2024
Nanoparticle-Binding Immunoglobulins Predict Variable Complement Responses in Healthy and Diseased Cohorts
Li Y, Saba L, Scheinman R, Banda N, Holers M, Monte A, Dylla L, Moghimi S, Simberg D. Nanoparticle-Binding Immunoglobulins Predict Variable Complement Responses in Healthy and Diseased Cohorts. ACS Nano 2024, 18: 28649-28658. PMID: 39395006, PMCID: PMC11651220, DOI: 10.1021/acsnano.4c05087.Peer-Reviewed Original ResearchConceptsPegylated Liposomal DoxorubicinComplement activationPredictive valuePlasma concentrationsC-reactive protein levelsAnti-PEG IgGTriggers proinflammatory responsesAnti-PEG IgMEfficacy of nanomedicinesPoor predictive valueAnti-PEG antibodiesLiposomal doxorubicinIron oxide nanowormsHealthy donorsHigher complement activationAcute infectionInflammatory disease conditionsChronic inflammationProinflammatory responseSystemic administrationComplement cascadeComplement factorsComplement responseIgMProtein levelsDetection of Chikungunya Virus RNA in Oral Fluid and Urine: An Alternative Approach to Diagnosis?
Jacob-Nascimento L, Portilho M, Anjos R, Moreira P, Stauber C, Weaver S, Kitron U, Reis M, Ribeiro G. Detection of Chikungunya Virus RNA in Oral Fluid and Urine: An Alternative Approach to Diagnosis? Viruses 2024, 16: 235. PMID: 38400011, PMCID: PMC10891727, DOI: 10.3390/v16020235.Peer-Reviewed Original ResearchConceptsChikungunya virus infectionAcute-phase seraOral fluidChikungunya virusIgM seroconversionChikungunya virus diagnosisUrine samplesAcute febrile illnessConvalescent-phase seraAcute chikungunyaChikungunya patientsChikungunya virus RNADisease courseFebrile illnessPaired seraRT-qPCRAcute phaseIgM detectionConvalescent-phasePatientsControl group samplesSerumUrineCHIKV transmissionIgM
2019
What B cell memories are made of
Tomayko MM, Allman D. What B cell memories are made of. Current Opinion In Immunology 2019, 57: 58-64. PMID: 30861463, DOI: 10.1016/j.coi.2019.01.003.Peer-Reviewed Original ResearchConceptsMemory B cellsB cell memoryB cellsPlasma cellsCell memoryAntigen-specific B cell receptorProtective serum antibodiesB cell receptorHumoral immunityIgG antibodiesSerum antibodiesSecondary exposureCell receptorUltimate outcomeAntigenAntibodiesMolecular eventsSame cellular pathwaysCellsCellular pathwaysIgMPathwayImmunityReceptors
2018
Elevated IgM against Nε-(Carboxyethyl)lysine-modified Apolipoprotein A1 peptide 141–147 in Taiwanese with Alzheimer's disease
Lin CY, Sheu JJ, Tsai IS, Wang ST, Yang LY, Hsu IU, Chang HW, Lee HM, Kao SH, Lee CK, Chen CH, Lin YF. Elevated IgM against Nε-(Carboxyethyl)lysine-modified Apolipoprotein A1 peptide 141–147 in Taiwanese with Alzheimer's disease. Clinical Biochemistry 2018, 56: 75-82. PMID: 29680706, DOI: 10.1016/j.clinbiochem.2018.04.009.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAlzheimer DiseaseAntibody SpecificityApolipoprotein A-IAutoantibodiesAutoimmunityBiomarkersCase-Control StudiesEnzyme-Linked Immunosorbent AssayFemaleGlycation End Products, AdvancedHumansImmunoglobulin MLysineMalePeptide FragmentsProtein Processing, Post-TranslationalPsychiatric Status Rating ScalesROC CurveTaiwanUp-RegulationConceptsAdvanced glycation end productsSpecific advanced glycation end productsAlzheimer's diseaseMini-Mental State Examination scoreMental State Examination scoreEarly AD markersEarly AD pathologyState Examination scoreEarly disease statesGlycation end productsRelated autoantibodiesAD markersIgM levelsAD pathologyElevated IgMAD seraAD patientsDisease progressionAD biomarkersApolipoprotein A1IgMAutoantibodiesApoA1Serum samplesWestern blotting
2017
Seroprevalence of Chikungunya Virus in a Rural Community in Brazil
Cunha R, Trinta K, Montalbano C, Sucupira M, de Lima M, Marques E, Romanholi I, Croda J. Seroprevalence of Chikungunya Virus in a Rural Community in Brazil. PLOS Neglected Tropical Diseases 2017, 11: e0005319. PMID: 28107342, PMCID: PMC5287455, DOI: 10.1371/journal.pntd.0005319.Peer-Reviewed Original ResearchConceptsCases of chikungunyaCHIKV infectionChikungunya virusCHIKV IgMSymptomatic CHIKV infectionIgM-specific antibodiesFeira de SantanaIgG-specific antibodiesEpidemiological surveillance systemBrazilian Epidemiological Surveillance SystemCHIKV IgGModerate seroprevalenceSeropositive patientsJoint painIgG antibodiesCHIKV transmissionFirst serosurveySeroprevalenceInfectionMagnitude of transmissionAntibodiesPatientsFirst caseSerosurveyIgM
2016
Immunoglobulin M for Acute Infection: True or False?
Landry ML. Immunoglobulin M for Acute Infection: True or False? MSphere 2016, 23: 540-545. PMID: 27193039, PMCID: PMC4933779, DOI: 10.1128/cvi.00211-16.Peer-Reviewed Original ResearchConceptsClear clinical utilityFalse-positive IgMImmunoglobulin M testAcute infectionInappropriate therapyFalse-positive resultsDiagnostic workupEpidemiologic findingsIgM detectionInfection controlClinical utilityImmunoglobulin MSerial samplesAccurate diagnosisPremature closurePublic healthTherapyNumerous reportsDiagnosisPatientsPrognosisIgMWorkupInfectionClinicians
2015
Contactin-1 and Neurofascin-155/-186 Are Not Targets of Auto-Antibodies in Multifocal Motor Neuropathy
Doppler K, Appeltshauser L, Krämer HH, Ng JK, Meinl E, Villmann C, Brophy P, Dib-Hajj SD, Waxman SG, Weishaupt A, Sommer C. Contactin-1 and Neurofascin-155/-186 Are Not Targets of Auto-Antibodies in Multifocal Motor Neuropathy. PLOS ONE 2015, 10: e0134274. PMID: 26218529, PMCID: PMC4517860, DOI: 10.1371/journal.pone.0134274.Peer-Reviewed Original ResearchConceptsMultifocal motor neuropathyMotor neuropathyContactin-1Neurofascin 155Multifocal motor neuropathy patientsChronic inflammatory demyelinating polyneuropathyInflammatory demyelinating polyneuropathySubgroup of patientsNeurofascin-186Enzyme-linked immunosorbentHuman embryonic kidney 293 cellsDemyelinating polyneuropathyAuto antibodiesEmbryonic kidney 293 cellsMuscle weaknessNeuropathy patientsPatient seraConduction blockParanodal proteinsNeuropathyPatientsKidney 293 cellsIgMSerumDifferent assays
2014
Lasting Antibody Responses Are Mediated by a Combination of Newly Formed and Established Bone Marrow Plasma Cells Drawn from Clonally Distinct Precursors
Chernova I, Jones DD, Wilmore JR, Bortnick A, Yucel M, Hershberg U, Allman D. Lasting Antibody Responses Are Mediated by a Combination of Newly Formed and Established Bone Marrow Plasma Cells Drawn from Clonally Distinct Precursors. The Journal Of Immunology 2014, 193: 4971-4979. PMID: 25326027, PMCID: PMC4234148, DOI: 10.4049/jimmunol.1401264.Peer-Reviewed Original ResearchConceptsBM plasma cellsPlasma cellsLong-term Ab responsesLong-term humoral responseBone marrow plasma cellsT cell-dependent AgSerum Ab titersIgG-secreting cellsRole of subpopulationsMarrow plasma cellsActivated B cellsPC poolAb titersHumoral responseAntibody responseIgG AbsAb responsesL chain usageIgM AbsB cellsHapten-protein conjugatesPC subsetsChain usageIgM
2013
Management Problems of Trans-Frontier Yellow Fever Cases in Burkina Faso 2010
Yaro S, Ouoba A, Zango A, Rouamba J, Drabo A, Ouangraoua S, Samandoulougou-Kirakoya F, Macq J, Robert A, Ouedraogo J. Management Problems of Trans-Frontier Yellow Fever Cases in Burkina Faso 2010. Advances In Infectious Diseases 2013, 2013: 84-88. DOI: 10.4236/aid.2013.32013.Peer-Reviewed Original ResearchHealth districtYellow feverYellow fever casesIvory CostNational Reference LaboratorySpecific IgMHealth centersFever casesPositive seraHealth authoritiesCase management problemsConfirmed casesFeverELISA testRT-PCRReference laboratoryPasteur InstituteRegional laboratoriesBurkina FasoPositive resultsSerumRelative lackCasesIgMSindou
2008
BLyS inhibition eliminates primary B cells but leaves natural and acquired humoral immunity intact
Scholz JL, Crowley JE, Tomayko MM, Steinel N, O'Neill PJ, Quinn WJ, Goenka R, Miller JP, Cho YH, Long V, Ward C, Migone TS, Shlomchik MJ, Cancro MP. BLyS inhibition eliminates primary B cells but leaves natural and acquired humoral immunity intact. Proceedings Of The National Academy Of Sciences Of The United States Of America 2008, 105: 15517-15522. PMID: 18832171, PMCID: PMC2563088, DOI: 10.1073/pnas.0807841105.Peer-Reviewed Original ResearchConceptsMemory B cellsAntibody-secreting cellsB cellsImmune responseAntigen-experienced B cellsSecondary immune responsePrimary immune responseB cell numbersPeritoneal B1 cellsHumoral immunityPrimary B cellsPlasma cellsB1 cellsNaïve cellsCell numberMemory poolMemory cellsCellsCytokinesIgMImmunityPreimmuneAntibodiesBLySResponseIdentification of Initiator B Cells, a Novel Subset of Activation-Induced Deaminase-Dependent B-1-Like Cells That Mediate Initiation of Contact Sensitivity
Kerfoot SM, Szczepanik M, Tung JW, Askenase PW. Identification of Initiator B Cells, a Novel Subset of Activation-Induced Deaminase-Dependent B-1-Like Cells That Mediate Initiation of Contact Sensitivity. The Journal Of Immunology 2008, 181: 1717-1727. PMID: 18641308, DOI: 10.4049/jimmunol.181.3.1717.Peer-Reviewed Original ResearchConceptsContact sensitivityB cellsCS initiationInflammatory responseT cell-mediated inflammationProinflammatory T cellsCell-mediated inflammationAdoptive transfer experimentsDelayed-type hypersensitivityAg-specific IgMReceptor gene mutationsSensitized miceVascular activationDeficient recipientsT cellsNovel subsetSomatic hypermutationNovel subpopulationGene mutationsIgMMiceActivation-induced deaminaseWT cellsCellsChain gene
2006
Immunogenic gangliosides in human ovarian carcinoma
Ravindranath MH, Muthugounder S, Presser N, Selvan SR, Santin AD, Bellone S, Saravanan TS, Morton DL. Immunogenic gangliosides in human ovarian carcinoma. Biochemical And Biophysical Research Communications 2006, 353: 251-258. PMID: 17188646, DOI: 10.1016/j.bbrc.2006.12.001.Peer-Reviewed Original ResearchConceptsOEC patientsAscitic fluidGD1a IgMTotal ganglioside levelsPlasma of patientsOvarian epithelial cancer cell linesExpression of GM3Human ovarian carcinomaEpithelial cancer cell linesCancer cell linesPresence of GM3IgM responseIgM titersOvarian carcinomaPresence of GD1aHealthy volunteersSame patientPatientsSignificant expressionCell linesIgMGD1aTitersPositive correlationGM1b
2004
The Occurrence of Antibodies to Components of the Natural Coagulation Inhibitor System, Protein Z and Protheombin in Normal Pregnancy.
Ku D, Arkel Y, Paidas M, Triche E, Huang S, Musto J, Lockwood C. The Occurrence of Antibodies to Components of the Natural Coagulation Inhibitor System, Protein Z and Protheombin in Normal Pregnancy. Blood 2004, 104: 3995. DOI: 10.1182/blood.v104.11.3995.3995.Peer-Reviewed Original ResearchNon-pregnant controlsAnti-PC IgMAdverse pregnancy outcomesNormal pregnancyIgM antibodiesPS IgGOccurrence of antibodiesAnticardiolipin syndromeProthrombotic processesPregnancy outcomesAntibody levelsMost pregnanciesAutoimmune diseasesAntibody responseIgG antibodiesHemostatic balanceImmune responseTrimesterCoagulation factorsChronic responsesPregnancyIgMIgGGestationAntibodies
2001
Reactivity of serum samples of dogs and horses tested by use of class-specific recombinant-based enzyme-linked immunosorbent assays for detection of granulocytic ehrlichiosis.
Magnarelli LA, Ijdo JW, Van Andel AE, Wu C, Oliver JH, Fikrig E. Reactivity of serum samples of dogs and horses tested by use of class-specific recombinant-based enzyme-linked immunosorbent assays for detection of granulocytic ehrlichiosis. American Journal Of Veterinary Research 2001, 62: 1365-9. PMID: 11560261, DOI: 10.2460/ajvr.2001.62.1365.Peer-Reviewed Original ResearchConceptsIgG antibodiesSerum samplesHGE agentGranulocytic ehrlichiosisClient-owned dogsDog serum samplesHuman granulocytic ehrlichiosis (HGE) agentEnzyme-linked immunosorbentPositive resultsWestern blot analysisTick-infested areasEhrlichia phagocytophila genogroupTotal immunoglobulinHorse serum samplesPromyelocytic leukemia cellsClinical relevanceHuman promyelocytic leukemia cellsProtein antigensIgMELISADogsLeukemia cellsAntibodiesBlot analysisAntigen
1998
Pulmonary Immunocytoma With Massive Crystal Storing Histiocytosis
Prasad M, Charney D, Sarlin J, Keller S. Pulmonary Immunocytoma With Massive Crystal Storing Histiocytosis. The American Journal Of Surgical Pathology 1998, 22: 1148-1153. PMID: 9737249, DOI: 10.1097/00000478-199809000-00015.Peer-Reviewed Case Reports and Technical NotesConceptsImmunoglobulin M antibodiesLymphoid tissue lymphomaMarginal zone lymphomaB-cell originCrystal-storing histiocytesLymphoplasmacytic aggregatesLymph nodesLymphoplasmacytoid cellsTissue lymphomaReactive histiocytesRight lungAltered intraBronchial mucosaM antibodiesCrystal-Storing HistiocytosisLymphoplasmacytic disordersExcessive productionMore casesSame antibodyHistiocytesLymphomaImmunocytomaLungIgMType I
1997
The Early Humoral Response in Human Granulocytic Ehrlichiosis
IJdo J, Zhang Y, Hodzic E, Magnarelli L, Wilson M, Telford S, Barthold S, Fikrig E. The Early Humoral Response in Human Granulocytic Ehrlichiosis. The Journal Of Infectious Diseases 1997, 176: 687-692. PMID: 9291316, DOI: 10.1086/514091.Peer-Reviewed Original ResearchConceptsHuman granulocytic ehrlichiosisAntibody responseGranulocytic ehrlichiosisHGE agentC3H/HeJ miceEarly humoral responseEarly antibody responseStrong antibody responseHumoral responseHeJ miceClinical infectionPatientsAntigenHL-60 cellsMiceInfectionIgGEhrlichiosisSerumWeeksResponseIgMAgentsDiseaseDiagnosisA survey for antibodies to Lassa virus among health workers in Nigeria
Bajani M, Tomori O, Rollin P, Harry T, Bukbuk N, Wilson L, Childs J, Peters C, Ksiazek T. A survey for antibodies to Lassa virus among health workers in Nigeria. Transactions Of The Royal Society Of Tropical Medicine And Hygiene 1997, 91: 379-381. PMID: 9373625, DOI: 10.1016/s0035-9203(97)90247-9.Peer-Reviewed Original ResearchConceptsHealth workersAntibody prevalenceHealth facilitiesSecondary health facilitiesVirus IgM antibodiesImmunoglobulin G antibodiesEnzyme-linked immunosorbentTertiary centerSpecific IgMIgM antibodiesRecent infectionHealth centersG antibodiesLassa feverLassa virusDifferent occupational groupsPrevalenceAntibodiesOccupational groupsFeverSeroprevalenceIgMInfectionWorkersNurses
1989
Class-specific and polyvalent enzyme-linked immunosorbent assays for detection of antibodies to Borrelia burgdorferi in equids.
Magnarelli L, Anderson J. Class-specific and polyvalent enzyme-linked immunosorbent assays for detection of antibodies to Borrelia burgdorferi in equids. Journal Of The American Veterinary Medical Association 1989, 195: 1365-8. PMID: 2684937, DOI: 10.2460/javma.1989.195.10.1365.Peer-Reviewed Original ResearchConceptsPolyvalent ELISATick-infested areas of ConnecticutTick-infested areasPolyvalent enzyme-linked immunosorbent assayEquine serumAntibodies to Borrelia burgdorferiAreas of ConnecticutEnzyme-linked immunosorbent assayELISA procedureBlood samplesIgM antibodiesDetect IgM antibodiesImmunosorbent assayPoniesHorsesEquineEquidsELISAIgG antibodiesIgMSerumDetection of antibodies to Borrelia burgdorferiPolyvalentSeropositivityAntibodies
1986
Antigens of Borrelia burgdorferi recognized during Lyme disease. Appearance of a new immunoglobulin M response and expansion of the immunoglobulin G response late in the illness.
Craft JE, Fischer DK, Shimamoto GT, Steere AC. Antigens of Borrelia burgdorferi recognized during Lyme disease. Appearance of a new immunoglobulin M response and expansion of the immunoglobulin G response late in the illness. Journal Of Clinical Investigation 1986, 78: 934-939. PMID: 3531237, PMCID: PMC423723, DOI: 10.1172/jci112683.Peer-Reviewed Original ResearchConceptsIgG responsesIgM responseEarly diseaseLyme diseaseImmunoglobulin M responseImmunoglobulin G responseBorrelia burgdorferiSpirochetal antigensG responsesIgG antibodiesProlonged illnessPatientsM responseIllnessDiseaseAntigenB. burgdorferiMonthsLimited responseIgMBurgdorferiSuch responsesResponseArthritisYearsThe Role of Parvovirus B19 in Aplastic Crisis and Erythema Infectiosum (Fifth Disease)
Chorba T, Coccia P, Holman R, Tattersall P, Anderson L, Sudman J, Young N, Kurczynski E, Saarinen U, Moir R, Lawrence D, Jason J, Evatt B. The Role of Parvovirus B19 in Aplastic Crisis and Erythema Infectiosum (Fifth Disease). The Journal Of Infectious Diseases 1986, 154: 383-393. PMID: 3016109, DOI: 10.1093/infdis/154.3.383.Peer-Reviewed Original ResearchConceptsErythema infectiosumAplastic crisisParvovirus B19B19-specific IgMSecondary attack rateSimultaneous outbreaksThroat garglesB19 infectionClinical entityRecent infectionAsymptomatic infectionSusceptible contactsPatientsInfectionB19Attack rateSerumComparison groupIgMHousehold membersOutbreakGargleEpidemiologyUrine
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