2025
Switching From Active Vitamin d and Phosphate Supplementation to Burosumab Significantly Corrects Lower Limb Malalignment in Pediatric X-Linked Hypophosphatemia
Ward L, Imel E, Frumberg D, Dilworth L, Siener C, Chen Z, Krolczyk S, Carpenter T. Switching From Active Vitamin d and Phosphate Supplementation to Burosumab Significantly Corrects Lower Limb Malalignment in Pediatric X-Linked Hypophosphatemia. Journal Of Bone And Mineral Research 2025, zjaf079. PMID: 40511857, DOI: 10.1093/jbmr/zjaf079.Peer-Reviewed Original ResearchLower limb malalignmentLimb malalignmentLower-limb malalignmentBaseline height z scoreZ-scoreLower extremity deformitiesLimbs of patientsX-linked hypophosphatemiaAssociated with greater changesFactor analysisLower limb malformationsDisease monitoring programsHeight z-scoreChance of improvementExtremity deformitiesGauge improvementYounger ageVitamin DBurosumab treatmentMalalignmentTreating physicianPediatric populationPhosphate supplementationRenal phosphate wastingActive vitamin DA head start: The relationship of placental factors to craniofacial and brain development
Carver A, Dunnwald M, Stevens H. A head start: The relationship of placental factors to craniofacial and brain development. Developmental Dynamics 2025 PMID: 40105397, DOI: 10.1002/dvdy.70018.Peer-Reviewed Original ResearchPlacental functionBrain developmentCraniofacial developmentInsulin-like growth factor-1Etiology of neurodevelopmental disordersPlacental hormone productionGrowth factor-1Placental factorsCraniofacial skeletal growthFetal neurodevelopmentVitamin DGrowth hormoneCraniofacial morphogenesisHormone productionFactor 1PlacentaNeurodevelopmental disordersSkeletal growthBrainHormoneNutrient deliveryHead StartFunctional influenceNeuroplacentologyProlactin
2024
Potential roles for vitamin D in preventing and treating impulse control disorders, behavioral addictions, and substance use disorders: A scoping review
Jalilian-Khave L, Kitaneh R, Ysrayl B, Borelli A, Funaro M, Potenza M, Angarita G. Potential roles for vitamin D in preventing and treating impulse control disorders, behavioral addictions, and substance use disorders: A scoping review. Addiction Neuroscience 2024, 14: 100190. PMID: 40083958, PMCID: PMC11902922, DOI: 10.1016/j.addicn.2024.100190.Peer-Reviewed Original ResearchImpulse control disordersSubstance use disordersControl disordersBehavioral addictionsTreating impulse control disordersVitamin DClinical studiesAddictive disordersSerotonergic circuitsExposure to vitamin DVitamin D deficiencyVitamin D levelsSymptom presenceDisordersPotential beneficial effectsJoanna Briggs InstituteD deficiencyPotential therapeutic mechanismAddictionD levelsWeb of ScienceTherapeutic mechanismQuality of studiesCochrane LibraryOvid MEDLINEVitamin D for very preterm infants—determining the how, when, and why
Taylor S. Vitamin D for very preterm infants—determining the how, when, and why. Pediatric Research 2024, 1-2. PMID: 39496874, DOI: 10.1038/s41390-024-03685-4.Peer-Reviewed Original ResearchVitamin D’s Capacity to Increase Amphetamine-Induced Dopamine Release in Healthy Humans: A Clinical Translational [11C]-PHNO Positron Emission Tomography Study
Worhunsky P, Mignosa M, Gallezot J, Pittman B, Nabulsi N, Stryjewski A, Jalilian-Khave L, Trinko R, DiLeone R, Carson R, Malison R, Potenza M, Angarita G. Vitamin D’s Capacity to Increase Amphetamine-Induced Dopamine Release in Healthy Humans: A Clinical Translational [11C]-PHNO Positron Emission Tomography Study. Biological Psychiatry 2024, 97: 651-658. PMID: 39395473, PMCID: PMC11839384, DOI: 10.1016/j.biopsych.2024.09.028.Peer-Reviewed Original ResearchVentral striatumEffects of medicationDorsal caudateDopamine releaseDorsal putamenDopaminergic tonePlacebo-controlled within-subject studyIncreased amphetamine-induced dopamine releaseAmphetamine-induced dopamine releaseAmphetamine-stimulated dopamine releaseSubstantia nigraDysregulated dopamine functionPositron emission tomography studiesTreatment of ADHDEmission tomography studiesWithin-subject studyPost-amphetamineD2/3 receptorsDopamine functionTransdiagnostic relevanceVitamin DPhasic releaseGlobus pallidusStriatumTyrosine hydroxylase7954 Vitamin D Deficiency Underlies Defective Endometrial Decidualization In Vivo and In Vitro
Yi M, Wang T, Jukic A, DeMayo F. 7954 Vitamin D Deficiency Underlies Defective Endometrial Decidualization In Vivo and In Vitro. Journal Of The Endocrine Society 2024, 8: bvae163.1783. PMCID: PMC11454223, DOI: 10.1210/jendso/bvae163.1783.Peer-Reviewed Original ResearchVitamin D receptorVitamin D signalingVitamin DIngenuity Pathway AnalysisTreatment of 1,25(OH)<sub>2</sub>D<sub>3</sub> atDecidualization markersUterine stromal cell differentiationD signalingKnockdown of VDRUterine decidual reactionHuman endometrial stroma cellsExpression of decidualization markersVitamin D-deficient dietAbility of estrogenStromal cell differentiationD-deficient dietEndometrial stromal cellsIn vitro decidualizationEndometrial stroma cellsUpstream regulatorVitamin D receptor siRNATranscription factor vitamin D receptorResponse to exogenous hormonesB-estradiolDecidual reactionImpact of Food Avoidance on Vitamin D Intake in Inflammatory Bowel Disease Patients
Almahmoud E, Larson D, Gaidos J, Feagins L, Burgermaster M. Impact of Food Avoidance on Vitamin D Intake in Inflammatory Bowel Disease Patients. Journal Of Nutrition Education And Behavior 2024, 56: s62-s63. DOI: 10.1016/j.jneb.2024.05.144.Peer-Reviewed Original ResearchVitamin D intakeAssociated with vitamin D intakeInflammatory bowel diseaseD intakeInflammatory bowel disease patientsFlare-upVitamin DIntake of vitamin DCross-sectional studyFood avoidanceVitamin D. Vitamin D deficiencyInflammatory bowel disease centerChronic inflammatory diseaseDiet recallMeans foodStudy designAcademic hospitalD deficiencyDisease activityGastrointestinal symptomsInflammatory diseasesParticipantsBowel diseaseDietary restrictionDisease patientsVitamin D and Toxic Metals in Pregnancy - a Biological Perspective
Fisher M, Weiler H, Kuiper J, Borghese M, Buckley J, Shutt R, Ashley-Martin J, Subramanian A, Arbuckle T, Potter B, Little J, Morisset A, Jukic A. Vitamin D and Toxic Metals in Pregnancy - a Biological Perspective. Current Epidemiology Reports 2024, 11: 153-163. PMID: 39156920, PMCID: PMC11329583, DOI: 10.1007/s40471-024-00348-0.Peer-Reviewed Original ResearchVitamin DPregnant womenHigher vitamin D statusToxic metalsPrevention of adverse outcomesTrials of vitamin D supplementationVitamin D statusVitamin D supplementationOverall nutritional statusNutritional interventionPotential biological mechanismsPregnant populationEpidemiological studiesBlood metalsNutritional statusD statusD supplementationNorth American studiesProspective studyAdverse outcomesAbsorption of metalsPregnancyIntestinal absorptionMetal exposureEndocrine disruption155-OR: Genetic Variation and Time to Progression in TN10 (Teplizumab)
MICHALEK D, ONENGUT-GUMUSCU S, CHEN W, BRUSKO T, STECK A, GOTTLIEB P, ORAM R, KRISCHER J, PARIKH H, REDONDO M, HEROLD K, RICH S. 155-OR: Genetic Variation and Time to Progression in TN10 (Teplizumab). Diabetes 2024, 73 DOI: 10.2337/db24-155-or.Peer-Reviewed Original ResearchGenome-wide analysisTime to progressionInfluence time to progressionPolygenic scoresDrug response genesNon-HLA variantsGenome-wide arrayRandomized phase 2 clinical trialAssociated with time to progressionPhase 2 clinical trialProgression to type 1 diabetesCox proportional hazards regression modelsGenetic variationTn10Proportional hazards regression modelsGenetic modifiersHigh-risk participantsHazards regression modelsLociType 1 diabetesNovel pathwaysTeplizumab groupTeplizumabVitamin DImmune-relevantVitamin D status and supplementation, calcium supplementation, and timing of natural menopause
Jukic A, Sandler D, Weinberg C, O'Brien K. Vitamin D status and supplementation, calcium supplementation, and timing of natural menopause. Maturitas 2024, 182: 107916. PMID: 38266360, PMCID: PMC11000149, DOI: 10.1016/j.maturitas.2024.107916.Peer-Reviewed Original ResearchConceptsCalcium supplement useTiming of natural menopauseVitamin D statusTime of menopauseNatural menopauseFollow-upVitamin DSupplement useD statusMenstrual periodAssociated with timing of menopauseHazard ratioMultivariate Cox proportional hazards modelAssociated with ovarian reserveVitamin D supplement useYears of follow-upVitamin D supplementationLoss to follow-upCox proportional hazards modelsFollow-up time pointsYear Follow-UpBody mass indexConfidence intervalsSister Study cohortEstimate hazard ratiosChapter 39 Role in reproductive biology and dysfunction in women
Pal L, Taylor H. Chapter 39 Role in reproductive biology and dysfunction in women. 2024, 873-888. DOI: 10.1016/b978-0-323-91386-7.00036-2.Peer-Reviewed Original ResearchVitamin DMaternal vitamin D statusVitamin D inadequacyVitamin D deficiencyVitamin D statusActive hormonal formReproductive physiologyBeneficial roleVitamin D signalingSpectrum of disordersFemale reproductive functionHuman reproductive physiologyD deficiencyD statusDihydroxyvitamin DFemale reproductive physiologyInsulin resistanceCardiovascular diseaseHormonal formMetabolic milieuD signalingReproductive functionPleotropic effectsPathological processesLimited data
2023
Associations between maternal urinary rare earth elements during pregnancy and birth weight-for-gestational age: Roles of cord blood vitamin D levels
Fang X, Xie Y, Cao S, Liu J, Shi Y, Yu L, Zheng T, Liu H, Li Y, Xu S, Xia W. Associations between maternal urinary rare earth elements during pregnancy and birth weight-for-gestational age: Roles of cord blood vitamin D levels. The Science Of The Total Environment 2023, 912: 169222. PMID: 38081430, DOI: 10.1016/j.scitotenv.2023.169222.Peer-Reviewed Original ResearchCord blood vitamin D levelsBlood vitamin D levelsCord blood vitamin DVitamin D levelsBlood vitamin DFetal growth restrictionGestational ageD levelsVitamin DPrenatal exposureBirth weightUrinary concentrationsGrowth restrictionLow vitamin D levelsZ-scoreMother-newborn pairsAdverse birth outcomesLower BWAverage urinary concentrationsBirth outcomesFetal growthCord bloodHigher oddsEnvironmental exposuresExposure-mediator interactionIncreased serum 1,25-dihydroxyvitamin D levels in gynecologic cancer patients with Post-Acute-Covid-Sequela (PASC)/Long COVID
Bellone S, Siegel E, Santin A. Increased serum 1,25-dihydroxyvitamin D levels in gynecologic cancer patients with Post-Acute-Covid-Sequela (PASC)/Long COVID. Gynecologic Oncology Reports 2023, 50: 101301. PMID: 38029227, PMCID: PMC10654147, DOI: 10.1016/j.gore.2023.101301.Peer-Reviewed Original ResearchGynecologic cancer patientsLong COVIDCancer patientsVitamin DPotent anti-inflammatory activityDihydroxyvitamin D levelsPost-acute sequelaeLong COVID symptomsAnti-inflammatory activityMental health impairmentControl cancer patientsExtrarenal conversionPost-AcuteControl patientsAcute infectionBone healthLC patientsPersistent inflammationD levelsCOVID symptomsImmune cellsPlasmatic levelsNovel biomarkersPatientsAbnormal levelsVitamin D Insufficiency as a Risk Factor for Paclitaxel-Induced Peripheral Neuropathy in SWOG S0221.
Chen C, Zirpoli G, Barlow W, Budd G, McKiver B, Pusztai L, Hortobagyi G, Albain K, Damaj M, Godwin A, Thompson A, Henry N, Ambrosone C, Stringer K, Hertz D. Vitamin D Insufficiency as a Risk Factor for Paclitaxel-Induced Peripheral Neuropathy in SWOG S0221. Journal Of The National Comprehensive Cancer Network 2023, 21: 1172-1180.e3. PMID: 37935109, PMCID: PMC10976748, DOI: 10.6004/jnccn.2023.7062.Peer-Reviewed Original ResearchConceptsChemotherapy-induced peripheral neuropathyVitamin D insufficiencyD insufficiencyVitamin DPaclitaxel scheduleMechanical hypersensitivityPeripheral neuropathyRisk factorsDeficient dietPaclitaxel-induced peripheral neuropathyEarly-stage breast cancerPaclitaxel-containing chemotherapyVitamin D supplementationSufficient vitamin DVitamin D deficiencyBody mass indexMultiple logistic regressionSelf-reported raceD supplementationD deficiencySensitized miceProspective trialFemale patientsMass indexPredictive biomarkersFRI694 Hypercalcemia And Renal Failure As Initial Presentation Of A Rare Case Of Primary Splenic Large B Cell Lymphoma
Ding N, Majumdar S. FRI694 Hypercalcemia And Renal Failure As Initial Presentation Of A Rare Case Of Primary Splenic Large B Cell Lymphoma. Journal Of The Endocrine Society 2023, 7: bvad114.462. PMCID: PMC10555323, DOI: 10.1210/jendso/bvad114.462.Peer-Reviewed Original ResearchSplenic large B-cell lymphomaLarge B-cell lymphomaB-cell lymphomaDihydroxy vitamin DRenal failureVitamin DPg/mLCell lymphomaPg/Diffuse large B-cell lymphomaR-CHOP therapyPatient underwent splenectomyBence Jones proteinuriaBone marrow biopsyPrimary splenic lymphomaNon-Hodgkin lymphomaPrimary care doctorsAbdominal painElderly patientsInitial presentationUnderwent splenectomyCalcium 1000Further workupMRI abdomenRare etiologyVitamin D and infertility
Simpson S, Pal L. Vitamin D and infertility. Current Opinion In Obstetrics & Gynecology 2023, 35: 300-305. PMID: 37266579, DOI: 10.1097/gco.0000000000000887.Peer-Reviewed Original ResearchConceptsPolycystic ovarian syndromeVitamin DGynaecological disordersVitamin D serum levelsOvarian reserve parametersD serum levelsVitamin D deficiencyVitamin D statusDiminished ovarian reserveCommon gynaecological disorderReproductive health burdenHigher pregnancy rateD deficiencyD statusOvarian reserveOvarian syndromeInfertile womenSerum levelsUterine myomaMenstrual regularityEndometriosis patientsInsulin levelsUterine fibroidsHealth burdenPregnancy rateMineral bone disorder in children with chronic kidney disease: Data from the KNOW-Ped CKD (Korean cohort study for outcome in patients with pediatric chronic kidney disease) study
Jung J, Lee K, Park E, Park Y, Kang H, Ahn Y, Ha I, Kim S, Cho H, Han K, Cho M, Choi H, Lee J, Shin J. Mineral bone disorder in children with chronic kidney disease: Data from the KNOW-Ped CKD (Korean cohort study for outcome in patients with pediatric chronic kidney disease) study. Frontiers In Pediatrics 2023, 11: 994979. PMID: 36873652, PMCID: PMC9982157, DOI: 10.3389/fped.2023.994979.Peer-Reviewed Original ResearchChronic kidney disease stageFractional excretion of phosphateMineral bone disorderChronic kidney diseasePediatric CKD patientsIntact parathyroid hormoneVitamin DSerum phosphateCKD patientsFGF-23Levels of 1,25-dihydroxy vitamin DUrine calcium-to-creatinine ratioMedian serum calcium levelBone disordersKidney diseaseSerum intact parathyroid hormoneCalcium to creatinine ratioChronic kidney disease stage 3bZ-scorePrevalence of hyperphosphatemiaSerum calcium levelsSerum vitamin DActive vitamin DFibroblast growth factor 23Abnormal mineral metabolism
2022
Age-related changes in Folliculogenesis and potential modifiers to improve fertility outcomes - A narrative review
Esencan E, Beroukhim G, Seifer D. Age-related changes in Folliculogenesis and potential modifiers to improve fertility outcomes - A narrative review. Reproductive Biology And Endocrinology 2022, 20: 156. PMID: 36397149, PMCID: PMC9670479, DOI: 10.1186/s12958-022-01033-x.Peer-Reviewed Original ResearchConceptsInsulin-like growth factor-1Vascular endothelial growth factorAge-related changesAntimullerian hormoneFertility outcomesIndividual studiesGrowth factor-1Endothelial growth factorObstetrical outcomesVitamin DOocyte quantityOvarian agingFollicular depletionFollicular fluidIntraovarian regulatorsRodent studiesHealthy oocytesNarrative reviewReproductive agingPotential modifiersCumulus cellsGrowth factorFactor 1Mitochondrial functionOutcomesThe Effect of Aerobic Training and Cholecalciferol on IGF-I and IGFBP-3 in the Bone Tissue of Rats Poisoned with Hydrogen Peroxide
Eimari Eskandari R, Matinhomaee H, Moradi L. The Effect of Aerobic Training and Cholecalciferol on IGF-I and IGFBP-3 in the Bone Tissue of Rats Poisoned with Hydrogen Peroxide. Jentashapir Journal Of Cellular And Molecular Biology 2022, 13 DOI: 10.5812/jjcmb-130129.Peer-Reviewed Original ResearchExpression of IGF-IGene expression of IGF-IIGFBP-3Bone tissue of ratsIGF-IEffects of aerobic trainingTissues of ratsVitamin DLevels of IGF-IGrowth factorAerobic trainingIGFBP-3 expressionIncreased bone turnoverReduce bone lossImprove bone densityInteractive effects of Aerobic trainingBonferroni post hoc testAdult Wistar ratsBody weightGene expressionReal-time (RT)-PCRPost Hoc AnalysisPost hoc testBone tissueBone turnoverDiffering effects of oral conjugated equine estrogen and transdermal estradiol on vitamin D metabolism in postmenopausal women: a 4-year longitudinal study
Santoro AM, Simpson CA, Cong E, Haas A, Sullivan RR, Parziale S, Deng Y, Insogna KL. Differing effects of oral conjugated equine estrogen and transdermal estradiol on vitamin D metabolism in postmenopausal women: a 4-year longitudinal study. Menopause The Journal Of The North American Menopause Society 2022, 29: 1200-1203. PMID: 35969885, DOI: 10.1097/gme.0000000000002045.Peer-Reviewed Original ResearchConceptsTransdermal estradiol groupConjugated equine estrogensVitamin D metabolismTransdermal estradiolEquine estrogensPostmenopausal womenEstradiol groupTreatment armsD metabolismVitamin DD levelsKronos Early Estrogen Prevention StudyConjugated equine estrogen groupOral conjugated equine estrogenVitamin D insufficientLeast square mean valuesEstrogen groupMicronized progesteroneEstrogen replacementPrevention StudySignificant treatment effectStudy groupTreatment groupsShort-term benefitsTreatment assignment
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