2025
Two chromosomal reference genome sequences for the malaria mosquito, Anopheles (Nyssorhynchus) darlingi, Root, 1926 from French Guiana and Peru
Gendrin M, Heu K, Moreno M, Gamboa D, Vinetz J, Tong C, Conn J, Johnson H, Heaton H, Wagah M, Collins J, Krasheninnikova K, Pelan S, Pointon D, Torrance J, Tracey A, Uliano-Silva M, Wood J, von Wyschetzki K, McCarthy S, Lawniczak M, Neafsey D, Makunin A. Two chromosomal reference genome sequences for the malaria mosquito, Anopheles (Nyssorhynchus) darlingi, Root, 1926 from French Guiana and Peru. Wellcome Open Research 2025, 10: 187. DOI: 10.12688/wellcomeopenres.23989.1.Peer-Reviewed Original ResearchGenome sequenceChromosome arm 2RReference genome sequenceX sex chromosomeFrench GuianaChromosomal pseudomoleculesGenome assemblyMitochondrial genomeWild populationsGenomeMalaria mosquitoesNyssorhynchusChromosomeSequenceGuianaAssemblyAnophelesFemale AnophelesPseudomoleculesMegabasesKilobasesDarlingiPeruMosquitoesPublic health significance of the white-tailed deer (Odocoileus virginianus) and its role in the eco-epidemiology of tick- and mosquito-borne diseases in North America
Rochlin I, Kenney J, Little E, Molaei G. Public health significance of the white-tailed deer (Odocoileus virginianus) and its role in the eco-epidemiology of tick- and mosquito-borne diseases in North America. Parasites & Vectors 2025, 18: 43. PMID: 39915849, PMCID: PMC11803971, DOI: 10.1186/s13071-025-06674-6.Peer-Reviewed Original ResearchConceptsWhite-tailed deerOdocoileus virginianusMosquito-borne diseasesEco-epidemiologyNorth AmericaMosquito-borne pathogensPopulation dynamicsPathogensEffective disease managementDeerPathogen transmissionEastern United StatesReproductive potentialPublic health significanceTick-borneVector-borne diseasesOdocoileusBiological adaptationTicksMosquito vectorsBiological characteristicsSoutheastern CanadaTransmission cycleHealth significanceMosquitoesmosGILT antibodies interfere with Plasmodium sporogony in Anopheles gambiae
Dolan B, Correa Gaviria T, Dong Y, Cresswell P, Dimopoulos G, Chuang Y, Fikrig E. mosGILT antibodies interfere with Plasmodium sporogony in Anopheles gambiae. Nature Communications 2025, 16: 592. PMID: 39799117, PMCID: PMC11724845, DOI: 10.1038/s41467-025-55902-1.Peer-Reviewed Original ResearchConceptsCausative agent of malariaTransmission-blocking vaccinesMurine infection modelPlasmodium life cycleAgent of malariaGamma-interferon-inducible lysosomal thiol reductaseP. falciparumInfection modelAnopheles gambiaeMosquito midgutPlasmodiumLysosomal thiol reductaseCausative agentAntibodiesOocyst stageInfection prevalenceThiol reductaseMalariaGambiaInfectionMosquitoesPrevalenceVaccine
2024
Aedes aegypti adiponectin receptor-like protein signaling facilitates Zika virus infection
Chen T, Marín-López A, Raduwan H, Fikrig E. Aedes aegypti adiponectin receptor-like protein signaling facilitates Zika virus infection. MBio 2024, 15: e02433-24. PMID: 39373507, PMCID: PMC11559040, DOI: 10.1128/mbio.02433-24.Peer-Reviewed Original ResearchReceptor-like proteinZika virus infectionVirus infectionDevelopment of effective control strategiesSignificant public health challengeTranscriptome analysisTrypsin genesMetabolic pathwaysProtein signalingPublic health challengeViral infectionTransmission of viral diseasesAedes aegypti</i>InfectionBlood digestionZika virusProteinSignificance of signalsComplex interactionsVirusEffective control strategiesViral diseasesZikaMosquitoesPathwayImproved species assignments across the entire Anopheles genus using targeted sequencing
Boddé M, Makunin A, Teltscher F, Akorli J, Andoh N, Bei A, Chaumeau V, Desamours I, Ekpo U, Govella N, Kayondo J, Kobylinski K, Ngom E, Niang E, Okumu F, Omitola O, Ponlawat A, Rakotomanga M, Rasolonjatovoniaina M, Ayala D, Lawniczak M. Improved species assignments across the entire Anopheles genus using targeted sequencing. Frontiers In Genetics 2024, 15: 1456644. PMID: 39364005, PMCID: PMC11446804, DOI: 10.3389/fgene.2024.1456644.Peer-Reviewed Original ResearchSpecies assignmentSequence dataAmplicon sequencing dataSpecies population structureAccurate species identificationSamples to species levelNuclear lociPopulation structureAmplicon panelSpecies levelSpecies identificationTarget sequenceAnopheles genusGenusSpeciesAmpliconsComparison of samplesSequenceLociMosquitoesIncreased powerMadagascarControl measuresA naturally isolated symbiotic bacterium suppresses flavivirus transmission by Aedes mosquitoes
Zhang L, Wang D, Shi P, Li J, Niu J, Chen J, Wang G, Wu L, Chen L, Yang Z, Li S, Meng J, Ruan F, He Y, Zhao H, Ren Z, Wang Y, Liu Y, Shi X, Wang Y, Liu Q, Li J, Wang P, Wang J, Zhu Y, Cheng G. A naturally isolated symbiotic bacterium suppresses flavivirus transmission by Aedes mosquitoes. Science 2024, 384: eadn9524. PMID: 38669573, DOI: 10.1126/science.adn9524.Peer-Reviewed Original ResearchConceptsColony forming unitsFlavivirus envelope proteinCommensal microbiotaIrreversible conformational changesGlucose dehydrogenaseMosquito gutConformational changesGut lumenPrevent viral infectionGutBacteriumFlavivirus transmissionEnvelope proteinsVector competencePrevent viral entryViral entryRefractory to infectionDengue virusForming unitsField mosquitoesTransmission of dengue virusFlavivirusesMosquitoesSemifield conditionsAdult mosquitoesmosGILT controls innate immunity and germ cell development in Anopheles gambiae
Arora G, Tang X, Cui Y, Yang J, Chuang Y, Joshi J, Sajid A, Dong Y, Cresswell P, Dimopoulos G, Fikrig E. mosGILT controls innate immunity and germ cell development in Anopheles gambiae. BMC Genomics 2024, 25: 42. PMID: 38191283, PMCID: PMC10775533, DOI: 10.1186/s12864-023-09887-0.Peer-Reviewed Original ResearchConceptsGerm cell developmentAnopheles gambiaeCell developmentOvarian developmentReductase-like proteinWild-type mosquitoesPlasmodium life cycleBiological controlGrowth genesEssential regulatorRNA sequencingA. gambiaeGenesGambiaeAltered expressionImpaired ovarian developmentMosquito vectorsLife cycleMosquitoesImmune activationPlasmodium infectionTranscriptomeOogenesisRegulatorProtein
2023
Signaling between mammalian adiponectin and a mosquito adiponectin receptor reduces Plasmodium transmission
Chuang Y, Stone H, Abouneameh S, Tang X, Fikrig E. Signaling between mammalian adiponectin and a mosquito adiponectin receptor reduces Plasmodium transmission. MBio 2023, 15: e02257-23. PMID: 38078744, PMCID: PMC10790699, DOI: 10.1128/mbio.02257-23.Peer-Reviewed Original ResearchBlood mealComplex life cycleMosquito fitnessMammalian hostsMammalian adiponectinPathogen infectivityLipid transportersVertebrate hostsAdiponectin receptorsHematophagous arthropodsFemale mosquitoesPlasmodium transmissionLife cycleMosquitoesImportant lipid transporterPathwayHostInfectious agentsVector-borne infectious agentsArthropodsAdiponectinReceptorsInfectionTransportersMealPhylogenomics reveals the history of host use in mosquitoes
Soghigian J, Sither C, Justi S, Morinaga G, Cassel B, Vitek C, Livdahl T, Xia S, Gloria-Soria A, Powell J, Zavortink T, Hardy C, Burkett-Cadena N, Reeves L, Wilkerson R, Dunn R, Yeates D, Sallum M, Byrd B, Trautwein M, Linton Y, Reiskind M, Wiegmann B. Phylogenomics reveals the history of host use in mosquitoes. Nature Communications 2023, 14: 6252. PMID: 37803007, PMCID: PMC10558525, DOI: 10.1038/s41467-023-41764-y.Peer-Reviewed Original ResearchConceptsVector speciesDisease vector speciesHost-use patternsImportant vector speciesMosquito lineageTaxonomic samplingHost usePhylogenomic analysisOrtholog groupsMajor lineagesHost associationsVertebrate classesGenomic dataMosquito speciesDiverse arrayPhylogenySpeciesLineagesMosquitoesDiversificationPhylogenomicsNumerous timesDrift eventsHuman healthEarly TriassicTrends in mosquito species distribution modeling: insights for vector surveillance and disease control
Lippi C, Mundis S, Sippy R, Flenniken J, Chaudhary A, Hecht G, Carlson C, Ryan S. Trends in mosquito species distribution modeling: insights for vector surveillance and disease control. Parasites & Vectors 2023, 16: 302. PMID: 37641089, PMCID: PMC10463544, DOI: 10.1186/s13071-023-05912-z.Peer-Reviewed Original ResearchConceptsSpecies distribution modelsSpecies distribution modelling methodsSpecies distribution modelling literatureDisease vectorsDistribution modelMosquito-borne disease riskInfectious disease vectorsGlobal changeMosquito speciesSpeciesMethodological focusNorth AmericaOutbreak riskDisease riskGeographyMosquitoesModeling effortsRegional modelSystematic reviewEcologyTransmission-blocking activity of antimalarials for Plasmodium vivax malaria in Anopheles darlingi
Andrade A, Santos N, Bastos A, Pontual J, Araújo J, Silva A, Martinez L, Lima A, Aguiar A, Teles C, Medeiros J, Pereira D, Vinetz J, Gazzinelli R, Araújo M. Transmission-blocking activity of antimalarials for Plasmodium vivax malaria in Anopheles darlingi. PLOS Neglected Tropical Diseases 2023, 17: e0011425. PMID: 37327209, PMCID: PMC10310017, DOI: 10.1371/journal.pntd.0011425.Peer-Reviewed Original ResearchConceptsDensity of gametocytesTransmission-blocking efficacyPlasmodium vivax malariaTransmission-blocking activityImportant infectious diseasesOne-doseVivax malariaP. vivaxMosquito infectionPlasmodium vivaxTreatment groupsPatient's bloodGametocyte productionMalaria transmissionInfectious diseasesGenus PlasmodiumMalariaTreatmentChloroquinePrimaquineVivaxBloodDirect membraneBiological characteristicsMosquitoesMalaria: influence of Anopheles mosquito saliva on Plasmodium infection
Arora G, Chuang Y, Sinnis P, Dimopoulos G, Fikrig E. Malaria: influence of Anopheles mosquito saliva on Plasmodium infection. Trends In Immunology 2023, 44: 256-265. PMID: 36964020, PMCID: PMC10074230, DOI: 10.1016/j.it.2023.02.005.Peer-Reviewed Original ResearchConceptsAnopheles salivaPlasmodium infectionInfected female mosquitoesMosquito salivary proteinsLocal host responseComponents of salivaMosquito salivaTherapeutic strategiesHost responsePlasmodium sporozoitesVector salivaPlasmodium protozoaBlood vesselsSalivaFemale mosquitoesBlood mealAnopheline mosquitoesInfectionMalariaVector-borne diseasesSkinHost-pathogen interactionsSporozoitesSalivary proteinsMosquitoesGenomic and phenotypic analyses suggest moderate fitness differences among Zika virus lineages
Oliveira G, Vogels C, Zolfaghari A, Saraf S, Klitting R, Weger-Lucarelli J, P Leon K, Ontiveros C, Agarwal R, Tsetsarkin K, Harris E, Ebel G, Wohl S, Grubaugh N, Andersen K. Genomic and phenotypic analyses suggest moderate fitness differences among Zika virus lineages. PLOS Neglected Tropical Diseases 2023, 17: e0011055. PMID: 36753510, PMCID: PMC9907835, DOI: 10.1371/journal.pntd.0011055.Peer-Reviewed Original ResearchConceptsHuman primary cellsFitness differencesVirus lineagesRapid molecular evolutionPrimary cellsShort generation timeAmino acid sitesFitness changesHigh mutation ratePhenotypic evolutionMolecular evolutionPositive selectionMutation rateLineagesPhenotypic analysisPhenotypic changesRNA virusesGeneration timeRecombinant virusesAedes aegypti mosquitoesReplicative fitnessFitnessAegypti mosquitoesMosquitoesZika virus
2022
Interactions between seasonal temperature variation and temporal synchrony drive increased arbovirus co-infection incidence
Poterek ML, Vogels CBF, Grubaugh ND, Ebel GD, Perkins T, Cavany SM. Interactions between seasonal temperature variation and temporal synchrony drive increased arbovirus co-infection incidence. Royal Society Open Science 2022, 9: 220829. PMID: 36277835, PMCID: PMC9579765, DOI: 10.1098/rsos.220829.Peer-Reviewed Original ResearchThe Strategy of Paratransgenesis for the Control of Malaria Transmission
Fofana A, Yerbanga R, Bilgo E, Ouedraogo G, Gendrin M, Ouedraogo J. The Strategy of Paratransgenesis for the Control of Malaria Transmission. Frontiers In Tropical Diseases 2022, 3: 867104. DOI: 10.3389/fitd.2022.867104.Peer-Reviewed Original ResearchMalaria parasitesGenetic engineering strategiesParatransgenesis approachWHO African RegionInsect-borne diseasesInsect hostsVector control measuresSpread of resistanceInsect vectorsImportant burdenGlobal deathsMalaria transmissionPlasmodium transmissionMalariaMicrobial strainsParatransgenesisSubtropical countriesEngineering strategiesDiseaseDeathParasitesControl measuresNovel strategyMosquitoesDifferent stepsA volatile from the skin microbiota of flavivirus-infected hosts promotes mosquito attractiveness
Zhang H, Zhu Y, Liu Z, Peng Y, Peng W, Tong L, Wang J, Liu Q, Wang P, Cheng G. A volatile from the skin microbiota of flavivirus-infected hosts promotes mosquito attractiveness. Cell 2022, 185: 2510-2522.e16. PMID: 35777355, DOI: 10.1016/j.cell.2022.05.016.Peer-Reviewed Original ResearchSkin microbiotaMosquito-transmitted flavivirusDengue patientsFlavivirus infectionFlavivirus life cycleDietary administrationHealthy peopleCommensal bacteriaZika virusHost skinMosquito attractivenessArboviral transmissionRELMαAedes mosquitoesMicrobiotaMosquito olfactionInfected hostAntimicrobial proteinsHematophagous arthropodsHost-seeking activityMosquitoesIsotretinoinPatientsInfectionMiceMetabolic interactions between disease-transmitting vectors and their microbiota
Song X, Zhong Z, Gao L, Weiss BL, Wang J. Metabolic interactions between disease-transmitting vectors and their microbiota. Trends In Parasitology 2022, 38: 697-708. PMID: 35643853, DOI: 10.1016/j.pt.2022.05.002.Peer-Reviewed Original ResearchConceptsDisease-transmitting vectorsSymbiotic microbesPathogen defenseHost biologyHematophagous arthropodsBacterial metabolic activitySand fliesArthropod vectorsImportant vectorAnimals/humansMetabolic interactionsEndogenous microbiotaTsetse fliesFliesRecent discoveryVector-borne diseasesBiologyMetabolic activityMosquitoesMicrobiotaDifferent arthropod vectorsArthropodsMicrobesOrganismsTicksSeasonal Dynamics of Mosquito-Borne Viruses in the Southwestern Florida Everglades, 2016, 2017.
Anderson J, Fish D, Armstrong P, Misencik M, Bransfield A, Ferrandino F, Andreadis T, Stenglein M, Kapuscinski M. Seasonal Dynamics of Mosquito-Borne Viruses in the Southwestern Florida Everglades, 2016, 2017. American Journal Of Tropical Medicine And Hygiene 2022, 106: 610-622. PMID: 35008051, PMCID: PMC8832897, DOI: 10.4269/ajtmh.20-1547.Peer-Reviewed Original ResearchConceptsSpecies of virusesSpecies of mosquitoesGumbo LimboShotgun metagenomic sequencingShark RiverSpecies complexWest Nile virusHardwood hammocksEverglades virusNotable speciesMosquito-Borne VirusesMetagenomic sequencingAnopheles speciesNile virusSeasonal dynamicsSpeciesFlorida EvergladesTensaw virusCulex nigripalpusEvergladesPools of CxCypress swampsNigripalpusMosquitoesAnopheles crucians
2021
Culex Mosquitoes at Stormwater Control Measures and Combined Sewer Overflow Outfalls after Heavy Rainfall
Chan A, Kim H, Bell M. Culex Mosquitoes at Stormwater Control Measures and Combined Sewer Overflow Outfalls after Heavy Rainfall. Water 2021, 14: 31. DOI: 10.3390/w14010031.Peer-Reviewed Original ResearchA human-blood-derived microRNA facilitates flavivirus infection in fed mosquitoes
Zhu Y, Zhang C, Zhang L, Yang Y, Yu X, Wang J, Liu Q, Wang P, Cheng G. A human-blood-derived microRNA facilitates flavivirus infection in fed mosquitoes. Cell Reports 2021, 37: 110091. PMID: 34910910, DOI: 10.1016/j.celrep.2021.110091.Peer-Reviewed Original Research
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