2025
Selective presynaptic inhibition of leg proprioception in behaving Drosophila
Dallmann C, Luo Y, Agrawal S, Mamiya A, Chou G, Cook A, Sustar A, Brunton B, Tuthill J. Selective presynaptic inhibition of leg proprioception in behaving Drosophila. Nature 2025, 1-9. PMID: 40963018, DOI: 10.1038/s41586-025-09554-2.Peer-Reviewed Original ResearchPresynaptic inhibitionCalcium imagingInhibitory descending pathwaysClasses of interneuronsProprioceptive sensory neuronsSensory neuronsPassive leg movementGABAergic presynaptic inhibitionInterneuronsControl armDescending pathwaysCircuit mechanismsDescending inputsNeural circuitsDrosophilaAxonsLeg movementsProprioceptorsCalciumLeg proprioceptorsAlgorithmic dissection of optic flow memory in larval zebrafish
Tanaka R, Portugues R. Algorithmic dissection of optic flow memory in larval zebrafish. Current Biology 2025 PMID: 40961930, DOI: 10.1016/j.cub.2025.08.047.Peer-Reviewed Original ResearchCoordination of distinct sources of excitatory inputs enhances motion selectivity in the mouse visual thalamus
Fei Y, Luh M, Ontiri A, Ghauri D, Hu W, Liang L. Coordination of distinct sources of excitatory inputs enhances motion selectivity in the mouse visual thalamus. Neuron 2025 PMID: 40812301, PMCID: PMC12476077, DOI: 10.1016/j.neuron.2025.07.015.Peer-Reviewed Original ResearchVisual thalamusTwo-photon calcium imagingSource of excitatory inputRetinotopic organizationImage-forming visionRetinal ganglion cellsMouse visual thalamusAwake miceShell neuronsThalamic neuronsExcitatory inputCalcium imagingTemporal directionGanglion cellsCollicular inputColliculus neuronsRetinal axonsSuperior colliculus neuronsThalamusNeuronsNon-retinalRetinal inputMultiple sourcesVisual responsesMiceNeural activity underpins dynamic BOLD signals: findings from simultaneous wide-field fluorescent calcium imaging and fMRI.
Mandino F, Horien C, Shen X, Papademetris X, Keilholz S, Xu N, Lake E. Neural activity underpins dynamic BOLD signals: findings from simultaneous wide-field fluorescent calcium imaging and fMRI. Proceedings Of The International Society For Magnetic Resonance In Medicine ... Scientific Meeting And Exhibition. 2025 DOI: 10.58530/2025/1012.Peer-Reviewed Original ResearchQuasi-periodic patternsBOLD fMRIMeasured whole brain activityBOLD fMRI dataCross-modal agreementWhole-brain activityDynamic activity patternsNeural underpinningsSpatiotemporal structureBOLD signalCalcium imagingFluorescence calcium imagingLow-frequencyBrain activityNeural activityCortical activitySubject levelFMRIActivity patternsBOLDNeural originInter-subject variabilityMultimodal identification of the mouse brain using simultaneous Ca2+ imaging and fMRI
Mandino F, Horien C, Shen X, Desrosiers-Grégoire G, Luo W, Markicevic M, Constable R, Papademetris X, Chakravarty M, Betzel R, Lake E. Multimodal identification of the mouse brain using simultaneous Ca2+ imaging and fMRI. Communications Biology 2025, 8: 665. PMID: 40287579, PMCID: PMC12033268, DOI: 10.1038/s42003-025-08037-4.Peer-Reviewed Original ResearchConceptsBOLD fMRIBOLD fMRI dataConnectome-based identificationCognitive neuroscientistsFMRI literatureHeterogeneous neurological conditionsWhole cortexFMRIMouse brainSimultaneous Ca2+ imagingCa2+ imagingAnimal modelsFluorescence calcium imagingCalcium imagingNeurological conditionsPersonalized treatmentNeuroimagingBOLDCortexNeuroscientistsBrainMiceMultimodal identificationCell-type specific signals
2024
Compartmentalized pooling generates orientation selectivity in wide-field amacrine cells
Lei W, Clark D, Demb J. Compartmentalized pooling generates orientation selectivity in wide-field amacrine cells. Proceedings Of The National Academy Of Sciences Of The United States Of America 2024, 121: e2411130121. PMID: 39602271, PMCID: PMC11626119, DOI: 10.1073/pnas.2411130121.Peer-Reviewed Original ResearchConceptsOrientation selectivityBand-pass spatial frequency tuningVisual systemReceptive fieldsSpatial frequency tuningWide-field amacrine cellsReceptive field modelOrientation detectionKappa-opioid receptorsAmacrine cellsDetecting orientationVisual sceneFrequency tuningGlycinergic inhibitionOpioid receptorsField modelSpecific membrane resistanceExcitatory inputSynaptic inputsCalcium imagingMouse retinaCalcium signalingDendritic compartmentsMicrocircuit levelPolarization
2023
Human REM sleep recalibrates neural activity in support of memory formation
Lendner J, Niethard N, Mander B, van Schalkwijk F, Schuh-Hofer S, Schmidt H, Knight R, Born J, Walker M, Lin J, Helfrich R. Human REM sleep recalibrates neural activity in support of memory formation. Science Advances 2023, 9: eadj1895. PMID: 37624898, PMCID: PMC10456851, DOI: 10.1126/sciadv.adj1895.Peer-Reviewed Original ResearchConceptsRapid eye movementNeural activityMemory consolidationSleep-dependent memory consolidationIn vivo two-photon calcium imagingOvernight memory consolidationRegulation of neural activityHuman REM sleepLong-term memoryTwo-photon calcium imagingBenefit memoryLack of in vivo dataBrain activityMemory formationREM sleepNeural population activityCalcium imagingEye movementsMemoryPopulation activityNeural population dynamicsScalp electroencephalographyElectroencephalographyForgettingLongitudinal simultaneous fMRI and mesoscale calcium imaging in a mouse model of Alzheimer’s disease
Mandino F, Shen X, Desrosiers-Gregoire G, O'Connor D, Mukherjee B, DeLuca K, Hamodi A, Owens A, Ha Y, Qu A, Onofrey J, Papademetris X, Chakravarty M, Crair M, Strittmatter S, Lake E. Longitudinal simultaneous fMRI and mesoscale calcium imaging in a mouse model of Alzheimer’s disease. Proceedings Of The International Society For Magnetic Resonance In Medicine ... Scientific Meeting And Exhibition. 2023 DOI: 10.58530/2023/3914.Peer-Reviewed Original ResearchMouse model of Alzheimer's diseaseModel of Alzheimer's diseaseMesoscale calcium imagingAlzheimer's diseaseBehavioral deficitsExcitatory neural activityMultimodal neuroimagingBOLD signalSimultaneous fMRINeuroimaging changesNeural activityBOLD fMRIPreliminary evidenceCalcium imagingClinically accessible biomarkersMesoscopic calcium imagingSpontaneous activityFMRINeuroimagingBOLDDeficitsComplex relationshipExcitatory somatostatin interneurons in the dentate gyrus drive a widespread seizure network in cortical dysplasia
Zheng Y, Xu C, Sun J, Ming W, Dai S, Shao Y, Qiu X, Li M, Shen C, Xu J, Fei F, Fang J, Jiang X, Zheng G, Hu W, Wang Y, Wang S, Ding M, Chen Z. Excitatory somatostatin interneurons in the dentate gyrus drive a widespread seizure network in cortical dysplasia. Signal Transduction And Targeted Therapy 2023, 8: 186. PMID: 37193687, PMCID: PMC10188524, DOI: 10.1038/s41392-023-01404-9.Peer-Reviewed Original ResearchConceptsSomatostatin-positive interneuronsCortical dysplasiaSeizure networkDentate gyrusParvalbumin-positive interneuronsSomatostatin-positive neuronsExcitatory transmissionDysplastic lesionsSomatostatin interneuronsPoor prognosisSomatostatin-positiveEpileptic hippocampusImmunohistochemical studiesCalcium imagingDysplasiaInterneuronsElectrophysiological recordingsSeizure generalizationCellular basisSeizuresInhibitory roleHippocampusOptogenetic studiesDentateCellular substrates
2022
Brainstem serotonin neurons selectively gate retinal information flow to thalamus
Reggiani J, Jiang Q, Barbini M, Lutas A, Liang L, Fernando J, Deng F, Wan J, Li Y, Chen C, Andermann M. Brainstem serotonin neurons selectively gate retinal information flow to thalamus. Neuron 2022, 111: 711-726.e11. PMID: 36584680, PMCID: PMC10131437, DOI: 10.1016/j.neuron.2022.12.006.Peer-Reviewed Original ResearchConceptsVisual information streamsRetinal ganglion cell typesBrainstem serotonin neuronsFiber photometry recordingsGanglion cell typesTwo-photon calcium imagingSerotonin neuronsVisual thalamusGlutamate releaseSerotonergic axonsRGC axonsSerotonin axonsThalamocortical neuronsAxon stimulationAwake micePresynaptic terminalsCalcium imagingOptogenetic stimulationCalcium activityLocal visual stimuliAxonsThalamusBoutonsVisual stimuliNeuronsGabrb3 is required for the functional integration of pyramidal neuron subtypes in the somatosensory cortex
Babij R, Ferrer C, Donatelle A, Wacks S, Buch A, Niemeyer J, Ma H, Duan Z, Fetcho R, Che A, Otsuka T, Schwartz T, Huang B, Liston C, De Marco García N. Gabrb3 is required for the functional integration of pyramidal neuron subtypes in the somatosensory cortex. Neuron 2022, 111: 256-274.e10. PMID: 36446382, PMCID: PMC9852093, DOI: 10.1016/j.neuron.2022.10.037.Peer-Reviewed Original ResearchConceptsAssociated with autism spectrum disorderNeuronal subtypesAngelman syndromePyramidal neuron subtypesAssociated with neurodevelopmental disordersGABAergic synapsesWidefield calcium imagingPyramidal neuronsAutism spectrum disorderNeonatal stageTwo-photonCalcium imagingResponse to tactile stimulationGABRB3Developmental decreaseSomatosensory cortexAtypical connectivityNetwork synchronyFunctional connectivitySpectrum disorderInterhemispheric circuitInhibitory functionSensory processingNeurodevelopmental disordersASD subjectsA transcriptomic axis predicts state modulation of cortical interneurons
Bugeon S, Duffield J, Dipoppa M, Ritoux A, Prankerd I, Nicoloutsopoulos D, Orme D, Shinn M, Peng H, Forrest H, Viduolyte A, Reddy C, Isogai Y, Carandini M, Harris K. A transcriptomic axis predicts state modulation of cortical interneurons. Nature 2022, 607: 330-338. PMID: 35794483, PMCID: PMC9279161, DOI: 10.1038/s41586-022-04915-7.Peer-Reviewed Original ResearchConceptsOscillatory brain statesInhibitory subtypesBrain statesPrimary visual cortexInhibitory neuronsIn vivo two-photon calcium imagingTwo-photon calcium imagingInhibitory cholinergic receptorsCortical inhibitory neuronsEx vivo slicesV1 subtypeVisual cortexCortical interneuronsDiverse patterns of activityLow input resistanceCholinergic receptorsState modulationInput resistanceCalcium imagingSubtypesAxonal projectionsCortical processingStateBrainNeuronsTowards understanding the neural origins of hibernation
Junkins MS, Bagriantsev SN, Gracheva EO. Towards understanding the neural origins of hibernation. Journal Of Experimental Biology 2022, 225 PMID: 34982152, DOI: 10.1242/jeb.229542.Peer-Reviewed Original Research
2021
Intravital Imaging of Neocortical Heterotopia Reveals Aberrant Axonal Pathfinding and Myelination around Ectopic Neurons
Li AM, Hill RA, Grutzendler J. Intravital Imaging of Neocortical Heterotopia Reveals Aberrant Axonal Pathfinding and Myelination around Ectopic Neurons. Cerebral Cortex 2021, 31: 4340-4356. PMID: 33877363, PMCID: PMC8328209, DOI: 10.1093/cercor/bhab090.Peer-Reviewed Original ResearchConceptsNeuronal clustersEarly postnatal developmentVivo calcium imagingEctopic neuronal clustersAxonal patternNeocortical heterotopiaHeterotopic neuronsCortical heterotopiaHeterotopia formationEctopic neuronsAnimal modelsTractable animal modelPostnatal developmentCalcium imagingBrain regionsInducible modelIntravital imagingNeuronsAxonal pathfindingAberrant patternsHeterotopiaMyelinationAxon guidanceCognitive disabilitiesLive miceVagus nerve stimulation induces widespread cortical and behavioral activation
Collins L, Boddington L, Steffan P, McCormick D. Vagus nerve stimulation induces widespread cortical and behavioral activation. Current Biology 2021, 31: 2088-2098.e3. PMID: 33740425, DOI: 10.1016/j.cub.2021.02.049.Peer-Reviewed Original ResearchConceptsVagus nerve stimulationCalcium imagingNeuromodulatory systemsVagus nerve transectionAuditory cortical regionsWidefield calcium imagingArousal stateDose-dependent activationNerve transectionVNS effectsNerve stimulationExcitatory activityCortical axonsModulatory pathwaysExcitatory neuronsLight anesthesiaNeurological conditionsTherapeutic mechanismMouse modelStimulation inducesArousal state changesCortical activityCortical stateMotor activityCortical regions
2020
Imaging and optogenetic modulation of vascular mural cells in the live brain
Tong L, Hill RA, Damisah EC, Murray KN, Yuan P, Bordey A, Grutzendler J. Imaging and optogenetic modulation of vascular mural cells in the live brain. Nature Protocols 2020, 16: 472-496. PMID: 33299155, DOI: 10.1038/s41596-020-00425-w.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsRegional cerebral blood flowMural cellsBlood-brain barrier maintenanceCerebral ischemia mouse modelAge-related neurodegenerative diseasesCerebral blood flowSmooth muscle cell physiologyBrain blood vesselsIschemia mouse modelVascular mural cellsBrain microvesselsHigh-resolution intravital imagingVascular disordersMouse modelBlood flowMuscle cell physiologyTransgenic miceCalcium transientsAlzheimer's diseaseCalcium imagingCell subtypesBarrier maintenanceNeurodegenerative diseasesTwo-photon optogeneticsBlood vesselsSensory Discrimination of Blood and Floral Nectar by Aedes aegypti Mosquitoes
Jové V, Gong Z, Hol F, Zhao Z, Sorrells T, Carroll T, Prakash M, McBride C, Vosshall L. Sensory Discrimination of Blood and Floral Nectar by Aedes aegypti Mosquitoes. Neuron 2020, 108: 1163-1180.e12. PMID: 33049200, PMCID: PMC9831381, DOI: 10.1016/j.neuron.2020.09.019.Peer-Reviewed Original ResearchConceptsBlood componentsSpecific blood componentsBlood-feeding mosquitoesAdditional blood componentsAedes aegypti mosquitoesAedes aegypti femalesCalcium imagingNeuron classesBloodMeal sizeSpecialized neuronsAegypti mosquitoesMetabolic fateMillions of peopleAegypti femalesBlood mealSensory discriminationDisease transmissionFeeding programsNeuronsSensory detectionMosquitoesTaste qualityVector-borne disease transmissionMealMechanism for analogous illusory motion perception in flies and humans
Agrochao M, Tanaka R, Salazar-Gatzimas E, Clark DA. Mechanism for analogous illusory motion perception in flies and humans. Proceedings Of The National Academy Of Sciences Of The United States Of America 2020, 117: 23044-23053. PMID: 32839324, PMCID: PMC7502748, DOI: 10.1073/pnas.2002937117.Peer-Reviewed Original ResearchCumulative Effects of Social Stress on Reward-Guided Actions and Prefrontal Cortical Activity
Barthas F, Hu MY, Siniscalchi MJ, Ali F, Mineur YS, Picciotto MR, Kwan AC. Cumulative Effects of Social Stress on Reward-Guided Actions and Prefrontal Cortical Activity. Biological Psychiatry 2020, 88: 541-553. PMID: 32276717, PMCID: PMC7434704, DOI: 10.1016/j.biopsych.2020.02.008.Peer-Reviewed Original ResearchConceptsPrefrontal cortical activityCortical activityIndividual layer 2/3 pyramidal neuronsLayer 2/3 pyramidal neuronsStress exposureDepressive-like phenotypeTwo-photon calcium imagingSocial stressChronic social stressIndividual prefrontal neuronsMedial prefrontal cortexPyramidal neuronsMotor subregionsNeural dysfunctionResilient miceCalcium imagingPrefrontal neuronsAbnormal levelsPrefrontal cortexSocial defeatDistinct neural responsesStress-induced lossGoal-directed actionsEnsemble activityDefeat sessions
2019
GABAergic Restriction of Network Dynamics Regulates Interneuron Survival in the Developing Cortex
Duan Z, Che A, Chu P, Modol L, Bollmann Y, Babij R, Fetcho R, Otsuka T, Fuccillo M, Liston C, Pisapia D, Cossart R, De Marco García N. GABAergic Restriction of Network Dynamics Regulates Interneuron Survival in the Developing Cortex. Neuron 2019, 105: 75-92.e5. PMID: 31780329, PMCID: PMC6982374, DOI: 10.1016/j.neuron.2019.10.008.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisCell SurvivalExcitatory Postsynaptic PotentialsFemaleGABAergic Neuronsgamma-Aminobutyric AcidInhibitory Postsynaptic PotentialsInterneuronsMaleMedian EminenceMembrane PotentialsMiceMice, TransgenicNeural PathwaysNeurogenesisParvalbuminsPyramidal CellsSomatosensory CortexSomatostatinSynaptic PotentialsConceptsPyramidal cellsGanglionic eminenceReduction of GABA releaseIncreased network synchronyAssembly of neuronal circuitsEffects of GABAMedial ganglionic eminenceCaudal ganglionic eminenceSpontaneous activity patternsGABA releaseInterneuron survivalPostnatal daySomatostatin interneuronsNeonatal developmentMouse pupsSynaptic inputsCalcium imagingInterneuronsDeveloping cortexIncreased SurvivalNeuronal circuitsSomatosensory cortexAberrant patternsNetwork synchronySensory cortex
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