2020
Chorioamnionitis versus intraamniotic infection among preterm deliveries—is postpartum infectious morbidity different?
Denoble AE, Wu J, Mitchell CJ, Hughes BL, Dotters-Katz SK. Chorioamnionitis versus intraamniotic infection among preterm deliveries—is postpartum infectious morbidity different? American Journal Of Obstetrics & Gynecology MFM 2020, 2: 100176. PMID: 33345890, DOI: 10.1016/j.ajogmf.2020.100176.Peer-Reviewed Original ResearchConceptsPostpartum infectious morbidityIntraamniotic infectionClinical chorioamnionitisPostpartum endometritisAntibiotic treatmentMaternal temperatureAmerican CollegeInfectious morbidityPreterm deliveryPotential confoundersGynecologists criteriaAdditional clinical risk factorsAntenatal magnesium sulfateIntrapartum antibiotic treatmentPostpartum endometritis ratePostpartum infectious complicationsClinical risk factorsMultivariate logistic regressionOriginal study populationProportion of womenEndometritis ratesFetal morbidityInfectious complicationsPreterm birthPrimary outcomeUsing the new definition of intraamniotic infection – is there morbidity among the women left out?
Smith MM, Daifotis HA, DeNoble AE, Dotters-Katz SK. Using the new definition of intraamniotic infection – is there morbidity among the women left out? The Journal Of Maternal-Fetal & Neonatal Medicine 2020, 34: 4148-4152. PMID: 31928262, DOI: 10.1080/14767058.2020.1711723.Peer-Reviewed Original ResearchConceptsPostpartum infectionIntraamniotic infectionPrimary outcomePostpartum infectious morbidityUrinary tract infectionSingle academic centerFourth-degree lacerationsBackward stepwise eliminationACOG criteriaAntibiotic receiptGestational hypertensionIntrapartum characteristicsMaternal feverMaternal tachycardiaDegree lacerationsInfectious morbidityRetrospective cohortTract infectionsDiagnostic criteriaAcademic centersInfectionWomenBivariate statisticsMorbidityFever
2019
Chorioamnionitis versus intraamniotic infection among preterm deliveries: is postpartum infectious morbidity different?
DeNoble A, Mitchell C, Hughes B, Dotters-Katz S. Chorioamnionitis versus intraamniotic infection among preterm deliveries: is postpartum infectious morbidity different? American Journal Of Obstetrics And Gynecology 2019, 221: 666-667. DOI: 10.1016/j.ajog.2019.10.073.Peer-Reviewed Original ResearchPostpartum infectious morbidityIntraamniotic infectionPreterm deliveryInfectious morbidityMorbidityInfectionUsing the New Definition of Intraamniotic Infection: Is There Morbidity in the Women Left Out? [27D]
Smith M, Daifotis H, Denoble A, Dotters-Katz S. Using the New Definition of Intraamniotic Infection: Is There Morbidity in the Women Left Out? [27D]. Obstetrics And Gynecology 2019, 133: 50s-48s. DOI: 10.1097/01.aog.0000558983.61677.1d.Peer-Reviewed Original ResearchPostpartum infectious morbidityIntraamniotic infectionUrinary tract infectionInfectious morbidityPrimary outcomeSingle academic centerBackward stepwise eliminationAntibiotic receiptGestational hypertensionIntrapartum characteristicsMaternal feverMaternal tachycardiaDegree lacerationsRetrospective cohortTract infectionsAmerican CollegeDiagnostic criteriaAcademic centersIRB approvalMorbidityMore symptomsInfectionWomenBivariate statisticsChorioamnionitisSpiking in the Second Stage: The Significance of Isolated Maternal Fever During Labor [16A]
Smith M, Daifotis H, Denoble A, Dotters-Katz S. Spiking in the Second Stage: The Significance of Isolated Maternal Fever During Labor [16A]. Obstetrics And Gynecology 2019, 133: 14s-14s. DOI: 10.1097/01.aog.0000559363.72958.65.Peer-Reviewed Original ResearchAdverse maternal outcomesMaternal outcomesAntibiotic receiptPostpartum infectionMaternal feverBlood transfusionAdverse postpartum outcomesIsolated maternal feverPostpartum maternal outcomesPostpartum venous thromboembolismRetrospective cohort studyTwin vaginal deliverySigns of infectionTiming of deliveryAntepartum complicationsDelivery BMIIntraamniotic infectionMaternal morbidityVenous thromboembolismCohort studyHospital readmissionPrimary outcomeVaginal deliveryPostpartum outcomesNineteen womenManagement of Intraamniotic Infection After Spontaneous Vaginal Delivery: Is Nothing Really Enough? [24C]
Daifotis H, Smith M, Denoble A, Dotters-Katz S. Management of Intraamniotic Infection After Spontaneous Vaginal Delivery: Is Nothing Really Enough? [24C]. Obstetrics And Gynecology 2019, 133: 37s-37s. DOI: 10.1097/01.aog.0000559445.77903.c7.Peer-Reviewed Original ResearchPostpartum infectious complicationsSpontaneous vaginal deliveryIntraamniotic infectionUrinary tract infectionInfectious complicationsAntibiotic therapyVaginal deliveryIntrapartum antibiotic therapyHigh-risk criteriaHigh-risk womenSingle academic centerWeeks of deliveryCase-control studyAntepartum complicationsTract infectionsWeeks' gestationRisk factorsAntimicrobial therapyCurrent guidelinesAcademic centersIRB approvalControl studyDemographic dataComplicationsInfection
2007
The receptor for advanced glycation end products (RAGE) system in women with intraamniotic infection and inflammation
Buhimschi IA, Zhao G, Pettker CM, Bahtiyar MO, Magloire LK, Thung S, Fairchild T, Buhimschi CS. The receptor for advanced glycation end products (RAGE) system in women with intraamniotic infection and inflammation. American Journal Of Obstetrics And Gynecology 2007, 196: 181.e1-181.e13. PMID: 17306673, DOI: 10.1016/j.ajog.2006.09.001.Peer-Reviewed Original ResearchConceptsIntra-amniotic infectionPolymerase chain reactionAF cultureAdvanced glycation end productsAmniotic fluid inflammationThird-trimester controlsEarlier gestational agePlacental villous tissueDegree of inflammationAcute histologic chorioamnionitisNegative AF culturePositive AF cultureExtravillous trophoblast cellsGlycation end productsGestational age dependenceReal-time polymerase chain reactionQuantitative real-time polymerase chain reactionHistologic chorioamnionitisIntraamniotic infectionPreterm deliveryInflammatory biomarkersPlacental pathologyGestational ageRAGE systemAcute inflammation
2006
Thrombin and Interleukin-1β Regulate HOXA10 Expression in Human Term Decidual Cells: Implications for Preterm Labor
Sarno JL, Schatz F, Lockwood CJ, Huang S, Taylor HS. Thrombin and Interleukin-1β Regulate HOXA10 Expression in Human Term Decidual Cells: Implications for Preterm Labor. The Journal Of Clinical Endocrinology & Metabolism 2006, 91: 2366-2372. PMID: 16551735, DOI: 10.1210/jc.2005-1807.Peer-Reviewed Original ResearchConceptsTerm decidual cellsIL-1betaDecidual cellsProgesterone resistancePreterm laborHOXA10 mRNAHOXA10 expressionMedroxyprogesterone acetate treatmentProtein expressionHOXA10 protein expressionAcademic medical centerIntraamniotic infectionPreterm deliveryQuantitative RT-PCRProgestin resistanceMedroxyprogesterone acetateProgesterone withdrawalProinflammatory cytokinesMAIN OUTCOMEMedical CenterProgesterone responsivenessProstaglandin receptorsHuman parturitionAcetate treatmentAddition of thrombin
1998
The role of amniotic fluid L-selectin, GRO-α, and interleukin-8 in the pathogenesis of intraamniotic infection
Hsu C, Meaddough E, Aversa K, Copel J. The role of amniotic fluid L-selectin, GRO-α, and interleukin-8 in the pathogenesis of intraamniotic infection. American Journal Of Obstetrics And Gynecology 1998, 178: 428-432. PMID: 9539502, DOI: 10.1016/s0002-9378(98)70414-4.Peer-Reviewed Original ResearchMeSH KeywordsAdultAmniocentesisAmniotic FluidCarboxylic Ester HydrolasesChemokine CXCL1ChemokinesChemokines, CXCChemotactic FactorsCreatinineFemaleGlucoseGrowth SubstancesHumansInfectionsIntercellular Signaling Peptides and ProteinsInterleukin-8Leukocyte CountL-SelectinPregnancyStatistics, NonparametricConceptsSoluble L-selectinIntraamniotic infectionAmniotic fluid levelsInterleukin-8L-selectinPregnant womenRank correlation testFluid levelsAmniotic fluid creatinine levelsPositive amniotic fluid cultureAmniotic fluid glucose concentrationAmniotic fluid leukocytesRupture of membranesAmniotic fluid leukocyte countsMann-Whitney UtestAmniotic fluid testsPotent leukocyte chemoattractantLeukocyte esterase activityAmniotic fluid cultureEnzyme-linked immunoassayPreterm contractionsCreatinine levelsSpearman rank correlation testLeukocyte countFluid cultureDual Roles of Amniotic Fluid Nitric Oxide and Prostaglandin E2 in Preterm Labor with Intra-Amniotic Infection
Hsu C, Meaddough E, Aversa K, Hong S, Lee I, Bahodo-Singh R, Lu L, Copel J. Dual Roles of Amniotic Fluid Nitric Oxide and Prostaglandin E2 in Preterm Labor with Intra-Amniotic Infection. American Journal Of Perinatology 1998, 15: 683-687. PMID: 10333395, DOI: 10.1055/s-2007-999302.Peer-Reviewed Original ResearchConceptsIntra-amniotic infectionNitric oxide metabolitesPreterm labor patientsAmniotic fluid nitric oxide metabolitesProstaglandin E2Preterm laborLabor patientsNitric oxideIntraamniotic infectionAmniotic fluidAmniotic fluid nitric oxidePositive amniotic fluid cultureAmniotic fluid creatinineProinflammatory nitric oxidePro-inflammatory nitric oxideAmniotic fluid concentrationsAmniotic fluid levelsNitric oxide synthaseCyclo-oxygenase-2Amniotic fluid cultureEnzyme-linked immunoassayOxide metabolitesLeukocyte countFluid cultureOxide synthase
1997
Elevated amniotic fluid nitric oxide metabolites and cyclic guanosine 3′,5′-monophosphate in pregnant women with intraamniotic infection
Hsu C, Aversa K, Meaddough E, Lee I, Copel J. Elevated amniotic fluid nitric oxide metabolites and cyclic guanosine 3′,5′-monophosphate in pregnant women with intraamniotic infection. American Journal Of Obstetrics And Gynecology 1997, 177: 793-796. PMID: 9369821, DOI: 10.1016/s0002-9378(97)70270-9.Peer-Reviewed Original ResearchConceptsAmniotic fluid nitric oxide metabolitesNitric oxide metabolitesCyclic guanosine monophosphateIntraamniotic infectionOxide metabolitesPregnant womenLeukocyte esterase activityGuanosine monophosphateLeukocyte countAmniotic fluid nitric oxidePositive amniotic fluid cultureAmniotic fluid glucose concentrationCyclic guanosineCyclic guanosine monophosphate levelsAmniotic fluid levelsRupture of membranesAmniotic fluid Gram stainAmniotic fluid leukocyte countsGuanosine monophosphate levelsAmniotic fluid culturePanel of testsPreterm contractionsEndogenous nitriteFluid cultureFluid levels
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