2025
Public Water Arsenic and Birth Outcomes in the Environmental Influences on Child Health Outcomes Cohort
Nigra A, Bloomquist T, Rajeev T, Burjak M, Casey J, Goin D, Herbstman J, Ornelas Van Horne Y, Wylie B, Cerna-Turoff I, Braun J, McArthur K, Karagas M, Ames J, Sherris A, Bulka C, Padula A, Howe C, Fry R, Eaves L, Breton C, Cassidy-Bushrow A, Lewis J, MacKenzie D, Beene D, Farzan S, Sathyanarayana S, Hipwell A, Morello-Frosch R, Snyder B, Hartert T, Elliott A, O’Connor T, Kress A, Smith P, Newby L, Adair L, Jacobson L, Catellier D, McGrath M, Douglas C, Duggal P, Knapp E, Kress A, Blackwell C, Mansolf M, Lai J, Ho E, Cella D, Gershon R, Macy M, Das S, Freedman J, Mallal S, McLean J, Shah R, Shilts M, Alshawabkeh A, Cordero J, Meeker J, Trasande L, Camargo C, Hasegawa K, Zhu Z, Sullivan A, Dabelea D, Perng W, Bekelman T, Wilkening G, Magzamen S, Moore B, Starling A, Rinehart D, Koinis Mitchell D, D'Sa V, Deoni S, Mueller H, Duarte C, Monk C, Canino G, Posner J, Murray T, Lugo-Candelas C, Dunlop A, Brennan P, Hockett C, Elliott A, Ferrara A, Croen L, Hedderson M, Ainsworth J, Bacharier L, Bendixsen C, Gern J, Gold D, Hartert T, Jackson D, Johnson C, Joseph C, Kattan M, Khurana Hershey G, Lemanske, Jr. R, Lynch S, Miller R, O’Connor G, Ober C, Ownby D, Rivera-Spoljaric K, Ryan P, Seroogy C, Singh A, Wood R, Zoratti E, Habre R, Farzan S, Gilliland F, Hertz-Picciotto I, Bennett D, Schweitzer J, Schmidt R, LaSalle J, Hipwell A, Karr C, Bush N, LeWinn K, Sathyanarayana S, Zhao Q, Tylavsky F, Carroll K, Loftus C, Leve L, Ganiban J, Neiderhiser J, Weiss S, Litonjua A, McEvoy C, Spindel E, Tepper R, Newschaffer C, Lyall K, Volk H, Landa R, Ozonoff S, Piven J, Hazlett H, Pandey J, Schultz R, Dager S, Botteron K, Messinger D, Stone W, Ames J, O'Connor T, Miller R, Oken E, Hacker M, James-Todd T, O'Shea T, Fry R, Frazier J, Singh R, Rollins C, Montgomery A, Vaidya R, Joseph R, Washburn L, Gogcu S, Bear K, Rollins J, Hooper S, Taylor G, Jackson W, Thompson A, Daniels J, Hernandez M, Lu K, Msall M, Lenski M, Obeid R, Pastyrnak S, Jensen E, Sakai C, Santos H, Kerver J, Paneth N, Barone C, Elliott M, Ruden D, Fussman C, Herbstman J, Margolis A, Schantz S, Geiger S, Aguiar A, Tabb K, Strakovsky R, Woodruff T, Morello-Frosch R, Padula A, Stanford J, Porucznik C, Giardino A, Wright R, Wright R, Collett B, Baumann-Blackmore N, Gangnon R, McKennan C, Wilson J, Altman M, Aschner J, Stroustrup A, Merhar S, Moore P, Pryhuber G, Hudak M, Reynolds Lyndaker A, Lampland A, Rochelson B, Jan S, Blitz M, Katzow M, Brown Z, Chiuzan C, Rafael T, Lewis D, Meirowitz N, Poindexter B, Gebretsadik T, Osmundson S, Straughen J, Eapen A, Cassidy-Bushrow A, Wegienka G, Sitarik A, Woodcroft K, Urquhart A, Levin A, Johnson-Hooper T, Davidson B, Ma T, Barrett E, Blaser M, Dominguez-Bello M, Horton D, Jimenez M, Rosen T, Palomares K, Avalos L, Zhu Y, Hunt K, Newman R, Bloom M, Alkis M, Roberts J, Mumford S, Burris H, DeMauro S, Yee L, Hamvas A, Olidipo A, Haddad A, Eiland L, Spillane N, Suri K, Fisher S, Goldstein J, Mithal L, DeRegnier R, Maitre N, Nguyen R, JaKa M, Sidebottom A, Paidas M, Potter J, Ruby N, Duthely L, Jayakumar A, Young K, Maldonado I, Miller M, Slaughter J, Keim S, Lynch C, Venkatesh K, Whitworth K, Symanski E, Northrup T, Mendez-Figueroa H, Mosquera R, Karagas M, Madan J, MacKenzie D, Lewis J, Rennie B, Leventhal B, Kim Y, Bishop S, Nozadi S, Luo L, Lester B, Marsit C, Everson T, Loncar C, McGowan E, Sheinkopf S, Carter B, Check J, Helderman J, Neal C, Smith L. Public Water Arsenic and Birth Outcomes in the Environmental Influences on Child Health Outcomes Cohort. JAMA Network Open 2025, 8: e2514084. PMID: 40522663, PMCID: PMC12171937, DOI: 10.1001/jamanetworkopen.2025.14084.Peer-Reviewed Original ResearchConceptsBirth weight-for-gestational age z-scoreLow birth weightAge z-scoreAdjusted risk ratiosAdverse birth outcomesBirth outcomesBirth weightMaximum contaminant levelWater arsenicWater arsenic exposureRisk ratioGestational agePreterm birthZ-scoreContamination levelsCohort studyAssociated with adverse birth outcomesHigher risk of low birth weightArsenic exposureParent-infant dyadsRisk of low birth weightUS Environmental Protection Agency maximum contaminant levelChild health outcomesAssociated with birth outcomesEnvironmental Protection Agency maximum contaminant level
2024
Mediating Role of Liver Dysfunction in the Association between Arsenic Exposure and Diabetes in Chinese Adults: A Nationwide Cross-Sectional Study of China National Human Biomonitoring (CNHBM) 2017–2018
Ji S, Qu Y, Sun Q, Zhao F, Qiu Y, Li Z, Li Y, Song H, Zhang M, Zhang W, Fu H, Cai J, Zhang Z, Zhu Y, Cao Z, Lv Y, Shi X. Mediating Role of Liver Dysfunction in the Association between Arsenic Exposure and Diabetes in Chinese Adults: A Nationwide Cross-Sectional Study of China National Human Biomonitoring (CNHBM) 2017–2018. Environmental Science And Technology 2024, 58: 2693-2703. PMID: 38285630, DOI: 10.1021/acs.est.3c08718.Peer-Reviewed Original ResearchConceptsSerum alanine aminotransferaseLiver dysfunctionAlanine aminotransferaseNationwide cross-sectional studyRestricted cubic spline modelsGeneralized linear mixed modelsEffects of liver dysfunctionMediation analysisCross-sectional studyArsenic exposureAspartate aminotransferaseCubic spline modelsHuman biomonitoringAssociated with TADiabetes prevalenceChinese adultsLow-to-moderateLinear mixed modelsUrinary totalLowest quartileAlcohol consumptionLiver diseaseOverall populationDiabetes
2020
The role of Hipk2-p53 pathways in arsenic-induced autistic behaviors: A translational study from rats to humans
Zhou H, Lin Y, Zhao W, Teng Y, Cui Y, Wang T, Li C, Jiang YH, Zhang JJ, Wang Y. The role of Hipk2-p53 pathways in arsenic-induced autistic behaviors: A translational study from rats to humans. Environmental Pollution 2020, 267: 115568. PMID: 33254717, DOI: 10.1016/j.envpol.2020.115568.Peer-Reviewed Original ResearchConceptsCase-control studySerum levelsArsenic exposureHealthy controlsNeuronal apoptosisFrontal cortexAge-matched healthy controlsGestational arsenic exposureHuman case-control studiesASD developmentHigher serum levelsAutistic behaviorASD childrenDose-dependent mannerAutism spectrum disorderPotential mediating pathwaysRat modelRat pupsKey molecular changesImmunohistochemistry analysisTranslational studiesWestern blottingMolecular changesTranslational strategiesMediating pathways
2013
Blood pressure hyperreactivity
Kunrath J, Gurzau E, Gurzau A, Goessler W, Gelmann ER, Thach TT, McCarty KM, Yeckel CW. Blood pressure hyperreactivity. Journal Of Hypertension 2013, 31: 361-369. PMID: 23203141, PMCID: PMC3542419, DOI: 10.1097/hjh.0b013e32835c175f.Peer-Reviewed Original ResearchConceptsBlood pressure hyperreactivityBlood pressure recoveryHypertensive responseUnexposed groupMiddle-aged menCold pressor testInorganic arsenic exposureInorganic arsenicCardiovascular stress reactivityNormotensive menBlood pressureEssential hypertensionHypertension riskPressor testHyperreactivityChronic exposureArsenic exposureArsenic-endemic regionEarly signsStress-induced changesFunctional evaluationUrine samplesDrinking waterStress reactivityGreater probabilityArsenic Exposure and Calpain-10 Polymorphisms Impair the Function of Pancreatic Beta-Cells in Humans: A Pilot Study of Risk Factors for T2DM
Díaz-Villaseñor A, Cruz L, Cebrián A, Hernández-Ramírez RU, Hiriart M, García-Vargas G, Bassol S, Sordo M, Gandolfi AJ, Klimecki WT, López-Carillo L, Cebrián ME, Ostrosky-Wegman P. Arsenic Exposure and Calpain-10 Polymorphisms Impair the Function of Pancreatic Beta-Cells in Humans: A Pilot Study of Risk Factors for T2DM. PLOS ONE 2013, 8: e51642. PMID: 23349674, PMCID: PMC3551951, DOI: 10.1371/journal.pone.0051642.Peer-Reviewed Original ResearchConceptsBeta-cell functionLower beta-cell functionSNP-43Risk factorsInsulin sensitivitySNP-44IAs exposureSingle nucleotide polymorphismsChronic exposureCAPN-10Type 2 diabetes mellitusOutcomes of T2DMCalpain-10 polymorphismsGenetic risk factorsPancreatic beta cellsAction of insulinCalpain-10 geneDiabetes mellitusInverse associationInsulin secretionT2DMBeta cellsRisk genotypesArsenic exposurePilot study
2010
Activation of Hedgehog Signaling by the Environmental Toxicant Arsenic May Contribute to the Etiology of Arsenic-Induced Tumors
Fei D, Li H, Kozul C, Black K, Singh S, Gosse J, DiRenzo J, Martin K, Wang B, Hamilton J, Karagas M, Robbins D. Activation of Hedgehog Signaling by the Environmental Toxicant Arsenic May Contribute to the Etiology of Arsenic-Induced Tumors. Cancer Research 2010, 70: 1981-1988. PMID: 20179202, PMCID: PMC2831120, DOI: 10.1158/0008-5472.can-09-2898.Peer-Reviewed Original ResearchConceptsArsenic exposureBladder cancerEnvironmental toxicant arsenicBladder cancer patientsSignificant health problemVariety of tumorsHedgehog signalingCancer patientsHealth problemsHigh levelsTumor samplesCancerHedgehog activitySame cancerHuman carcinogenesisMillions of peopleEtiologyTumorsExposureProgressionHedgehogTissue culture cellsActivationSignalingPatients
2006
Seafood arsenic: Implications for human risk assessment
Borak J, Hosgood HD. Seafood arsenic: Implications for human risk assessment. Regulatory Toxicology And Pharmacology 2006, 47: 204-212. PMID: 17092619, DOI: 10.1016/j.yrtph.2006.09.005.Peer-Reviewed Original ResearchConceptsComplex organic compoundsCarcinogenic mechanismsChronic arsenic exposureMargin of exposureOrganic compoundsDose-response curveArsenic speciesDietary seafoodHuman risk assessmentCarcinogenic dosesRodent studiesWorkplace exposuresArsenic exposureUS dietAdverse effectsInorganic formsFormation of metabolitesConservative dose estimatesCompoundsDose estimatesArsenical compoundsArsenicExposureSmall proportionRecent studies
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