2021
Smoking‐aggravated oral candidiasis: Nrf2 pathway dampens NLRP3 inflammasome
Osman M, Papon N. Smoking‐aggravated oral candidiasis: Nrf2 pathway dampens NLRP3 inflammasome. Journal Of Cellular And Molecular Medicine 2021, 25: 9473-9475. PMID: 34486221, PMCID: PMC8500950, DOI: 10.1111/jcmm.16901.Peer-Reviewed Original ResearchConceptsNrf2 pathwayOral Candida infectionCandida albicans infectionCigarette smoke compoundsImmune dysfunctionImmunosuppressive effectsNLRP3 inflammasomeOral diseasesOral mucosaCandida infectionsAlbicans infectionSmokingInfectionRelevant targetsSmoke compoundsMolecular medicineNLRP3DysfunctionMucosaInflammasomePathwayNrf2Disease
2015
Synaptic lipids in cortical function and psychiatric disorders
Stutz B, Horvath TL. Synaptic lipids in cortical function and psychiatric disorders. EMBO Molecular Medicine 2015, 8: 3-5. PMID: 26671988, PMCID: PMC4718156, DOI: 10.15252/emmm.201505749.Peer-Reviewed Original ResearchConceptsPsychiatric disordersClinical therapeutic strategiesPathophysiologic mechanismsCortical circuitryCortical functionExcitatory neuronsTherapeutic strategiesAnimal modelsReliable biomarkersPsychiatric diseasesPsychiatric consequencesEMBO Molecular MedicinePsychiatric conditionsMillions of peopleHuman subjectsCircuit functionDisordersLipidsMolecular medicinePatientsPathophysiologyEtiologyDiseaseMiceNeurons
2013
Deep Brain Stimulation, Brain Maps and Personalized Medicine: Lessons from the Human Genome Project
Fins J, Shapiro Z. Deep Brain Stimulation, Brain Maps and Personalized Medicine: Lessons from the Human Genome Project. Brain Topography 2013, 27: 55-62. PMID: 23749308, DOI: 10.1007/s10548-013-0297-7.Peer-Reviewed Original Research
2010
Cellular Endocytosis and Gene Delivery
Ziello J, Huang Y, Jovin I. Cellular Endocytosis and Gene Delivery. Molecular Medicine 2010, 16: 222-229. PMID: 20454523, PMCID: PMC2864810, DOI: 10.2119/molmed.2009.00101.Peer-Reviewed Original ResearchConceptsGene therapyNonviral vectorsClathrin-independent endocytic processVariety of vectorsUnderstanding of endocytosisClathrin-dependent endocytosisCurrent molecular medicineMechanism of endocytosisGene deliveryLipid raftsEndocytic processVector deliveryCellular traffickingCellular endocytosisEndocytosisMolecular medicineTraffickingTarget cellsCellsMetabolic diseasesTherapeutic potentialCaveolaeGenesDeliveryAdeno
2005
Molecular mechanisms in the inherited red cell membrane disorders
Liem R, Gallagher P. Molecular mechanisms in the inherited red cell membrane disorders. Drug Discovery Today Disease Mechanisms 2005, 2: 539-545. DOI: 10.1016/j.ddmec.2005.11.004.Peer-Reviewed Original ResearchRed cell membrane disordersSingle molecular defectEpigenetic controlMRNA processingProtein functionGene expressionMolecular mechanismsMolecular defectsErythrocyte membrane structureRed cell membrane abnormalitiesMembrane structureMolecular medicineMutationsMembrane disordersDiverse groupCurrent knowledgeGenesRegion mutationsMolecular heterogeneityPromoter mutationsCell membrane abnormalitiesErythrocyte membranesInherited disorderMembrane abnormalitiesProteinChapter 19 Transcriptional Channelopathies of the Nervous System New Targets for Molecular Medicine
Waxman S. Chapter 19 Transcriptional Channelopathies of the Nervous System New Targets for Molecular Medicine. 2005, 319-338. DOI: 10.1016/b978-012738903-5/50020-5.Peer-Reviewed Original ResearchTranscriptional channelopathiesIon channel genesChannel genesUnique amino acid sequenceAmino acid sequenceVoltage-gated sodium channelsGene productsAcid sequenceNew therapeutic opportunitiesProtein structureGenesTranscriptionNeuronal functionMolecular targetsMolecular medicineChannel transcriptionNew targetsNew therapeutic strategiesTherapeutic opportunitiesSodium channelsSpecific targetingComplete understandingChannelopathiesTherapeutic strategiesNervous system
2004
Breast cancer biomarkers and molecular medicine: part II
Ross JS, Linette GP, Stec J, Clark E, Ayers M, Leschly N, Symmans WF, Hortobagyi GN, Pusztai L. Breast cancer biomarkers and molecular medicine: part II. Expert Review Of Molecular Diagnostics 2004, 4: 169-188. PMID: 14995904, DOI: 10.1586/14737159.4.2.169.Peer-Reviewed Original ResearchMeSH KeywordsBiomarkers, TumorBreast NeoplasmsCell Adhesion MoleculesDNADrug Resistance, MultipleEndopeptidasesFemaleGene Expression ProfilingGenes, Tumor SuppressorHumansOncogenesPharmacogeneticsPrognosisProto-Oncogene Proteins c-bcl-2Receptors, EstrogenReceptors, ProgesteroneTelomeraseTranscription FactorsConceptsInvasion-associated proteinsMolecular medicineTumor suppressor geneTranscriptional profilingTranscription factorsDNA repairCell adhesion moleculeDrug resistance proteinsGenomic microarraysApoptosis regulatorSuppressor geneHormone receptor proteinsReceptor proteinBreast cancer biomarkersResistance proteinCancer biomarkersProteinBreast cancer prognostic factorsAdhesion moleculesCancer prognostic factorsPrognostic factorsTherapy responseGenesMethylationTelomerase
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