliniciansMental healthPatient informationMental health knowledgeMental health careMental health issuesHealth knowledgeAbstracted informationExperienced cliniciansClinical expertiseIntermediate traineesCliniciansHealth issuesPatient-therapist interactionHealth careMillions of peopleHealthPatientsFunction of experienceCareStriatal-Enriched Protein Tyrosine Phosphatase in Alzheimer’s Disease
Xu J, Kurup P, Nairn AC, Lombroso PJ. Striatal-Enriched Protein Tyrosine Phosphatase in Alzheimer’s Disease. Advances In Pharmacology 2012, 64: 303-325. PMID: 22840751, PMCID: PMC3740556, DOI: 10.1016/b978-0-12-394816-8.00009-x.Peer-Reviewed Original ResearchConceptsAlzheimer's diseaseNeurofibrillary tanglesStriatal-enriched protein tyrosine phosphataseAmyloid plaquesTreatment of ADHyperphosphorylated tau proteinSubstantial economic burdenProgressive diseasePotential clinical applicationsClinical symptomsBeta amyloidGlutamate receptorsEconomic burdenTau proteinCortical accumulationCognitive functionMemory lossBeneficial effectsDiseaseNeuronal membranesCommon formMultiple intracellularMillions of peopleClinical applicationImportant target
2010
Activation of Hedgehog Signaling by the Environmental Toxicant Arsenic May Contribute to the Etiology of Arsenic-Induced Tumors
Fei D, Li H, Kozul C, Black K, Singh S, Gosse J, DiRenzo J, Martin K, Wang B, Hamilton J, Karagas M, Robbins D. Activation of Hedgehog Signaling by the Environmental Toxicant Arsenic May Contribute to the Etiology of Arsenic-Induced Tumors. Cancer Research 2010, 70: 1981-1988. PMID: 20179202, PMCID: PMC2831120, DOI: 10.1158/0008-5472.can-09-2898.Peer-Reviewed Original ResearchConceptsArsenic exposureBladder cancerEnvironmental toxicant arsenicBladder cancer patientsSignificant health problemVariety of tumorsHedgehog signalingCancer patientsHealth problemsHigh levelsTumor samplesCancerHedgehog activitySame cancerHuman carcinogenesisMillions of peopleEtiologyTumorsExposureProgressionHedgehogTissue culture cellsActivationSignalingPatients
2009
IMAGING | SPECT in Epilepsy Research
Purcaro M, Blumenfeld H. IMAGING | SPECT in Epilepsy Research. 2009, 558-564. DOI: 10.1016/b978-012373961-2.00024-2.Peer-Reviewed Original ResearchEpilepsy researchUseful imaging modalityInterictal SPECT imagesSingle photon emissionIctal dystoniaExtratemporal epilepsyPresurgical localizationHypothalamic hamartomaSurgical interventionInfantile spasmsSurgical successEpileptogenic focusPostsurgical outcomesSeizure localizationNeurological disordersEpilepsyImaging modalitiesMillions of peoplePhoton emissionSPECT imagesSPECTMedicationsSpasmDystoniaHamartoma
2003
Developing a Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome Therapeutic Research Agenda for Resource-Limited Countries: A Consensus Statement
Vermund SH, Powderly WG, Association of IDSA O. Developing a Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome Therapeutic Research Agenda for Resource-Limited Countries: A Consensus Statement. Clinical Infectious Diseases 2003, 37: s4-s12. PMID: 12822127, DOI: 10.1086/375367.Peer-Reviewed Original ResearchConceptsResource-limited countriesAntiretroviral therapyResource-limited settingsDelivery of ARTImmunodeficiency syndrome careClinical Trials NetworkHealth care providersResource limited countriesHealth care practitionersHealth care advocatesHIV diseaseHIV/Consensus statementTreatment accessCare providersCare practitionersTrials NetworkART provisionCare advocatesTherapyMillions of peoplePharmaceutical expertsPatient monitoringCommunity representativesDisease
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