2025
Mikrobiom, Ernährung und Rheuma
Heidt C, Kriegel M. Mikrobiom, Ernährung und Rheuma. Rheuma Plus 2025, 1-10. DOI: 10.1007/s12688-025-00861-0.Peer-Reviewed Original ResearchShort-chain fatty acidsSystemic lupus erythematosusIntestinal microbiotaImmune responseRheumatic diseasesGut barrierProduction of short-chain fatty acidsRheumatoid arthritisRegulatory T cellsProinflammatory immune responseProgressive tissue damagePersistent inflammatory processPotential therapeutic approachT cellsAnti-inflammatory propertiesCommensal bacteriaImmunological dysregulationLupus erythematosusGenetic predispositionNutritional interventionImmunomodulatory effectsTherapeutic conceptsFiber-rich dietTherapeutic approachesInflammatory processRegulation of inflammatory processes by caspases
Beltrán-Visiedo M, Soler-Agesta R, Sarosiek K, Green D, Galluzzi L. Regulation of inflammatory processes by caspases. Nature Reviews Molecular Cell Biology 2025, 1-18. PMID: 40603684, DOI: 10.1038/s41580-025-00869-6.Peer-Reviewed Original ResearchApoptotic caspasesMammalian caspasesNegative regulatorNon-apoptotic cell death modalitiesRegulation of inflammatory processesCell death pathwaysCell death modalitiesNegative regulator of inflammatory processesApoptotic stimuliInflammatory caspasesOrganismal homeostasisDeath pathwaysCellular demiseCaspaseDeath modalitiesBiological functionsMolecular mechanismsCellsComplex interplayMammalsInflammatory processInflammatory responseHomeostasisPathwayRegulationB cell-derived nociceptin/orphanin FQ contributes to impaired glucose tolerance and insulin resistance in obesity
Puente-Ruiz S, Ide L, Schuller J, Ben-Kraiem A, Hoffmann A, Ghosh A, Noé F, Wolfrum C, Krause K, Gericke M, Klöting N, Brüning J, Wunderlich F, Blüher M, Jais A. B cell-derived nociceptin/orphanin FQ contributes to impaired glucose tolerance and insulin resistance in obesity. IScience 2025, 28: 112819. PMID: 40662198, PMCID: PMC12256348, DOI: 10.1016/j.isci.2025.112819.Peer-Reviewed Original ResearchMacrophage recruitmentMetabolic inflammationGlucose toleranceEffects of nociceptin/orphanin FQInsulin resistanceN/OFQ-NOP systemAdverse metabolic effectsImpaired glucose toleranceImmune cell migrationDiet-induced obesityNociceptin/orphanin FQB cellsEnhanced insulin sensitivityKnockout miceOpioid peptidesImmune regulationGlucose intoleranceMetabolic effectsImmunomodulatory propertiesInflammatory processN/OFQInsulin sensitivityObesityTherapeutic targetAdipose tissueImpact of body weight on IVF: pathophysiology, outcomes, and clinical considerations
Sekula N, Basar M, Pal L. Impact of body weight on IVF: pathophysiology, outcomes, and clinical considerations. Current Opinion In Obstetrics & Gynecology 2025, 37: 130-140. PMID: 40172001, DOI: 10.1097/gco.0000000000001023.Peer-Reviewed Original ResearchConceptsIVF outcomesExcess weightIVF cycle outcomesIVF treatment cyclesLive birth rateCycle outcomesImpact of excess weightAssociation of excess weightImpact of body weightClinical pregnancyExcess body weightBirth rateBody weightIVFAdverse implicationsUterine receptivityDetrimental implicationsWeight excessTreatment cyclesInflammatory processInsulin resistancePathogenic mechanismsClinical considerationsOutcomesDNA repairGenetic Associations Among Inflammation, White Matter Architecture, and Extracellular Free Water
Rodrigue A, Knowles E, Mollon J, Mathias S, Peralta J, Leandro A, Fox P, Kochunov P, Olvera R, Almasy L, Curran J, Blangero J, Glahn D. Genetic Associations Among Inflammation, White Matter Architecture, and Extracellular Free Water. Human Brain Mapping 2025, 46: e70101. PMID: 39757975, PMCID: PMC11702472, DOI: 10.1002/hbm.70101.Peer-Reviewed Original ResearchConceptsGenetic correlationsDiffusion tensor imagingCirculating cytokine levelsPeripheral inflammatory responseWhite matter architectureFA measurementsCytokine levelsCytokine measurementsWhite matter integrityProinflammatory cytokinesSingle-compartment modelIL-8Inflammatory processInflammatory responseFree water volumeFree waterGenetic relationshipsWhite matterWhite matter microstructureExtracellular free waterGenetic association
2024
Prenatal exposure to per- and polyfluoroalkyl substances (PFAS) and their influence on inflammatory biomarkers in pregnancy: Findings from the LIFECODES cohort
Siwakoti R, Harris S, Ferguson K, Hao W, Cantonwine D, Mukherjee B, McElrath T, Meeker J. Prenatal exposure to per- and polyfluoroalkyl substances (PFAS) and their influence on inflammatory biomarkers in pregnancy: Findings from the LIFECODES cohort. Environment International 2024, 194: 109145. PMID: 39550829, PMCID: PMC11663107, DOI: 10.1016/j.envint.2024.109145.Peer-Reviewed Original ResearchC-reactive proteinNested case-control study of preterm birthCase-control study of preterm birthInflammatory biomarkersIL-10TNF-aInterquartile range increaseNested Case-Control StudyStudy of preterm birthPre-pregnancy BMIQuantile-based g-computation approachIL-6Prenatal PFAS exposureInflammatory processPregnancy plasma samplesMeasurement of inflammatory biomarkersBirth outcomesLinear mixed modelsInverse associationRange increaseMaternal raceMaternal demographicsTNF-a levelsAdverse pregnancyAfrican AmericansCheckpoint Inhibitor-Induced Autoimmune Diabetes: An Autoinflammatory Disease.
Quandt Z, Perdigoto A, Anderson M, Herold K. Checkpoint Inhibitor-Induced Autoimmune Diabetes: An Autoinflammatory Disease. Cold Spring Harbor Perspectives In Medicine 2024, 15: a041603. PMID: 39038853, PMCID: PMC11917379, DOI: 10.1101/cshperspect.a041603.Peer-Reviewed Original ResearchAutoimmune diabetesBlockade of programmed cell death protein 1Agents targeting immune checkpointsCell death protein 1Autoimmune side effectsPD-L1Immune checkpointsAutoimmune disease riskClinical findingsAdverse eventsLevels of lipaseSide effectsInflammatory processIslets of LangerhansProtein 1DiabetesDisease riskIncreased levelsCheckpointAutoantibodiesBlockadeCancerPancreasDiagnosisLangerhans1965-LB: Metabolomic and Transcriptomic Signatures of Gestational Diabetes Mellitus (GDM) Suggest Nutritional and Inflammatory Pathways in Intergenerational Transfer of Risk
THAKER V, FIRESTEIN M, MASSON C, LIU Z, REDDY U, GALLAGHER D, LEDUC C. 1965-LB: Metabolomic and Transcriptomic Signatures of Gestational Diabetes Mellitus (GDM) Suggest Nutritional and Inflammatory Pathways in Intergenerational Transfer of Risk. Diabetes 2024, 73 DOI: 10.2337/db24-1965-lb.Peer-Reviewed Original ResearchGestational diabetes mellitusMetabolic riskC-peptideCord blood C-peptideCord blood metabolitesBlood C-peptideMother-baby dyadsCord plasmaCord bloodSteroid hormone signalingMaternal milieuTransport abnormalitiesPlacental tissuePregnancy ageDiabetes mellitusOffspring birthweightPlacental transcriptomePlasma fructosamineInflammatory pathwaysInflammatory processPlacenta tissueINSR expressionCordMetabolite profilesObesityManagement of postinfectious inflammatory arthritis
Baker H, Amaral J, Schoen R. Management of postinfectious inflammatory arthritis. Current Opinion In Rheumatology 2024, 36: 155-162. PMID: 38411201, DOI: 10.1097/bor.0000000000001009.Peer-Reviewed Original ResearchConceptsTreatment of acute infectionsAcute infectionInflammatory arthritisBenefits of antimicrobial therapyTreatment of infectionsTargeted synthetic DMARDsSpectrum of diseasesRefractory arthritisAntimicrobial therapySynthetic DMARDsFraction of casesTreatment optionsConventional therapyDisease-modifying treatmentsReactive arthritisInflammatory arthritidesInflammatory processPrompt identificationSelf-limitingChronic arthritisArthritisInfectionTreatmentTherapyArthralgiaMaresins as novel anti-inflammatory actors and putative therapeutic targets in sepsis
Sun Y, Sun S, Chen P, Dai Y, Yang D, Lin Y, Yi L. Maresins as novel anti-inflammatory actors and putative therapeutic targets in sepsis. Pharmacological Research 2024, 202: 107113. PMID: 38387744, DOI: 10.1016/j.phrs.2024.107113.Peer-Reviewed Original ResearchInflammatory response associated with sepsisIntensive care unit admissionDiagnosis of sepsisManagement of patientsHost response to infectionSuboptimal treatment strategyResponse to infectionFamily of lipid mediatorsUnit admissionUnfavorable outcomeTreatment strategiesSepsisClinical syndromeInflammatory processSepsis treatmentInflammation resolutionLipid mediatorsTherapeutic targetInaccurate diagnosisMaresinsDocosahexaenoic acidTermination of inflammatory processesImaging Cardiac and Vascular Inflammation
Tavakoli S, Sadeghi M. Imaging Cardiac and Vascular Inflammation. 2024, 511-530. DOI: 10.1093/med/9780190095659.003.0025.Peer-Reviewed Original ResearchRisk stratification of patientsStratification of patientsPathogenesis of cardiovascular diseaseEvaluating cardiovascular pathologiesPrecision medicine toolsRisk stratificationClinical studiesEarly diagnosisInflammatory processCardiovascular diseaseMedicine toolsCardiovascular pathologyTherapeutic interventionsClinical settingImaging strategiesMolecular imagingImaging Cardiac and Vascular Inflammation
Tavakoli S, Sadeghi M. Imaging Cardiac and Vascular Inflammation. 2024, 131-133. DOI: 10.1093/med/9780197521434.003.0025.Peer-Reviewed Original ResearchRisk stratification of patientsStratification of patientsPathogenesis of cardiovascular diseaseEvaluating cardiovascular pathologiesPrecision medicine toolsRisk stratificationClinical studiesEarly diagnosisInflammatory processCardiovascular diseaseMedicine toolsCardiovascular pathologyTherapeutic interventionsClinical settingImaging strategiesMolecular imaging
2023
A unique maternal and placental galectin signature upon SARS-CoV-2 infection suggests galectin-1 as a key alarmin at the maternal–fetal interface
Zhao F, Tallarek A, Wang Y, Xie Y, Diemert A, Lu-Culligan A, Vijayakumar P, Kittmann E, Urbschat C, Bayo J, Arck P, Farhadian S, Dveksler G, Garcia M, Blois S. A unique maternal and placental galectin signature upon SARS-CoV-2 infection suggests galectin-1 as a key alarmin at the maternal–fetal interface. Frontiers In Immunology 2023, 14: 1196395. PMID: 37475853, PMCID: PMC10354452, DOI: 10.3389/fimmu.2023.1196395.Peer-Reviewed Original ResearchConceptsSARS-CoV-2 infectionPregnancy-specific glycoprotein 1SARS-CoV-2Maternal-fetal interfacePregnant womenSuccessful pregnancyGal-1Gal-3SARS-CoV-2-infected patientsAcute respiratory syndrome coronavirus 2 pandemicSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemicMaternal immune systemCoronavirus 2 pandemicMaternal immune adaptationRisk of infectionΒ-galactoside-binding proteinKey alarminUninfected womenHealthy pregnancyPregnancy parametersGal-9Inflammatory processVirus infectionImmune responseGalectin signatureRole of Inflammatory Processes in Hemorrhagic Stroke
Ohashi S, DeLong J, Kozberg M, Mazur-Hart D, van Veluw S, Alkayed N, Sansing L. Role of Inflammatory Processes in Hemorrhagic Stroke. Stroke 2023, 54: 605-619. PMID: 36601948, DOI: 10.1161/strokeaha.122.037155.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsHemorrhagic strokeIntracerebral hemorrhageInflammatory processCerebral amyloid angiopathy-related haemorrhageAngiopathy-related hemorrhageRole of inflammationCerebral amyloid angiopathyInflammatory immune responseEffective therapeutic strategyCentral nervous systemBrain residentAmyloid angiopathyImmune cellsTissue injuryCommon causeImmune responseHemorrhageTherapeutic strategiesNervous systemMajor subtypesDisease pathologyStrokeOlder individualsTissue recoveryDeadliest form
2022
Genetic liability to suicidal thoughts and behaviors and risk of suicide attempt in US military veterans: moderating effects of cumulative trauma burden
Nichter B, Koller D, De Angelis F, Wang J, Girgenti M, Na P, Hill M, Norman S, Krystal J, Gelernter J, Polimanti R, Pietrzak R. Genetic liability to suicidal thoughts and behaviors and risk of suicide attempt in US military veterans: moderating effects of cumulative trauma burden. Psychological Medicine 2022, 53: 6325-6333. PMID: 36444557, DOI: 10.1017/s0033291722003646.Peer-Reviewed Original ResearchConceptsPolygenic risk scoresUS military veteransLifetime suicide attemptsSuicide attemptsTrauma exposureTrauma burdenGenetic liabilityMilitary veteransDrug repurposing analysisPopulation-based sampleCumulative trauma exposureLifetime trauma exposureLow trauma exposureSuicide prediction modelsChronic inflammationInflammatory processNervous system developmentRisk scorePsychiatric characteristicsSuicidal behaviorExposure interactionsLarge genome-wide association studiesHigh levelsVeteransSuicidalityPlatelet in thrombo-inflammation: Unraveling new therapeutic targets
Sharma S, Tyagi T, Antoniak S. Platelet in thrombo-inflammation: Unraveling new therapeutic targets. Frontiers In Immunology 2022, 13: 1039843. PMID: 36451834, PMCID: PMC9702553, DOI: 10.3389/fimmu.2022.1039843.Peer-Reviewed Original ResearchConceptsRole of plateletsViral infectionPlatelet activationCoagulation pathwayThrombo-inflammatory disordersAcute ischemic strokeContribution of plateletsAnti-inflammatory potentialThrombo-inflammatory diseasesCoronavirus disease 2019Sickle cell diseaseNon-pathologic conditionsNew therapeutic targetsRecruitment of leukocytesPathologic platelet activationPlatelet surface receptorsFormation of thrombiInitial platelet activationSuperficial thrombophlebitisAntiphospholipid syndromeIschemic strokeMicrovascular thrombosisClinical manifestationsInflammatory processCell diseaseChikungunya Arthritis
Amaral J, Pal T, Schoen R. Chikungunya Arthritis. Rare Diseases Of The Immune System 2022, 179-190. DOI: 10.1007/978-3-031-05002-2_14.Peer-Reviewed Original ResearchDisease-modifying anti-rheumatic drugsAnti-rheumatic drugsInflammatory rheumatic diseasesChikungunya arthritisChronic arthritisSupportive careBiphasic illnessRheumatic diseasesRheumatoid arthritisInflammatory processViral infectionArthritisAlphavirus infectionMillions of peopleIllnessInfectionDiseaseChikungunyaSubtropical worldArthralgiaRashPatientsFeverMethotrexateCarePD-L1–PD-1 interactions limit effector regulatory T cell populations at homeostasis and during infection
Perry J, Shallberg L, Clark J, Gullicksrud J, DeLong J, Douglas B, Hart A, Lanzar Z, O’Dea K, Konradt C, Park J, Kuchroo J, Grubaugh D, Zaretsky A, Brodsky I, Malefyt R, Christian D, Sharpe A, Hunter C. PD-L1–PD-1 interactions limit effector regulatory T cell populations at homeostasis and during infection. Nature Immunology 2022, 23: 743-756. PMID: 35437326, PMCID: PMC9106844, DOI: 10.1038/s41590-022-01170-w.Peer-Reviewed Original ResearchConceptsPD-1ETreg cellsPD-L1Interleukin-10T cellsCell expressionInhibitory receptor PD-1Regulatory T cell populationDevelopment of immunopathologyTreg cell populationRegulatory T cellsEffector T cellsPD-1 interactionReceptor PD-1T cell populationsCell populationsMyeloid cell expressionT cell receptor activationLineage-specific deletionTreg cellsEffector phenotypeInfected miceCell receptor activationInflammatory processEarly interferonRemodeling of the Cortical Structural Connectome in Posttraumatic Stress Disorder: Results From the ENIGMA-PGC Posttraumatic Stress Disorder Consortium
Sun D, Rakesh G, Clarke-Rubright EK, Haswell CC, Logue MW, O'Leary EN, Cotton AS, Xie H, Dennis EL, Jahanshad N, Salminen LE, Thomopoulos SI, Rashid FM, Ching CRK, Koch SBJ, Frijling JL, Nawijn L, van Zuiden M, Zhu X, Suarez-Jimenez B, Sierk A, Walter H, Manthey A, Stevens JS, Fani N, van Rooij SJH, Stein MB, Bomyea J, Koerte I, Choi K, van der Werff SJA, Vermeiren RRJM, Herzog JI, Lebois LAM, Baker JT, Ressler KJ, Olson EA, Straube T, Korgaonkar MS, Andrew E, Zhu Y, Li G, Ipser J, Hudson AR, Peverill M, Sambrook K, Gordon E, Baugh LA, Forster G, Simons RM, Simons JS, Magnotta VA, Maron-Katz A, du Plessis S, Disner SG, Davenport ND, Grupe D, Nitschke JB, deRoon-Cassini TA, Fitzgerald J, Krystal JH, Levy I, Olff M, Veltman DJ, Wang L, Neria Y, De Bellis MD, Jovanovic T, Daniels JK, Shenton ME, van de Wee NJA, Schmahl C, Kaufman ML, Rosso IM, Sponheim SR, Hofmann DB, Bryant RA, Fercho KA, Stein DJ, Mueller SC, Phan KL, McLaughlin KA, Davidson RJ, Larson C, May G, Nelson SM, Abdallah CG, Gomaa H, Etkin A, Seedat S, Harpaz-Rotem I, Liberzon I, Wang X, Thompson PM, Morey RA. Remodeling of the Cortical Structural Connectome in Posttraumatic Stress Disorder: Results From the ENIGMA-PGC Posttraumatic Stress Disorder Consortium. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2022, 7: 935-948. PMID: 35307575, PMCID: PMC9835553, DOI: 10.1016/j.bpsc.2022.02.008.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderCortical thicknessStructural covarianceComorbid depressionControl subjectsLarge effect sizesStress disorderEffect sizeTrauma-exposed control subjectsCase-control differencesCortical surface areaInflammatory processClinical dataResting-state functional connectivity networksPositive pairwise correlationsCortical differencesCortical regionsCortical neuroanatomyStress hormonesFunctional connectivity networksPTSD casesSmall effect sizesGroup differencesStructural networkStructural connectomeThe immunology and immunopathology of COVID-19
Merad M, Blish CA, Sallusto F, Iwasaki A. The immunology and immunopathology of COVID-19. Science 2022, 375: 1122-1127. PMID: 35271343, DOI: 10.1126/science.abm8108.Peer-Reviewed Original ResearchConceptsImmune responseAcute respiratory syndrome coronavirus 2 infectionSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infectionSyndrome coronavirus 2 infectionFatal COVID-19Coronavirus 2 infectionPost-acute sequelaeCOVID-19 pathophysiologyProlongation of symptomsLong COVID syndromeMajor unmet needCOVID-19SARS-CoV-2COVID syndromeDisease resolutionInflammatory processChronic illnessUnmet needDefinitive findingsImmunology researchCOVID-19 researchImmunopathologySequelaePathophysiologySyndrome
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