2025
Vitamin D supplementation in pregnant or breastfeeding women or young children for preventing asthma
Patchen B, Best C, Boiteau J, Solvik B, Vonderschmidt A, Xu J, Cohen R, Cassano P. Vitamin D supplementation in pregnant or breastfeeding women or young children for preventing asthma. Cochrane Database Of Systematic Reviews 2025, 2025: cd013396. PMID: 40792481, PMCID: PMC12341026, DOI: 10.1002/14651858.cd013396.pub2.Peer-Reviewed Original ResearchConceptsHigh-dose vitamin DDose vitamin DVitamin D supplementationEffect of vitamin D supplementationAirway infectionD supplementationChildhood asthmaAirway inflammationAdverse eventsVitamin DAtopic dermatitisBreastfeeding womenChildhood wheezingEarly childhood asthmaRandomised controlled studySystematic reviewCochrane riskAllergic sensitisationHigh-dose vitamin D supplementationRisk of childhood wheezeRisk of vitamin D deficiencyEfficacy of vitamin D supplementationMeta-analysesRisk ratioCochrane risk of bias toolResiding in a low-income-low-food-access neighbourhood and asthma in early and middle childhood in the Environmental influences on Child Health Outcomes (ECHO) program: a multisite cohort study
Wang V, Habre R, Ryan P, Datta S, Luttmann-Gibson H, Blossom J, Aris I, Chandran A, Kress A, Gilliland F, Breton C, Farzan S, Camargo C, Liang D, Kerver J, Karr C, Leve L, Dabelea D, Karagas M, Bennett D, Nkoy F, Aschner J, O’Shea T, McEvoy C, Knapp E, Schuh H, Miller R, Gold D, Zanobetti A, Smith P, Newby L, Adair L, Jacobson L, Catellier D, McGrath M, Douglas C, Duggal P, Knapp E, Kress A, Blackwell C, Mansolf M, Lai J, Ho E, Cella D, Gershon R, Macy M, Das S, Freedman J, Mallal S, McLean J, Shah R, Shilts M, Alshawabkeh A, Cordero J, Meeker J, Trasande L, Camargo C, Hasegawa K, Zhu Z, Sullivan A, Dabelea D, Perng W, Bekelman T, Wilkening G, Magzamen S, Moore B, Starling A, Rinehart D, Koinis-Mitchell D, D'Sa V, Deoni S, Mueller H, Duarte C, Monk C, Canino G, Posner J, Murray T, Lugo-Candelas C, Dunlop A, Brennan P, Hockett C, Elliott A, Ferrara A, Croen L, Hedderson M, Ainsworth J, Bacharier L, Bendixsen C, Gern J, Gold D, Hartert T, Jackson D, Johnson C, Joseph C, Kattan M, Hershey G, Jackson D, Lemanske R, Lynch S, Miller R, O’Connor G, Ober C, Ownby D, Rivera-Spoljaric K, Ryan P, Seroogy C, Singh A, Wood R, Zoratti E, Habre R, Farzan S, Gilliland F, Hertz-Picciotto I, Bennett D, Schweitzer J, Schmidt R, LaSalle J, Hipwell A, Keenan K, Karr C, Bush N, LeWinn K, Sathyanarayana S, Zhao Q, Tylavsky F, Carroll K, Loftus C, Leve L, Ganiban J, Neiderhiser J, Weiss S, Litonjua A, McEvoy C, Spindel E, Tepper R, Newschaffer C, Lyall K, Volk H, Landa R, Ozonoff S, Piven J, Hazlett H, Pandey J, Schultz R, Dager S, Botteron K, Messinger D, Stone W, Ames J, O'Connor T, Miller R, Oken E, Hacker M, James-Todd T, O'Shea T, Fry R, Frazier J, Singh R, Rollins C, Montgomery A, Vaidya R, Joseph R, Washburn L, Gogcu S, Bear K, Rollins J, Hooper S, Taylor G, Jackson W, Thompson A, Daniels J, Hernandez M, Lu K, Msall M, Lenski M, Obeid R, Pastyrnak S, Jensen E, Sakai C, Santos H, Kerver J, Paneth N, Barone C, Elliott M, Ruden D, Fussman C, Herbstman J, Margolis A, Schantz S, Geiger S, Aguiar A, Tabb K, Strakovsky R, Woodruff T, Morello-Frosch R, Padula A, Stanford J, Porucznik C, Giardino A, Wright R, Wright R, Collett B, Baumann-Blackmore N, Gangnon R, McKennan C, Wilson J, Altman M, Aschner J, Stroustrup A, Merhar S, Moore P, Pryhuber G, Hudak M, Lyndaker A, Lampland A, Rochelson B, Jan S, Blitz M, Katzow M, Brown Z, Chiuzan C, Rafael T, Lewis D, Meirowitz N, Poindexter B, Gebretsadik T, Osmundson S, Straughen J, Eapen A, Cassidy-Bushrow A, Wegienka G, Sitarik A, Woodcroft K, Urquhart A, Levin A, Johnson-Hooper T, Davidson B, Ma T, Barrett E, Blaser M, Dominguez-Bello M, Horton D, Jimenez M, Rosen T, Palomares K, Avalos L, Zhu Y, Hunt K, Newman R, Bloom M, Alkis M, Roberts J, Mumford S, Burris H, DeMauro S, Yee L, Hamvas A, Olidipo A, Haddad A, Eiland L, Spillane N, Suri K, Fisher S, Goldstein J, Mithal L, DeRegnier R, Maitre N, Nguyen R, JaKa M, Sidebottom A, Paidas M, Potter J, Ruby N, Duthely L, Jayakumar A, Young K, Maldonado I, Miller M, Slaughter J, Keim S, Lynch C, Venkatesh K, Whitworth K, Symanski E, Northrup T, Mendez-Figueroa H, Mosquera R, Karagas M, Madan J, MacKenzie D, Lewis J, Rennie B, Leventhal B, Kim Y, Bishop S, Nozadi S, Luo L, Lester B, Marsit C, Everson T, Loncar C, McGowan E, Sheinkopf S, Carter B, Check J, Helderman J, Neal C, Smith L. Residing in a low-income-low-food-access neighbourhood and asthma in early and middle childhood in the Environmental influences on Child Health Outcomes (ECHO) program: a multisite cohort study. BMJ Open 2025, 15: e094317. PMID: 40588377, PMCID: PMC12211854, DOI: 10.1136/bmjopen-2024-094317.Peer-Reviewed Original ResearchConceptsLow maternal educationAsthma incidenceMaternal educationRural areasParental historyRisk of childhood asthmaCohort studyParental history of asthmaChild health outcomesChildhood asthma incidenceLow food accessLower food insecurityProspective cohort studyHistory of asthmaAge 5 yearsHealth outcomesFood optionsChildhood asthmaCensus tractsHispanic childrenLow-incomeAffordable foodChild sexHazard ratioGestational smokingTMEM16A Antagonism: Therapeutic Potential with Desensitization of β-Agonist Responsiveness in Asthma.
Wu A, Kuforiji A, Zhang Y, Xu D, Perez-Zoghbi J, Emala C, Danielsson J. TMEM16A Antagonism: Therapeutic Potential with Desensitization of β-Agonist Responsiveness in Asthma. American Journal Of Respiratory Cell And Molecular Biology 2025, 72: 510-519. PMID: 39560606, PMCID: PMC12051930, DOI: 10.1165/rcmb.2024-0231oc.Peer-Reviewed Original ResearchConceptsAirway smooth muscleHuman ASM cellsTMEM16A antagonistsFunctional desensitizationASM cellsB-adrenoceptorB agonistAirway smooth muscle relaxationHuman airway smooth muscleRelaxes airway smooth muscleCalcium-activated chloride channelBronchial airway smooth muscleTransmembrane member 16AMurine airway smooth muscleContractility studiesWire myographyChronic pretreatmentAcute antagonismContractile mediatorsPrevented desensitizationSmooth muscleUpper airwayCAMP productionChloride channelsTMEM16AChild Opportunity Index at birth and asthma with recurrent exacerbations in the US ECHO program
Miller R, Schuh H, Chandran A, Habre R, Angal J, Aris I, Aschner J, Bendixsen C, Blossom J, Bosquet-Enlow M, Breton C, Camargo C, Carroll K, Commodore S, Croen L, Dabelea D, Deoni S, Ferrara A, Fry R, Ganiban J, Geiger S, Gern J, Gilliland F, Gogcu S, Gold D, Hare M, Harte R, Hartert T, Hertz-Picciotto I, Hipwell A, Jackson D, Karagas M, Hershey G, Kim H, Litonjua A, Marsit C, McEvoy C, Mendonça E, Moore P, Nguyen A, Nkoy F, O’Connor T, Oken E, Ownby D, Perzanowski M, Rivera-Spoljaric K, Sathyanarayana S, Singh A, Stanford J, Stroustrup A, Towe-Goodman N, Wang V, Woodruff T, Wright R, Wright R, Zanobetti A, Zoratti E, Johnson C, Consortium E, D'Sa V, Mueller H, Duarte C, Monk C, Canino G, Posner J, Murray T, Lugo-Candelas C, Dunlop A, Brennan P, Hockett C, Elliott A, Hedderson M, Ainsworth J, Bacharier L, Bendixsen C, Joseph C, Kattan M, Lemanske R, Lynch S, O’Connor G, Ober C, Ryan P, Seroogy C, Wood R, Farzan S, Bennett D, Schweitzer J, Schmidt R, LaSalle J, Keenan K, Karr C, Bush N, LeWinn K, Zhao Q, Tylavsky F, Loftus C, Leve L, Neiderhiser J, Weiss S, Litonjua A, Spindel E, Tepper R, Newschaffer C, Lyall K, Volk H, Landa R, Ozonoff S, Piven J, Hazlett H, Pandey J, Schultz R, Dager S, Botteron K, Messinger D, Stone W, Ames J, Miller R, Hacker M, James-Todd T, O'Shea T, Frazier J, Singh R, Rollins C, Montgomery A, Vaidya R, Joseph R, Washburn L, Bear K, Rollins J, Hooper S, Taylor G, Jackson W, Thompson A, Daniels J, Hernandez M, Lu K, Msall M, Lenski M, Obeid R, Pastyrnak S, Jensen E, Sakai C, Santos H, Kerver J, Paneth N, Barone C, Elliott M, Ruden D, Fussman C, Herbstman J, Margolis A, Schantz S, Aguiar A, Tabb K, Strakovsky R, Morello-Frosch R, Padula A, Porucznik C, Giardino A, Collett B, Baumann-Blackmore N, Gangnon R, McKennan C, Wilson J, Altman M, Merhar S, Pryhuber G, Hudak M, Lyndaker A, Lampland A, Rochelson B, Jan S, Blitz M, Katzow M, Brown Z, Chiuzan C, Rafael T, Lewis D, Meirowitz N, Poindexter B, Gebretsadik T, Osmundson S, Straughen J, Eapen A, Cassidy-Bushrow A, Wegienka G, Sitarik A, Urquhart A, Levin A, Johnson-Hooper T, Davidson B, Ma T, Barrett E, Blaser M, Dominguez-Bello M, Horton D, Jimenez M, Rosen T, Palomares K, Avalos L, Zhu Y, Hunt K, Newman R, Bloom M, Alkis M, Roberts J, Mumford S, Burris H, DeMauro S, Yee L, Hamvas A, Olidipo A, Haddad A, Eiland L, Spillane N, Suri K, Fisher S, Goldstein J, Mithal L, DeRegnier R, Maitre N, Nguyen R, JaKa M, Sidebottom A, Paidas M, Potter J, Ruby N, Duthely L, Jayakumar A, Young K, Maldonado I, Miller M, Slaughter J, Keim S, Lynch C, Venkatesh K, Whitworth K, Symanski E, Northrup T, Mendez-Figueroa H, Mosquera R, Madan J, MacKenzie D, Lewis J, Rennie B, Leventhal B, Kim Y, Bishop S, Nozadi S, Luo L, Lester B, Everson T, Loncar C, McGowan E, Sheinkopf S, Carter B, Check J, Helderman J, Neal C, Smith L. Child Opportunity Index at birth and asthma with recurrent exacerbations in the US ECHO program. Journal Of Allergy And Clinical Immunology 2025, 156: 627-639. PMID: 40089117, PMCID: PMC12353621, DOI: 10.1016/j.jaci.2025.02.036.Peer-Reviewed Original ResearchConceptsChild Opportunity IndexParental history of asthmaHistory of asthmaIncidence rateParental historyNon-Hispanic white childrenChildren aged 2 to 4 yearsWhite childrenChildhood asthma phenotypesUnder-resourced communitiesRisk associated with raceOpportunity IndexAged 2 to 4 yearsHighest incidence of casesIndividual-level characteristicsECHO programSocial determinantsNeighborhood opportunityEffect modifiersSocial disadvantageHigher incidenceIR ratioEnvironmental exposuresRecurrent exacerbationsBlack childrenMaintenance of an Asthma Intervention Post-Trial: Use of a Patient-Activated Reliever-Triggered Inhaled Corticosteroid (PARTICS) Strategy in Black and Latinx Patients
Cardet J, Bailey J, Hurley L, Maher N, Staton E, Yawn B, Zaeh S, Israel E, investigators; O, Apter A, Bradford P, Calderon-Candelario R, Carroll J, Chupp G, Cohen R, Ericson B, Fuhlbrigge A, Kaplan B, Kruse J, Nazario S, Pace W, Pasarica M, Phipatanakul W, Riley I, Rodriguez-Louis J, Shenoy K, Stranges P, Tapp H, Wechsler M. Maintenance of an Asthma Intervention Post-Trial: Use of a Patient-Activated Reliever-Triggered Inhaled Corticosteroid (PARTICS) Strategy in Black and Latinx Patients. The Journal Of The American Board Of Family Medicine 2025, 38: 378-382. PMID: 40578913, DOI: 10.3122/jabfm.2024.240014r2.Peer-Reviewed Original ResearchConceptsShort-acting beta-agonistsPost-trialUsual carePatients' perceptionsTrial participantsHealthcare system levelPatient perception of efficacyModerate-severe asthmaYears post-trialCare cliniciansInhaled CorticosteroidsLatinx adultsLatinx patientsTrial exitInsurance coveragePerceptions of efficacyAsthma exacerbationsCareAsthmaParticipantsBeta-agonistsLatinxCorticosteroidsPatientsHealthcareβ-Ionone facilitates ex vivo airway smooth muscle relaxation via extraocular opsin-3 light receptor activation
Uribe S, Shany E, Zhang Y, Wu A, Dan W, Perez-Zoghbi J, Emala C, Yim P. β-Ionone facilitates ex vivo airway smooth muscle relaxation via extraocular opsin-3 light receptor activation. American Journal Of Physiology - Lung Cellular And Molecular Physiology 2025, 328: l526-l537. PMID: 39937635, DOI: 10.1152/ajplung.00227.2024.Peer-Reviewed Original ResearchConceptsAirway smooth muscle relaxationOpsin 3Severity of asthma exacerbationsAirway smooth muscle cellsDose-dependent relaxationTherapeutic agentsAirways in vitroPrecision-cut lung slicesSmooth muscle relaxationSmooth muscle cellsAttenuated relaxationWire myographyDietary intakeDecreased relaxationAirway pathologyIncreased riskReceptor activationAsthma exacerbationsMuscle cellsLower airwaysLung slicesMRNA expressionMuscle relaxationTracheal ringsAirwayThe Interplay Between Respiratory Syncytial Virus and Asthma Inception: Insights Gained From the COVID‐19 Pandemic
Amram T, Duek O, Golan‐Tripto I, Goldbart A, Greenberg D, Hazan G. The Interplay Between Respiratory Syncytial Virus and Asthma Inception: Insights Gained From the COVID‐19 Pandemic. Pediatric Pulmonology 2025, 60: e27474. PMID: 39760467, PMCID: PMC11748096, DOI: 10.1002/ppul.27474.Peer-Reviewed Original ResearchConceptsRespiratory syncytial virusYears of ageSyncytial virusRespiratory syncytial virus bronchiolitisRespiratory syncytial virus infectionRespiratory syncytial virus exposureRSV-induced inflammationRespiratory syncytial virus activityMultivariate logistic regressionAirway changesAsthma inceptionRetrospective studyAsthma surrogateIncreased riskLogistic regressionAsthmaCause of asthmaCOVID-19 pandemicHealthcare organizationsPredispositionIncreased rateChildrenCOVID-19AgeVirus
2024
Guben Kechuan granule attenuates bronchial asthma by inhibiting NF-κB/STAT3 signaling pathway-mediated apoptosis
Dai C, Liu D, Qin C, Fang J, Cheng G, Xu C, Wang Q, Lu T, Guo Z, Wang J, Zhong T, Guo Q. Guben Kechuan granule attenuates bronchial asthma by inhibiting NF-κB/STAT3 signaling pathway-mediated apoptosis. Journal Of Ethnopharmacology 2024, 340: 119124. PMID: 39694430, DOI: 10.1016/j.jep.2024.119124.Peer-Reviewed Original ResearchConceptsTranscription factor STAT3Bcl-2 expressionAlveolar lavage samplesNF-kBBronchial asthmaBcl-2Caspase-3 expressionProteomic analysisProteomic resultsCaspase-3Rat model of bronchial asthmaRat modelSignaling pathwayAsthma-induced airway inflammationOxidative-stress damageApoptosisModel of bronchial asthmaInflammatory cell infiltrationTranscriptionSTAT3Oxidative-stressCytokines TNF-aOxidative stress damageAirway inflammationIL-5Research Priorities in Pediatric Asthma Morbidity: Addressing the Impacts of Systemic Racism on Children with Asthma in the United States. An Official American Thoracic Society Workshop Report
Lovinsky-Desir S, Riley I, Bryant-Stephens T, De Keyser H, Forno E, Kozik A, Louisias M, Matsui E, Sheares B, Thakur N, Apter A, Beck A, Bentley-Edwards K, Berkowitz C, Braxton C, Dean J, Jones C, Koinis-Mitchell D, Okelo S, Taylor-Cousar J, Teach S, Wechsler M, Gaffin J, Federico M. Research Priorities in Pediatric Asthma Morbidity: Addressing the Impacts of Systemic Racism on Children with Asthma in the United States. An Official American Thoracic Society Workshop Report. Annals Of The American Thoracic Society 2024, 21: 1349-1364. PMID: 39352175, PMCID: PMC11451894, DOI: 10.1513/annalsats.202407-767st.Peer-Reviewed Original ResearchConceptsImpact of systemic racismAsthma morbidityChildhood asthmaSocial determinants of healthAsthma health outcomesPediatric asthma morbidityDeterminants of healthSystemic racismCommunity engagementDrivers of disparitiesEmergency department visitsResearch teamChildhood asthma outcomesImpact of interventionsMultidisciplinary research teamEffects of systemic racismInnovative study designsImpact of racismAsthma disparitiesSocial determinantsHealthcare accessAsthma outcomesHealth outcomesDepartment visitsEvaluate interventionsBeyond Air Pollution: Addressing Multifactorial Contributors to Asthma Disparities in Black and Latinx Populations.
Ou J, Yuan Y, Fu X, Sun Y. Beyond Air Pollution: Addressing Multifactorial Contributors to Asthma Disparities in Black and Latinx Populations. American Journal Of Respiratory And Critical Care Medicine 2024, 210: 696-697. PMID: 38935619, PMCID: PMC11389579, DOI: 10.1164/rccm.202405-1031le.Peer-Reviewed Original ResearchA common polymorphism in the Intelectin-1 gene influences mucus plugging in severe asthma
Everman J, Sajuthi S, Liegeois M, Jackson N, Collet E, Peters M, Chioccioli M, Moore C, Patel B, Dyjack N, Powell R, Rios C, Montgomery M, Eng C, Elhawary J, Mak A, Hu D, Huntsman S, Salazar S, Feriani L, Fairbanks-Mahnke A, Zinnen G, Michel C, Gomez J, Zhang X, Medina V, Chu H, Cicuta P, Gordon E, Zeitlin P, Ortega V, Reisdorph N, Dunican E, Tang M, Elicker B, Henry T, Bleecker E, Castro M, Erzurum S, Israel E, Levy B, Mauger D, Meyers D, Sumino K, Gierada D, Hastie A, Moore W, Denlinger L, Jarjour N, Schiebler M, Wenzel S, Woodruff P, Rodriguez-Santana J, Pearson C, Burchard E, Fahy J, Seibold M. A common polymorphism in the Intelectin-1 gene influences mucus plugging in severe asthma. Nature Communications 2024, 15: 3900. PMID: 38724552, PMCID: PMC11082194, DOI: 10.1038/s41467-024-48034-5.Peer-Reviewed Original ResearchConceptsAirway epithelial cellsIntelectin-1Mucus pluggingGene expressionAirways of severe asthmaticsEpithelial cellsHuman airway epithelial cellsAirway epithelial brushingsMucus secretory cellsT2-high asthmaFormation of mucus plugsAssociated with protectionC-terminusGenetic variantsAirway mucus pluggingMolecular roleSecretory cellsSecreted componentsEpithelial brushingsT2-lowIL-13Mucus obstructionTarget pathwaysSevere asthmaticsClinical significanceImplementing Antiinflammatory Reliever Strategies in Asthma The Evolving Paradigm of Asthma Management
Zaeh S, Eakin M, Chupp G. Implementing Antiinflammatory Reliever Strategies in Asthma The Evolving Paradigm of Asthma Management. CHEST Journal 2024, 165: 250-252. PMID: 38336438, DOI: 10.1016/j.chest.2023.09.004.Peer-Reviewed Original Research
2023
Sputum alarmins delineate distinct T2 cytokine pathways and unique subtypes of patients with asthma
Gautam S, Chu J, Cohen A, Kaur R, Lee S, Wilson G, Liu Q, Gomez J, Rajaveen H, Yan X, Cohn L, Clark B, Chupp G. Sputum alarmins delineate distinct T2 cytokine pathways and unique subtypes of patients with asthma. Allergy 2023, 78: 3274-3277. PMID: 37874609, PMCID: PMC10842366, DOI: 10.1111/all.15915.Peer-Reviewed Original ResearchEpigenome-wide DNA methylation association study of circulating IgE levels identifies novel targets for asthma
Recto K, Kachroo P, Huan T, Van Den Berg D, Lee G, Bui H, Lee D, Gereige J, Yao C, Hwang S, Joehanes R, Weiss S, Consortium N, Abe N, Abecasis G, Aguet F, Albert C, Almasy L, Alonso A, Ament S, Anderson P, Anugu P, Applebaum-Bowden D, Ardlie K, Arking D, Arnett D, Ashley-Koch A, Aslibekyan S, Assimes T, Auer P, Avramopoulos D, Ayas N, Balasubramanian A, Barnard J, Barnes K, Barr R, Barron-Casella E, Barwick L, Beaty T, Beck G, Becker D, Becker L, Beer R, Beitelshees A, Benjamin E, Benos T, Bezerra M, Bielak L, Bis J, Blackwell T, Blangero J, Blue N, Boerwinkle E, Bowden D, Bowler R, Brody J, Broeckel U, Broome J, Brown D, Bunting K, Burchard E, Bustamante C, Buth E, Cade B, Cardwell J, Carey V, Carrier J, Carson A, Carty C, Casaburi R, Romero J, Casella J, Castaldi P, Chaffin M, Chang C, Chang Y, Chasman D, Chavan S, Chen B, Chen W, Chen Y, Cho M, Choi S, Chuang L, Chung M, Chung R, Clish C, Comhair S, Conomos M, Cornell E, Correa A, Crandall C, Crapo J, Cupples L, Curran J, Curtis J, Custer B, Damcott C, Darbar D, David S, Davis C, Daya M, de Andrade M, de las Fuentes L, de Vries P, DeBaun M, Deka R, DeMeo D, Devine S, Dinh H, Doddapaneni H, Duan Q, Dugan-Perez S, Duggirala R, Durda J, Dutcher S, Eaton C, Ekunwe L, Boueiz A, Ellinor P, Emery L, Erzurum S, Farber C, Farek J, Fingerlin T, Flickinger M, Fornage M, Franceschini N, Frazar C, Fu M, Fullerton S, Fulton L, Gabriel S, Gan W, Gao S, Gao Y, Gass M, Geiger H, Gelb B, Geraci M, Germer S, Gerszten R, Ghosh A, Gibbs R, Gignoux C, Gladwin M, Glahn D, Gogarten S, Gong D, Goring H, Graw S, Gray K, Grine D, Gross C, Gu C, Guan Y, Guo X, Gupta N, Haessler J, Hall M, Han Y, Hanly P, Harris D, Hawley N, He J, Heavner B, Heckbert S, Hernandez R, Herrington D, Hersh C, Hidalgo B, Hixson J, Hobbs B, Hokanson J, Hong E, Hoth K, Hsiung C, Hu J, Hung Y, Huston H, Hwu C, Irvin M, Jackson R, Jain D, Jaquish C, Johnsen J, Johnson A, Johnson C, Johnston R, Jones K, Kang H, Kaplan R, Kardia S, Kelly S, Kenny E, Kessler M, Khan A, Khan Z, Kim W, Kimoff J, Kinney G, Konkle B, Kooperberg C, Kramer H, Lange C, Lange E, Lange L, Laurie C, Laurie C, LeBoff M, Lee J, Lee S, Lee W, LeFaive J, Levine D, Levy D, Lewis J, Li X, Li Y, Lin H, Lin H, Lin X, Liu S, Liu Y, Liu Y, Loos R, Lubitz S, Lunetta K, Luo J, Magalang U, Mahaney M, Make B, Manichaikul A, Manning A, Manson J, Martin L, Marton M, Mathai S, Mathias R, May S, McArdle P, McDonald M, McFarland S, McGarvey S, McGoldrick D, McHugh C, McNeil B, Mei H, Meigs J, Menon V, Mestroni L, Metcalf G, Meyers D, Mignot E, Mikulla J, Min N, Minear M, Minster R, Mitchell B, Moll M, Momin Z, Montasser M, Montgomery C, Muzny D, Mychaleckyj J, Nadkarni G, Naik R, Naseri T, Natarajan P, Nekhai S, Nelson S, Neltner B, Nessner C, Nickerson D, Nkechinyere O, North K, O'Connell J, O'Connor T, Ochs-Balcom H, Okwuonu G, Pack A, Paik D, Palmer N, Pankow J, Papanicolaou G, Parker C, Peloso G, Peralta J, Perez M, Perry J, Peters U, Peyser P, Phillips L, Pleiness J, Pollin T, Post W, Becker J, Boorgula M, Preuss M, Psaty B, Qasba P, Qiao D, Qin Z, Rafaels N, Raffield L, Rajendran M, Ramachandran V, Rao D, Rasmussen-Torvik L, Ratan A, Redline S, Reed R, Reeves C, Regan E, Reiner A, Reupena M, Rice K, Rich S, Robillard R, Robine N, Roden D, Roselli C, Rotter J, Ruczinski I, Runnels A, Russell P, Ruuska S, Ryan K, Sabino E, Saleheen D, Salimi S, Salvi S, Salzberg S, Sandow K, Sankaran V, Santibanez J, Schwander K, Schwartz D, Sciurba F, Seidman C, Seidman J, Sériès F, Sheehan V, Sherman S, Shetty A, Shetty A, Sheu W, Shoemaker M, Silver B, Silverman E, Skomro R, Smith A, Smith J, Smith J, Smith N, Smith T, Smoller S, Snively B, Snyder M, Sofer T, Sotoodehnia N, Stilp A, Storm G, Streeten E, Su J, Sung Y, Sylvia J, Szpiro A, Taliun D, Tang H, Taub M, Taylor K, Taylor M, Taylor S, Telen M, Thornton T, Threlkeld M, Tinker L, Tirschwell D, Tishkoff S, Tiwari H, Tong C, Tracy R, Tsai M, Vaidya D, Van Den Berg D, VandeHaar P, Vrieze S, Walker T, Wallace R, Walts A, Wang F, Wang H, Wang J, Watson K, Watt J, Weeks D, Weinstock J, Weir B, Weiss S, Weng L, Wessel J, Willer C, Williams K, Williams L, Williams S, Wilson C, Wilson J, Winterkorn L, Wong Q, Wu B, Wu J, Xu H, Yanek L, Yang I, Yu K, Zekavat S, Zhang Y, Zhao S, Zhao W, Zhu X, Ziv E, Zody M, Zoellner S, O’Connor G, Levy D, DeMeo D. Epigenome-wide DNA methylation association study of circulating IgE levels identifies novel targets for asthma. EBioMedicine 2023, 95: 104758. PMID: 37598461, PMCID: PMC10462855, DOI: 10.1016/j.ebiom.2023.104758.Peer-Reviewed Original ResearchConceptsMethylation quantitative trait lociAssociation studiesNovel epigenetic signatureIdentifies novel targetsQuantitative trait lociTranscription factor bindingEpigenome-wide association studiesGene ontology analysisWide association studyClosest genesTrait lociCausal regulatorsDrug target analysisTranscription patternsOntology analysisDNA methylationEpigenetic signaturesFactor bindingGene expressionMolecular mechanismsMendelian randomizationCosta Rica StudyPotential therapeutic targetNovel targetGenetic epidemiologyDifferences in Mortality Among Patients With Asthma and COPD Hospitalized With COVID-19
Liu Y, Rajeevan H, Simonov M, Lee S, Wilson F, Desir G, Vinetz J, Yan X, Wang Z, Clark B, Possick J, Price C, Lutchmansingh D, Ortega H, Zaeh S, Gomez J, Cohn L, Gautam S, Chupp G. Differences in Mortality Among Patients With Asthma and COPD Hospitalized With COVID-19. The Journal Of Allergy And Clinical Immunology In Practice 2023, 11: 3383-3390.e3. PMID: 37454926, PMCID: PMC10787810, DOI: 10.1016/j.jaip.2023.07.006.Peer-Reviewed Original ResearchConceptsChronic obstructive pulmonary diseaseType 2 inflammationCOVID-19 severitySOFA scoreAirway diseaseNoneosinophilic asthmaSequential Organ Failure Assessment scoreOrgan Failure Assessment scoreSevere coronavirus disease 2019Higher SOFA scoreMedian SOFA scoreRetrospective cohort studyObstructive pulmonary diseaseOdds of mortalityLower SOFA scoresCells/μLCOVID-19 outcomesCoronavirus disease 2019Logistic regression analysisCOVID-19Clinical confoundersAsthma patientsCohort studyImmunological factorsClinical featuresGlobal, regional, and national burden of allergic disorders and their risk factors in 204 countries and territories, from 1990 to 2019: A systematic analysis for the Global Burden of Disease Study 2019
Shin Y, Hwang J, Kwon R, Lee S, Kim M, Collaborators G, Shin J, Yon D. Global, regional, and national burden of allergic disorders and their risk factors in 204 countries and territories, from 1990 to 2019: A systematic analysis for the Global Burden of Disease Study 2019. Allergy 2023, 78: 2232-2254. PMID: 37431853, PMCID: PMC10529296, DOI: 10.1111/all.15807.Peer-Reviewed Original ResearchConceptsDisability-adjusted life yearsSocio-demographic IndexDisability-adjusted life year ratesAge-standardized prevalence rateGlobal Burden of DiseaseBurden of asthmaHigher Body Mass IndexBody mass indexPrevalence ratesDeaths due to asthmaHighest disability-adjusted life yearsSocio-demographic index quintilesGlobal burdenDisease burden of asthmaGlobal Burden of Disease StudyMass indexBurden of Disease StudyAge-standardized prevalenceDisease burdenAge-specific prevalence ratesAtopic dermatitisRisk Factors StudyRisk factorsIncidence of asthmaBurden of diseaseIs there a best strategy to prevent asthma exacerbations in inner-city patients with asthma?
Zaeh S, Chupp G, Eakin M. Is there a best strategy to prevent asthma exacerbations in inner-city patients with asthma? Annals Of Allergy Asthma & Immunology 2023, 132: 11-12. PMID: 37433383, PMCID: PMC10774450, DOI: 10.1016/j.anai.2023.07.003.Commentaries, Editorials and LettersEfficacy of Tezepelumab in Severe, Uncontrolled Asthma: Pooled Analysis of the PATHWAY and NAVIGATOR Clinical Trials
Corren J, Menzies-Gow A, Chupp G, Israel E, Korn S, Cook B, Ambrose C, Hellqvist Å, Roseti S, Molfino N, Llanos J, Martin N, Bowen K, Griffiths J, Parnes J, Colice G. Efficacy of Tezepelumab in Severe, Uncontrolled Asthma: Pooled Analysis of the PATHWAY and NAVIGATOR Clinical Trials. American Journal Of Respiratory And Critical Care Medicine 2023, 208: 13-24. PMID: 37015033, PMCID: PMC10870853, DOI: 10.1164/rccm.202210-2005oc.Peer-Reviewed Original ResearchConceptsAsthma exacerbation rateUncontrolled asthmaExacerbation rateSecondary outcomesClinical trialsOverall populationRelevant subgroupsMeaningful reductionEfficacy of tezepelumabExacerbation-related hospitalizationsSafety of tezepelumabPlacebo-controlled trialEmergency department visitsInflammatory biomarker levelsNitric oxide levelsAdverse eventsAllergy statusBaseline bloodClinical characteristicsDepartment visitsPooled analysisNAVIGATOR trialBiomarker levelsOxide levelsTezepelumabEffect of tezepelumab on healthcare utilization in patients with severe, uncontrolled asthma The NAVIGATOR study
Menzies-Gow A, Bourdin A, Chupp G, Israel E, Hellqvist Å, Hunter G, Roseti S, Ambrose C, Llanos J, Cook B, Corren J, Colice G. Effect of tezepelumab on healthcare utilization in patients with severe, uncontrolled asthma The NAVIGATOR study. Annals Of Allergy Asthma & Immunology 2023, 131: 343-348.e2. PMID: 37263380, DOI: 10.1016/j.anai.2023.05.028.Peer-Reviewed Original ResearchConceptsExacerbation-related hospitalizationsHealthcare utilizationUncontrolled asthmaNAVIGATOR studyAsthma-related healthcare utilizationEffect of tezepelumabPatient healthcare utilizationRecipients of placeboThymic stromal lymphopoietinHealth-related qualityIntensive care daysHuman monoclonal antibodySubcutaneous tezepelumabAsthma controlAsthma exacerbationsLung functionSpecialist visitsEmergency departmentCare daysOverall burdenTezepelumabMAIN OUTCOMEPlaceboAmbulance transportHospitalizationDupilumab improves long‐term outcomes in patients with uncontrolled, moderate‐to‐severe GINA‐based type 2 asthma, irrespective of allergic status
Rabe K, Pavord I, Busse W, Chupp G, Izuhara K, Altincatal A, Gall R, Pandit‐Abid N, Deniz Y, Rowe P, Jacob‐Nara J, Radwan A. Dupilumab improves long‐term outcomes in patients with uncontrolled, moderate‐to‐severe GINA‐based type 2 asthma, irrespective of allergic status. Allergy 2023, 78: 2148-2156. PMID: 37073882, DOI: 10.1111/all.15747.Peer-Reviewed Original ResearchConceptsParent study baselineType 2 inflammationPre-bronchodilator FEVAsthma exacerbation rateType 2 asthmaAllergic asthmaExacerbation rateSevere asthma exacerbation ratesSevere type 2 asthmaAsthma Control Questionnaire scoreACQ-5 scoresReduced exacerbation ratesLong-term outcomesLong-term treatmentAllergic statusDupilumab efficacyGINA guidelinesQUEST studyWeek 96Asthma controlUncontrolled asthmaWeek 48Allergic phenotypeLung functionQuestionnaire scores
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