2025
Ethnic and racial differences in children and young people with respiratory and neurological post-acute sequelae of SARS-CoV-2: an electronic health record-based cohort study from the RECOVER Initiative
Rao S, Azuero-Dajud R, Lorman V, Landeo-Gutierrez J, Rhee K, Ryu J, Kim C, Carmilani M, Gross R, Mohandas S, Suresh S, Bailey L, Castro V, Senathirajah Y, Esquenazi-Karonika S, Murphy S, Caddle S, Kleinman L, Castro-Baucom L, Oliveira C, Klein J, Chung A, Cowell L, Madlock-Brown C, Geary C, Sills M, Thorpe L, Szmuszkovicz J, Tantisira K, Diaz I, Kenny R, Mirhaji P, Jhaveri R, Rosenman M, Bailey L, Forrest C, Tarini B, Morizono H, Pajor N, Jones W, Curtis K, Kamaleswaran R, Deshpande N, Blecker S, Pulgarin C, Sills M, Hinkman E, Fort D, Guthrie T, Chuang C, Hwang W, Christakis D, Ranade D, Herring S, Mishkin A, Fernandez S, Thomas N, Bisyuk Y, Fuloria J, Chrischilles E, Knosp B, Oxner A, Tsalatsanis A, Cowell L, Reeder P, Downs S, Ostasiewski B, Kaushal R, Campion T, Snowden J, Irby K, Darden P, Dixon L, Evans D, Garbe C, Hobart-Porter L, Howard L, Hummel K, Krehbiel H, Spradlin H, Yount P, Elliott A, Adam G, Angal J, Barber M, Clark K, Dos Reis C, Freesemann M, Friedrich C, Hockett C, Johannsen R, Johnson-Vonk E, Kaiser C, Kruse A, Lang J, Lim P, McCoy M, Miller L, Petereit S, RiChard J, Seiler J, Sundleaf B, Svendsen J, Trosper B, Vermeulen O, Young S, Palumbo A, Dabney S, Fahrner M, Gallagher T, Martini K, McNally M, Stiverson S, Kosut J, Balaraman V, Cheung J, Hong T, Kalua S, Minami E, Siu A, Tong M, Teufel R, Atz A, Dantas M, Kasmarcak T, Milks K, Ross J, Ikomi C, Meyer M, Nguyen C, Pellicciotti G, Phan T, Ravin K, Reynolds V, Strang A, Thacker D, Eckrich D, Goetter A, Katz C, Kowal K, McDevitt C, Zimmerman E, Roman G, Alshawabkeh A, Ortiz I, Casey V, Cordero J, De Jesus J, Galan C, Huerta-Montanez G, Otero N, Robles M, Roman P, Roman G, Rosario-Pabon Z, Santiago X, Velez-Vega C, Vergara C, Hsia D, Albarado B, Allen T, Attuso A, Ayers T, Bebler E, Bella G, Bennett A, Brown J, Carville A, Darby S, Devall K, Dragg A, Elderedge A, Fontenot E, Fry G, Gildersleeve B, Goff S, Harrington L, Jones L, Kaiser V, Lee Y, Lee S, LeJeune E, Leonhard R, Levatino J, Lewis D, Lloyd A, Monce R, Munro S, Phillips M, Pucheu B, Rachal E, Rood J, Roussel S, Rumsey R, Sanford C, Santos M, Stafford A, Thomassie A, Waguespack C, Walgamotte K, Welch M, Windham A, Stevenson M, Bell T, Boyd J, Dasgupta S, Deans S, Harris K, Hemmerle M, King S, McGuire C, Merten B, Morris S, Ray M, Reinhardt B, Shemwell S, Simeon T, Walker K, Watson S, Weakley K, McCulloh R, Figliomeni J, Fischer L, Hoover D, Morse M, Nabower A, Roberts E, Sato A, Von Bon J, Raissy H, Archuleta D, Brito R, Campbell R, Chavez J, Dehority W, Garcia-Soberanez N, Gronert E, Kadish M, Larrabee J, Lovato D, Luo K, Martinez N, Merlino A, Reese E, Ward S, Wilson K, Bogie A, Brown R, Butchee R, Fergeson G, McKee R, Mohler B, Moore T, Owens V, Stubbs S, Van Wagoner T, Cowan K, Bethel M, Chassereau L, Lahiri T, Cottrell L, Lake L, Moffett K, Polak E, Stutler S, Workman C, Warburton D, Mohandas S, Wood J, Carpenter E, Dhindsa I, Mejia S, Moghadam N, Mulder C, O'Neil S, Osornio A, Rios A, Rosen S, Smith A, Tabibi D, Tang S, Teame A, Stockwell M, Milner J, Rosenzweig E, Anderson B, Aquino T, Berg E, Caddle S, Catallozzi M, Chung W, Connors T, De A, Perez A, DiLorenzo M, Dumitriu D, Farooqi K, Fremed M, Goldman S, Kaplan K, Krishnan U, Layton A, Lignelli-Dipple A, McClaren S, Overdevest J, Rodriguez M, Selman J, Silver W, Silverio R, de Romero A, Vargas C, Werzberger A, Caputo D, Leggieri C, Pretsch P, Kleinman L, Gaur S, Cerracchio L, Folnagy A, Gennaro M, Gzemski S, Hao Y, Li S, Moroso S, Ness-Cochinwala M, Patel A, Richlin B, Sharma H, Soto D, Suarez C, Forero B, Olson L, Davis K, Fiks A, Griffith M, Harris D, Macario E, Steffes J, Torres A, Selvarangan R, Banerjee D, Day C, Howell K, Mains M, Salazar J, Zempsky W, Bean E, DeFelice C, Chebib H, Herbst K, Lesmes S, Michelow I, Santos M, Schulman N, Pace W, Brooks-Greien A, Colin K, Hester C, Juarez-Colunga A, Manning B, Shields J, Westfall J, York D, Aschner J, Clouser K, Griswold J, Lee D, Nowakowski A, Riordan M, Bukulmez H, Kaelber D, Aamir R, Abuzahrieh M, Bangalore N, Brown A, Dalton W, Fortuna S, Minium J, Rosolowski B, Nolan S, Ahmed A, Braniecki S, Contreras M, Dozor A, Jain S, Kaseta S, Krishnan S, Messer Z, Ramirez A, Singh A, Williams R, Rhee K, Tantisira K, Akerlundh A, Akshoomoff N, Arroyo M, Barrientos W, Bhattacharjee R, Chao B, Diaz M, Garcia S, Garcia S, Gomez G, Herrera T, Holguin M, Khare M, Kiernan E, Gutierrez J, Matta I, Reyes S, Ryu J, Sanchez C, Schreck A, Warner M, Hasan U, Ricciardi E, Trespalacios V, Faustino V, Kluko M, Oliveira C, Rhee K, Tantisira K, Akerlundh A, Akshoomoff N, Barrientos W, Bhattacharjee R, Chao B, Diaz M, Garcia S, Glenn-Arroyo M, Gomez G, Herrera T, Holguin M, Khare M, Kiernan E, Landeo-Gutierrez J, Madan A, Vallejo L, Reyes S, Ryu J, Sanchez C, Schreck A, Suarez M, Warner M, Kinser P, Salisbury A, Espinoza J, Moyer S, Rider A, Russell S, Schecter M, Stevenson L, Stein C, Caldas S, Ovalle T, Chung A, Farkas J, Isidoro-Chino M, Kesebir D, Kim E, Quarless A, Schlechter A, Srinivasan R, D'Sa V, Barry F, Burton P, Lorente R, Cummins C, Wehbe S, Brown S, Dale A, Jernigan T, Rhee K, Tapert S, Aguilar J, Benjamin D, Buchbinder N, Castro N, Emerson B, Garavan H, Graves J, Guerrero A, Linkersdoerfer J, Schooley R, Thompson W, Trinh T, Yang R, Herting M, Sowell E, Cisneros C, Goedde L, Manlhiot C, Gonzalez R, Laird A, Limia J, Aupperle R, Paulus M, Curry M, El-Sabbagh N, Gray K, Squeglia L, Agbeh S, Herring C, Mckenzie B, Nagel B, Espinoza A, Hill A, Morales A, Baker F, Muller-Oehring E, Colrain I, Durley I, Dapretto M, Uddin L, Bookheimer S, Caldera C, Dzul J, Zarate C, Banich M, Badilla P, Keith J, Kumar G, Messinger D, Prazak K, Nixon S, Cardoso M, Sullivan M, Villard S, Chang L, Ernst T, Cloak C, Liang H, Ryan M, Heitzerg M, Conley J, Puttler L, Luciana M, Iacono W, Schroeder A, Clark D, Kim D, Retucci M, Freedman E, Foxe J, Mhurchu S, Spallina S, McGlade E, Yurgelun-Todd D, Bell L, Cline K, Heinrich L, Renshaw P, Garavan H, Potter A, Barrett C, Lozon S, Spear S, Larson C, Lisdahl K, Clearwater T, Kaiver C, Nelson C, Paltzer Z, Peteet B, Bjork J, Neale M, Calonge O, Slattery N, Straub L, Barch D, Heath A, Madden P, Powell T, Schmitz D, Gee D, Epie B, Hobbs R, Williams A, Xiang Z, Miller J, Newburger J, Trachtenberg F, Amarnath A, Ambrosoli J, Artis D, Bandari S, Birmingham E, Eyob L, Hayes K, Hu C, Joyce M, Kazlova V, Liu I, Marshall A, Mbizdenyuy D, Mu P, Rowe R, Sayles B, Zhang M, Jone P, Carr M, Goodell L, Kar W, Hof K, Sexson K, Moussi E, Olukayode D, Pena S, Pignatelli R, Serrano F, Tejtel S, Shekerdemian L, Dionne A, Newburger J, Baker A, DeFerrantini S, Giorgio T, Khan N, Mahanta S, Son M, Oster M, Burnett M, Sanders-Lewis K, Rao S, Chavez S, Reis G, Szmuszkovicz J, Behzadian F, Canas C, Cheng A, Gawad M, Johnson P, Kazarians A, Mohandas S, Sarkissian A, Scott B, Secules C, Su J, Vargas C, Votava-Smith J, Wagner-Lees S, Wang S, Wong P, Sanil Y, Aggarwal S, Almasnaah A, Kannikeswaran N, Meert K, Singh G, Spencer P, Sullivan N, Sundaralingam S, Undyala V, Ward E, Weber A, Farr C, Bradford T, Johnston M, Elias M, Fiks A, Forrest C, Albizem D, Coffin S, Giglia T, Lupton K, Marks G, Morrison T, O'Connor S, Forsha D, Nelson J, Sachdeva R, Watkins D, Harahsheh A, Britton J, Fetch A, Krishnan A, Tariq O, Lang S, Almaguer M, Cnota J, Dugan L, Pickering E, Rathge K, Mitchell E, Capone C, Misra N, Shamailova O, Russell M, Doman T, Harris L, Hasbani K, Jani S, McCrindle B, Bainton J, Chrisant M, Alaby D, Barton N, Katz D, Smith P, Handler S, Block J, Cole R, Maldonado J, McHugh K, Atz A, Bickford M, Buckley J, Costello J, Dennis D, Emrath-Zwick E, Freeman M, Jackson L, Johnson M, Kasmarcak T, Mack E, Pletzer S, Ruth N, Taylor C, Zyblewski S, Farooqi K, Anderson B, Golub K, Rojas C, Rosalind K, Sanchez C, Srivastava S, Prospero C, Thacker D, Williams E, Zadokar V, Sabati A, Domian K, Herzberg A, Khanna S, Nowlen T, Park S, Porche J, Stack S, Truong D, Dunn A, Fagatele L, Joyce E, Lambert L, Dummer K, Bandy S, Burns J, Crane K, Hedge S, Pancheri J, Tremoulet A, Payne R, Stumpf M, Portman M, Kajimoto H, Hebson C, Hock K, Osakwe O, Morato J, Shakti D, Kadish M, Raissy H, Larrabee J, Sharma K, Anguiano W, Ikemba C, Lozano A, Martinez M, Rojas W, Morgan L, Macias I, Owada C, Rangel M, Sykes M. Ethnic and racial differences in children and young people with respiratory and neurological post-acute sequelae of SARS-CoV-2: an electronic health record-based cohort study from the RECOVER Initiative. EClinicalMedicine 2025, 80: 103042. PMID: 39850015, PMCID: PMC11753962, DOI: 10.1016/j.eclinm.2024.103042.Peer-Reviewed Original ResearchSocial drivers of healthArea Deprivation IndexElectronic health recordsDrivers of healthPost-acute sequelae of SARS-CoV-2Logistic regression modelsDeprivation indexHealthcare utilizationNon-Hispanic white individualsCohort studyYears seeking careMultivariate logistic regression modelRegression modelsPost-acute sequelaeEthnic minority groupsNational Institutes of HealthHealth recordsHealth systemInstitutes of HealthRetrospective cohort studyCohort entrySociodemographic characteristicsHigher oddsSocial Vulnerability IndexMeasure associations
2024
Postacute Sequelae of COVID-19 in Pediatric Patients Within the United States: A Scoping Review
Miller C, Borre C, Green A, Funaro M, Oliveira C, Iwasaki A. Postacute Sequelae of COVID-19 in Pediatric Patients Within the United States: A Scoping Review. American Journal Of Medicine Open 2024, 12: 100078. PMID: 39639960, PMCID: PMC11617896, DOI: 10.1016/j.ajmo.2024.100078.Peer-Reviewed Original ResearchClinical epidemiologyPost-acute sequelae of COVID-19High risk of biasLack of standardized definitionsPost-acute sequelaeRisk of biasSequelae of COVID-19United StatesScoping ReviewComprehensive literature searchUS childrenShort follow-up durationFollow-up durationInclusion criteriaFemale sexOlder ageRisk factorsSARS-CoV-2 infectionLiterature searchChest painHigh riskOptimal preventionPediatric patientsPersistent symptomsCOVID-19Increased von Willebrand and Factor VIII plasma levels in gynecologic patients with Post-Acute-COVID-Sequela (PASC)/Long COVID
Bellone S, Siegel E, Scheim D, Santin A. Increased von Willebrand and Factor VIII plasma levels in gynecologic patients with Post-Acute-COVID-Sequela (PASC)/Long COVID. Gynecologic Oncology Reports 2024, 51: 101324. PMID: 38273933, PMCID: PMC10809113, DOI: 10.1016/j.gore.2024.101324.Peer-Reviewed Original ResearchElevated von Willebrand factorFactor VIII levelsVon Willebrand factorLong COVIDGynecologic patientsVIII levelsControl patientsD-dimerPlasma levelsFactor VIIID-dimer levelsPost-acute sequelaeLong COVID symptomsFactor VIII plasma levelsMicrovascular damageMicrovascular inflammationRed blood cellsThrombotic complicationsAcute infectionLC patientsPersistent inflammationPathophysiological mechanismsCancer patientsCOVID symptomsPatients
2023
COVID-19 Convalescent Plasma Therapy: Long-term Implications
Yoon H, Li Y, Goldfeld K, Cobb G, Sturm-Reganato C, Ostrosky-Zeichner L, Jayaweera D, Philley J, Desruisseaux M, Keller M, Hochman J, Pirofski L, Ortigoza M, Hochman J, Cronstein B, Keeling D, Rappoport N, Saraga J, Holahan J, Ortigoza M, Pirofski L, Yoon H, Sturm-Reganato C, Cobb G, Andela R, Darwish Y, Taveras M, Xin P, LaFleur J, Cleare L, Goldfeld K, Li Y, Ortigoza M, O'Keeffe M, Cobb G, Sturm-Reganato C, Rahman F, Ajayi A, Rodriguez S, Iturrate E, Gallagher J, Thomas O, Ramos D, Fong C, Pirofski L, Yoon H, Keller M, Asencio A, Eke I, Castro J, Shan J, Chalco A, LaFleur J, Cleare L, Desruisseaux M, Cortezzo G, Rocco E, Ndunge O, Parmelee C, Solomon G, Cahil S, Jayaweera D, Lee C, Ransford D, Dasmany D, Corona A, Moreno K, Martinez G, Otero C, McPherson D, Ostrosky-Zeichner L, Patel B, Nigo M, Huebinger R, Dronavalli G, Grimes C, Umana V, Hernandez M, Nielsen L, Stutz T, Mammadova M, Dentino A, Heath T, Martin J, Bello F, Hinojosa E, Philley J, Devine M, Hibbard R, Ford A. COVID-19 Convalescent Plasma Therapy: Long-term Implications. Open Forum Infectious Diseases 2023, 11: ofad686. PMID: 38269049, PMCID: PMC10807994, DOI: 10.1093/ofid/ofad686.Peer-Reviewed Original ResearchPost-acute sequelaePROMIS scoresCOVID-19 convalescent plasma (CCP) therapySARS-CoV-2 infection symptomsSARS-CoV-2 infectionAcute COVID-19Convalescent plasma therapyGlobal health assessmentPhysical health scoresCOVID-19 hospitalizationCOVID-19 trialsSelf-reported symptomsRespective reference groupsRace/ethnicityPASC symptomsRandomization armAcute infectionAcute treatmentPlasma therapyGeneral symptomsSymptom SurveyLong-term effectsHealth scoresOverall healthDisease severityResearching COVID to enhance recovery (RECOVER) pregnancy study: Rationale, objectives and design
Metz T, Clifton R, Gallagher R, Gross R, Horwitz L, Jacoby V, Martin-Herz S, Peralta-Carcelen M, Reeder H, Beamon C, Chan J, Chang A, Costantine M, Fitzgerald M, Foulkes A, Gibson K, Güthe N, Habli M, Hackney D, Hoffman M, Hoffman M, Hughes B, Katz S, Laleau V, Mallett G, Mendez-Figueroa H, Monzon V, Palatnik A, Palomares K, Parry S, Pettker C, Plunkett B, Poppas A, Reddy U, Rouse D, Saade G, Sandoval G, Schlater S, Sciurba F, Simhan H, Skupski D, Sowles A, Thaweethai T, Thomas G, Thorp J, Tita A, Weiner S, Weigand S, Yee L, Flaherman V, Initiative O. Researching COVID to enhance recovery (RECOVER) pregnancy study: Rationale, objectives and design. PLOS ONE 2023, 18: e0285351. PMID: 38128008, PMCID: PMC10734909, DOI: 10.1371/journal.pone.0285351.Peer-Reviewed Original ResearchConceptsSARS-CoV-2 infectionSARS-CoV-2Long-term outcomesMonths of agePregnancy cohortMaternal-Fetal Medicine Units NetworkHealth outcomesSARS-CoV-2 antibody testingAdverse long-term outcomesEunice Kennedy Shriver National InstitutePost-acute sequelaeLong-term sequelaeClinical trial registrationMaternal-child dyadsNational InstituteMulti-site observational studyCalifornia San FranciscoUnique physiologic changesPregnancy modifiesMaternal infectionMultiple gestationsOverall cohortRetrospective cohortAntibody testingLong COVIDDifferential cardiopulmonary haemodynamic phenotypes in PASC-related exercise intolerance
Kahn P, Joseph P, Heerdt P, Singh I. Differential cardiopulmonary haemodynamic phenotypes in PASC-related exercise intolerance. ERJ Open Research 2023, 10: 00714-2023. PMID: 38348243, PMCID: PMC10860209, DOI: 10.1183/23120541.00714-2023.Peer-Reviewed Original ResearchInvasive cardiopulmonary exercise testingRight heart catheterizationPASC patientsExertional intoleranceCardiac outputPulmonary artery wedge pressurePeak VO 2Supranormal cardiac outputPeak exercise capacityCardiopulmonary exercise testingMaximal voluntary ventilationPost-acute sequelaeBody mass indexSystemic oxygen extractionMild acute illnessSARS-CoV-2Exercise hemodynamicsHFpEF patientsHFpEF phenotypeHeart catheterizationWedge pressureAcute illnessExercise capacityExercise testingHemodynamic abnormalitiesPrevalence of covid-19 and long covid in collegiate student athletes from spring 2020 to fall 2021: a retrospective survey
Massey D, Saydah S, Adamson B, Lincoln A, Aukerman D, Berke E, Sikka R, Krumholz H. Prevalence of covid-19 and long covid in collegiate student athletes from spring 2020 to fall 2021: a retrospective survey. BMC Infectious Diseases 2023, 23: 876. PMID: 38093182, PMCID: PMC10717379, DOI: 10.1186/s12879-023-08801-z.Peer-Reviewed Original ResearchConceptsLong COVIDCOVID-19SARS-CoV-2 infectionPost-acute sequelaeSymptomatic COVID-19SARS-CoV-2Student athletesPost-COVID conditionsMental health consequencesHealthy athletesCollegiate Student-AthletesHealthy peopleRetrospective surveyMore weeksHealth consequencesPrevalenceConclusionsThis studyConvenience sampleFall 2020College athletesFurther studiesAthletesCOVIDSpring 2020Relevant time periodCortical GABA Levels Are Reduced in Post-Acute COVID-19 Syndrome
Marinkovic K, White D, Myers A, Parker K, Arienzo D, Mason G. Cortical GABA Levels Are Reduced in Post-Acute COVID-19 Syndrome. Brain Sciences 2023, 13: 1666. PMID: 38137114, PMCID: PMC10741691, DOI: 10.3390/brainsci13121666.Peer-Reviewed Original ResearchAcute COVID-19 illnessCOVID-19 illnessGABA levelsN-acetylaspartatePost-acute COVID-19 syndromeCortical GABA levelsPersistent cognitive dysfunctionPost-acute sequelaeCOVID-19 syndromeExcitation/inhibition imbalancePoor sleep qualityProton magnetic resonance spectroscopyDepression/anxietyQuality of lifePersistent neuroinflammationBrain fogCortical hyperexcitabilityLong COVIDAlcohol intakeCognitive dysfunctionNeuronal integrityNeurocognitive dysfunctionNeurochemical aspectsSleep qualityOccipital cortexUsing Multi-Modal Electronic Health Record Data for the Development and Validation of Risk Prediction Models for Long COVID Using the Super Learner Algorithm
Jin W, Hao W, Shi X, Fritsche L, Salvatore M, Admon A, Friese C, Mukherjee B. Using Multi-Modal Electronic Health Record Data for the Development and Validation of Risk Prediction Models for Long COVID Using the Super Learner Algorithm. Journal Of Clinical Medicine 2023, 12: 7313. PMID: 38068365, PMCID: PMC10707399, DOI: 10.3390/jcm12237313.Peer-Reviewed Original ResearchComposite risk scoreRisk scoreElectronic health recordsAnalyses identified several factorsValidation of risk prediction modelsModerate discriminatory abilityRisk prediction modelPost-acute sequelae of COVID-19Health recordsCombined risk scorePost-AcuteIdentification of individualsPrevention effortsSuper Learner algorithmMedical recordsHealthcare challengesPublic healthMedical phenotypesCOVID-19Increased riskPredictive factorsCOVID-19 infectionRecord dataPost-acute sequelaeHigh riskIncreased serum 1,25-dihydroxyvitamin D levels in gynecologic cancer patients with Post-Acute-Covid-Sequela (PASC)/Long COVID
Bellone S, Siegel E, Santin A. Increased serum 1,25-dihydroxyvitamin D levels in gynecologic cancer patients with Post-Acute-Covid-Sequela (PASC)/Long COVID. Gynecologic Oncology Reports 2023, 50: 101301. PMID: 38029227, PMCID: PMC10654147, DOI: 10.1016/j.gore.2023.101301.Peer-Reviewed Original ResearchGynecologic cancer patientsLong COVIDCancer patientsVitamin DPotent anti-inflammatory activityDihydroxyvitamin D levelsPost-acute sequelaeLong COVID symptomsAnti-inflammatory activityMental health impairmentControl cancer patientsExtrarenal conversionPost-AcuteControl patientsAcute infectionBone healthLC patientsPersistent inflammationD levelsCOVID symptomsImmune cellsPlasmatic levelsNovel biomarkersPatientsAbnormal levelsCharacterization of long COVID temporal sub-phenotypes by distributed representation learning from electronic health record data: a cohort study
Dagliati A, Strasser Z, Abad Z, Klann J, Wagholikar K, Mesa R, Visweswaran S, Morris M, Luo Y, Henderson D, Samayamuthu M, Tan B, Verdy G, Omenn G, Xia Z, Bellazzi R, EHR T, Aaron J, Agapito G, Albayrak A, Albi G, Alessiani M, Alloni A, Amendola D, Angoulvant F, Anthony L, Aronow B, Ashraf F, Atz A, Avillach P, Azevedo P, Balshi J, Beaulieu-Jones B, Bell D, Bellasi A, Bellazzi R, Benoit V, Beraghi M, Bernal-Sobrino J, Bernaux M, Bey R, Bhatnagar S, Blanco-Martínez A, Bonzel C, Booth J, Bosari S, Bourgeois F, Bradford R, Brat G, Bréant S, Brown N, Bruno R, Bryant W, Bucalo M, Bucholz E, Burgun A, Cai T, Cannataro M, Carmona A, Caucheteux C, Champ J, Chen J, Chen K, Chiovato L, Chiudinelli L, Cho K, Cimino J, Colicchio T, Cormont S, Cossin S, Craig J, Cruz-Bermúdez J, Cruz-Rojo J, Dagliati A, Daniar M, Daniel C, Das P, Devkota B, Dionne A, Duan R, Dubiel J, DuVall S, Esteve L, Estiri H, Fan S, Follett R, Ganslandt T, Barrio N, Garmire L, Gehlenborg N, Getzen E, Geva A, Gradinger T, Gramfort A, Griffier R, Griffon N, Grisel O, Gutiérrez-Sacristán A, Han L, Hanauer D, Haverkamp C, Hazard D, He B, Henderson D, Hilka M, Ho Y, Holmes J, Hong C, Huling K, Hutch M, Issitt R, Jannot A, Jouhet V, Kavuluru R, Keller M, Kennedy C, Key D, Kirchoff K, Klann J, Kohane I, Krantz I, Kraska D, Krishnamurthy A, L'Yi S, Le T, Leblanc J, Lemaitre G, Lenert L, Leprovost D, Liu M, Loh N, Long Q, Lozano-Zahonero S, Luo Y, Lynch K, Mahmood S, Maidlow S, Makoudjou A, Malovini A, Mandl K, Mao C, Maram A, Martel P, Martins M, Marwaha J, Masino A, Mazzitelli M, Mensch A, Milano M, Minicucci M, Moal B, Ahooyi T, Moore J, Moraleda C, Morris J, Morris M, Moshal K, Mousavi S, Mowery D, Murad D, Murphy S, Naughton T, Neto C, Neuraz A, Newburger J, Ngiam K, Njoroge W, Norman J, Obeid J, Okoshi M, Olson K, Omenn G, Orlova N, Ostasiewski B, Palmer N, Paris N, Patel L, Pedrera-Jiménez M, Pfaff E, Pfaff A, Pillion D, Pizzimenti S, Prokosch H, Prudente R, Prunotto A, Quirós-González V, Ramoni R, Raskin M, Rieg S, Roig-Domínguez G, Rojo P, Rubio-Mayo P, Sacchi P, Sáez C, Salamanca E, Samayamuthu M, Sanchez-Pinto L, Sandrin A, Santhanam N, Santos J, Vidorreta F, Savino M, Schriver E, Schubert P, Schuettler J, Scudeller L, Sebire N, Serrano-Balazote P, Serre P, Serret-Larmande A, Shah M, Abad Z, Silvio D, Sliz P, Son J, Sonday C, South A, Spiridou A, Strasser Z, Tan A, Tan B, Tan B, Tanni S, Taylor D, Terriza-Torres A, Tibollo V, Tippmann P, Toh E, Torti C, Trecarichi E, Tseng Y, Vallejos A, Varoquaux G, Vella M, Verdy G, Vie J, Visweswaran S, Vitacca M, Wagholikar K, Waitman L, Wang X, Wassermann D, Weber G, Wolkewitz M, Wong S, Xia Z, Xiong X, Ye Y, Yehya N, Yuan W, Zambelli A, Zhang H, Zo¨ller D, Zuccaro V, Zucco C, Murphy S, Holmes J, Estiri H. Characterization of long COVID temporal sub-phenotypes by distributed representation learning from electronic health record data: a cohort study. EClinicalMedicine 2023, 64: 102210. PMID: 37745021, PMCID: PMC10511779, DOI: 10.1016/j.eclinm.2023.102210.Peer-Reviewed Original ResearchElectronic health record dataHealth record dataAdvancing Translational SciencesCohort studyNational InstituteMulti-center observational cohort studyHospitalized COVID-19 patientsObservational cohort studyPost-acute sequelaeRecord dataCOVID-19 patientsHealthcare systemLongitudinal electronic health record dataMedical Research CouncilTranslational scienceNational Medical Research CouncilPASC symptomsJoint painTotal cohortClinical characterizationHigh prevalenceMultiple symptomsNeurological disordersAverage prevalenceInfectious diseasesSARS-CoV-2 reservoir in post-acute sequelae of COVID-19 (PASC)
Proal A, VanElzakker M, Aleman S, Bach K, Boribong B, Buggert M, Cherry S, Chertow D, Davies H, Dupont C, Deeks S, Eimer W, Ely E, Fasano A, Freire M, Geng L, Griffin D, Henrich T, Iwasaki A, Izquierdo-Garcia D, Locci M, Mehandru S, Painter M, Peluso M, Pretorius E, Price D, Putrino D, Scheuermann R, Tan G, Tanzi R, VanBrocklin H, Yonker L, Wherry E. SARS-CoV-2 reservoir in post-acute sequelae of COVID-19 (PASC). Nature Immunology 2023, 24: 1616-1627. PMID: 37667052, DOI: 10.1038/s41590-023-01601-2.Peer-Reviewed Original ResearchConceptsSARS-CoV-2 reservoirPost-acute sequelaeImmune responseHost immune responseCoronavirus SARS-CoV-2COVID-19SARS-CoV-2Neuroimmune abnormalitiesAcute infectionLong COVIDClinical trialsViral RNAMillions of peopleSequelaeFurther studiesViral proteinsPathologyResearch prioritiesRNA/proteinBiological factorsPASCAntiviralsInfectionAbnormalitiesTrialsResearching COVID to Enhance Recovery (RECOVER) adult study protocol: Rationale, objectives, and design
Horwitz L, Thaweethai T, Brosnahan S, Cicek M, Fitzgerald M, Goldman J, Hess R, Hodder S, Jacoby V, Jordan M, Krishnan J, Laiyemo A, Metz T, Nichols L, Patzer R, Sekar A, Singer N, Stiles L, Taylor B, Ahmed S, Algren H, Anglin K, Aponte-Soto L, Ashktorab H, Bassett I, Bedi B, Bhadelia N, Bime C, Bind M, Black L, Blomkalns A, Brim H, Castro M, Chan J, Charney A, Chen B, Chen L, Chen P, Chestek D, Chibnik L, Chow D, Chu H, Clifton R, Collins S, Costantine M, Cribbs S, Deeks S, Dickinson J, Donohue S, Durstenfeld M, Emery I, Erlandson K, Facelli J, Farah-Abraham R, Finn A, Fischer M, Flaherman V, Fleurimont J, Fonseca V, Gallagher E, Gander J, Gennaro M, Gibson K, Go M, Goodman S, Granger J, Greenway F, Hafner J, Han J, Harkins M, Hauser K, Heath J, Hernandez C, Ho O, Hoffman M, Hoover S, Horowitz C, Hsu H, Hsue P, Hughes B, Jagannathan P, James J, John J, Jolley S, Judd S, Juskowich J, Kanjilal D, Karlson E, Katz S, Kelly J, Kelly S, Kim A, Kirwan J, Knox K, Kumar A, Lamendola-Essel M, Lanca M, Lee-Lannotti J, Lefebvre R, Levy B, Lin J, Logarbo B, Logue J, Longo M, Luciano C, Lutrick K, Malakooti S, Mallett G, Maranga G, Marathe J, Marconi V, Marshall G, Martin C, Martin J, May H, McComsey G, McDonald D, Mendez-Figueroa H, Miele L, Mittleman M, Mohandas S, Mouchati C, Mullington J, Nadkarni G, Nahin E, Neuman R, Newman L, Nguyen A, Nikolich J, Ofotokun I, Ogbogu P, Palatnik A, Palomares K, Parimon T, Parry S, Parthasarathy S, Patterson T, Pearman A, Peluso M, Pemu P, Pettker C, Plunkett B, Pogreba-Brown K, Poppas A, Porterfield J, Quigley J, Quinn D, Raissy H, Rebello C, Reddy U, Reece R, Reeder H, Rischard F, Rosas J, Rosen C, Rouphael N, Rouse D, Ruff A, Saint Jean C, Sandoval G, Santana J, Schlater S, Sciurba F, Selvaggi C, Seshadri S, Sesso H, Shah D, Shemesh E, Sherif Z, Shinnick D, Simhan H, Singh U, Sowles A, Subbian V, Sun J, Suthar M, Teunis L, Thorp J, Ticotsky A, Tita A, Tragus R, Tuttle K, Urdaneta A, Utz P, VanWagoner T, Vasey A, Vernon S, Vidal C, Walker T, Ward H, Warren D, Weeks R, Weiner S, Weyer J, Wheeler J, Whiteheart S, Wiley Z, Williams N, Wisnivesky J, Wood J, Yee L, Young N, Zisis S, Foulkes A. Researching COVID to Enhance Recovery (RECOVER) adult study protocol: Rationale, objectives, and design. PLOS ONE 2023, 18: e0286297. PMID: 37352211, PMCID: PMC10289397, DOI: 10.1371/journal.pone.0286297.Peer-Reviewed Original ResearchConceptsSARS-CoV-2 infectionRisk factorsClinical risk factorsPost-acute sequelaePrimary study outcomeProportional hazards regressionCommunity-based outreachMulti-site observational studyPASC symptomsQuarterly questionnairesRetrospective cohortVaccination statusOrgan dysfunctionAcute phaseLong COVIDHazards regressionEligible participantsTreatment optionsPrior infectionStudy protocolClinical trialsNew symptomsLongitudinal cohortLaboratory examinationsObservational studyNew‐onset type 1 diabetes in children and adolescents as postacute sequelae of SARS‐CoV‐2 infection: A systematic review and meta‐analysis of cohort studies
Rahmati M, Yon D, Lee S, Udeh R, McEVoy M, Kim M, Gyasi R, Oh H, Sánchez G, Jacob L, Li Y, Koyanagi A, Shin J, Smith L. New‐onset type 1 diabetes in children and adolescents as postacute sequelae of SARS‐CoV‐2 infection: A systematic review and meta‐analysis of cohort studies. Journal Of Medical Virology 2023, 95: e28833. PMID: 37264687, DOI: 10.1002/jmv.28833.Peer-Reviewed Original ResearchConceptsPooled effect sizeNew-onset T1DMSequelae of SARS-CoV-2 infectionNew-onset type 1 diabetesSARS-CoV-2 infectionMeta-analysis of cohort studiesSystematic reviewRisk ratioEffect sizeConfidence intervalsPublic health practitionersNational health registriesMeta-analysisType 1 diabetesDiabetic ketoacidosisPostacute sequelae of SARS-CoV-2 infectionPost-acute sequelae of SARS-CoV-2 infectionPost-acute sequelaeAssociated with higher riskHigh riskDerSimonian-Laird methodSARS-CoV-2Non-COVID-19Health registriesHealth practitionersProteomic profiling demonstrates inflammatory and endotheliopathy signatures associated with impaired cardiopulmonary exercise hemodynamic profile in Post Acute Sequelae of SARS‐CoV‐2 infection (PASC) syndrome
Singh I, Leitner B, Wang Y, Zhang H, Joseph P, Lutchmansingh D, Gulati M, Possick J, Damsky W, Hwa J, Heerdt P, Chun H. Proteomic profiling demonstrates inflammatory and endotheliopathy signatures associated with impaired cardiopulmonary exercise hemodynamic profile in Post Acute Sequelae of SARS‐CoV‐2 infection (PASC) syndrome. Pulmonary Circulation 2023, 13: e12220. PMID: 37091121, PMCID: PMC10113513, DOI: 10.1002/pul2.12220.Peer-Reviewed Original ResearchInvasive cardiopulmonary exercise testPASC patientsPost-acute sequelaeAcute sequelaeInfection syndromeUnexplained exertional intoleranceCardiopulmonary exercise testSystemic oxygen deliveryPersistent inflammatory stateVenous blood plasmaExertional intolerancePeak exerciseEndothelial dysfunctionHemodynamic profileInflammatory stateExercise testFibrotic processPathophysiological hallmarkAberrant protein expressionExpression of proteinsOxygen deliveryOxygen extractionProteomic profilingPatientsPhysiologic responsesBiomarker identification in fatal and post-acute sequelae of SARS-CoV-2 (PASC) lungs leads to epigenetic targeting in PASC-related fibrosis
Espindola M, Hohman M, Sá Y, Garcia S, Creyns B, Coelho A, Yao C, Chiang G, Parimon T, Strip B, Chen P, Hogaboam C. Biomarker identification in fatal and post-acute sequelae of SARS-CoV-2 (PASC) lungs leads to epigenetic targeting in PASC-related fibrosis. 2023, 201. DOI: 10.1183/23120541.lsc-2023.201.Peer-Reviewed Original ResearchCharacterizing and Predicting Post-Acute Sequelae of SARS CoV-2 Infection (PASC) in a Large Academic Medical Center in the US
Fritsche L, Jin W, Admon A, Mukherjee B. Characterizing and Predicting Post-Acute Sequelae of SARS CoV-2 Infection (PASC) in a Large Academic Medical Center in the US. Journal Of Clinical Medicine 2023, 12: 1328. PMID: 36835863, PMCID: PMC9967320, DOI: 10.3390/jcm12041328.Peer-Reviewed Original ResearchPost-Acute Sequelae of SARS CoV-2 infectionElectronic health record dataPhenotype risk scoreHealth record dataCase-control study designPhenome-wide scanAcademic medical centerRisk prediction modelPost-COVID-19Risk stratification approachStudy designRecord dataRisk scoreHistory of COVID-19Medical CenterCOVID-19Increased riskPre-COVID-19Post-acute sequelaePre-COVID-19 periodRiskPost-COVID-19 periodCohortStratification approachSARS CoV-2 infectionImprovement of Long COVID symptoms over one year
Oliveira C, Jason L, Unutmaz D, Bateman L, Vernon S. Improvement of Long COVID symptoms over one year. Frontiers In Medicine 2023, 9: 1065620. PMID: 36698810, PMCID: PMC9868805, DOI: 10.3389/fmed.2022.1065620.Peer-Reviewed Original ResearchME/CFS patientsDePaul Symptom QuestionnaireME/CFSPositive COVID-19 testPASC patientsCFS patientsPost-exertional malaiseSignificant symptom improvementCOVID-19 testSymptom improvementDiagnostic criteriaMyalgic encephalomyelitis/chronic fatigue syndromeCOVID-19CFS diagnostic criteriaObservational cohort studyFlu-like symptomsIrritable bowel symptomsPost-acute sequelaeLong COVID symptomsChronic fatigue syndromeClinical diagnostic criteriaSymptoms of fatigueSimilar symptom severityFixed-effects modelBowel symptoms
2022
Molecular states during acute COVID-19 reveal distinct etiologies of long-term sequelae
Thompson R, Simons N, Wilkins L, Cheng E, Del Valle D, Hoffman G, Cervia C, Fennessy B, Mouskas K, Francoeur N, Johnson J, Lepow L, Le Berichel J, Chang C, Beckmann A, Wang Y, Nie K, Zaki N, Tuballes K, Barcessat V, Cedillo M, Yuan D, Huckins L, Roussos P, Marron T, Glicksberg B, Nadkarni G, Heath J, Gonzalez-Kozlova E, Boyman O, Kim-Schulze S, Sebra R, Merad M, Gnjatic S, Schadt E, Charney A, Beckmann N. Molecular states during acute COVID-19 reveal distinct etiologies of long-term sequelae. Nature Medicine 2022, 29: 236-246. PMID: 36482101, PMCID: PMC9873574, DOI: 10.1038/s41591-022-02107-4.Peer-Reviewed Original ResearchConceptsImmunoglobulin-related genesPost-acute sequelaeAdaptive immune cellsTiter-dependent mannerLong-term sequelaeGene expression signaturesSARS-CoV-2 infectionAcute COVID-19Acute host responseImmune cellsAcute infectionSevere acute respiratory syndrome coronavirus 2Acute respiratory syndrome coronavirus 2Respiratory syndrome coronavirus 2External cohortMultiple etiologiesSequelaePost-acute sequelae of severe acute respiratory syndrome coronavirus 2Molecular etiologyTranscriptome-wide investigationSyndrome coronavirus 2Expression signaturesHost responseAntibody productionGene expression patternsPost-acute sequelae of COVID-19 symptom phenotypes and therapeutic strategies: A prospective, observational study
Frontera JA, Thorpe LE, Simon NM, de Havenon A, Yaghi S, Sabadia SB, Yang D, Lewis A, Melmed K, Balcer LJ, Wisniewski T, Galetta SL. Post-acute sequelae of COVID-19 symptom phenotypes and therapeutic strategies: A prospective, observational study. PLOS ONE 2022, 17: e0275274. PMID: 36174032, PMCID: PMC9521913, DOI: 10.1371/journal.pone.0275274.Peer-Reviewed Original ResearchConceptsPost-acute sequelaeDifferent therapeutic interventionsTherapeutic interventionsTherapeutic strategiesAcute SARS-CoV-2 infectionOccupational therapySARS-CoV-2 infectionOutcome metricsSimilar therapeutic interventionsProspective cohort studyShortness of breathAnti-anxiety medicationsLogistic regression analysisCOVID-19Individual treatment programsPASC symptomsCohort studySymptom improvementUnsupervised hierarchical cluster analysisTreatment strategiesObservational studySleep disordersVariable symptomatologySymptom groupsCognitive symptoms
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