2025
Association between in utero exposure to organochlorine pesticides and steroids in cord blood
Chen H, Zhang H, Zheng T, Xia W, Xu S, Chen T, Li Y. Association between in utero exposure to organochlorine pesticides and steroids in cord blood. Environmental Pollution 2025, 382: 126727. PMID: 40578747, DOI: 10.1016/j.envpol.2025.126727.Peer-Reviewed Original ResearchOrganochlorine pesticide exposureOrganochlorine pesticidesRestricted cubic splinesOCP exposureCord bloodUtero exposure to organochlorine pesticidesExposure to organochlorine pesticidesConcentrations of dichlorodiphenyltrichloroethaneSteroid levelsAssociated with hormone levelsCord serum concentrationsLevels of newbornsMother-infant pairsDose-response relationshipCesarean sectionCross-sectional studyEndocrine disruptorsMale infantDose-dependentlyHormone levelsHexachlorocyclohexaneDichlorodiphenyltrichloroethaneSteroidsSteroid concentrationsCordAssociation between Organochlorine Exposures and Lung Functions Modified by Thyroid Hormones and Mediated by Inflammatory Factors among Healthy Older Adults
Guo X, Ren H, Zhang J, Ma X, Tong S, Tang S, Mao C, Shi X. Association between Organochlorine Exposures and Lung Functions Modified by Thyroid Hormones and Mediated by Inflammatory Factors among Healthy Older Adults. Biomedical And Environmental Sciences 2025, 38: 144-153. PMID: 40159168, DOI: 10.3967/bes2025.015.Peer-Reviewed Original ResearchConceptsLung functionInflammatory factorsIL-13Hormone groupThyroid hormonesEffects of IL-2Organochlorine exposureHealthy older adultsInterleukin (IL)-2Thyroid hormone levelsAssociated with forced vital capacityOlder adultsForced Vital CapacityIL-7IL-2Hormone levelsIL-8Wearable passive samplersEffects of organochlorinesAssociated with changesVital capacityLungMediation analysisParticipants' lung functionBlood samples[Association of urine cadmium levels with thyroid hormone levels among middle-aged and older adults aged 40-89 years in selected areas of China].
Wu C, Wang X, Chen Y, Li Z, Zhang Y, Wei Y, Wu B, Zhang W, Yang Z, Dong X, Hao R, Ye X, Wei L, Qu Y, Chu H, Lyu Y, Zhu Y, Xu D, Shi X. [Association of urine cadmium levels with thyroid hormone levels among middle-aged and older adults aged 40-89 years in selected areas of China]. Chinese Preventive Medicine 2025, 59: 209-215. PMID: 39938993, DOI: 10.3760/cma.j.cn112150-20240625-00500.Peer-Reviewed Original ResearchConceptsThyroid hormone levelsRestricted cubic splinesUrinary cadmium levelsHormone levelsUrinary cadmiumFasting venous bloodAssociated with T3Dose-response relationshipMiddle-agedMidstream urineCadmium levelsUrine cadmium levelsMixed effects modelsLinear mixed effects modelsPositive nonlinear associationOlder adultsMulti-stage stratified random sampling methodPhysical examinationUrinary creatinineVenous bloodDietary frequencyDisease statusEffects modelOne-unit increaseCubic splines
2024
Inflammation and Ovarian Function in Reproductive‐Aged Women
Long A, Steiner A, Thompson A, Jahnke H, Harris B, Jukic A. Inflammation and Ovarian Function in Reproductive‐Aged Women. American Journal Of Human Biology 2024, 37: e24196. PMID: 39623697, PMCID: PMC11671284, DOI: 10.1002/ajhb.24196.Peer-Reviewed Original ResearchFollicle-stimulating hormoneC-reactive proteinAnti-Mullerian hormoneOvarian functionInhibin BOvarian reserveFollicular phase follicle-stimulating hormoneMarkers of immune activationBiomarker of ovarian functionTime to ConceiveInhibin B levelsDiminished ovarian reserveAnti-Mullerian hormone levelsCross-sectional analysis of dataPolycystic ovarian syndromeCohort study sampleSecondary cross-sectional analysisNatural-logInhibin B.Menstrual cycleImmune activationLogistic regression modelsFollicular phaseHormone levelsHigher inflammationNeuroactive steroids fluctuate with regional specificity in the central and peripheral nervous system across the rat estrous cycle
Cioffi L, Diviccaro S, Chrostek G, Caruso D, Garcia-Segura L, Melcangi R, Giatti S. Neuroactive steroids fluctuate with regional specificity in the central and peripheral nervous system across the rat estrous cycle. The Journal Of Steroid Biochemistry And Molecular Biology 2024, 243: 106590. PMID: 39053702, DOI: 10.1016/j.jsbmb.2024.106590.Peer-Reviewed Original ResearchNeuroactive steroidsMenstrual cycleNervous systemEstrous cycleRat estrous cycleNeuroactive steroid levelsLevels of pregnenoloneSex steroid hormone levelsOvarian cycleRegulation of nervous functionsPeripheral nervous systemSteroid hormone levelsPsychiatric disordersSteroid patternBrain regionsHormone levelsTherapeutic consequencesNeuropathological eventsPeripheral nervesSteroid levelsNeuroprotective agentsNervous functionSteroidsPhysiological regulationProgesteroneReproductive Health Assessment and Reports of Fertility Counseling in Pediatric and Adolescent Patients with Sickle Cell Disease After Hematopoietic Cell Transplantation
George S, Veludhandi A, Xiang Y, Liu K, Stenger E, Arnold S, Mehta A, Schirmer D, Spencer J, Guilcher G, Bhatia M, Abraham A, Gomez-Lobo V, Krishnamurti L, Meacham L. Reproductive Health Assessment and Reports of Fertility Counseling in Pediatric and Adolescent Patients with Sickle Cell Disease After Hematopoietic Cell Transplantation. Transplantation And Cellular Therapy 2024, 30: 912.e1-912.e13. PMID: 38972510, PMCID: PMC11344653, DOI: 10.1016/j.jtct.2024.06.029.Peer-Reviewed Original ResearchHematopoietic cell transplantationSickle cell diseaseFollicle-stimulating hormone levelsPost-HCTParent-proxyConditioning regimensCell transplantationFertility counselingHormone levelsCell diseaseCyclophosphamide equivalent doseSickle cell disease patientsPremature ovarian insufficiencyElevated FSH levelsDiminished ovarian reserveAnti-Mullerian hormone levelsBone marrow stem cellsEffective method of educationGonadal hormone productionHealth Survey dataReproductive health assessmentReproductive health issuesMarrow stem cellsSibling donorOvarian insufficiencyCorrelation of serum anti-Müllerian hormone (AMH) levels on identification of premenopausal patients (pts) with hormone receptor positive (HR+), HER2-negative, node-positive breast cancer most likely to benefit from adjuvant chemotherapy in SWOG S1007 (RxPONDER).
Kalinsky K, Barlow W, Pathak H, Gralow J, Albain K, Hayes D, Lin N, Perez E, Goldstein L, Chia S, Rastogi P, Schott A, Shak S, Tripathy D, Hortobagyi G, Meric-Bernstam F, Sharma P, Pusztai L, Thompson A, Godwin A. Correlation of serum anti-Müllerian hormone (AMH) levels on identification of premenopausal patients (pts) with hormone receptor positive (HR+), HER2-negative, node-positive breast cancer most likely to benefit from adjuvant chemotherapy in SWOG S1007 (RxPONDER). Journal Of Clinical Oncology 2024, 42: 505-505. DOI: 10.1200/jco.2024.42.16_suppl.505.Peer-Reviewed Original ResearchInvasive disease-free survivalAnti-Mullerian hormoneFollicular stimulating hormoneAnti-Mullerian hormone levelsPremenopausal patientsRecurrence scoreChemotherapy benefitLuteinizing hormoneHormone levelsInhibin BBreast cancerBenefit of endocrine therapyNode-positive breast cancerPhase 3 randomized trialFluorescent bead-based immunoassayDisease-free survivalInvasive breast cancerNormal ovarian reserveSelf-reported menopausal statusSerum anti-Mullerian hormoneBaseline serum samplesSelection of patientsSerum hormone levelsBaseline hormone levelsUniversity of Kansas Medical CenterMaternal intake of paracetamol during pregnancy and biomarkers of male fecundity in young adult sons
Laursen T, Ramlau-Hansen C, Tøttenborg S, Liew Z, Toft G, Gaml-Sørensen A, Hougaard K, Bonde J, Ernst A. Maternal intake of paracetamol during pregnancy and biomarkers of male fecundity in young adult sons. Reproductive Toxicology 2024, 127: 108626. PMID: 38815769, DOI: 10.1016/j.reprotox.2024.108626.Peer-Reviewed Original ResearchIntake of paracetamolMaternal intakeHigher DNA fragmentation indexDanish National Birth CohortDNA fragmentation indexSemen characteristicsLong durationImpaired semen qualityConfidence intervalsImpaired semen characteristicsNational Birth CohortReproductive hormone levelsAssociated with biomarkersDuration of exposureYears of ageFetal programmingNo intakeImmotile spermatozoaSons of mothersFollow-upYoung adult menHormone levelsSemen qualityMale fecundityTrimester-specificNeural control of fluid homeostasis is engaged below 10°C in hibernation
Junkins M, Feng N, Murphy L, Curtis G, Merriman D, Bagriantsev S, Gracheva E. Neural control of fluid homeostasis is engaged below 10°C in hibernation. Current Biology 2024, 34: 923-930.e5. PMID: 38325375, PMCID: PMC11232715, DOI: 10.1016/j.cub.2024.01.035.Peer-Reviewed Original ResearchConceptsAntidiuretic hormone arginine vasopressinSupraoptic nucleusFluid homeostasisC-Fos immunohistochemistryControl of fluid homeostasisHeart rateHypothalamic supraoptic nucleusReduced plasma levelsHormone arginine vasopressinPlasma hormone levelsSlow heart rateSON neuronsArginine vasopressinMassive fluid lossPlasma levelsPosterior pituitaryHormone levelsFiber photometryC-fosBlood pressureNeuronal activityHormonal responsesThirteen-lined ground squirrelsOxytocinInterbout arousalSex-specific outcomes in cancer therapy: the central role of hormones
Bakhshi P, Ho J, Zanganeh S. Sex-specific outcomes in cancer therapy: the central role of hormones. Frontiers In Medical Technology 2024, 6: 1320690. PMID: 38362126, PMCID: PMC10867131, DOI: 10.3389/fmedt.2024.1320690.Peer-Reviewed Original ResearchHormone replacement therapyHormone-sensitive cancersSex hormonesTreatment outcomesCancer therapyCancer progressionEstrogen receptor-negativeEstrogen receptor-positiveAndrogen receptor signalingSex-specific outcomesInhibit cancer progressionReceptor-negativeReceptor-positiveAromatase inhibitorsReplacement therapyTreatment responseAnti-androgenHormone levelsTherapeutic outcomesPersonalized therapyHormonal profileReceptor signalingTherapyCancer treatmentCancer
2023
Association between serum 25-hydroxyvitamin D and antimüllerian hormone levels in a cohort of African-American women
Subramanian A, Harmon Q, Bernardi L, Carnethon M, Marsh E, Baird D, Jukic A. Association between serum 25-hydroxyvitamin D and antimüllerian hormone levels in a cohort of African-American women. Fertility And Sterility 2023, 121: 642-650. PMID: 38145700, PMCID: PMC10978232, DOI: 10.1016/j.fertnstert.2023.12.023.Peer-Reviewed Original ResearchHigher AMH levelsLower AMH levelsAMH levelsAfrican American womenHigher oddsMAIN OUTCOMELower oddsAntimüllerian hormone levelsSerum AMH levelsPolycystic ovary syndromeHormonal contraceptive useBody mass indexTime of enrollmentCross-sectional studyExclusion of participantsClinical trial designAntimüllerian hormoneOvarian reserveOvary syndromeProspective cohortMass indexPrior diagnosisD levelsHormone levelsContraceptive usePer- and polyfluoroalkyl substances (PFAS) and thyroid hormone measurements in dried blood spots and neonatal characteristics: a pilot study
Rosen Vollmar A, Lin E, Nason S, Santiago K, Johnson C, Ma X, Godri Pollitt K, Deziel N. Per- and polyfluoroalkyl substances (PFAS) and thyroid hormone measurements in dried blood spots and neonatal characteristics: a pilot study. Journal Of Exposure Science & Environmental Epidemiology 2023, 33: 737-747. PMID: 37730931, PMCID: PMC10541328, DOI: 10.1038/s41370-023-00603-4.Peer-Reviewed Original ResearchConceptsThyroid hormone concentrationsNeonatal characteristicsThyroid hormone measurementsHormone concentrationsThyroid hormonesBlood spotsPilot studyNewborn DBSHormone measurementsPopulation-based studyThyroid hormone levelsEnvironmental risk factorsPFAS concentrationsNewborn screening testNon-parametric WilcoxonThyroid diseaseRisk factorsHormone levelsKruskal-Wallis testPFAS exposureThyroid hormone dataScreening testNeonatal DBSEnvironmental exposuresPerformance liquid chromatography-mass spectrometryPrediagnostic Hormone Levels and Risk of Testicular Germ Cell Tumors: A Nested Case-Control Study in the Janus Serum Bank.
Wu Z, Trabert B, Guillemette C, Caron P, Bradwin G, Graubard B, Weiderpass E, Ursin G, Langseth H, McGlynn K. Prediagnostic Hormone Levels and Risk of Testicular Germ Cell Tumors: A Nested Case-Control Study in the Janus Serum Bank. Cancer Epidemiology Biomarkers & Prevention 2023, 32: 1564-1571. PMID: 37619591, PMCID: PMC10655159, DOI: 10.1158/1055-9965.epi-23-0772.Peer-Reviewed Original ResearchConceptsTesticular germ cell tumorsDevelopment of testicular germ cell tumorsRisk of testicular germ cell tumorsGerm cell tumorsNested Case-Control StudyFollicle-stimulating hormoneCase-control studyFSH levelsHigher FSH levelsSertoli cellsCell tumorsLuteinizing hormoneHormone levelsLevels of serum gonadotropinsTesticular germ cell tumour riskJanus Serum Bank CohortAssociated with TGCT riskSex hormone binding globulinIncreased FSH levelsConfidence intervalsMultivariate logistic regressionLevels of androgensSex steroid hormonesLH levelsBinding globulinThe lncOb rs10487505 polymorphism impairs insulin sensitivity and glucose tolerance in children and adolescents with obesity
Umano G, Cirillo G, Sanchez G, Rondinelli G, Foderini M, Ferrara S, Di Sessa A, Marzuillo P, Papparella A, Santoro N, del Giudice E. The lncOb rs10487505 polymorphism impairs insulin sensitivity and glucose tolerance in children and adolescents with obesity. Obesity 2023, 31: 2359-2364. PMID: 37550829, DOI: 10.1002/oby.23835.Peer-Reviewed Original ResearchConceptsHomeostasis model assessmentInsulin resistanceDisposition indexLower whole-body insulin sensitivity indexModel assessmentWhole-body insulin sensitivity indexRisk of prediabetesHigher fasting insulinLower disposition indexPlasma leptin levelsInsulin sensitivity indexBMI z-scoreLeptin plasma levelsLeptin gene transcriptionFasting insulinGlucose toleranceLeptin levelsCC patientsRetrospective studyPlasma levelsAnthropometrical evaluationInsulin sensitivityHormone levelsHigh prevalenceHigh riskEffects of Ovarian Hormone Levels on Stress, Cigarette Craving, and Smoking in a Laboratory Relapse Paradigm Among Females Who Smoke Daily
Schick M, Baker N, Hood C, Tomko R, Gray K, Ramakrishnan V, Saladin M, McClure E. Effects of Ovarian Hormone Levels on Stress, Cigarette Craving, and Smoking in a Laboratory Relapse Paradigm Among Females Who Smoke Daily. Nicotine & Tobacco Research 2023, 26: 392-396. PMID: 37493638, PMCID: PMC10882430, DOI: 10.1093/ntr/ntad132.Peer-Reviewed Original ResearchConceptsAssociated with stress reactivityNeuroendocrine responses to stressRelapse paradigmStress reactivityCigarette cravingResponse to stressOvarian hormone levelsOvarian hormonesSex-specific factorsSubjective stress reactivityAd libitum smokingPsychological factorsFemale participantsFluctuating levels of ovarian hormonesHormone levelsLevels of ovarian hormonesEstrogen to progesterone ratioDaily cigarette smokingLikelihood of smokingSex-specific risk factorsLevels of estradiolCravingAssociated with smokingLaboratory sessionsAssociated with increased likelihoodDecidualization dampens toll-like receptor mediated inflammatory responses in human endometrial stromal cells by upregulating IκBα
Tong M, Scott J, Whirledge S, Abrahams V. Decidualization dampens toll-like receptor mediated inflammatory responses in human endometrial stromal cells by upregulating IκBα. Journal Of Reproductive Immunology 2023, 159: 103988. PMID: 37451159, PMCID: PMC10530124, DOI: 10.1016/j.jri.2023.103988.Peer-Reviewed Original ResearchConceptsEndometrial stromal cellsInflammatory responseStromal cellsHuman endometrial stromal cellsToll-like receptor signalingSex hormone levelsMenstrual cycle stageToll-like receptorsImmune response changesViral double-stranded RNAHuman EnSCsEndometrial responseProinflammatory cytokinesSuccessful pregnancyMenstrual cycleHuman endometriumHormone levelsMajor cell typesImmune responseNFκB p65Viral infectionDecidualizationBacterial lipopolysaccharideReceptor signalingBacterial componentsSex steroid hormone levels associated with dopamine D2/3 receptor availability in people who smoke cigarettes
Zakiniaeiz Y, Gueorguieva R, Peltier M, Verplaetse T, Roberts W, McKee S, Cosgrove K. Sex steroid hormone levels associated with dopamine D2/3 receptor availability in people who smoke cigarettes. Frontiers In Behavioral Neuroscience 2023, 17: 1192740. PMID: 37358969, PMCID: PMC10288103, DOI: 10.3389/fnbeh.2023.1192740.Peer-Reviewed Original ResearchSex steroid hormone levelsSteroid hormone levelsLow estradiol levelsTobacco smokingSex-matched counterpartsHormone levelsFree testosteroneEstradiol levelsAmphetamine administrationR availabilityPositron emission tomography scanPrimary addictive componentEmission tomography scanDopamine D2/3 receptor availabilityEffects of nicotineSex steroid hormonesAge-matched controlsCortical brain regionsD2/3 receptor availabilityNicotinic acetylcholine receptorsSex differencesDorsolateral prefrontal cortexDrug-taking behaviorDopaminergic actionsAddictive componentAnti-Müllerian Hormone Level Decline in Patients Undergoing Hysterectomy With and Without Oophorectomy Compared With Natural Menopause
Santoro N, Flyckt R, Davis A, Finkelstein J, Crawford S, Sun F, Derby C, Morrison A, Sluss P, Zhang H. Anti-Müllerian Hormone Level Decline in Patients Undergoing Hysterectomy With and Without Oophorectomy Compared With Natural Menopause. Obstetrics And Gynecology 2023, 141: 331-340. PMID: 36649324, PMCID: PMC9858351, DOI: 10.1097/aog.0000000000005049.Peer-Reviewed Original ResearchConceptsFinal menstrual periodAnti-Müllerian hormone levelsAMH levelsNatural menopauseHormone levelsUndetectable AMH levelsCommunity-based studyOvarian conservationOvarian reserveAMH measurementOvarian failureMenstrual periodSurgery dateHysterectomyLinear mixed modelingMenopauseSurvival analysisPatientsImmediate reductionMixed modelingWomenOvariesSimilar patternRapid declineBSO
2022
Exposure to heavy metals and hormone levels in midlife women: The Study of Women's Health Across the Nation (SWAN)
Wang X, Ding N, Harlow S, Randolph J, Mukherjee B, Gold E, Park S. Exposure to heavy metals and hormone levels in midlife women: The Study of Women's Health Across the Nation (SWAN). Environmental Pollution 2022, 317: 120740. PMID: 36436662, PMCID: PMC9897061, DOI: 10.1016/j.envpol.2022.120740.Peer-Reviewed Original ResearchConceptsUrinary metal concentrationsExposure to heavy metalsHeavy metalsMetal concentrationsStudy of Women's HealthAssociation of heavy metalsEnvironmental heavy metal exposureHeavy metal exposureSex hormone-binding globulinFollicle-stimulating hormoneWomen's healthBayesian kernel machine regressionAssociated with E<sub>2</sub>, TMidlife womenKernel machine regressionMetal exposureSerum hormone levelsMetal mixturesHealth-related factorsNation Multi-Pollutant StudyCalculate percent changesCadmiumHormone levelsProspective cohort studyLinear mixed effects modelsAssociations between pituitary-ovarian hormones and cognition in recently menopausal women independent of type of hormone therapy
Kling J, Dowling N, Bimonte-Nelson H, Gleason C, Kantarci K, Stonnington C, Harman S, Naftolin F, Pal L, Cedars M, Manson J, James T, Brinton E, Miller V. Associations between pituitary-ovarian hormones and cognition in recently menopausal women independent of type of hormone therapy. Maturitas 2022, 167: 113-122. PMID: 36395695, PMCID: PMC10077876, DOI: 10.1016/j.maturitas.2022.10.002.Peer-Reviewed Original ResearchConceptsComplex attention tasksLatent growth curve modelsPoor cognitive performancePoorer global cognitionGrowth curve modelsAuditory attentionAttention taskCognitive factorsMental flexibilityVisual attentionExecutive functionCognitive domainsCognitive performanceCognitive trajectoriesGlobal cognitionPituitary-ovarian hormonesHormone therapyBaseline cognitionCognitionHormone levelsNeuropsychological testingMonth 18Menopausal womenEstrone levelsMonth 48
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