2019
A Randomized, Double-Blinded, Placebo-Controlled, Phase 1 Study of a Replication-Defective Herpes Simplex Virus (HSV) Type 2 Vaccine, HSV529, in Adults With or Without HSV Infection
Dropulic L, Oestreich M, Pietz H, Laing K, Hunsberger S, Lumbard K, Garabedian D, Turk S, Chen A, Hornung R, Seshadri C, Smith M, Hosken N, Phogat S, Chang L, Koelle D, Wang K, Cohen J. A Randomized, Double-Blinded, Placebo-Controlled, Phase 1 Study of a Replication-Defective Herpes Simplex Virus (HSV) Type 2 Vaccine, HSV529, in Adults With or Without HSV Infection. The Journal Of Infectious Diseases 2019, 220: 990-1000. PMID: 31058977, PMCID: PMC6688060, DOI: 10.1093/infdis/jiz225.Peer-Reviewed Original ResearchConceptsHerpes simplex virus 2T cell responsesCD4+ T cell responsesHerpes simplex virusDose of vaccinePlacebo recipientsDouble-blindCD8+ T cell responsesReplication-defective herpes simplex virusSolicited injection site reactionsHerpes simplex virus infectionThird dose of vaccineSystemic reactions to vaccinationPlacebo-controlled trialPhase 1 studyInjection site reactionsNeutralizing antibody titersPlacebo-ControlledGenital herpesThird doseSite reactionsSimplex virusVaccine recipientsNeutralizing antibodiesReactions to vaccination
2017
Criteria to Screen Molecular Tests for the Diagnosis of Herpes Simplex Virus in the Central Nervous System have no Propensity to Harm
Hauser RG, Brandt CA, Martinello RA. Criteria to Screen Molecular Tests for the Diagnosis of Herpes Simplex Virus in the Central Nervous System have no Propensity to Harm. Journal Of Pathology Informatics 2017, 8: 4. PMID: 28400993, PMCID: PMC5360015, DOI: 10.4103/2153-3539.201113.Peer-Reviewed Original ResearchCerebrospinal fluidHSV PCRPCR testingCentral nervous system infectionHerpes simplex virus infectionHSV PCR testingPositive HSV PCRVeterans Affairs patientsNervous system infectionPositive cerebrospinal fluidSimplex virus infectionCentral nervous systemHerpes simplex virusAcyclovir treatmentSystem infectionRecord reviewClinical criteriaMedical recordsVirus infectionSimplex virusPatientsNervous systemMolecular testsStudy periodPCR results
2013
Generating protective immunity against genital herpes
Shin H, Iwasaki A. Generating protective immunity against genital herpes. Trends In Immunology 2013, 34: 487-494. PMID: 24012144, PMCID: PMC3819030, DOI: 10.1016/j.it.2013.08.001.Peer-Reviewed Original ResearchConceptsGenital herpesHerpes simplex virus infectionSimplex virus infectionSignificant risk factorsClinical vaccine trialsRecurrent symptomsHSV infectionProtective immunityViral sheddingVaccine trialsRisk factorsChronic diseasesVirus infectionHIV-1Clear infectionAntiviral drugsHost responseHerpesVaccine designInfectionMillions of peopleSpread of diseaseDiseaseRecent studiesVaccine
2010
In Vivo Requirement for Atg5 in Antigen Presentation by Dendritic Cells
Lee HK, Mattei LM, Steinberg BE, Alberts P, Lee YH, Chervonsky A, Mizushima N, Grinstein S, Iwasaki A. In Vivo Requirement for Atg5 in Antigen Presentation by Dendritic Cells. Immunity 2010, 32: 227-239. PMID: 20171125, PMCID: PMC2996467, DOI: 10.1016/j.immuni.2009.12.006.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigen PresentationAutophagy-Related Protein 5Cells, CulturedDendritic CellsFemaleHerpes SimplexHerpesvirus 2, HumanHistocompatibility Antigens Class IILymphocyte ActivationMiceMice, Inbred C57BLMice, KnockoutMicrotubule-Associated ProteinsRadiation ChimeraRNA, Small InterferingConceptsMHC-II presentationMHC class IIDendritic cellsAntigen presentationClass IIHerpes simplex virus infectionToll-like receptor stimuliT cell primingSimplex virus infectionCell primingAbsence of ATG5Microbial antigensVirus infectionMHC ICytosolic antigensConditional deletionAntigenReceptor stimuliAutophagic machineryKey autophagy genesRapid diseasePresentationATG5Lysosome fusionAutophagy genes
1996
Herpes, Syphilis, and Other Ulcerogenital Conditions.
Braverman P. Herpes, Syphilis, and Other Ulcerogenital Conditions. Adolescent Medicine Clinics 1996, 7: 93-118. PMID: 10359960.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
1993
Trends in the Incidence of Outcomes Defining Acquired Immunodeficiency Syndrome (AIDS) in the Multicenter AIDS Cohort Study: 1985–1991
Muñoz A, Schrager L, Bacellar H, Speizer I, Vermund S, Detels R, Saah A, Kingsley L, Seminara D, Phair J. Trends in the Incidence of Outcomes Defining Acquired Immunodeficiency Syndrome (AIDS) in the Multicenter AIDS Cohort Study: 1985–1991. American Journal Of Epidemiology 1993, 137: 423-438. PMID: 8096356, DOI: 10.1093/oxfordjournals.aje.a116691.Peer-Reviewed Original ResearchMeSH KeywordsAcquired Immunodeficiency SyndromeAIDS-Related Opportunistic InfectionsCD4-Positive T-LymphocytesCohort StudiesCytomegalovirus InfectionsHerpes SimplexHIV SeropositivityHIV-1HumansIncidenceLeukocyte CountLymphomaMaleNervous System DiseasesPneumonia, PneumocystisProspective StudiesRegression AnalysisRisk FactorsSarcoma, KaposiUnited StatesConceptsAcquired Immunodeficiency SyndromeP. carinii pneumoniaCarinii pneumoniaProgressive immunosuppressionKaposi's sarcomaImmunodeficiency syndromeOpportunistic infectionsHerpes simplex virus infectionHuman immunodeficiency virus type 1Multicenter AIDS Cohort StudyImmunodeficiency virus type 1Use of chemoprophylaxisUse of prophylaxisIncidence of outcomesPneumocystis carinii pneumoniaSimplex virus infectionAIDS Cohort StudyVirus type 1Antiretroviral therapyCohort studyClinical outcomesInitial diagnosisSecondary diagnosisLower incidenceNeurologic disease
1987
Effect of 2'-fluoro-5-methyl-ara-uracil and cyclophosphamide on herpes simplex virus infection in guinea pigs.
Zheng ZM, Landry ML, Mayo DR, Hsiung GD. Effect of 2'-fluoro-5-methyl-ara-uracil and cyclophosphamide on herpes simplex virus infection in guinea pigs. Acta Pharmacologica Sinica 1987, 8: 158-63. PMID: 2959004.Peer-Reviewed Original Research
1981
An unusual and fatal case of disseminated cutaneous herpes simplex Infection in a patient with cutaneous T cell lymphoma (mycosis fungoides)
Goldgeier M, Cohen S, Braverman I, Stenn K. An unusual and fatal case of disseminated cutaneous herpes simplex Infection in a patient with cutaneous T cell lymphoma (mycosis fungoides). Journal Of The American Academy Of Dermatology 1981, 4: 176-180. PMID: 7217388, DOI: 10.1016/s0190-9622(81)70021-5.Peer-Reviewed Original ResearchConceptsHerpes simplex infectionMycosis fungoidesSimplex infectionViral cultureCutaneous herpes simplex virus infectionCutaneous herpes simplex infectionCutaneous T-cell lymphomaHerpes simplex virus infectionPlaque stage mycosis fungoidesSerial antibody titersSimplex virus infectionStage mycosis fungoidesT-cell lymphomaCutaneous ulcersImmunocompromised hostCutaneous ulcerationAntibody titersFatal casesTzanck preparationVesicular lesionsHistologic examinationVirus infectionCell lymphomaSkin lesionsHerpes virus
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