2025
Mood and Anxiety Disorders and Suicidality in Patients With Newly Diagnosed Focal Epilepsy
Kanner A, Saporta A, Kim D, Barry J, Altalib H, Omotola H, Jette N, O'Brien T, Nadkarni S, Winawer M, Sperling M, French J, Abou-Khalil B, Alldredge B, Bebin M, Cascino G, Cole A, Cook M, Detyniecki K, Devinsky O, Dlugos D, Faught E, Ficker D, Fields M, Gidal B, Gelfand M, Glynn S, Halford J, Haut S, Hegde M, Holmes M, Kalviainen R, Kang J, Klein P, Knowlton R, Krishnamurthy K, Kuzniecky R, Kwan P, Lowenstein D, Marcuse L, Meador K, Mintzer S, Pardoe H, Park K, Penovich P, Singh R, Somerville E, Szabo C, Szaflarski J, Thio L, Trinka E, Burneo J. Mood and Anxiety Disorders and Suicidality in Patients With Newly Diagnosed Focal Epilepsy. Neurology 2025, 105: e213520. PMID: 40982776, DOI: 10.1212/wnl.0000000000213520.Peer-Reviewed Original ResearchSubcortical Structures and Epilepsy.
Herlopian A. Subcortical Structures and Epilepsy. Stereotactic And Functional Neurosurgery 2025, 1-32. PMID: 40911506, DOI: 10.1159/000548279.Peer-Reviewed Original ResearchSubcortical structuresCortical-subcortical networksSubcortical circuitsLimbic systemNeuromodulation studiesCortical structuresNetwork disorderEpilepsyRisk of surgical failureFocal epilepsySeizure initiationEpilepsy researchNetwork dynamicsCritical nodesThalamusSeizuresFocus modelDisordersSurgical failureNeuromodulationDiagnostic evaluationEpileptic networkTherapeutic strategiesParadigmPatient outcomesMagnetic resonance (MR) and computed tomography (CT) imaging of temporal lobe encephalocele–associated epilepsy: a pictorial review
De Jesus G, Nitz D, Damisah E, Mahajan A, Herlopian A, Vadivelu K, Bronen R. Magnetic resonance (MR) and computed tomography (CT) imaging of temporal lobe encephalocele–associated epilepsy: a pictorial review. Clinical Radiology 2025, 87: 106980. PMID: 40602241, DOI: 10.1016/j.crad.2025.106980.Peer-Reviewed Original ResearchTemporal lobe encephalocelePictorial reviewCerebrospinal fluidIdiopathic intracranial hypertensionEpilepsy patientsHerniation of brain tissueElevated intracranial pressureSurgically treatable conditionsMiddle cranial fossaIntracranial hypertensionCranial fossaUnusual locationIntracranial pressureTreatable conditionAssociated with conditionsCT imagesImaging appearanceEpilepsyPatientsBrain tissueDiagnosisImage featuresAutomated detection of interictal epileptiform discharges with few electroencephalographic channels
Alkofer M, Yang C, Ganglberger W, Beal J, Hegde M, Kang J, Yoo J, Gelfand M, Thio L, Kutluay E, Campbell Z, Schmitt S, Gleichgerrcht E, Waterhouse E, Lopez M, Eisenschenk S, Galanti M, Singh R, Wills K, Meulenbrugge E, Dlugos D, Dean B, Halford J, Goldenholz D, Jing J, Thomas R, Westover M. Automated detection of interictal epileptiform discharges with few electroencephalographic channels. Epilepsia 2025, 66: e114-e120. PMID: 40317534, PMCID: PMC12291011, DOI: 10.1111/epi.18431.Peer-Reviewed Original ResearchArea under the receiver operating characteristic curveInterictal epileptiform dischargesMedian AUCEpileptiform dischargesFocal interictal epileptiform dischargesReceiver operating characteristic curveArea under the receiver operating characteristic curve valuesEpilepsy diagnosisDetection of interictal epileptiform dischargesClinically available productsDetecting interictal epileptiform dischargesClinically relevant metricsPatient populationPatientsCharacteristic curveDeep neural networksDiagnosisEpilepsyClinicNeural networkIED detectionElectroencephalographic channelsEEG setupElectroencephalographic samplesAutomated detectionOn‐scalp magnetoencephalography based on optically pumped magnetometers to investigate temporal lobe epilepsy
Feys O, Wens V, Depondt C, Rikir E, Gaspard N, Van Paesschen W, Aeby A, Bodart O, Carrette E, Holmes N, Brookes M, Ferez M, Corvilain P, De Tiège X. On‐scalp magnetoencephalography based on optically pumped magnetometers to investigate temporal lobe epilepsy. Epilepsia 2025, 66: e142-e151. PMID: 40317508, DOI: 10.1111/epi.18439.Peer-Reviewed Original ResearchInterictal epileptiform dischargesOptically pumped magnetometersTemporal lobe epilepsyOn-scalp magnetoencephalographyLobe epilepsyRefractory temporal lobe epilepsySignal-to-noise ratioInvestigate temporal lobe epilepsySurgical resection cavityExtratemporal lobe epilepsyOn-scalpResection cavityEpileptiform dischargesPatientsEpilepsyTemporal lobeMEG recordingsMagnetoencephalographyMagnetometerAmplitude
2024
The development of Stereo-Electroencephalography (SEEG) in Southeast Asia and Oceania: Challenges to equity across the region.
Fong M, Lim K, Fong S, Chen C, Kwan S, Lee C, Suwanpakdee P, Nagangchang C, Le M, Khine Y, Gill D, Wong C. The development of Stereo-Electroencephalography (SEEG) in Southeast Asia and Oceania: Challenges to equity across the region. Neurophysiologie Clinique 2024, 55: 103033. PMID: 39644808, DOI: 10.1016/j.neucli.2024.103033.Peer-Reviewed Original ResearchEpilepsy surgery education and practice around the globe: An ILAE taskforce report
Enslin J, Muh C, Wang X, de Olivera T, McKhann G, Damisah E, Al‐Otaibi F, Rydenhag B, Ali R, Dorfer C, Englot D, Cukiert A, Epilepsy E. Epilepsy surgery education and practice around the globe: An ILAE taskforce report. Epilepsia 2024, 66: 319-327. PMID: 39636690, PMCID: PMC11827745, DOI: 10.1111/epi.18199.Peer-Reviewed Original ResearchEpilepsy surgery unitInternational League Against EpilepsySurgery unitEpilepsy surgerySurgery educationDrug-resistant epilepsyHealth care providersExperience of neurosurgeonsMiddle-income countriesCare providersSurgeryLack of adequate numbersEpilepsyTaskforce reportEnhanced trainingPatientsTask ForceTrained neurosurgeonsNeurosurgeonsMapping Cognition in Epilepsy: From the Lab to the Clinic.
Bearden D, Stasenko A, Prentice F, Benjamin C, Hamberger M, Reppert L, Jones J, Sepeta L. Mapping Cognition in Epilepsy: From the Lab to the Clinic. Epilepsy Currents 2024, 15357597241280485. PMID: 39582595, PMCID: PMC11580000, DOI: 10.1177/15357597241280485.Peer-Reviewed Original ResearchAutomatic responsiveness testing in epilepsy with wearable technology: The ARTiE Watch
Wheeler L, Kremen V, Mersereau C, Ornelas G, Yadav T, Cormier D, Derry A, Lopez A, McQuown K, Sladky V, Benjamin C, Giacino J, Worrell G, Blumenfeld H, Team S. Automatic responsiveness testing in epilepsy with wearable technology: The ARTiE Watch. Epilepsia 2024, 66: 104-116. PMID: 39559901, PMCID: PMC11817799, DOI: 10.1111/epi.18181.Peer-Reviewed Original ResearchCloud infrastructureElectrographic seizuresSmartphone softwareMobile platformWearable technologySmartwatchTest sequencesMonitor unit settingsVideo-electroencephalographic monitoringLong-term video-electroencephalographic monitoringEpilepsy monitoring unitMayo ClinicDiagnostic evaluationDecreased responseUnit settingSeizuresBehavioral responsesPlatformAssessment of behavioral responsesMonitor unitsEpilepsyResponse phenotypesWatchResponse testEvaluation of behavioral responsesThe network is more important than the node: stereo-EEG evidence of neurocognitive networks in epilepsy
Murray N, Kneebone A, Graham P, Wong C, Savage G, Gillinder L, Fong M. The network is more important than the node: stereo-EEG evidence of neurocognitive networks in epilepsy. Frontiers In Network Physiology 2024, 4: 1424004. PMID: 39114571, PMCID: PMC11303167, DOI: 10.3389/fnetp.2024.1424004.Peer-Reviewed Original ResearchNeuropsychological dataNeuropsychological assessmentCognitive impairmentCognitive profile of patientsProfile of impairmentManifestations of cognitive impairmentNetwork activityNeurocognitive networksCognitive profileLesion studiesCognitive featuresSeizure onsetFocal interpretationFocal epilepsyImpairmentCognitionPresurgical work-upProfile of patientsGrowing bodyNormative standardsSite of seizure onsetEpilepsyRefractory focal epilepsySeizure onset zoneDirection of propagationCase Report: Focal, generalized, or both: does generalized network involvement preclude successful epilepsy surgery?
Cui C, Wong W, Wong C, Gill D, Fong M. Case Report: Focal, generalized, or both: does generalized network involvement preclude successful epilepsy surgery? Frontiers In Network Physiology 2024, 4: 1425329. PMID: 39055857, PMCID: PMC11269090, DOI: 10.3389/fnetp.2024.1425329.Peer-Reviewed Original ResearchSlow spike-and-wave patternGeneralized paroxysmal fast activitySpike-and-wave patternEpilepsy surgeryLong-term seizure freedomParoxysmal fast activityFocal cortical resectionComplex motor seizuresCurative epilepsy surgeryCortical resectionEEG assessmentEpileptic encephalopathySeizure freedomFocal seizuresMotor seizuresFast activityGeneralized epilepsyFocal epilepsySurgeryEpilepsyPatientsScalp electroencephalographySeizuresElectroencephalographyMaleDo psychotropic drugs cause seizures?
Gopaul M, Altalib H. Do psychotropic drugs cause seizures? Epilepsy & Behavior Reports 2024, 27: 100679. PMID: 38881884, PMCID: PMC11179069, DOI: 10.1016/j.ebr.2024.100679.Peer-Reviewed Original ResearchAttention-deficit/hyperactivity disorderPsychiatric comorbiditiesPsychotropic medicationsTricyclic antidepressantsCNS stimulantsSerotonin reuptake inhibitorsConcurrent psychiatric disordersSeizure riskReuptake inhibitorsAttention-deficit/hyperactivityPsychiatric disordersPsychiatric symptomsIncreased seizure riskPsychotropic drugsBidirectional associationsAnticonvulsant effectsAntidepressantsIatrogenic seizuresAntipsychoticsTreatment outcomesDisordersHigh dosesClinical decision-makingSeizure onsetEpilepsyMultifocal Epilepsy and Non-dominant Cingulate Lesion
Herlopian A, Gray T, Quraishi I. Multifocal Epilepsy and Non-dominant Cingulate Lesion. 2024, 393-429. DOI: 10.1007/978-3-031-23828-4_18.ChaptersMultifocal epilepsyEEG findings of patientsFindings of patientsAnti-seizure medicationsPrognostic roleSurgical outcomesEEG findingsEEG changesCingulate epilepsyHabitual seizuresIctal tachycardiaAnterior cingulate gyrusEpilepsy monitoring unitVascular lesionsIctal speechPredictive valueOutcome determinantsPatientsMonitor unitsCingulate cortexEpilepsyCingulate gyrusCingulateCortexEEGBilateral Lesional Epilepsy
Herlopian A. Bilateral Lesional Epilepsy. 2024, 819-847. DOI: 10.1007/978-3-031-23828-4_33.Peer-Reviewed Original ResearchNon-dominant, Non-lesional Insular epilepsy
Herlopian A. Non-dominant, Non-lesional Insular epilepsy. 2024, 287-326. DOI: 10.1007/978-3-031-23828-4_13.Peer-Reviewed Original ResearchDominant, Lesional Post-Traumatic Temporal Lobe Epilepsy
Herlopian A. Dominant, Lesional Post-Traumatic Temporal Lobe Epilepsy. 2024, 135-160. DOI: 10.1007/978-3-031-23828-4_7.Peer-Reviewed Original ResearchTraumatic brain injuryImprove medication complianceIntracranial monitoringPatient populationExtent of cerebral injuryAnalysis of patientsNeuroimaging modalitiesPost-traumatic epilepsyMedication adherenceMedication compliancePredictors of outcomeBrain injuryStages of epileptogenesisSurgical outcomesIctal onsetResection surgerySurgical interventionTonic seizuresCerebral injuryHistopathological analysisPatientsVisual phenomenaEpilepsyOutcomesInjuryNon-dominant, Lesional Posterior Quadrant Epilepsy
Herlopian A. Non-dominant, Lesional Posterior Quadrant Epilepsy. 2024, 633-652. DOI: 10.1007/978-3-031-23828-4_25.Peer-Reviewed Original ResearchArterio-venous malformationsIntracranial monitoringImpact of topiramatePosterior quadrantic epilepsyTreat pharmacoresistant epilepsySurgical outcomesTransient encephalopathyElectrographic seizuresSurgical interventionOutcome predictorsClinical significancePharmacoresistant epilepsyEpileptogenesis mechanismsEpilepsy patientsPatientsWada testAuditory hallucinationsLanguage reorganizationMalformationsEpilepsyCognitive functionOutcomesAuditory illusionTopiramateDominant, Mesial Temporal Lobe Epilepsy Due to Hippocampal Sclerosis
Herlopian A. Dominant, Mesial Temporal Lobe Epilepsy Due to Hippocampal Sclerosis. 2024, 735-745. DOI: 10.1007/978-3-031-23828-4_29.Peer-Reviewed Original ResearchHippocampal sclerosisOlfactory hallucinationsNeuropsychological outcomesTemporal lobe epilepsyMesial temporal lobe epilepsyDeep brain stimulationHippocampalVisual field defectsBrain stimulationLobe epilepsyThermoablative therapyField defectsSeizure outcomePost-ablationFebrile seizuresPharmacoresistant epilepsyPotential complicationsTherapyPatientsPalilaliaSclerosisHallucinationsHippocampusEpilepsySniffingNon-dominant, Non-lesional Mesial Temporal Lobe Epilepsy
Herlopian A, Mattson R. Non-dominant, Non-lesional Mesial Temporal Lobe Epilepsy. 2024, 63-86. DOI: 10.1007/978-3-031-23828-4_4.Peer-Reviewed Original ResearchTemporal lobe epilepsyLobe epilepsySurgical outcomesMRI-negative temporal lobe epilepsyInterictal PET scanPharmacoresistant temporal lobe epilepsyPost-operative resultsFavorable post-operative resultsTemporal lobe seizuresSlow wave activityMRI-negativePET scansHypermotor symptomsPharmacoresistant epilepsyRespiratory manifestationsNon-lesionalFronto-parietal cortexPatientsEpilepsyImpaired awarenessNon-dominant, Lesional Temporal Lobe Epilepsy
Herlopian A. Non-dominant, Lesional Temporal Lobe Epilepsy. 2024, 361-374. DOI: 10.1007/978-3-031-23828-4_16.Peer-Reviewed Original Research
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