2024
6612 Both Overt And Mild Hypercortisolism Accelerate Biological Aging
Yu K, Saini J, Farr J, Vanessa F, Khosla S, Bancos I. 6612 Both Overt And Mild Hypercortisolism Accelerate Biological Aging. Journal Of The Endocrine Society 2024, 8: bvae163.126. PMCID: PMC11454948, DOI: 10.1210/jendso/bvae163.126.Peer-Reviewed Original ResearchMild autonomous cortisol secretionP16<sup>INK4a</sup> expressionAutonomous cortisol secretionCushing's syndromeAdvanced glycation end productsP16<sup>INK4a</sup>Frailty index scoreSex-matched reference subjectsCortisol secretionCell senescenceReference subjectsSingle-center cross-sectional studyCompared to reference subjectsAdvanced glycation end product readerPresence of hypercortisolismOvert Cushing's syndromeIndex scoreHistory of cardiovascular diseaseEvidence of cell senescenceAssociated with history of cardiovascular diseaseAssociated with hypercortisolismRisk of comorbiditiesAssociated with CVDAging-related comorbiditiesAssociated with historyPre‐diagnostic plasma advanced glycation end‐products and soluble receptor for advanced glycation end‐products and mortality in colorectal cancer patients
Li J, Baker J, Aglago E, Zhao Z, Jiao L, Freisling H, Hughes D, Eriksen A, Tjønneland A, Severi G, Katzke V, Kaaks R, Schulze M, Masala G, Pala V, Pasanisi F, Tumino R, Padroni L, Vermeulen R, Gram I, Braaten T, Jakszyn P, Sánchez M, Gómez‐Gómez J, Moreno‐Iribas C, Amiano P, Papier K, Weiderpass E, Huybrechts I, Heath A, Schalkwijk C, Jenab M, Fedirko V. Pre‐diagnostic plasma advanced glycation end‐products and soluble receptor for advanced glycation end‐products and mortality in colorectal cancer patients. International Journal Of Cancer 2024, 155: 1982-1995. PMID: 39057841, DOI: 10.1002/ijc.35114.Peer-Reviewed Original ResearchConceptsAssociated with CRC-specificAdvanced glycation end productsPlasma advanced glycation end productsColorectal cancerCRC-specificOverall mortalityGlycation end productsSoluble receptorCancer patientsIntracellular signaling alterationsMultivariable-adjusted Cox proportional hazards regressionCancer and NutritionCox proportional hazards regressionEuropean Prospective InvestigationFollow-up periodColorectal cancer casesColorectal cancer patientsProportional hazards regressionUltra-performance liquid chromatography mass spectrometryColorectal cancer diagnosisEnzyme-linked immunosorbent assayColorectal cancer survivalProspective InvestigationChronic inflammationSRAGE
2022
HMGB1-mediated restriction of EPO signaling contributes to anemia of inflammation
Dulmovits BM, Tang Y, Papoin J, He M, Li J, Yang H, Addorisio ME, Kennedy L, Khan M, Brindley E, Ashley RJ, Ackert-Bicknell C, Hale J, Kurita R, Nakamura Y, Diamond B, Barnes BJ, Hermine O, Gallagher PG, Steiner LA, Lipton JM, Taylor N, Mohandas N, Andersson U, Al-Abed Y, Tracey KJ, Blanc L. HMGB1-mediated restriction of EPO signaling contributes to anemia of inflammation. Blood 2022, 139: 3181-3193. PMID: 35040907, PMCID: PMC9136881, DOI: 10.1182/blood.2021012048.Peer-Reviewed Original ResearchConceptsAnemia of inflammationDamage-associated molecular pattern moleculesHigh-mobility group box 1 proteinMobility group box 1 proteinErythroid precursorsGroup box 1 proteinAdvanced glycation end productsAnti-HMGB1 antibodyGlycation end productsMolecular pattern moleculesChronic phaseSepsis onsetChronic diseasesHMGB1 receptorsAnemia developmentPattern moleculesAnemiaGenetic ablationInflammationMurine precursorRefractory stateHMGB1Reduced expansionEPO signalingDeleterious effectsAdvanced Glycation End Products-Mediated Oxidative Stress and Regulated Cell Death Signaling in Cancer
Pathak C, Vaidya F, Waghela B, Chhipa A, Tiwari B, Ranjan K. Advanced Glycation End Products-Mediated Oxidative Stress and Regulated Cell Death Signaling in Cancer. 2022, 535-550. DOI: 10.1007/978-981-15-9411-3_44.ChaptersRegulated cell deathCell deathDanger-associated molecular patternsOxidative stressTranscription factorsMolecular mechanismsCancer progressionCellular dysfunctionMolecular patternsRedox imbalanceCancer cellsPathological consequencesTypes of cancerROS generationCurrent understandingAGEs/RAGENucleic acidsAdvanced glycation end productsEnd productsGlycation of proteinsRAGE interactionAccumulationPathophysiological effectsGenesGlycation end products
2021
HMGB1, neuronal excitability and epilepsy
Dai S, Zheng Y, Wang Y, Chen Z. HMGB1, neuronal excitability and epilepsy. Acta Epileptologica 2021, 3: 13. DOI: 10.1186/s42494-021-00048-y.Peer-Reviewed Original ResearchN-methyl-D-aspartateModulation of neuronal excitabilityAnimal models of epilepsyToll-like receptor 4Antiepileptic drug therapyInterleukin (IL)-1bTranslocation of HMGB1Multiple animal modelsDevelopment of epilepsyAnti-epileptic drugsMobility group protein B1HMGB1-related pathwayModels of epilepsyNuclear factor kappa BPotential of HMGB1Advanced glycation end productsFactor kappa BGlycation end productsNeuronal excitabilityBlocking HMGB1Downstream Signaling PathwaysGlutamate receptorsHMGB1 signalingHyperexcitable neuronsDrug therapy
2020
Protective Role of Tangshen Formula on the Progression of Renal Damage in db/db Mice by TRPC6/Talin1 Pathway in Podocytes
Wang Q, Tian X, Zhou W, Wang Y, Zhao H, Li J, Zhou X, Zhang H, Zhao T, Li P. Protective Role of Tangshen Formula on the Progression of Renal Damage in db/db Mice by TRPC6/Talin1 Pathway in Podocytes. Journal Of Diabetes Research 2020, 2020: 3634974. PMID: 33015191, PMCID: PMC7519445, DOI: 10.1155/2020/3634974.Peer-Reviewed Original ResearchMeSH KeywordsActinsAnimalsCell AdhesionCell MovementCell SurvivalCytoskeletonDiabetes Mellitus, ExperimentalDiabetes Mellitus, Type 2Disease ProgressionDrugs, Chinese HerbalHumansKidney DiseasesKidney GlomerulusMaleMedicine, Chinese TraditionalMiceMice, Inbred C57BLPodocytesProteinuriaTalinTRPC6 Cation ChannelWound HealingConceptsDiabetic kidney diseasePrimary mouse podocytesTangshen FormulaTransient receptor potential canonical channel 6Renal functionKidney diseaseTSF treatmentMouse podocytesType 2 diabetic kidney diseaseProtective roleDb/db miceAdvanced glycation end productsTRPC6-dependent CaProteinuric kidney diseaseActivated T cells 2Chinese medicine formulaGlycation end productsExpression of Talin1T cells 2Foot process effacementLoss of talin1Renal damageDb micePodocyte numberMurine model
2019
Biocatalytic Reversal of Advanced Glycation End Product Modification
Kim NY, Goddard TN, Sohn S, Spiegel DA, Crawford J. Biocatalytic Reversal of Advanced Glycation End Product Modification. ChemBioChem 2019, 20: 2402-2410. PMID: 31013547, PMCID: PMC6768434, DOI: 10.1002/cbic.201900158.Peer-Reviewed Original ResearchConceptsImproved catalytic propertiesCondensation of sugarsLysine structureStructural homology analysisCatalytic propertiesSite-directed mutagenesisLead catalystFree amino acid formAcid formEnzyme variantsMaillard reactionHomology analysisCausal agentAuthentic ligandMolecular levelAdvanced glycation end product modificationAmino acid formMnmCLack of toolsAdvanced glycation end productsCatalystPeptidomimeticsLigandsVariantsMolecules
2018
Elevated IgM against Nε-(Carboxyethyl)lysine-modified Apolipoprotein A1 peptide 141–147 in Taiwanese with Alzheimer's disease
Lin CY, Sheu JJ, Tsai IS, Wang ST, Yang LY, Hsu IU, Chang HW, Lee HM, Kao SH, Lee CK, Chen CH, Lin YF. Elevated IgM against Nε-(Carboxyethyl)lysine-modified Apolipoprotein A1 peptide 141–147 in Taiwanese with Alzheimer's disease. Clinical Biochemistry 2018, 56: 75-82. PMID: 29680706, DOI: 10.1016/j.clinbiochem.2018.04.009.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAlzheimer DiseaseAntibody SpecificityApolipoprotein A-IAutoantibodiesAutoimmunityBiomarkersCase-Control StudiesEnzyme-Linked Immunosorbent AssayFemaleGlycation End Products, AdvancedHumansImmunoglobulin MLysineMalePeptide FragmentsProtein Processing, Post-TranslationalPsychiatric Status Rating ScalesROC CurveTaiwanUp-RegulationConceptsAdvanced glycation end productsSpecific advanced glycation end productsAlzheimer's diseaseMini-Mental State Examination scoreMental State Examination scoreEarly AD markersEarly AD pathologyState Examination scoreEarly disease statesGlycation end productsRelated autoantibodiesAD markersIgM levelsAD pathologyElevated IgMAD seraAD patientsDisease progressionAD biomarkersApolipoprotein A1IgMAutoantibodiesApoA1Serum samplesWestern blotting
2017
Correlation between follicular fluid levels of sRAGE and vitamin D in women with PCOS
Garg D, Grazi R, Lambert-Messerlian GM, Merhi Z. Correlation between follicular fluid levels of sRAGE and vitamin D in women with PCOS. Journal Of Assisted Reproduction And Genetics 2017, 34: 1507-1513. PMID: 28825156, PMCID: PMC5699991, DOI: 10.1007/s10815-017-1011-6.Peer-Reviewed Original ResearchConceptsAdvanced glycation end productsFollicular fluidVitamin DPro-inflammatory advanced glycation end productsHigher anti-Mullerian hormone levelsAnti-Mullerian hormone levelsProtective anti-inflammatory roleFollicular fluid levelsLevels of sRAGEAnti-inflammatory rolePathogenesis of PCOSGlycation end productsPotential therapeutic targetDay 5 embryosConclusionsIn womenSRAGE levelsOvarian dysfunctionOvarian levelHormone levelsPCOSSRAGESoluble receptorTherapeutic targetDay 3Fluid levels
2016
Soluble Receptor for Advanced Glycation End Products Improves Stromal Cell–Derived Factor-1 Activity in Model Diabetic Environments
Olekson MP, Faulknor RA, Hsia HC, Schmidt AM, Berthiaume F. Soluble Receptor for Advanced Glycation End Products Improves Stromal Cell–Derived Factor-1 Activity in Model Diabetic Environments. Advances In Wound Care 2016, 5: 527-538. PMID: 28078186, PMCID: PMC5165672, DOI: 10.1089/wound.2015.0674.Peer-Reviewed Original ResearchStromal cell-derived factor-1Advanced glycation end productsPeripheral blood mononuclear cellsCellular responsesSoluble RAGEGlycation end productsBaseline ROS levelsGrowth factorExtracellular signalsExogenous SDF-1Mouse peripheral blood mononuclear cellsStem cell recruitmentHuman leukaemia 60 cellsCell-derived factor-1Exogenous growth factorsReactive oxygen species generationDiabetic murine woundsReceptor CXCR-4Blood mononuclear cellsWound healingCellular migrationCell migrationOxygen species generationMurine excisional wound modelROS levelsRelationship between Advanced Glycation End Products and Steroidogenesis in PCOS
Garg D, Merhi Z. Relationship between Advanced Glycation End Products and Steroidogenesis in PCOS. Reproductive Biology And Endocrinology 2016, 14: 71. PMID: 27769286, PMCID: PMC5073880, DOI: 10.1186/s12958-016-0205-6.Peer-Reviewed Original ResearchMeSH Keywords3-Hydroxysteroid DehydrogenasesAnimalsCholesterol Side-Chain Cleavage EnzymeFemaleGlycation End Products, AdvancedGonadal Steroid HormonesGranulosa CellsHumansOvaryPhosphoproteinsPolycystic Ovary SyndromeReceptors, LHReceptors, PeptideReceptors, Transforming Growth Factor betaSteroid 17-alpha-HydroxylaseTheca CellsConceptsAdvanced glycation end productsOvaries of womenTheca cell functionGlycation end productsCell functionHormone receptor expressionSteroidogenic enzyme activitiesSteroidogenic acute regulatory proteinAbnormal steroidogenesisPCOS modelOvarian dysfunctionAcute regulatory proteinReceptor expressionPCOSFollicular developmentTheca cellsGranulosa cellsSystematic reviewNew interventionsHormone receptorsEnzyme cytochrome P450SteroidogenesisEnd productsGranulosaCytochrome P450Advanced Glycation End Products and its Soluble Receptors in the Pathogenesis of Thoracic Aortic Aneurysm
Prasad K, Sarkar A, Zafar M, Shoker A, Moselhi H, Tranquilli M, Ziganshin B, Elefteriades J. Advanced Glycation End Products and its Soluble Receptors in the Pathogenesis of Thoracic Aortic Aneurysm. Aorta 2016, 4 DOI: 10.12945/j.aorta.2016.15.018.Peer-Reviewed Original ResearchAdvanced glycation end productsThoracic aortic aneurysmGlycation end productsAortic aneurysmSoluble receptorEnd productsAneurysmsPathogenesisReceptorsAdvanced Glycation End Products and its Soluble Receptors in the Pathogenesis of Thoracic Aortic Aneurysm
Prasad K, Sarkar A, Zafar MA, Shoker A, Moselhi HE, Tranquilli M, Ziganshin BA, Elefteriades JA. Advanced Glycation End Products and its Soluble Receptors in the Pathogenesis of Thoracic Aortic Aneurysm. Aorta 2016, 04: 1-10. PMID: 27766267, PMCID: PMC5068493, DOI: 10.12945/j.aorta.2015.15.018.Peer-Reviewed Original ResearchAdvanced glycation end productsEndogenous secretory RAGEThoracic aortic aneurysmGlycation end productsMatrix metalloproteinasesSerum sRAGEAortic aneurysmSoluble receptorFormation of TAALevels of AGEsPathogenesis of TAALevels of sRAGEAGE-RAGE axisLevels of cytokinesProduction of cytokinesRelease of cytokinesAGEs/Control subjectsRisk factorsStudy populationSRAGEBlood samplesMMP-2CytokinesELISA kit
2015
Advanced Glycation End Products: Link between Diet and Ovulatory Dysfunction in PCOS?
Garg D, Merhi Z. Advanced Glycation End Products: Link between Diet and Ovulatory Dysfunction in PCOS? Nutrients 2015, 7: 10129-10144. PMID: 26690206, PMCID: PMC4690076, DOI: 10.3390/nu7125524.Peer-Reviewed Original ResearchConceptsOvulatory dysfunctionAdvanced glycation end productsHigh AGE dietReproductive-aged womenPro-inflammatory receptorGlycation end productsDietary AGEsPharmacological therapyOvulatory problemsExpression of AGEsCommon causeOvarian healthPCOSOvarian tissueAnovulationModification of foodVariety of dietsWomenAgeDysfunctionDietReproductive alterationsSubsequent developmentNon-enzymatic reactionEnd products
2014
The Receptor for Advanced Glycation End Products (RAGE) Affects T Cell Differentiation in OVA Induced Asthma
Akirav EM, Henegariu O, Preston-Hurlburt P, Schmidt AM, Clynes R, Herold KC. The Receptor for Advanced Glycation End Products (RAGE) Affects T Cell Differentiation in OVA Induced Asthma. PLOS ONE 2014, 9: e95678. PMID: 24759895, PMCID: PMC3997417, DOI: 10.1371/journal.pone.0095678.Peer-Reviewed Original ResearchConceptsAdaptive immune responsesT cell responsesEffects of RAGEGlycation end productsT cell activationT cellsImmune responseWT miceCellular infiltrationCell activationCell responsesBronchial alveolar lavage fluidAdvanced glycation end productsMediastinal lymph nodesT cell infiltrationIL-5 productionOT-II miceRAGE-deficient miceT cell subsetsAlveolar lavage fluidMultiplex bead analysisRole of RAGET cell proliferationDeficient T cellsT cell differentiationVitamin D Increases Serum Levels of the Soluble Receptor for Advanced Glycation End Products in Women With PCOS
Irani M, Minkoff H, Seifer DB, Merhi Z. Vitamin D Increases Serum Levels of the Soluble Receptor for Advanced Glycation End Products in Women With PCOS. The Journal Of Clinical Endocrinology & Metabolism 2014, 99: e886-e890. PMID: 24606102, DOI: 10.1210/jc.2013-4374.Peer-Reviewed Original ResearchConceptsAdvanced glycation end productsPolycystic ovary syndromeAnti-Mullerian hormoneSerum anti-Mullerian hormoneGlycation end productsVitamin DSerum sRAGED3 supplementationDeficient womenAMH concentrationsVit D3Soluble receptorDeposition of AGEsAbnormal ovarian folliculogenesisDihydroxyvitamin D3 supplementationSerum sRAGE levelsVit D3 supplementationVitamin D supplementationSerum AMH levelsVitamin D deficiencyBody mass indexD supplementationAMH levelsD deficiencySRAGE levels
2009
Using proteomics in perinatal and neonatal sepsis: hopes and challenges for the future
Buhimschi CS, Bhandari V, Han YW, Dulay AT, Baumbusch MA, Madri JA, Buhimschi IA. Using proteomics in perinatal and neonatal sepsis: hopes and challenges for the future. Current Opinion In Infectious Diseases 2009, 22: 235-243. PMID: 19395960, PMCID: PMC2763282, DOI: 10.1097/qco.0b013e32832a5963.Peer-Reviewed Original ResearchConceptsNeonatal sepsisEarly-onset neonatal sepsisInsulin-like growth factor-binding protein-1Growth factor-binding protein-1Proteomic biomarkersAdvanced glycation end productsAmniotic fluid biomarkersAmniotic fluid inflammationFetal immune responsePoor neurodevelopmental outcomesIntra-amniotic infectionRisk of sepsisGlycation end productsHistological chorioamnionitisPreterm birthInflammatory statusNeurodevelopmental outcomesNeuroprotection strategiesInflammatory stateNeurological injuryFluid biomarkersInflammatory processImmune responseAmniotic fluidDefensin 2Receptor for advanced glycation end products is required for normal T cell activation and development of T cell induced lung inflammation (36.10)
Akirav E, Henegariu O, Clynes R, Schmidt A, Herold K. Receptor for advanced glycation end products is required for normal T cell activation and development of T cell induced lung inflammation (36.10). The Journal Of Immunology 2009, 182: 36.10-36.10. DOI: 10.4049/jimmunol.182.supp.36.10.Peer-Reviewed Original ResearchRAGE-/- miceT cell activationIntranasal OVA challengeT cellsOT-IICell activationNormal T cell activationOVA challengeRobust T cell infiltrationReduced T cell activationTranscription factor T-betAdvanced glycation end productsMediastinal lymph nodesT cell infiltrationOT-II miceGlycation end productsAdvanced glycation endproductsGATA-3 expressionIL5 productionCD62L expressionLung inflammationIFNγ expressionLymph nodesCellular infiltrateWT mice
2008
A Role for the Receptor for Advanced Glycation End Products in Idiopathic Pulmonary Fibrosis
Englert JM, Hanford LE, Kaminski N, Tobolewski JM, Tan RJ, Fattman CL, Ramsgaard L, Richards TJ, Loutaev I, Nawroth PP, Kasper M, Bierhaus A, Oury TD. A Role for the Receptor for Advanced Glycation End Products in Idiopathic Pulmonary Fibrosis. American Journal Of Pathology 2008, 172: 583-591. PMID: 18245812, PMCID: PMC2258251, DOI: 10.2353/ajpath.2008.070569.Peer-Reviewed Original ResearchConceptsIdiopathic pulmonary fibrosisAdvanced glycation end productsRAGE-null micePulmonary fibrosisGlycation end productsIPF pathogenesisMouse modelNovel therapeutic targetHealthy adult animalsIPF patientsWild-type controlsDismal prognosisSevere fibrosisIPF tissueEffective therapyFibrotic lungsTherapeutic targetHistological scoringFibrosisLoss of RAGECell surface receptorsAdult animalsMiceEnd productsSoluble isoform
2007
The receptor for advanced glycation end products (RAGE) system in women with intraamniotic infection and inflammation
Buhimschi IA, Zhao G, Pettker CM, Bahtiyar MO, Magloire LK, Thung S, Fairchild T, Buhimschi CS. The receptor for advanced glycation end products (RAGE) system in women with intraamniotic infection and inflammation. American Journal Of Obstetrics And Gynecology 2007, 196: 181.e1-181.e13. PMID: 17306673, DOI: 10.1016/j.ajog.2006.09.001.Peer-Reviewed Original ResearchConceptsIntra-amniotic infectionPolymerase chain reactionAF cultureAdvanced glycation end productsAmniotic fluid inflammationThird-trimester controlsEarlier gestational agePlacental villous tissueDegree of inflammationAcute histologic chorioamnionitisNegative AF culturePositive AF cultureExtravillous trophoblast cellsGlycation end productsGestational age dependenceReal-time polymerase chain reactionQuantitative real-time polymerase chain reactionHistologic chorioamnionitisIntraamniotic infectionPreterm deliveryInflammatory biomarkersPlacental pathologyGestational ageRAGE systemAcute inflammation
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply