2017
Correlation between follicular fluid levels of sRAGE and vitamin D in women with PCOS
Garg D, Grazi R, Lambert-Messerlian GM, Merhi Z. Correlation between follicular fluid levels of sRAGE and vitamin D in women with PCOS. Journal Of Assisted Reproduction And Genetics 2017, 34: 1507-1513. PMID: 28825156, PMCID: PMC5699991, DOI: 10.1007/s10815-017-1011-6.Peer-Reviewed Original ResearchConceptsAdvanced glycation end productsFollicular fluidVitamin DPro-inflammatory advanced glycation end productsHigher anti-Mullerian hormone levelsAnti-Mullerian hormone levelsProtective anti-inflammatory roleFollicular fluid levelsLevels of sRAGEAnti-inflammatory rolePathogenesis of PCOSGlycation end productsPotential therapeutic targetDay 5 embryosConclusionsIn womenSRAGE levelsOvarian dysfunctionOvarian levelHormone levelsPCOSSRAGESoluble receptorTherapeutic targetDay 3Fluid levels
2016
Evidence for participation of neutrophil gelatinase‐associated lipocalin/matrix metalloproteinase‐9 (NGAL•MMP‐9) complex in the inflammatory response to infection in pregnancies complicated by preterm birth
Rood KM, Buhimschi IA, Rodewald Millen K, Bahtiyar MO, Thung S, Summerfield T, Zhao G, Ackerman W, Shellhaas C, Samuels P, Buhimschi CS. Evidence for participation of neutrophil gelatinase‐associated lipocalin/matrix metalloproteinase‐9 (NGAL•MMP‐9) complex in the inflammatory response to infection in pregnancies complicated by preterm birth. American Journal Of Reproductive Immunology 2016, 76: 108-117. PMID: 27251223, PMCID: PMC4942349, DOI: 10.1111/aji.12523.Peer-Reviewed Original ResearchConceptsIntra-amniotic infection/inflammationNeutrophil Gelatinase-Associated LipocalinMatrix metalloproteinase-9Preterm birthNGAL mRNA expressionGelatinase-Associated LipocalinNormal pregnancy outcomeAmniotic fluid levelsInfection/inflammationPlacental villous trophoblastNGAL levelsPregnancy outcomesInflammatory conditionsInflammatory responseMetalloproteinase-9Villous trophoblastFluid levelsInnate immunityCollagenolytic effectMRNA expressionGelatinolytic activityPregnancyHost-microbe interactionsQRT-PCRAmniochorion
2015
Alpha-Fetoprotein as a Tool to Distinguish Amniotic Fluid From Urine, Vaginal Discharge, and Semen
Mor A, Tal R, Haberman S, McCalla S, Irani M, Perlman J, Seifer DB, Minkoff H. Alpha-Fetoprotein as a Tool to Distinguish Amniotic Fluid From Urine, Vaginal Discharge, and Semen. Obstetrics And Gynecology 2015, 125: 448-452. PMID: 25569004, DOI: 10.1097/aog.0000000000000635.Peer-Reviewed Original ResearchConceptsNormal vaginal dischargeAlpha-fetoprotein concentrationDiagnosis of ruptureVaginal dischargeAmniotic fluidAlpha-fetoproteinPregnant womenReceiver operator characteristic curve analysisSanitary padsOperator characteristic curve analysisProspective cohort studyAlpha-fetoprotein levelsAmniotic fluid levelsCharacteristic curve analysisAmniotic fluid specimensCohort studyInfertility evaluationMaternal urineAFP levelsFluid specimensFluid levelsSemen specimensCurve analysisUrineAFP quantification
2011
PROINFLAMMATORY AND “RESILIENCY” PROTEINS IN THE CSF OF PATIENTS WITH MAJOR DEPRESSION
Martinez JM, Garakani A, Yehuda R, Gorman JM. PROINFLAMMATORY AND “RESILIENCY” PROTEINS IN THE CSF OF PATIENTS WITH MAJOR DEPRESSION. Depression And Anxiety 2011, 29: 32-38. PMID: 21898706, DOI: 10.1002/da.20876.Peer-Reviewed Original ResearchMeSH KeywordsAdultAntidepressive Agents, Second-GenerationBrain-Derived Neurotrophic FactorCyclohexanolsDepressive Disorder, MajorFemaleHumansInflammationInflammation MediatorsInterleukin-1Interleukin-6MaleMiddle AgedNeuropeptide YSeverity of Illness IndexTumor Necrosis Factor-alphaUp-RegulationVenlafaxine HydrochlorideConceptsInflammatory cytokinesDepressed patientsHealthy controlsMajor depressionCSF cytokine levelsCSF of patientsCerebrospinal fluid levelsLumbar puncture procedureNormal comparison groupInflammatory hypothesisNPY concentrationsNPY levelsCytokine levelsIL-6Lumbar punctureClinical severityTreatment protocolIL-1CSF samplesPatientsNeuroprotective peptideFluid levelsSuicidal ideationPuncture procedureSmall sample size
2006
Decreased Cerebrospinal Fluid Allopregnanolone Levels in Women with Posttraumatic Stress Disorder
Rasmusson AM, Pinna G, Paliwal P, Weisman D, Gottschalk C, Charney D, Krystal J, Guidotti A. Decreased Cerebrospinal Fluid Allopregnanolone Levels in Women with Posttraumatic Stress Disorder. Biological Psychiatry 2006, 60: 704-713. PMID: 16934764, DOI: 10.1016/j.biopsych.2006.03.026.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderPremenopausal womenALLO levelsStress disorderCerebrospinal fluid levelsPTSD re-experiencing symptomsAllopregnanolone levelsOral contraceptivesGABAergic neurotransmissionDHEAS levelsPsychotropic medicationsFollicular phaseMenstrual cycleDHEA ratioExcitatory neurotransmissionNeurotransmitter systemsRe-experiencing symptomsDepressive symptomsPTSD subjectsFluid levelsGroup differencesIllicit drugsWomenNeurotransmissionProgesterone
1998
Elevated amniotic fluid levels of leukemia inhibitory factor, interleukin 6, and interleukin 8 in intra-amniotic infection
Hsu C, Meaddough E, Aversa K, Hong S, Lu L, Jones D, Copel J. Elevated amniotic fluid levels of leukemia inhibitory factor, interleukin 6, and interleukin 8 in intra-amniotic infection. American Journal Of Obstetrics And Gynecology 1998, 179: 1267-1270. PMID: 9822513, DOI: 10.1016/s0002-9378(98)70144-9.Peer-Reviewed Original ResearchConceptsIntra-amniotic infectionAmniotic fluid levelsLeukemia inhibitory factorInterleukin-6Interleukin-8Fluid levelsInhibitory factorCreatinine levelsPregnant womenPositive amniotic fluid culture resultsAmniotic fluid creatinine levelsElevated amniotic fluid levelsAmniotic fluid culture resultsAmniotic fluid testsEnzyme-linked immunoassayPreterm contractionsPremature rupturePrognostic importanceLeukocyte countSignificant elevationAmniotic fluidMedian levelsCulture resultsInfectionGram stainImmunohistochemical localization of inducible nitric oxide synthase on human fetal amnion in intra-amniotic infection
Hsu C, Meaddough E, Lu L, Chelouche A, Liang R, Copel J, Parkash V. Immunohistochemical localization of inducible nitric oxide synthase on human fetal amnion in intra-amniotic infection. American Journal Of Obstetrics And Gynecology 1998, 179: 1271-1274. PMID: 9822514, DOI: 10.1016/s0002-9378(98)70145-0.Peer-Reviewed Original ResearchConceptsInducible nitric oxide synthaseIntra-amniotic infectionNitric oxide synthaseFetal amniotic membranesOxide synthaseFetal amnionNitric oxideAmniotic membranePositive amniotic fluid culturePlacental pathologic featuresAmniotic fluid levelsNitric oxide metabolitesAnti-inducible nitric oxide synthaseAmniotic fluid cultureNormal rabbit serumOvarian carcinoma cellsHuman inducible nitric oxide synthaseInfectious productsPathologic featuresOxide metabolitesFluid culturePositive immunostainingRabbit polyclonal antibodyImmunohistochemical localizationFluid levelsBasic Fibroblast Growth Factor: Peritoneal and Follicular Fluid Levels and its Effect on Early Embryonic Development
Seli E, Zeyneloglu H, Senturk L, Bahtiyar O, Olive D, Arici A. Basic Fibroblast Growth Factor: Peritoneal and Follicular Fluid Levels and its Effect on Early Embryonic Development. Fertility And Sterility 1998, 69: 1145-1148. PMID: 9627307, DOI: 10.1016/s0015-0282(98)00074-0.Peer-Reviewed Original ResearchConceptsBasic fibroblast growth factorFibroblast growth factorPeritoneal fluidFollicular fluidBasic FGF levelsFollicular fluid levelsPresence of endometriosisFGF levelsBlastocyst formationException of ageOvulation inductionProspective studyMenstrual cycleMAIN OUTCOMEFluid levelsEndometriosisMurine preimplantation embryonic developmentGrowth factorFGF concentrationsPreimplantation embryonic developmentWomenTwo-cell murine embryosPreimplantation embryosEmbryonic developmentReproductive parametersThe role of amniotic fluid L-selectin, GRO-α, and interleukin-8 in the pathogenesis of intraamniotic infection
Hsu C, Meaddough E, Aversa K, Copel J. The role of amniotic fluid L-selectin, GRO-α, and interleukin-8 in the pathogenesis of intraamniotic infection. American Journal Of Obstetrics And Gynecology 1998, 178: 428-432. PMID: 9539502, DOI: 10.1016/s0002-9378(98)70414-4.Peer-Reviewed Original ResearchMeSH KeywordsAdultAmniocentesisAmniotic FluidCarboxylic Ester HydrolasesChemokine CXCL1ChemokinesChemokines, CXCChemotactic FactorsCreatinineFemaleGlucoseGrowth SubstancesHumansInfectionsIntercellular Signaling Peptides and ProteinsInterleukin-8Leukocyte CountL-SelectinPregnancyStatistics, NonparametricConceptsSoluble L-selectinIntraamniotic infectionAmniotic fluid levelsInterleukin-8L-selectinPregnant womenRank correlation testFluid levelsAmniotic fluid creatinine levelsPositive amniotic fluid cultureAmniotic fluid glucose concentrationAmniotic fluid leukocytesRupture of membranesAmniotic fluid leukocyte countsMann-Whitney UtestAmniotic fluid testsPotent leukocyte chemoattractantLeukocyte esterase activityAmniotic fluid cultureEnzyme-linked immunoassayPreterm contractionsCreatinine levelsSpearman rank correlation testLeukocyte countFluid cultureThe Peritoneal Fluid Levels of Interleukin‐12 in Women with Endometriosis
Zeyneloglu H, Senturk L, Seli E, Bahtiyar O, Olive D, Arici A. The Peritoneal Fluid Levels of Interleukin‐12 in Women with Endometriosis. American Journal Of Reproductive Immunology 1998, 39: 152-156. PMID: 9506213, DOI: 10.1111/j.1600-0897.1998.tb00347.x.Peer-Reviewed Original ResearchConceptsPeritoneal fluid levelsIL-12Peritoneal fluidMesothelial cell culturesInterleukin-12Fluid levelsPg/High-sensitivity enzyme-linked immunosorbentNatural killer cell activityKiller cell activityIL-12 levelsPresence of endometriosisNatural killer cellsPeritoneal fluid samplesMonocytes/macrophagesEnzyme-linked immunosorbentKiller cellsT cellsEndometriosisCell culturesCell activityWomenFluid samplesSignificant differencesStromal
1997
Elevated amniotic fluid nitric oxide metabolites and cyclic guanosine 3′,5′-monophosphate in pregnant women with intraamniotic infection
Hsu C, Aversa K, Meaddough E, Lee I, Copel J. Elevated amniotic fluid nitric oxide metabolites and cyclic guanosine 3′,5′-monophosphate in pregnant women with intraamniotic infection. American Journal Of Obstetrics And Gynecology 1997, 177: 793-796. PMID: 9369821, DOI: 10.1016/s0002-9378(97)70270-9.Peer-Reviewed Original ResearchConceptsAmniotic fluid nitric oxide metabolitesNitric oxide metabolitesCyclic guanosine monophosphateIntraamniotic infectionOxide metabolitesPregnant womenLeukocyte esterase activityGuanosine monophosphateLeukocyte countAmniotic fluid nitric oxidePositive amniotic fluid cultureAmniotic fluid glucose concentrationCyclic guanosineCyclic guanosine monophosphate levelsAmniotic fluid levelsRupture of membranesAmniotic fluid Gram stainAmniotic fluid leukocyte countsGuanosine monophosphate levelsAmniotic fluid culturePanel of testsPreterm contractionsEndogenous nitriteFluid cultureFluid levelsAssessment of diurnal variation of cerebrospinal fluid tryptophan and 5-hydroxyindoleacetic acid in healthy human females
Kirwin P, Anderson G, Chappell P, Saberski L, Leckman J, Geracioti T, Heninger G, Price L, McDougle C. Assessment of diurnal variation of cerebrospinal fluid tryptophan and 5-hydroxyindoleacetic acid in healthy human females. Life Sciences 1997, 60: 899-907. PMID: 9061047, DOI: 10.1016/s0024-3205(97)00021-0.Peer-Reviewed Original ResearchConceptsCSF samplingCSF tryptophanNeuropsychiatric illnessCerebrospinal fluid tryptophanMultiple lumbar puncturesCerebrospinal fluid levelsPlasma TRP levelsRole of serotoninHealthy female volunteersLevels of tryptophanMajor neuropsychiatric disordersIntra-individual coefficientContinuous CSFCSF neurochemistryLumbar catheterLumbar puncturePlasma tryptophanHealthy subjectsTRP levelsFemale volunteersHealthy human femalesFluid levelsNeuropsychiatric disordersAnxiety disordersCSF
1995
Cerebrospinal fluid levels of kynurenine pathway metabolites in patients with eating disorders: Relation to clinical and biochemical variable
Demitrack M, Heyes M, Altemus M, Pigott T, Gold P. Cerebrospinal fluid levels of kynurenine pathway metabolites in patients with eating disorders: Relation to clinical and biochemical variable. Biological Psychiatry 1995, 37: 512-520. PMID: 7542489, DOI: 10.1016/0006-3223(94)00173-z.Peer-Reviewed Original ResearchConceptsCerebrospinal fluid levelsKynurenic acidKynurenine pathwayQuinolinic acidFluid levelsBody weightAnorexia nervosaMedication-free female patientsN-methyl-D-aspartate receptor agonistExcitatory amino acid receptorsL-kynurenineNormal weight bulimia nervosaAcid levelsQuinolinic acid levelsAmino acid receptorsKynurenic acid levelsNormal body weightNormal-weight femalesL-tryptophanEating Disorder PatientsUnderweight anorecticsUnderweight phaseEating-disordered patientsNutritional recoveryFemale patients
1994
Changes in Cerebrospinal Fluid Neurochemistry During Treatment of Obsessive-compulsive Disorder With Clomipramine
Altemus M, Swedo S, Leonard H, Richter D, Rubinow D, Potter W, Rapoport J. Changes in Cerebrospinal Fluid Neurochemistry During Treatment of Obsessive-compulsive Disorder With Clomipramine. JAMA Psychiatry 1994, 51: 794-803. PMID: 7524463, DOI: 10.1001/archpsyc.1994.03950100042004.Peer-Reviewed Original ResearchConceptsCorticotropin-releasing hormoneLong-term treatmentObsessive-compulsive disorderCSF levelsHomovanillic acidCSF monoamine metabolite levelsCentral administrationCerebrospinal fluid levelsSignificant decreaseCSF homovanillic acidMonoamine metabolite levelsCerebrospinal fluid neurochemistryCSF oxytocin levelsOpposite behavioral effectsPharmacologic treatmentSomatostatin levelsMonoamine metabolitesPathophysiologic processesFluid levelsBehavioral effectsOxytocin levelsClomipramine hydrochlorideMetabolite levelsDisordersVasopressinElevated Cerebrospinal Fluid Levels of Oxytocin in Obsessive-compulsive Disorder: Comparison With Tourette's Syndrome and Healthy Controls
Leckman J, Goodman W, North W, Chappell P, Price L, Pauls D, Anderson G, Riddle M, McSwiggan-Hardin M, McDougle C, Barr L, Cohen D. Elevated Cerebrospinal Fluid Levels of Oxytocin in Obsessive-compulsive Disorder: Comparison With Tourette's Syndrome and Healthy Controls. JAMA Psychiatry 1994, 51: 782-792. PMID: 7524462, DOI: 10.1001/archpsyc.1994.03950100030003.Peer-Reviewed Original ResearchConceptsCerebrospinal fluid levelsObsessive-compulsive disorderCSF oxytocin levelsTourette syndromeArginine vasopressinFamily historyFluid levelsElevated cerebrospinal fluid levelsTic-related obsessive-compulsive disorderOxytocin levelsSubgroup of patientsSubset of patientsElevated CSF levelsCentral arginine vasopressinSubtype of OCDCSF levelsFamily genetic dataHealthy controlsTic disordersForms of OCDPatientsRelated syndromesCurrent severitySyndromeFamily study data
1993
Relation of dissociative phenomena to levels of cerebrospinal fluid monoamine metabolites and beta-endorphin in patients with eating disorders: A pilot study
Demitrack M, Putnam F, Rubinow D, Pigott T, Altemus M, Krahn D, Gold P. Relation of dissociative phenomena to levels of cerebrospinal fluid monoamine metabolites and beta-endorphin in patients with eating disorders: A pilot study. Psychiatry Research 1993, 49: 1-10. PMID: 7511247, DOI: 10.1016/0165-1781(93)90026-d.Peer-Reviewed Original ResearchConceptsMonoamine metabolitesCerebrospinal fluid monoamine metabolitesDissociative Experiences ScaleCerebrospinal fluid levelsMajor monoamine metabolitesState-dependent memoryNeurochemical disturbancesAcute phaseOpioid systemNeurochemical changesClinical expressionFluid levelsPatientsPilot studyDisordersNeurobiologic systemsExperiences ScaleMetabolitesDissociative capacityPrevious studiesDopaminergicDissociative phenomenaIllnessCerebrospinal fluid monoamine metabolites in fluoxetine-treated patients with major depression and in healthy volunteers
De Bellis M, Geracioti T, Altemus M, Kling M. Cerebrospinal fluid monoamine metabolites in fluoxetine-treated patients with major depression and in healthy volunteers. Biological Psychiatry 1993, 33: 636-641. PMID: 7687151, DOI: 10.1016/0006-3223(93)90103-k.Peer-Reviewed Original ResearchConceptsMedication-free patientsHealthy volunteersFluoxetine treatmentHomovanillic acidMean Hamilton Depression Rating Scale scoreHamilton Depression Rating Scale scoresDepression Rating Scale scoresPmol/CSF monoamine metabolite levelsFluoxetine-treated patientsCerebrospinal fluid levelsMajor depressive disorderMonoamine metabolite levelsRating Scale scoresCerebrospinal fluid monoamineHVA/5-HIAA ratioCSF HVA/5-HIAA ratioDepressive disorderMajor depressionScale scoreFluid levelsPatientsDSM-IIIMetabolite levelsVolunteersCerebrospinal fluid levels of homovanillic acid and 5-hydroxyindoleacetic acid in autism
Narayan M, Srinath S, Anderson G, Meundi DB. Cerebrospinal fluid levels of homovanillic acid and 5-hydroxyindoleacetic acid in autism. Biological Psychiatry 1993, 33: 630-635. PMID: 7687150, DOI: 10.1016/0006-3223(93)90102-j.Peer-Reviewed Original ResearchConceptsCSF homovanillic acidHomovanillic acidCerebrospinal fluid concentrationsCerebrospinal fluid levelsDopamine turnoverDopamine metabolitesCentral serotoninControl groupFluid levelsFluid concentrationsMarked alterationsGroup differencesAutistic disorderAutistic subjectsSerotoninChildrenAutistic childrenAlterationsGroupAutismPrevious studies
1988
Cerebrospinal fluid indoleacetic acid in autistic subjects
Anderson G, Ross D, Klykylo W, Feibel F, Cohen D. Cerebrospinal fluid indoleacetic acid in autistic subjects. Journal Of Autism And Developmental Disorders 1988, 18: 259-262. PMID: 3410814, DOI: 10.1007/bf02211951.Peer-Reviewed Original Research
1983
High-resolution computed tomography of the temporal bone: Its role in the evaluation of middle ear disease
Virapongse C, Sarwar M, Kier E, Sasaki C. High-resolution computed tomography of the temporal bone: Its role in the evaluation of middle ear disease. American Journal Of Otolaryngology 1983, 4: 107-112. PMID: 6673598, DOI: 10.1016/s0196-0709(83)80011-8.Peer-Reviewed Original Research
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