2025
Clinical Application of an Ergonomic Holographic Device to Optimize Port Placement in Robotic Mitral Valve Surgery: Proof-of-Concept Study
Agnino A, Amabile A, Brembilla V, Vialle M, Santarpino G, Giroletti L, Graniero A, Lanzarone E, Thomann G. Clinical Application of an Ergonomic Holographic Device to Optimize Port Placement in Robotic Mitral Valve Surgery: Proof-of-Concept Study. The Heart Surgery Forum 2025, 28: e363-e366. DOI: 10.59958/hsf.8419.Peer-Reviewed Original ResearchMitral valve surgeryRobotic mitral valve surgeryValve surgeryPort placementPreoperative computed tomography scansStandard port placementRobotic cardiac surgeryRobotic port placementComputed tomography scanCardiac surgical teamProof-of-concept studyCardiac surgeryPreoperative imagingTomography scanPatient-specific anatomySurgeryClinical useSurgical teamOptimal port placementClinical applicationRobotic assistanceViews of anatomyPlacementAnatomyHolographic modelBiomechanical analysis of clear aligners for mandibular anterior teeth intrusion and its clinical application in the design of new aligner attachment
Xiao S, Cheng C, Li H, Li L, Shen C, Feng Q, Zhao Y, Duan Y, Xia L, Chu F, Fang B. Biomechanical analysis of clear aligners for mandibular anterior teeth intrusion and its clinical application in the design of new aligner attachment. Progress In Orthodontics 2025, 26: 11. PMID: 40059251, PMCID: PMC11891119, DOI: 10.1186/s40510-025-00557-3.Peer-Reviewed Original ResearchConceptsIncisor mandibular plane angleMandibular anterior teethAnterior teethAligner attachmentsExcessive alveolar bone resorptionTreatment outcomesMandibular plane angleLower anterior teethAlveolar bone resorptionClinical treatment outcomesTooth intrusionLingual inclinationOrthodontic techniquesCBCT dataBone resorptionBone wallLabial movementPlane angleClinical practiceResultsSignificant differencesClinical applicationLingual movementTeethClinical issuesConclusionThis studyModeling thoracic aortic genetic variants in the zebrafish: useful for predicting clinical pathogenicity?
Prendergast A, Sheppard M, Famulski J, Nicoli S, Mukherjee S, Sips P, Elefteriades J. Modeling thoracic aortic genetic variants in the zebrafish: useful for predicting clinical pathogenicity? Frontiers In Cardiovascular Medicine 2025, 12: 1480407. PMID: 40066353, PMCID: PMC11892108, DOI: 10.3389/fcvm.2025.1480407.Peer-Reviewed Original ResearchPathogenicity of VUSProportion of variantsMedical genetic testingCausal genesPathogenicity assessmentClinical pathogensTested pathogensGenetic variantsCausative genesTAAD casesGenesGenetic defectsGenetic testingThoracic aortic aneurysmHeritable genetic defectsImpact cardiovascular morbidityPathogensVUSAortic aneurysmCardiovascular morbidityVariantsZebrafishTAADClinical applicationEnhance patient careAlpha rhythm and Alzheimer’s disease: Has Hans Berger’s dream come true?
Babiloni C, Arakaki X, Baez S, Barry R, Benussi A, Blinowska K, Bonanni L, Borroni B, Bayard J, Bruno G, Cacciotti A, Carducci F, Carino J, Carpi M, Conte A, Cruzat J, D'Antonio F, Della Penna S, Del Percio C, De Sanctis P, Escudero J, Fabbrini G, Farina F, Fraga F, Fuhr P, Gschwandtner U, Güntekin B, Guo Y, Hajos M, Hallett M, Hampel H, Hanoğlu L, Haraldsen I, Hassan M, Hatlestad-Hall C, Horváth A, Ibanez A, Infarinato F, Jaramillo-Jimenez A, Jeong J, Jiang Y, Kamiński M, Koch G, Kumar S, Leodori G, Li G, Lizio R, Lopez S, Ferri R, Maestú F, Marra C, Marzetti L, McGeown W, Miraglia F, Moguilner S, Moretti D, Mushtaq F, Noce G, Nucci L, Ochoa J, Onorati P, Padovani A, Pappalettera C, Parra M, Pardini M, Pascual-Marqui R, Paulus W, Pizzella V, Prado P, Rauchs G, Ritter P, Salvatore M, Santamaria-García H, Schirner M, Soricelli A, Taylor J, Tankisi H, Tecchio F, Teipel S, Kodamullil A, Triggiani A, Valdes-Sosa M, Valdes-Sosa P, Vecchio F, Vossel K, Yao D, Yener G, Ziemann U, Kamondi A. Alpha rhythm and Alzheimer’s disease: Has Hans Berger’s dream come true? Clinical Neurophysiology 2025, 172: 33-50. PMID: 39978053, DOI: 10.1016/j.clinph.2025.02.256.Peer-Reviewed Original ResearchConceptsPathological agingAlzheimer's diseaseExpert panelAlpha rhythmAD patient’s qualityQuality of lifeAging-Alzheimer's AssociationCognitive impairmentCognitive declineClinical workupNeuroscience SocietyCortical circuitsAD patientsUS National InstitutesOlder adultsRoutine useSenile dementiaDecades of researchPatients' qualityClinical guidelinesOscillatory synchronizationCause of dementiaClinical applicationNIA-AADementiaA comprehensive evaluation of the left atrium using cardiovascular magnetic resonance
Pradella M, Elbaz M, Lee D, Hong K, Passman R, Kholmovski E, Peters D, Baraboo J, Herzka D, Nezafat R, Edelman R, Kim D. A comprehensive evaluation of the left atrium using cardiovascular magnetic resonance. Journal Of Cardiovascular Magnetic Resonance 2025, 27: 101852. PMID: 39920924, PMCID: PMC11889362, DOI: 10.1016/j.jocmr.2025.101852.Peer-Reviewed Original ResearchCardiovascular magnetic resonanceLeft atriumCardiac imaging modalitiesLeft atrial appendageContext of atrial fibrillationAtrial fibrillationAtrial appendageHeart failureAtrial diseaseAtrial myopathyImaging modalitiesMagnetic resonanceCardiovascular medicineClinical applicationImaging parametersAtriumMyopathyTissue characterizationSalivary gland stem/progenitor cells: advancing from basic science to clinical applications
Langthasa J, Guan L, Jinagal S, Le Q. Salivary gland stem/progenitor cells: advancing from basic science to clinical applications. Cell Regeneration 2025, 14: 4. PMID: 39856475, PMCID: PMC11759724, DOI: 10.1186/s13619-025-00221-5.Peer-Reviewed Original ResearchSalivary gland stem/progenitor cellsBioengineered organ replacementTissue-based therapiesEffective clinical therapiesRadiation therapySjogren's syndromeStem/progenitor cellsClinical therapyTherapyDifferentiation pathwayClinical applicationRegenerative medicineSyndromeTissue regenerationOrgan replacementCulture techniquesSjogrenTransplantationPatientsInterferon-Stimulated Genes and Immune Metabolites as Broad-Spectrum Biomarkers for Viral Infections
Huang C, Laurent-Rolle M, Grove T, Hsu J. Interferon-Stimulated Genes and Immune Metabolites as Broad-Spectrum Biomarkers for Viral Infections. Viruses 2025, 17: 132. PMID: 39861921, PMCID: PMC11768885, DOI: 10.3390/v17010132.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsInterferon-stimulated genesReceiver Operating CharacteristicViral infectionAntiviral functionType I interferonTarget various stagesIFN-II interferonViral replicationClinical practiceDiagnostic potentialClinical applicationProtein levelsBiomarkersImmune defenseInfectionViral pathogensMetabolitesBroad spectrumGenesEffective translation
2024
Bioimaging of Neuroimmune Disorders: Physical Principles of Neuroimaging Modalities and Clinical Applications
Mayeli M, Ernst T, Chang L. Bioimaging of Neuroimmune Disorders: Physical Principles of Neuroimaging Modalities and Clinical Applications. 2024, 807-830. DOI: 10.1007/978-3-031-68237-7_45.Peer-Reviewed Original ResearchMagnetic resonance imagingPositron emission tomographyPsychiatric disordersSubstance use disordersAssess treatment efficacyMonitoring disease progressionChronic painMechanisms of diseaseDisease progressionTreatment efficacyViral infectionNeuroimmune aspectsNeuroimaging techniquesEmission tomographyResonance imagingNeuroimaging findingsClinical applicationNeuroimaging modalitiesModalitiesDisordersImaging techniquesDiseaseOptimizing public-private partnerships to support clinical cancer research
Herbst R, Blumenthal G, Khleif S, Lippman S, Meropol N, Rosati K, Shulman L, Smith H, Wang M, Winn R, Schilsky R. Optimizing public-private partnerships to support clinical cancer research. Journal Of The National Cancer Institute 2024, djae279. PMID: 39666955, DOI: 10.1093/jnci/djae279.Peer-Reviewed Original ResearchClinical cancer researchNational Cancer Policy ForumPublic-private partnershipEquitable care deliveryCancer researchCare deliveryEfficient drug developmentImplementation of public-private partnershipPromote collaborationTherapeutic innovationsClinical applicationPartnershipPolicy forumsDrug developmentNonprofit organizationsNeuroimaging Biomarkers in Parkinson’s Disease
Holmes S, Tinaz S. Neuroimaging Biomarkers in Parkinson’s Disease. Advances In Neurobiology 2024, 40: 617-663. PMID: 39562459, DOI: 10.1007/978-3-031-69491-2_21.Peer-Reviewed Original ResearchConceptsPublic health burdenNeuroimaging biomarkersTreatment developmentRisk of developing PDParkinson's diseaseHealth burdenDiagnosis of PDMultimodal neuroimaging techniquesIdiopathic Parkinson's diseaseNon-motorDifferential diagnosis of PDNeuroimaging techniquesProdromal phaseDifferential diagnosisSymptomatic treatmentDisease progressionClinical applicationBiomarkersDirect cardiac reprogramming via combined CRISPRa-mediated endogenous Gata4 activation and exogenous Mef2c and Tbx5 expression
Huang P, Xu J, Keepers B, Xie Y, Near D, Xu Y, Hua J, Spurlock B, Ricketts S, Liu J, Wang L, Qian L. Direct cardiac reprogramming via combined CRISPRa-mediated endogenous Gata4 activation and exogenous Mef2c and Tbx5 expression. Molecular Therapy - Nucleic Acids 2024, 35: 102390. PMID: 39720701, PMCID: PMC11666955, DOI: 10.1016/j.omtn.2024.102390.Peer-Reviewed Original ResearchActivity of endogenous factorsDirect cardiac reprogrammingInduced cardiomyocytesCardiac reprogrammingExpression of cardiac transcription factorsCardiac transcription factorsTranscription factorsReprogramming of fibroblastsSingle-guide RNAViral toxicityViral vectorsExogenous transcription factorsImmune responseEpigenetic barriersGATA4 activityRegenerative purposesClinical applicationEndogenous factorsEndogenous transcription factorsGenomic mutationsExogenous expressionReprogrammingFibroblastsEndogenous gene expressionHuman fibroblastsScaleable production of highly loaded protein nanoparticles for immune modulation
Caplan M, Baldwin R, Yin X, Grishin A, Eisenbarth S, Sampson H, Bottomly K, Prud’homme R. Scaleable production of highly loaded protein nanoparticles for immune modulation. Communications Materials 2024, 5: 191. DOI: 10.1038/s43246-024-00626-w.Peer-Reviewed Original ResearchAdjuvants to antigen-presenting cellsImmune modulationAntigen-presenting cellsMurine immune systemImmune system cellsPeanut-allergic patientsDesensitizer applicationPLG nanoparticlesAntigen deliverySystemic exposurePoly(lactide-co-glycolideBasophil activationClinical investigationAllergic responsesImmune systemSystem cellsProtein antigensClinical applicationDelivery of proteinsE. coli phospholipidsSafety evidenceAntigenProtein nanoparticlesDeliveryCellsContrastive Learning Approach for Assessment of Phonological Precision in Patients with Tongue Cancer Using MRI Data.
Arias-Vergara T, Pérez-Toro P, Liu X, Xing F, Stone M, Zhuo J, Prince J, Schuster M, Nöth E, Woo J, Maier A. Contrastive Learning Approach for Assessment of Phonological Precision in Patients with Tongue Cancer Using MRI Data. Annual Conference Of The International Speech Communication Association 2024, 2024: 927-931. PMID: 39726638, PMCID: PMC11671147, DOI: 10.21437/interspeech.2024-2236.Peer-Reviewed Original ResearchIon channels in osteoarthritis: emerging roles and potential targets
Zhou R, Fu W, Vasylyev D, Waxman S, Liu C. Ion channels in osteoarthritis: emerging roles and potential targets. Nature Reviews Rheumatology 2024, 20: 545-564. PMID: 39122910, DOI: 10.1038/s41584-024-01146-0.Peer-Reviewed Original ResearchIon channelsVoltage-dependent calcium channelsAcid-sensing ion channelsTransient receptor potential channelsVoltage-gated sodium channelsIon channel modulatorsFunction of ion channelsPotential clinical applicationsCalcium channelsPreclinical studiesClinical impactSymptomatic reliefPotassium channelsChloride channelsDisease-modifying treatmentsClinical trialsSodium channelsBone hyperplasiaChannel modulationIon channel biologySynovial inflammationClinical applicationPiezo channelsModel of OAPotential targetProstate-specific antigen screening for prostate cancer: Diagnostic performance, clinical thresholds, and strategies for refinement
Sundaresan V, Smani S, Rajwa P, Renzulli J, Sprenkle P, Kim I, Leapman M. Prostate-specific antigen screening for prostate cancer: Diagnostic performance, clinical thresholds, and strategies for refinement. Urologic Oncology Seminars And Original Investigations 2024, 43: 41-48. PMID: 39019723, DOI: 10.1016/j.urolonc.2024.06.003.Peer-Reviewed Original ResearchProstate specific antigenProstate cancerPSA-based prostate cancer screeningDiagnostic performanceProstate specific antigen densityProstate specific antigen velocityLow-grade prostate cancerProstate-specific antigen screeningFree prostate specific antigenTreatment of prostate cancerProstate cancer screeningClinical action thresholdsProstate volumeAntigen screeningMalignant cellsSpecific antigenCancer screeningScreening biomarkerProstateClinical roleTest characteristicsCancerClinical applicationClinical thresholdEarly detectionTranslation of Epigenetics in Cell-Free DNA Liquid Biopsy Technology and Precision Oncology
Tan W, Nagabhyrava S, Ang-Olson O, Das P, Ladel L, Sailo B, He L, Sharma A, Ahuja N. Translation of Epigenetics in Cell-Free DNA Liquid Biopsy Technology and Precision Oncology. Current Issues In Molecular Biology 2024, 46: 6533-6565. PMID: 39057032, PMCID: PMC11276574, DOI: 10.3390/cimb46070390.Peer-Reviewed Original ResearchCell-free DNA liquid biopsyCell-free DNALiquid biopsy technologiesLiquid biopsyBiopsy technologyEarly cancer detectionClinical applicationCfDNA-based liquid biopsyMonitoring residual diseaseEarly detection testsCancer detectionPotential of epigeneticsPersonalized cancer treatmentImprove cancer outcomesTissue of originFragmentation pattern analysisResidual diseaseDNA methylationMulti-cancer early detection testTreatment responseBiopsyCancer outcomesCancer preventionEpigeneticsPrecision oncologyUnderstanding nanoparticle-liver interactions in nanomedicine
He Y, Wang Y, Wang L, Jiang W, Wilhelm S. Understanding nanoparticle-liver interactions in nanomedicine. Expert Opinion On Drug Delivery 2024, 21: 829-843. PMID: 38946471, PMCID: PMC11281865, DOI: 10.1080/17425247.2024.2375400.Peer-Reviewed Original ResearchConceptsLiver Kupffer cellsNanoparticle physicochemical propertiesEnhanced delivery efficiencyAdministered nanoparticlesEffective nanomedicinesKupffer cellsLiver diseasePhagocytic functionClinical translationHepatic diseaseLiver accumulationClinical applicationNanomedicineDelivery efficiencyLiverPhagocytic roleDiseaseApplications, challenges, and prospects of induced pluripotent stem cells for vascular disease
Biswas P, Park J. Applications, challenges, and prospects of induced pluripotent stem cells for vascular disease. Molecules And Cells 2024, 47: 100077. PMID: 38825189, PMCID: PMC11260847, DOI: 10.1016/j.mocell.2024.100077.Peer-Reviewed Original ResearchConceptsHuman induced pluripotent stem cellsPluripotent stem cellsVascular diseaseStem cellsTissue-engineered blood vesselsDevelopment of human induced pluripotent stem cellsInduced pluripotent stem cellsField of regenerative medicinePeripheral arterial diseaseDisease modelsVascular organoidsArtery diseaseShear stressGlobal health issueHeart diseaseVascular cellsHuman pathophysiologyClinical applicationVascular physiologyBlood vesselsRegenerative medicineDiseaseCyclic stretchDrugOrganoidsAutocatalytic, Brain Tumor‐Targeting Delivery of Bardoxolone Methyl Self‐Assembled Nanoparticles for Glioblastoma Treatment
Ye Z, Sheu W, Qu H, Peng B, Liu J, Zhang L, Yuan F, Wei Y, Zhou J, Chen Q, Xiao X, Zhang S. Autocatalytic, Brain Tumor‐Targeting Delivery of Bardoxolone Methyl Self‐Assembled Nanoparticles for Glioblastoma Treatment. Small Science 2024, 4: 2400081. PMID: 40212541, PMCID: PMC11935168, DOI: 10.1002/smsc.202400081.Peer-Reviewed Original ResearchBlood-brain barrierBardoxolone methylGlioblastoma multiformeBrain tumorsSurvival of miceSelf-assembled nanoparticlesInhibited GBM tumor growthEnhance drug penetrationGlioblastoma multiforme treatmentKill GBM cellsLack of effective drugsTumor growthDrug penetrationIntravenous administrationP28 peptideEffective drugsGlioblastoma treatmentTumorClinical applicationGBM cellsPeptide-conjugatesTreatmentBrainBardoxoloneGlioblastomaTopical Clindamycin in the Management of Acne Vulgaris: Current Perspectives and Recent Therapeutic Advances.
Del Rosso J, Bunick C, Kircik L, Bhatia N. Topical Clindamycin in the Management of Acne Vulgaris: Current Perspectives and Recent Therapeutic Advances. Journal Of Drugs In Dermatology 2024, 23: 438-445. PMID: 38834223, DOI: 10.36849/jdd.8318.Peer-Reviewed Original ResearchConceptsAcne vulgarisTopical clindamycinTreatment of acne vulgarisManagement of acne vulgarisEmergence of antibiotic-resistant bacteriaAntibiotic-resistant bacteriaTopical agentsAnti-inflammatory propertiesTherapeutic advancesClindamycinClinical studiesTherapeutic outcomesClinical applicationAntimicrobial profileGram-positive bacteriaAnaerobic bacteriaMode of actionVulgarisMonotherapyPublished dataBacteriaTherapyAcneAntibiotics
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