2020
In Xenopus ependymal cilia drive embryonic CSF circulation and brain development independently of cardiac pulsatile forces
Dur AH, Tang T, Viviano S, Sekuri A, Willsey HR, Tagare HD, Kahle KT, Deniz E. In Xenopus ependymal cilia drive embryonic CSF circulation and brain development independently of cardiac pulsatile forces. Fluids And Barriers Of The CNS 2020, 17: 72. PMID: 33308296, PMCID: PMC7731788, DOI: 10.1186/s12987-020-00234-z.Peer-Reviewed Original ResearchConceptsCSF circulationOptical coherence tomographyCSF flowVentricular systemEpendymal ciliaCoherence tomographyBrain developmentCross-sectional imaging modalitiesBrain ventricular systemEarly time pointsVentricular morphologyCerebral ventricleRespiratory forceConclusionsOur dataCerebrospinal fluidChoroid plexusVentricular spaceCardiac forceEmbryonic brainPulsatile forcesDeadly diseaseTime pointsImaging modalitiesOCT imagingPathological expansionKRAS wild-type pancreatic ductal adenocarcinoma: molecular pathology and therapeutic opportunities
Luchini C, Paolino G, Mattiolo P, Piredda M, Cavaliere A, Gaule M, Melisi D, Salvia R, Malleo G, Shin J, Cargnin S, Terrazzino S, Lawlor R, Milella M, Scarpa A. KRAS wild-type pancreatic ductal adenocarcinoma: molecular pathology and therapeutic opportunities. Journal Of Experimental & Clinical Cancer Research 2020, 39: 227. PMID: 33115526, PMCID: PMC7594413, DOI: 10.1186/s13046-020-01732-6.Peer-Reviewed Original ResearchConceptsPancreatic ductal adenocarcinomaAnti-PD-1/PD-L1 agentsDefective DNA mismatch repairComprehensive molecular profilingMicrosatellite instabilityKinase fusion geneDetermination of KRASTherapeutic molecular targetsHistological diagnosisKRAS mutationsBRAF mutationsDuctal adenocarcinomaKinase inhibitorsTailored treatmentTumorMAPK inhibitorFusion geneGenetic landscapeMolecular targetsKRASDeadly diseaseDNA mismatch repairMolecular traitsLeptomeningeal disease in melanoma patients: An update to treatment, challenges, and future directions
Glitza IC, Smalley KSM, Brastianos PK, Davies MA, McCutcheon I, Liu JKC, Ahmed KA, Arrington JA, Evernden BR, Smalley I, Eroglu Z, Khushalani N, Margolin K, Kluger H, Atkins MB, Tawbi H, Boire A, Forsyth P. Leptomeningeal disease in melanoma patients: An update to treatment, challenges, and future directions. Pigment Cell & Melanoma Research 2020, 33: 527-541. PMID: 31916400, PMCID: PMC10126834, DOI: 10.1111/pcmr.12861.Peer-Reviewed Original ResearchConceptsLeptomeningeal diseaseMelanoma patientsCentral nervous system metastasesMelanoma Research FoundationParenchymal brain metastasesNervous system metastasesMoffitt Cancer CenterMultiple academic centersBrain metastasesCancer CenterTherapeutic managementAcademic centersClinical researchDeadly diseaseConsensus summaryDiseasePatientsMetastasisSecond summit
2019
Hybrid Neural Networks for Mortality Prediction from LDCT Images
Yan P, Guo H, Wang G, De Man R, Kalra MK. Hybrid Neural Networks for Mortality Prediction from LDCT Images. Annual International Conference Of The IEEE Engineering In Medicine And Biology Society (EMBC) 2019, 00: 6243-6246. PMID: 31947269, DOI: 10.1109/embc.2019.8857180.Peer-Reviewed Original ResearchConceptsLow-dose CTMortality predictionLung cancer patientsCancer mortality predictionsMortality risk predictionLung cancer subjectsCause mortalityHigh morbidityCancer patientsLung cancerImaging featuresCardiovascular diseaseCancer subjectsHigh riskMortality riskRisk scoreMortality rateClinical practiceDeadly diseaseRisk predictionLDCT imagesDiseaseRiskSame populationScoring method
2016
Pharmacological management of IPF
Borie R, Justet A, Beltramo G, Manali E, Pradère P, Spagnolo P, Crestani B. Pharmacological management of IPF. Respirology 2016, 21: 615-625. PMID: 27072575, DOI: 10.1111/resp.12778.Peer-Reviewed Original ResearchConceptsIdiopathic pulmonary fibrosisClinical trialsGoal of curing patientsKnowledge of disease pathophysiologyMedian survivalTargeted therapySafety profileHistorical cohortPulmonary fibrosisPharmacological managementDisease progressionDisease pathophysiologyNegative resultsFunctional declinePatientsDiseaseDeadly diseaseDrugTrialsMarketing authorizationNintedanibPirfenidoneIncreased knowledgeFibrosisTherapy
2012
Interstitial lung disease
Murray LA, Rubinowitz A, Herzog EL. Interstitial lung disease. Current Opinion In Rheumatology 2012, 24: 656-662. PMID: 22955020, DOI: 10.1097/bor.0b013e3283588de4.Peer-Reviewed Original ResearchConceptsIdiopathic pulmonary fibrosisInterstitial lung diseaseSSc-ILDClinical presentationPulmonary fibrosisLung diseaseRecent clinical trialsConcepts of pathogenesisLymphocyte subsetsOrigin of fibroblastsEpithelial injuryLung fibrosisPathologic criteriaPredictive biomarkersPathogenic roleClinical trialsDisease progressionCell injuryPutative biomarkersDiseaseFibrosisDeadly diseaseCommon formMillions of peopleDevastating disease
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