2024
Implementation and Impact of Intimate Partner Violence Screening Expansion in the Veterans Health Administration: Protocol for a Mixed Methods Evaluation
Portnoy G, Relyea M, Dichter M, Iverson K, Presseau C, Brandt C, Skanderson M, Bruce L, Martino S. Implementation and Impact of Intimate Partner Violence Screening Expansion in the Veterans Health Administration: Protocol for a Mixed Methods Evaluation. JMIR Research Protocols 2024, 13: e59918. PMID: 39194059, PMCID: PMC11391160, DOI: 10.2196/59918.Peer-Reviewed Original ResearchConceptsVeterans Health AdministrationImpact of screeningINTERNATIONAL REGISTERED REPORT IDENTIFIERHealth care systemIntimate partner violenceIPV screeningQualitative interviewsCare systemHealth AdministrationConsolidated Framework for Implementation ResearchVeterans Health Administration facilitiesElectronic health record dataIntimate partner violence screeningMixed methods evaluationHealth record dataNational health care systemLongitudinal observational designPotential implementation barriersSignificant public health problemMen's health careClinical practice implicationsPatient populationMethod evaluationRE-AIMPublic health problemGlial modulators as novel therapeutics for comorbid pain and opioid use disorder
Schwartz E, De Aquino J, Sofuoglu M. Glial modulators as novel therapeutics for comorbid pain and opioid use disorder. British Journal Of Clinical Pharmacology 2024, 90: 3054-3066. PMID: 38752593, DOI: 10.1111/bcp.16094.Peer-Reviewed Original ResearchOpioid use disorderChronic painGlial modulationNovel treatment approachesComorbid painPublic health problemTreatment approachesImproved pain measuresLiterature search of PubMedIncreased opioid prescriptionsSearch of PubMedAddiction-related outcomesSignificant public health problemComorbid disordersOpioid prescriptionsGoogle Scholar databasesPain measuresHealth problemsPain managementClinical studiesTreatment challengesClinical trialsPatient populationPainGlial activation
2023
Obesity and Peripheral Artery Disease: Current Evidence and Controversies
Lempesis I, Varrias D, Sagris M, Attaran R, Altin E, Bakoyiannis C, Palaiodimos L, Dalamaga M, Kokkinidis D. Obesity and Peripheral Artery Disease: Current Evidence and Controversies. Current Obesity Reports 2023, 12: 264-279. PMID: 37243875, PMCID: PMC10220347, DOI: 10.1007/s13679-023-00510-7.Peer-Reviewed Original ResearchConceptsPeripheral artery diseaseArtery diseaseCurrent evidenceLower extremity peripheral artery diseaseHigher Body Mass IndexSignificant public health problemPurpose of ReviewObesityPresence of obesityPotential pathophysiologic mechanismsRisk of morbidityBody mass indexBody fat distributionProgression of atherosclerosisMajor risk factorPublic health problemPotential protective roleMendelian randomization studyObesity paradoxAggressive treatmentCardiovascular manifestationsMass indexNormal weightPad developmentPathophysiologic mechanismsRisk factorsImplementation strategies to address the determinants of adoption, implementation, and maintenance of a clinical decision support tool for emergency department buprenorphine initiation: a qualitative study
Simpson M, Ritger C, Hoppe J, Holland W, Morris M, Nath B, Melnick E, Tietbohl C. Implementation strategies to address the determinants of adoption, implementation, and maintenance of a clinical decision support tool for emergency department buprenorphine initiation: a qualitative study. Implementation Science Communications 2023, 4: 41. PMID: 37081581, PMCID: PMC10117277, DOI: 10.1186/s43058-023-00421-7.Peer-Reviewed Original ResearchOpioid use disorderBuprenorphine initiationClinical decision support toolEmergency departmentED cliniciansSignificant public health problemCDS interventionsIntervention EDsUsual care armPragmatic clinical trialsPublic health problemEvidence-based treatmentsCare armED initiationBuprenorphine treatmentED settingIntervention armOngoing treatmentClinical trialsClinician experienceClinician trainingUse disordersBuprenorphineHealth problemsSecondary aim
2022
UBXN3B Controls Immunopathogenesis of Arthritogenic Alphaviruses by Maintaining Hematopoietic Homeostasis
Geng T, Yang D, Lin T, Cahoon J, Wang P. UBXN3B Controls Immunopathogenesis of Arthritogenic Alphaviruses by Maintaining Hematopoietic Homeostasis. MBio 2022, 13: e02687-22. PMID: 36377866, PMCID: PMC9765034, DOI: 10.1128/mbio.02687-22.Peer-Reviewed Original ResearchConceptsUbiquitin regulatory X domain-containing proteinDomain-containing proteinsDiverse cellular processesCell-intrinsic mannerCellular processesHematopoietic homeostasisPhysiological functionsRNA virus replicationEssential roleControl of infectionChikungunya virusHuman genomeArthritogenic alphavirusesImmune responseCHIKV replicationDNA virusesRNA virusesInnate immune responseVirus-specific immunoglobulin GO'nyong'nyong virusLong-term neurological disordersSignificant public health problemSerum cytokine levelsSpecific antiviral drugsHigh viral loadSpatiotemporal Patterns of Diarrhea Incidence in Ghana and the Impact of Meteorological and Socio-Demographic Factors
Asare EO, Warren JL, Pitzer VE. Spatiotemporal Patterns of Diarrhea Incidence in Ghana and the Impact of Meteorological and Socio-Demographic Factors. Frontiers In Epidemiology 2022, 2: 871232. PMID: 35822109, PMCID: PMC9272077, DOI: 10.3389/fepid.2022.871232.Peer-Reviewed Original ResearchSocio-demographic factorsDiarrhea incidenceHealth insurance schemeSignificant public health problemOverall diarrhea incidencePublic health problemGhana Health ServiceHigh-risk districtsConsiderable financial burdenDirection of associationDiarrhea controlDiarrhoea patternsHealth problemsDiarrheaHealth servicesPotential associationSignificant associationDiarrhea dataIncidence
2021
Epidemiology and autopsy findings of 500 drowning deaths
Girela-López E, Beltran-Aroca C, Dye A, Gill J. Epidemiology and autopsy findings of 500 drowning deaths. Forensic Science International 2021, 330: 111137. PMID: 34894613, DOI: 10.1016/j.forsciint.2021.111137.Peer-Reviewed Original ResearchConceptsDrowning deathsSignificant public health problemPopulation-based analysisUnintentional injury deathsDate of deathPublic health problemChief Medical ExaminerCircumstances of deathManner of deathCerebral edemaLung weightPulmonary edemaHeavy lungsBrain weightAutopsy findingsInjury deathsAnatomic findingsOrgan weightsSex distributionPostmortem diagnosisLarge seriesHealth problemsSaltwater drowningLungDeath rateGestational Hormone Concentrations Are Associated With Timing of Delivery in a Fetal Sex-Dependent Manner
Cathey A, Watkins D, Rosario Z, Vega C, Mukherjee B, O’Neill M, Loch-Caruso R, Alshawabkeh A, Cordero J, Meeker J. Gestational Hormone Concentrations Are Associated With Timing of Delivery in a Fetal Sex-Dependent Manner. Frontiers In Endocrinology 2021, 12: 742145. PMID: 34603214, PMCID: PMC8479114, DOI: 10.3389/fendo.2021.742145.Peer-Reviewed Original ResearchConceptsTime of deliveryFetal sexBody mass indexGestational ageMaternal agePreterm premature rupture of membranesPre-pregnancy body mass indexHormone concentrationsFetal sex-specific effectsPremature rupture of membranesOverall preterm birthPreterm premature ruptureSpontaneous preterm laborRupture of membranesReduced gestational ageOdds of PTBTime of laborSignificant public health problemTobacco smoke exposureGestational hormonesSpontaneous PTBPreterm laborWeeks gestationPreterm birthLongitudinal birth cohort
2020
Emergency Department Visits for Firearm-Related Injuries among Youth in the United States, 2006–2015
Lee V, Camp C, Jairam V, Park HS, Yu JB. Emergency Department Visits for Firearm-Related Injuries among Youth in the United States, 2006–2015. The Journal Of Law, Medicine & Ethics 2020, 48: 67-73. PMID: 33404319, DOI: 10.1177/1073110520979403.Peer-Reviewed Original ResearchConceptsNationwide Emergency Department SampleEmergency department visitsFirearm injuriesDepartment visitsInjury dataSignificant public health problemEmergency Department SampleEmergency Department DatabasesPublic health problemFirearm-related injuriesPatient ageEmergency departmentRisk factorsDepartment databaseNumber of childrenSignificant burdenImmense burdenHealth problemsDeath dataInjuryVisitsUnited StatesBurdenDescriptive analysisSafety measures
2018
Variation in National Opioid Prescribing Patterns Following Surgery for Kidney Stones
Leapman MS, DeRycke E, Skanderson M, Becker WC, Makarov DV, Gross CP, Driscoll M, Motamedinia P, Bathulapalli H, Mattocks K, Brandt CA, Haskell S, Bastian LA. Variation in National Opioid Prescribing Patterns Following Surgery for Kidney Stones. Pain Medicine 2018, 19: s12-s18. PMID: 30203013, DOI: 10.1093/pm/pny125.Peer-Reviewed Original ResearchConceptsPost-traumatic stress disorderWomen Veterans Cohort StudyOpioid prescribingOpioid prescriptionsSurgical treatmentKidney stonesSignificant public health problemOpioid Prescribing PatternsPostoperative opioid prescribingDiagnosis of PTSDPublic health problemExtracorporeal shockwave lithotripsyOpioid dosingPostoperative painPrescribing patternsCohort studyDose prescribedMedian ageSurgery typeMultivariable analysisOpioid misuseSurgical interventionMedian numberPercutaneous nephrolithotomyMultivariable regressionSuicidal ideation in military veterans with alcohol dependence and PTSD: The role of hostility
Kachadourian LK, Gandelman E, Ralevski E, Petrakis IL. Suicidal ideation in military veterans with alcohol dependence and PTSD: The role of hostility. American Journal On Addictions 2018, 27: 124-130. PMID: 29489046, DOI: 10.1111/ajad.12688.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderSuicidal ideationAlcohol dependencePTSD symptom severityDepression symptomsMilitary veteransPlacebo-controlled treatment studySymptom severitySignificant public health problemComorbid posttraumatic stress disorderPublic health problemRelevant risk factorsRisk of suicideLifetime suicidal ideationUS military veteransRisk factorsTreatment approachesHealth problemsTreatment studiesRole of hostilityCovert hostilityStress disorderCivilian samplesVeteransIdeation
2017
Classifying clinical notes with pain assessment using machine learning
Fodeh SJ, Finch D, Bouayad L, Luther SL, Ling H, Kerns RD, Brandt C. Classifying clinical notes with pain assessment using machine learning. Medical & Biological Engineering & Computing 2017, 56: 1285-1292. PMID: 29280092, PMCID: PMC6014866, DOI: 10.1007/s11517-017-1772-1.Peer-Reviewed Original ResearchConceptsPain care qualityPain assessmentClinical notesChronic painMusculoskeletal diagnosesSignificant public health problemCharacteristics of patientsIntensity of painType of painPublic health problemPain sitesPain complaintsPatient reportsPainPatientsHealth problemsCare qualityFiscal year 2011Health recordsMillions of peopleComplete dataClinical applicationDiagnosisDemographic variablesWide spectrumClassifying Clinical Notes with Pain Assessment.
Fodeh SJ, Finch D, Bouayad L, Luther S, Kerns RD, Brandt C. Classifying Clinical Notes with Pain Assessment. 2017, 245: 1261. PMID: 29295346.Peer-Reviewed Original ResearchConceptsPain care qualityPain assessmentChronic painSignificant public health problemPublic health problemHealth problemsClinical notesPainCare qualityPatientsAssessment
2016
Anticipatory reward processing among cocaine-dependent individuals with and without concurrent methadone-maintenance treatment: Relationship to treatment response
Yip SW, DeVito EE, Kober H, Worhunsky PD, Carroll KM, Potenza MN. Anticipatory reward processing among cocaine-dependent individuals with and without concurrent methadone-maintenance treatment: Relationship to treatment response. Drug And Alcohol Dependence 2016, 166: 134-142. PMID: 27430401, PMCID: PMC5082418, DOI: 10.1016/j.drugalcdep.2016.07.006.Peer-Reviewed Original ResearchConceptsMethadone maintenance treatmentCocaine-dependent individualsBOLD responseCocaine dependenceSignificant public health problemMethadone-maintained individualsMethadone-maintained populationsMethadone-maintained patientsElevated relapse ratesPublic health problemCocaine-negative urinesCocaine-dependent patientsAnticipatory reward processingPosterior cingulate cortexLoss processingDuration of abstinenceDorsolateral prefrontal cortexCD patientsRelapse rateWhole-brain ANOVAInferior frontal gyrusTreatment outcomesRight caudateHealthy comparison participantsPatients
2015
The epidemiology of substance use disorders in US Veterans: A systematic review and analysis of assessment methods
Lan CW, Fiellin DA, Barry DT, Bryant KJ, Gordon AJ, Edelman EJ, Gaither JR, Maisto SA, Marshall BD. The epidemiology of substance use disorders in US Veterans: A systematic review and analysis of assessment methods. American Journal On Addictions 2015, 25: 7-24. PMID: 26693830, PMCID: PMC5123305, DOI: 10.1111/ajad.12319.Peer-Reviewed Original ResearchConceptsPrevalence of SUDsSubstance use disordersUS veteransUse disordersDiagnostic criteriaComprehensive electronic database searchesMajor public health challengeSignificant public health problemUS veteran populationDrug use disordersPublic health problemElectronic database searchPublic health challengePast-year prevalenceHigh prevalenceInclusion criteriaYear prevalenceVeteran populationHealth problemsSystematic reviewClinical screeningHealth challengesPrevalenceHealth conditionsHealthcare systemCocaine Abuse
Kahn E, Mikhael H, Vadivelu N. Cocaine Abuse. 2015, 143-154. DOI: 10.1007/978-1-4939-1951-2_12.Chapters
2014
Variability in urinary phthalate metabolite levels across pregnancy and sensitive windows of exposure for the risk of preterm birth
Ferguson K, McElrath T, Ko Y, Mukherjee B, Meeker J. Variability in urinary phthalate metabolite levels across pregnancy and sensitive windows of exposure for the risk of preterm birth. Environment International 2014, 70: 118-124. PMID: 24934852, PMCID: PMC4104181, DOI: 10.1016/j.envint.2014.05.016.Peer-Reviewed Original ResearchConceptsAdjusted odds ratiosUrinary phthalate metabolite levelsPreterm birthPhthalate metabolite levelsOdds ratioOdds of preterm birthAssociated with increased odds of preterm birthIncreased risk of delivering pretermCases of preterm birthWeeks of completed gestationRisk of delivering pretermAssociated with increased oddsMetabolite levelsPresentation of preeclampsiaSignificant public health problemSpontaneous preterm birthIntrauterine growth restrictionLongitudinal birth cohortPhthalate metabolite concentrationsPublic health problemBirth outcomesBirth cohortGrowth restrictionThird trimesterPregnant womenInfluence of host iron status on Plasmodium falciparum infection
Clark M, Goheen M, Cerami C. Influence of host iron status on Plasmodium falciparum infection. Frontiers In Pharmacology 2014, 5: 84. PMID: 24834053, PMCID: PMC4018558, DOI: 10.3389/fphar.2014.00084.Peer-Reviewed Original ResearchHost iron statusIron deficiencyIron statusIron supplementationMechanisms of malaria pathogenesisPrevalence of iron deficiencyHost iron deficiencyPlasmodium falciparum infectionRoutine iron supplementationWorld Health OrganizationEffective antimalarial treatmentRisk of malariaSignificant public health problemFalciparum infectionFalciparum malariaMalaria pathogenesisMalaria infectionAntimalarial treatmentPublic health problemSignificant morbidityParasite virulence factorsImmune responseMalariaImmune functionEpidemiological data
2013
Global Patterns of Prostate Cancer Incidence, Aggressiveness, and Mortality in Men of African Descent
Rebbeck T, Devesa S, Chang B, Bunker C, Cheng I, Cooney K, Eeles R, Fernandez P, Giri V, Gueye S, Haiman C, Henderson B, Heyns C, Hu J, Ingles S, Isaacs W, Jalloh M, John E, Kibel A, Kidd L, Layne P, Leach R, Neslund-Dudas C, Okobia M, Ostrander E, Park J, Patrick A, Phelan C, Ragin C, Roberts R, Rybicki B, Stanford J, Strom S, Thompson I, Witte J, Xu J, Yeboah E, Hsing A, Zeigler-Johnson C. Global Patterns of Prostate Cancer Incidence, Aggressiveness, and Mortality in Men of African Descent. Prostate Cancer 2013, 2013: 560857. PMID: 23476788, PMCID: PMC3583061, DOI: 10.1155/2013/560857.Peer-Reviewed Original ResearchCAP incidenceSignificant public health problemProstate cancer incidenceAfrican descentPublic health problemLower mortality rateSub-Saharan AfricaHigher proportionAdvanced tumorsTumor stageCancer incidenceProstate cancerMortality rateProstate tumorsCancer ConsortiumHealth problemsMortalityIncidenceHealth careMenPercent gross domestic productAfrican AmericansTumorsCancerEstimated number
2012
Opioid Detoxification and Naltrexone Induction Strategies: Recommendations for Clinical Practice
Sigmon SC, Bisaga A, Nunes EV, O'Connor PG, Kosten T, Woody G. Opioid Detoxification and Naltrexone Induction Strategies: Recommendations for Clinical Practice. The American Journal Of Drug And Alcohol Abuse 2012, 38: 187-199. PMID: 22404717, PMCID: PMC4331107, DOI: 10.3109/00952990.2011.653426.Peer-Reviewed Original ResearchConceptsΜ-opioid receptor antagonist naltrexoneSignificant public health problemDose of buprenorphinePublic health problemLevel of careOral naltrexoneOpioid detoxificationAntagonist naltrexoneOpioid dependencePatient selectionOpioid agonistsAgonist maintenanceAncillary medicationsFavorable outcomeHigh riskTarget doseClinical practiceHealth problemsNaltrexoneExpert cliniciansTreatmentDoseMore researchUseful alternativeBest approach
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