2025
Initial and Subsequent Engagement of Recently Diagnosed Persons Living with HIV in Contact Tracing Interviews Conducted by Public Health Practitioners
Fulton J, Bertrand T, Khanna A, Steingrimsson J, Hogan J, MacAskill M, Bhattarai L, Novitsky V, Gillani F, Guang A, Hague J, Dunn C, Bandy U, Kantor R. Initial and Subsequent Engagement of Recently Diagnosed Persons Living with HIV in Contact Tracing Interviews Conducted by Public Health Practitioners. AIDS And Behavior 2025, 1-8. PMID: 40524111, DOI: 10.1007/s10461-025-04796-7.Peer-Reviewed Original ResearchPublic health practitionersHealth practitionersHIV-diagnosed personsPublic health praxisLikert scale scoresCronbach's alphaDiagnosed personsAssess engagementInternal consistencyRe-interviewedHIV transmissionHealth praxisLow engagementPaired Student's t-testPublic healthIndex scoreScale scoreInterviewsHigher engagementStudent's t-testT-testEngagement toolInterview conductDiminished engagementEngagement indexWhat’s in a leader? Association of perceived leadership effectiveness and psychological safety among clinical physician faculty
He C, de Guillebon E, Akhtar S, Pietrzak R, Ripp J, Peccoralo L. What’s in a leader? Association of perceived leadership effectiveness and psychological safety among clinical physician faculty. BMJ Leader 2025, leader-2024-001163. PMID: 40169245, DOI: 10.1136/leader-2024-001163.Peer-Reviewed Original ResearchLeadership effectivenessPsychological safetyPhysician facultyLeadership indexAssociated with psychological safetyPerceived leadership effectivenessCross-sectional surveyClinical faculty membersMultivariate logistic regression analysisOrganisational investmentHealthcare deliveryLogistic regression analysisSeven-itemUrban hospitalsOrganisation questionnaireSafety scorePositive downstream effectsNew York CityMedical CentrePhysiciansOccupational characteristicsAttrition ratesIndex scoreMultivariate modelOccupational correlatesWide-Awake Partial Fasciectomy for Dupuytren Contracture: A Nationwide Analysis of Adverse Events and Reimbursement.
Kammien A, Zhao K, Yu C, Grauer J, Colen D. Wide-Awake Partial Fasciectomy for Dupuytren Contracture: A Nationwide Analysis of Adverse Events and Reimbursement. Journal Of The American Academy Of Orthopaedic Surgeons 2025 PMID: 40073077, DOI: 10.5435/jaaos-d-24-00674.Peer-Reviewed Original ResearchElixhauser comorbidity index scoreComorbidity Index scoreWide-awake surgeryWound complicationsPartial fasciectomyStandardized anesthesiaAdverse eventsYear of index surgeryEmergency department visitsCollagenase injectionYears of follow-upDupuytren's contractureIndex scoreSingle-institution studyRetrospective cohort studyNeedle aponeurotomyCompare adverse eventsDepartment visitsAnalysis of adverse eventsIndex surgeryPearlDiver databasePostoperative eventsTreatment modalitiesMatched CohortTreatment optionsCerebrospinal Fluid Biomarkers and Cognition in Alzheimer Disease and Frontotemporal Dementia in a Memory Clinic Setting
Cayir S, Sadabad F, Mecca A, Matuskey D, Fesharaki-Zadeh A. Cerebrospinal Fluid Biomarkers and Cognition in Alzheimer Disease and Frontotemporal Dementia in a Memory Clinic Setting. Alzheimer Disease & Associated Disorders 2025, 39: 22-27. PMID: 40397510, DOI: 10.1097/wad.0000000000000656.Peer-Reviewed Original ResearchMoCA scoresMemory clinic settingHospital memory clinicCognitive performanceMontreal Cognitive AssessmentFrontotemporal dementiaAlzheimer's diseaseCognitive test scoresP-tauMemory clinicElectronic records of patientsRetrospective cohort studyT-tauCohort studyCognitive AssessmentElectronic recordsMoCACerebrospinal fluidRecords of patientsIndex scoreTau-related pathologyClinical settingDementiaConcentrations of T-tauScores
2024
The Most Socially Vulnerable Patients Benefit the Most Following Gender Affirming Facial Surgery
Parikh N, Hu K, Ihnat J, Allam O, Diatta F, Rancu A, Wood S, Flores-Pérez P, Persing J, Alperovich M. The Most Socially Vulnerable Patients Benefit the Most Following Gender Affirming Facial Surgery. Journal Of Craniofacial Surgery 2024, 36: 772-776. PMID: 39637358, DOI: 10.1097/scs.0000000000010718.Peer-Reviewed Original ResearchArea deprivation index scoreDeprivation index scoreSocial vulnerability index scoresSocial Vulnerability IndexMinor themesImpact of social vulnerabilityNeighborhood socioeconomic disadvantageIndex scorePatient-reported outcomesAppearance satisfactionSocioeconomic disadvantageHome addressFACE-Q modulesSocial vulnerabilityVulnerable patientsLinear regression analysisImpact of surgeryUnivariate linear regression analysisPatient benefitThemesGeo-codedLack of informationRegression analysisScoresTransportation theme6612 Both Overt And Mild Hypercortisolism Accelerate Biological Aging
Yu K, Saini J, Farr J, Vanessa F, Khosla S, Bancos I. 6612 Both Overt And Mild Hypercortisolism Accelerate Biological Aging. Journal Of The Endocrine Society 2024, 8: bvae163.126. PMCID: PMC11454948, DOI: 10.1210/jendso/bvae163.126.Peer-Reviewed Original ResearchMild autonomous cortisol secretionP16<sup>INK4a</sup> expressionAutonomous cortisol secretionCushing's syndromeAdvanced glycation end productsP16<sup>INK4a</sup>Frailty index scoreSex-matched reference subjectsCortisol secretionCell senescenceReference subjectsSingle-center cross-sectional studyCompared to reference subjectsAdvanced glycation end product readerPresence of hypercortisolismOvert Cushing's syndromeIndex scoreHistory of cardiovascular diseaseEvidence of cell senescenceAssociated with history of cardiovascular diseaseAssociated with hypercortisolismRisk of comorbiditiesAssociated with CVDAging-related comorbiditiesAssociated with historyTRPV1 corneal neuralgia mutation: Enhanced pH response, bradykinin sensitization, and capsaicin desensitization
Gualdani R, Barbeau S, Yuan J, Jacobs D, Gailly P, Dib-Hajj S, Waxman S. TRPV1 corneal neuralgia mutation: Enhanced pH response, bradykinin sensitization, and capsaicin desensitization. Proceedings Of The National Academy Of Sciences Of The United States Of America 2024, 121: e2406186121. PMID: 39226353, PMCID: PMC11406256, DOI: 10.1073/pnas.2406186121.Peer-Reviewed Original ResearchConceptsLaser-assisted in situ keratomileusisPhotorefractive keratectomyOcular Surface Disease Index scoreCapsaicin-induced desensitizationPhotorefractive keratectomy enhancementDisease Index scorePhysiological membrane potentialsCorneal neuralgiaTRPV1 variantsCorneal painRefractive surgeryRefractive errorCapsaicin desensitizationPersistent painBradykinin sensitivityNerve injuryM mutationPatch clampChannel activitySurgical techniqueLeftward shiftInflammatory mediatorsM-channelPainIndex scoreGuselkumab for Pityriasis Rubra Pilaris and Dysregulation of IL-23/IL-17 and NFkB Signaling
Velasco R, Shao C, Cutler B, Strunck J, Kent G, Cassidy P, Choate K, Greiling T. Guselkumab for Pityriasis Rubra Pilaris and Dysregulation of IL-23/IL-17 and NFkB Signaling. JAMA Dermatology 2024, 160: 641-645. PMID: 38598229, PMCID: PMC11007649, DOI: 10.1001/jamadermatol.2024.0257.Peer-Reviewed Original ResearchPsoriasis Area Severity IndexPityriasis rubra pilarisDermatology Life Quality Index scoresInvolvement of interleukinsQuality Index scoreFood and Drug Administration-approved treatmentPrimary outcomeUS Food and Drug Administration-approved treatmentPsoriasis area severity index scoreSex-matched healthy controlsIL-23p19 inhibitorsP19 subunit of IL-23Index scoreArea Severity IndexIL-23/IL-17Subunit of IL-23Per-protocol analysisClinical responseStudy drugDosing scheduleClinical respondersClinical improvementMale patientsIL-23GuselkumabDapagliflozin and quality of life measured using the EuroQol 5‐dimension questionnaire in patients with heart failure with reduced and mildly reduced/preserved ejection fraction
Yang M, Kondo T, Talebi A, Jhund P, Docherty K, Claggett B, Vaduganathan M, Bachus E, Hernandez A, Lam C, Inzucchi S, Martinez F, de Boer R, Kosiborod M, Desai A, Køber L, Ponikowski P, Sabatine M, Solomon S, McMurray J. Dapagliflozin and quality of life measured using the EuroQol 5‐dimension questionnaire in patients with heart failure with reduced and mildly reduced/preserved ejection fraction. European Journal Of Heart Failure 2024, 26: 1524-1538. PMID: 38700986, DOI: 10.1002/ejhf.3263.Peer-Reviewed Original ResearchConceptsVisual analogue scaleEjection fractionEQ-5D-5L visual analogue scaleHealth-related quality of lifeIndex scorePatient-level pooled analysisComposite of cardiovascular deathQuality of lifeSafety of dapagliflozinEffects of dapagliflozinReduced ejection fractionAssociated with better outcomesPrevalence of comorbiditiesEuroQol 5-dimension questionnaireMeasures of health-related quality of lifePatient self-reportDAPA-HFWorsening HFVAS scoreClinical characteristicsAtrial fibrillationComposite outcomeHeart failurePooled analysisAnalogue scaleTranslational Research of the Acute Effects of Negative Emotions on Vascular Endothelial Health: Findings From a Randomized Controlled Study
Shimbo D, Cohen M, McGoldrick M, Ensari I, Diaz K, Fu J, Duran A, Zhao S, Suls J, Burg M, Chaplin W. Translational Research of the Acute Effects of Negative Emotions on Vascular Endothelial Health: Findings From a Randomized Controlled Study. Journal Of The American Heart Association 2024, 13: e032698. PMID: 38690710, PMCID: PMC11179860, DOI: 10.1161/jaha.123.032698.Peer-Reviewed Original ResearchConceptsEndothelial cell-derived microparticlesEndothelium-dependent vasodilationCell-derived microparticlesEndothelial progenitor cellsGroup x time interactionEndothelial cell healthCirculating bone marrow-derived endothelial progenitor cellsIncreased risk of cardiovascular disease eventsIndex scoreEndothelial healthProgenitor cellsImpaired endothelium-dependent vasodilationRisk of cardiovascular disease eventsAcute effectsTime interactionBone marrow-derived endothelial progenitor cellsMarrow-derived endothelial progenitor cellsRecall taskStatistically significant group x time interactionsSignificant group x time interactionRandomized Controlled StudyCardiovascular disease eventsVascular endothelial healthRandomized controlled experimental studyNegative emotions
2023
P104: Heterogeneity of Response to methylphenidate in apathetic patients in the ADMET 2 Trial
Lanctôt K, Rivet L, Tumati S, Perin J, Vieira D, Rosenberg P, Herrmann N, Lerner A, Padala P, Brawman-Mintzer O, van Dyck C, Porsteinsson A, Craft S, Levey A, Mintzer J. P104: Heterogeneity of Response to methylphenidate in apathetic patients in the ADMET 2 Trial. International Psychogeriatrics 2023, 35: 125-126. DOI: 10.1017/s1041610223002557.Peer-Reviewed Original ResearchPotential predictors of treatment outcomePredictors of treatment outcomeResponse to methylphenidateClinically significant apathyAlzheimer's Disease Cooperative Study ActivitiesMedium effect sizeMonths of methylphenidateAlzheimer's diseaseNPI-aMethylphenidate treatmentSignificant apathyApathetic patientsBaseline anxietyAD participantsMethylphenidatePotential predictorsActivities of Daily Living ScaleCompared to placeboNeuropsychiatric symptomsIndex scoreDaily Living ScaleAlzheimer's Disease Cooperative Study Activities of Daily Living ScaleApathyEffect sizeLiving ScaleReal-world effectiveness of risankizumab in patients with moderate-to-severe psoriasis using the CorEvitas Psoriasis Registry
Strober B, Ferris L, Callis Duffin K, Janak J, Sima A, Eckmann T, Patel M, Photowala H, Garg V, Armstrong A. Real-world effectiveness of risankizumab in patients with moderate-to-severe psoriasis using the CorEvitas Psoriasis Registry. Journal Of The American Academy Of Dermatology 2023, 90: 82-90. PMID: 37739267, DOI: 10.1016/j.jaad.2023.08.097.Peer-Reviewed Original ResearchDermatology Life Quality Index scoresLife Quality Index scoresPsoriasis RegistryQuality Index scoresSevere psoriasisPsoriasis symptomsClear skinIndex scoreReal-world treatment effectivenessPrior biologic treatmentSevere plaque psoriasisInflammatory skin diseasePatient-reported outcomesEntire study populationReal-world effectivenessSignificant reductionPlaque psoriasisEligible adultsPatient adherenceBiologic treatmentActivity impairmentObservational studyStudy populationRisankizumabPsoriasisAssociation of Age and Frailty With 30‐Day Outcomes Among Patients Undergoing Oral Cavity Cancer Surgery
Boyi T, Williams L, Kafle S, Roche A, Judson B. Association of Age and Frailty With 30‐Day Outcomes Among Patients Undergoing Oral Cavity Cancer Surgery. Otolaryngology 2023, 169: 1523-1532. PMID: 37595108, DOI: 10.1002/ohn.476.Peer-Reviewed Original ResearchConceptsNational Quality Improvement Program databaseFrailty index scoreAdverse eventsSurgeons National Quality Improvement Program databaseIndex scoreOral cavity cancer surgeryQuality Improvement Program databaseRetrospective cross-sectional analysisHigher mFI scoresPostoperative adverse eventsImprovement Program databaseChronic obstructive diseaseCongestive heart failureFree flap reconstructionAssociation of ageImpact of ageCross-sectional analysisMore comorbiditiesOSCC resectionAnesthesiologists classificationPerioperative outcomesComposite resectionNeck dissectionHeart failureMFI scoreAnti–SARS-CoV-2 Pharmacotherapies Among Nonhospitalized US Veterans, January 2022 to January 2023
Yan L, Streja E, Li Y, Rajeevan N, Rowneki M, Berry K, Hynes D, Cunningham F, Huang G, Aslan M, Ioannou G, Bajema K. Anti–SARS-CoV-2 Pharmacotherapies Among Nonhospitalized US Veterans, January 2022 to January 2023. JAMA Network Open 2023, 6: e2331249. PMID: 37651140, PMCID: PMC10472184, DOI: 10.1001/jamanetworkopen.2023.31249.Peer-Reviewed Original ResearchConceptsCOVID-19 pharmacotherapyVeterans Health AdministrationVeterans Integrated Service NetworkSARS-CoV-2Higher Charlson Comorbidity Index scoresCharlson Comorbidity Index scoreNon-Hispanic veteransComorbidity Index scoreProportion of patientsSymptomatic COVID-19Multivariable logistic regressionCOVID-19 vaccinationCohort studyMedicare databaseVHA careUS veteransMAIN OUTCOMEMedical conditionsHispanic veteransPharmacotherapyHealth AdministrationIndex scoreCommunity careNonhospitalized personsWhite veteransRacial Differences in Presentation and Outcomes After Peripheral Arterial Interventions: Insights From the NCDR-PVI Registry
Julien H, Wang Y, Curtis J, Johnston-Cox H, Eberly L, Wang G, Nathan A, Fanaroff A, Khatana S, Groeneveld P, Secemsky E, Eneanya N, Vora A, Kobayashi T, Barbery C, Chery G, Kohi M, Kirksey L, Armstrong E, Jaff M, Giri J. Racial Differences in Presentation and Outcomes After Peripheral Arterial Interventions: Insights From the NCDR-PVI Registry. Circulation Cardiovascular Interventions 2023, 16: e011485. PMID: 37339237, DOI: 10.1161/circinterventions.121.011485.Peer-Reviewed Original ResearchConceptsDistressed Communities Index scorePeripheral arterial interventionsBlack patientsDrug-eluting technologiesWhite patientsArterial interventionsIndex scoreAcute kidney injuryRate of amputationSocioeconomic statusMultivariable logistic regressionPatient's zip codeZip codesMedicaid Services dataLow socioeconomic statusHigh ratePVI procedureKidney injuryMajor amputationIntervention RegistryHigh prevalenceAmerican CollegePatientsRevascularizationLogistic regressionPercutaneous Ablation, Osteoplasty, Reinforcement, and Internal Fixation for Pain and Ambulatory Function in Periacetabular Osteolytic Malignancies.
Dussik C, Toombs C, Alder K, Yu K, Berson E, Ibe I, Li F, Lindskog D, Friedlaender G, Latich I, Lee F. Percutaneous Ablation, Osteoplasty, Reinforcement, and Internal Fixation for Pain and Ambulatory Function in Periacetabular Osteolytic Malignancies. Radiology 2023, 307: e221401. PMID: 36916888, DOI: 10.1148/radiol.221401.Peer-Reviewed Original ResearchConceptsOsteolytic neoplasmAmbulatory functionInternal fixationEastern Cooperative Oncology Group scoreIndex scoreConversion hip arthroplastyRetrospective observational studySurgical site infectionKaplan-Meier analysisLong-term painQuality of lifeLong-term improvementWilcoxon signed-rank testNonambulatory patientsSecondary outcomesPrimary outcomeSite infectionOncologic careECOG scorePercutaneous ablationPeriacetabular metastasisProtrusio acetabuliFunctional improvementSigned-rank testClinical dataOral orismilast: Efficacy and safety in moderate‐to‐severe psoriasis and development of modified release tablets
Warren R, Strober B, Silverberg J, Guttman E, Andres P, Felding J, Tutkunkardas D, Kjøller K, Sommer M, French L. Oral orismilast: Efficacy and safety in moderate‐to‐severe psoriasis and development of modified release tablets. Journal Of The European Academy Of Dermatology And Venereology 2023, 37: 711-720. PMID: 36478476, DOI: 10.1111/jdv.18812.Peer-Reviewed Original ResearchConceptsPhase 1 trialPhase 2a trialSevere psoriasisAdverse eventsIR formulationPK propertiesWeek 16Psoriasis Area Severity Index (PASI) scorePlacebo-controlled trialSeverity Index scoreHigh-fat mealLow-fat mealPhosphodiesterase 4 inhibitorSimilar PK propertiesImmediate-release formulationGI disordersMR groupPlaceboFood effectPhase 2aIndex scorePsoriasisPharmacokinetic propertiesHealthy participantsMR formulation
2022
Total Hip Arthroplasty Imageless Navigation Does Not Reduce 90-Day Adverse Events or Five-Year Revisions in a Large National Cohort
Jayaram R, Gillinov S, Caruana D, Kammien A, Joo P, Rubin L, Grauer J. Total Hip Arthroplasty Imageless Navigation Does Not Reduce 90-Day Adverse Events or Five-Year Revisions in a Large National Cohort. The Journal Of Arthroplasty 2022, 38: 862-867. PMID: 36529197, DOI: 10.1016/j.arth.2022.12.012.Peer-Reviewed Original ResearchConceptsTotal hip arthroplastyAdverse eventsImageless navigationMultivariate analysisLarge national administrative databaseElixhauser comorbidity index scorePrimary total hip arthroplastyComorbidity Index scoreFive-year incidencePostoperative adverse eventsNational administrative databaseLarge national cohortLarge national databaseCause revisionTHA patientsWound dehiscenceNational cohortTHA casesAdministrative databasesDislocation rateHip arthroplastyHigher oddsNavigation groupIndex scoreComputer navigationNinety-Day Emergency Department Visits After Ankle Fracture Surgery
Kammien A, Ratnasamy P, Joo P, Grauer J. Ninety-Day Emergency Department Visits After Ankle Fracture Surgery. Journal Of The American Academy Of Orthopaedic Surgeons 2022, 31: e51-e57. PMID: 36548157, DOI: 10.5435/jaaos-d-22-00484.Peer-Reviewed Original ResearchConceptsAnkle fracture surgeryElixhauser comorbidity index scoreComorbidity Index scoreED visitsED utilizationFracture surgeryPostoperative weekRisk factorsSurgical siteIndex scoreIncidence of readmissionEmergency department visitsDay of surgeryMultivariate logistic regressionORIF patientsPatient ageAnkle fracturesDepartment visitsOpen reductionConcomitant fracturesMedicaid insuranceEntire cohortEmergency departmentInternal fixationCare pathwayAdverse Events After Total Hip Arthroplasty are not Sufficiently Characterized by 30-Day Follow-Up: A Database Study
Maloy GC, Kammien AJ, Rubin LE, Grauer JN. Adverse Events After Total Hip Arthroplasty are not Sufficiently Characterized by 30-Day Follow-Up: A Database Study. The Journal Of Arthroplasty 2022, 38: 525-529. PMID: 36272511, DOI: 10.1016/j.arth.2022.10.020.Peer-Reviewed Original ResearchConceptsTotal hip arthroplastyPostoperative adverse eventsAdverse eventsDay of surgeryHip arthroplastyDays of THAHigher Elixhauser-Comorbidity Index scoresElixhauser comorbidity index scoreComorbidity Index scoreLate adverse eventsTime of diagnosisPostoperative day 31THA patientsPredictive factorsPatient counselingPatient riskDatabase studyPrevention strategiesIndex scoreDay 31SurgeryInterquartile rangeAdministrative datasetsPatientsArthroplasty
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