2025
Clinicopathologic Features of Untreated Colorectal Cancer with Acellular Mucin-Only Lymph Nodes
Luo W, Hu S, Riahi I, Wang H, Shaker N, Abukhiran I, Wang T, Polydorides A, Akinsanya A, González I, Hagen C, Graham R, Lisovsky M, Longacre T, Challa B, Chen W, Harter D, Beech C, Najibi M, Cao W, Lee M, Lagana S, Liao X, Setia N, Westbrook L, Chandan V, Choi W, Ding X, Gonzalez R, Gopal P, Lee H, Navale P, Liu X, Panarelli N, Yang Z, Drage M, Song Z, Li F, Nagtegaal I, Zhang X. Clinicopathologic Features of Untreated Colorectal Cancer with Acellular Mucin-Only Lymph Nodes. Modern Pathology 2025, 38: 100811. PMID: 40513988, DOI: 10.1016/j.modpat.2025.100811.Peer-Reviewed Original ResearchUntreated colorectal cancerLymph nodesAcellular mucinColorectal cancerStudy groupClinicopathological featuresCRC casesFrequency of lymphovascular invasionPractice patternsCRC-related deathsControl groupTreat colorectal cancerPN0 groupLymphovascular invasionLocal recurrenceDistant metastasisPN1 groupMucinous featuresPN stageRight colonPN0Dutch nationwide pathology databankPathology DatabankPN1MetastasisGenomic and proteomic predictors of sites of metastases in renal cell carcinoma.
Steiner C, Saad E, Machaalani M, Saliby R, Eid M, Semaan K, Yekeduz E, Ascione L, Horst J, Lee J, Phillips N, Trowbridge R, Lee G, Harel M, Dicker A, McGregor B, Braun D, McKay R, Choueiri T, Xu W. Genomic and proteomic predictors of sites of metastases in renal cell carcinoma. Journal Of Clinical Oncology 2025, 43: 4538-4538. DOI: 10.1200/jco.2025.43.16_suppl.4538.Peer-Reviewed Original ResearchSite of metastasisRenal cell carcinomaDana-Farber Cancer InstituteMetastatic sitesLymph node metastasisLymph nodesCell carcinomaNode metastasisProteomic predictorsInstitutional cohort of patientsSites of RCC metastasisMetastatic renal cell carcinomaAssociated with bone metastasisAssociated with liver metastasisTwo-sided Fisher's exact testAssociated with lymph node metastasisCancer-specific outcomesPairwise comparison of patientsMetastasis to lungMultivariate modelTumor genomic alterationsCohort of patientsIndependent external cohortComparison of patientsAssociated with lungUS of the Neck beyond the Thyroid Gland: Parathyroid Glands.
Khot R, Dixe de Oliveira Santo I, Shen L, Itani M, Sailer A, Kirsch J, Revzin M. US of the Neck beyond the Thyroid Gland: Parathyroid Glands. RadioGraphics 2025, 45: e240182. PMID: 40440190, DOI: 10.1148/rg.240182.Peer-Reviewed Original ResearchConceptsParathyroid lesionsThyroid nodulesMinimally invasive parathyroidectomyFour-dimensional CTImaging modalitiesAbnormal parathyroid tissueSolitary parathyroid adenomaDetection of thyroid nodulesAlternative imaging modalityHyperparathyroidism managementNeck USEctopic glandsParathyroid adenomaParathyroid hyperplasiaParathyroid imagingLymph nodesParathyroid tissueParathyroid glandsMultiple adenomasThyroid glandImaging evaluationAdenomasPathological conditionsGlandThyroidEarly Compliance with Lung Cancer Lymph Node Standard 5.8: An Analysis of 2022 and 2023 Commission on Cancer Site Reviews
Baskin A, Funk E, Francescatti A, Sinco B, Palis B, Hieken T, Katz M, Boughey J, Weigel R, Dossett L, Boffa D. Early Compliance with Lung Cancer Lymph Node Standard 5.8: An Analysis of 2022 and 2023 Commission on Cancer Site Reviews. Journal Of Thoracic And Cardiovascular Surgery 2025 PMID: 40324749, DOI: 10.1016/j.jtcvs.2025.04.041.Peer-Reviewed Original ResearchCompliance ratePathology reportsQuality improvement toolsSite visitsSurgical lymph node evaluationSynoptic pathology reportingCurative-intent lung cancer resectionMedian percentageSupport hospitalLymph node evaluationLung cancer resectionImprovement toolsEligible sitesEligible casesEarly implementationSite complianceHilar stationMediastinal stationsNodal stagingCancer resectionLymph nodesCompliance dataImplementation of standardsVisitsNode evaluationLow-dose irradiation of the gut improves the efficacy of PD-L1 blockade in metastatic cancer patients
Chen J, Levy A, Tian A, Huang X, Cai G, Fidelle M, Rauber C, Ly P, Pizzato E, Sitterle L, Piccinno G, Liu P, Durand S, Mao M, Zhao L, Iebba V, Felchle H, Mallard de La Varende A, Fischer J, Thomas S, Greten T, Jones J, Monge C, Demaria S, Formenti S, Belluomini L, Dionisi V, Massard C, Blanchard P, Robert C, Quevrin C, Lopes E, Clémenson C, Mondini M, Meziani L, Zhan Y, Zeng C, Cai Q, Morel D, Sun R, Laurent P, Mangoni M, Di Cataldo V, Arilli C, Trommer M, Wegen S, Neppl S, Riechelmann R, Camandaroba M, Neto E, Fournier P, Segata N, Holicek P, Galluzzi L, Buqué A, Alves Costa Silva C, Derosa L, Kroemer G, Chen C, Zitvogel L, Deutsch E. Low-dose irradiation of the gut improves the efficacy of PD-L1 blockade in metastatic cancer patients. Cancer Cell 2025, 43: 361-379.e10. PMID: 40068595, PMCID: PMC11907695, DOI: 10.1016/j.ccell.2025.02.010.Peer-Reviewed Original ResearchConceptsPD-L1 blockadeLow-dose irradiationCancer patientsAbscopal effectEfficacy of PD-L1 blockadeCD8<sup>+</sup> T cell activationBenefit of immune checkpoint inhibitorsClinical benefit of immune checkpoint inhibitorsTumor-draining lymph nodesSecond-line immunotherapyImmune checkpoint inhibitorsPhase 2 studyProspective clinical trialTumor-bearing miceCohort of cancer patientsT cell activationMetastatic cancer patientsAnti-cancer efficacyCheckpoint inhibitorsLocal radiotherapyPD-L1Clinical benefitLymph nodesOptimal dosimetryRetrospective cohortEvaluating survival post-7 mo PSA response, stratified by response, disease extent, and intermittent vs. continuous ADT in mHSPC: The S9346 trial.
Sokolova A, Tangen C, Hussain M, Sweeney C, Dorff T, Thompson I, Lerner S. Evaluating survival post-7 mo PSA response, stratified by response, disease extent, and intermittent vs. continuous ADT in mHSPC: The S9346 trial. Journal Of Clinical Oncology 2025, 43: 268-268. DOI: 10.1200/jco.2025.43.5_suppl.268.Peer-Reviewed Original ResearchMetastatic hormone-sensitive prostate cancerPSA responseAndrogen deprivation therapyProstate-specific antigenContinuous androgen deprivation therapyContinuous ADTOverall survivalDisease extentCox regressionHormone-sensitive prostate cancerAssociated with worse OSDe-intensification strategiesBaseline clinical featuresSubsets of patientsTreatment effectsDeprivation therapyImproved OSExtensive diseaseMinimal diseasePrognostic significanceProstate cancerOptimal therapyCox analysisLymph nodesPrognostic markerPMA1-containing extracellular vesicles of Candida albicans triggers immune responses and colitis progression
Xu Z, Qiao S, Wang Z, Peng C, Hou Y, Liu B, Cao G, Wang T. PMA1-containing extracellular vesicles of Candida albicans triggers immune responses and colitis progression. Gut Microbes 2025, 17: 2455508. PMID: 39886799, PMCID: PMC11792855, DOI: 10.1080/19490976.2025.2455508.Peer-Reviewed Original ResearchConceptsPMA1 expressionExtracellular vesiclesCell differentiationAdaptor protein CARD9Th17 cell differentiationCARD9 deficiencyActivity of GAPDHVirulence factorsDecreased enzyme activityPma1Immune responseProteomic analysisCARD9Decreased glycolysisIL-17A productionMucosal immune responsesInduce Th17 cell differentiationMesenteric lymph nodesEditing systemAggravated colitisIL-17ALymph nodesColitis progressionAberrant changesGAPDH
2024
A Yale Dermatology perspective on cutaneous T cell lymphoma: Historic reflection to emerging therapies
Swallow M, Edelson R, Girardi M. A Yale Dermatology perspective on cutaneous T cell lymphoma: Historic reflection to emerging therapies. Clinics In Dermatology 2024, 43: 170-176. PMID: 39694197, DOI: 10.1016/j.clindermatol.2024.12.006.Peer-Reviewed Original ResearchCutaneous T-cell lymphomaT-cell lymphomaMycosis fungoidesSubtype of cutaneous T-cell lymphomaPathogenesis of cutaneous T-cell lymphomaNon-Hodgkin's lymphomaEvolving treatment landscapeSezary syndromeHistological variantsTreatment landscapeLymph nodesSchool of MedicineLymphomaYale School of MedicineFungoidesClinical careMalignancyLymphMycosisSyndromeSubtypesPathogenesisLeishmania major surface components and DKK1 signalling via LRP6 promote migration and longevity of neutrophils in the infection site
Ihedioha O, Marcarian H, Sivakoses A, Beverley S, McMahon-Pratt D, Bothwell A. Leishmania major surface components and DKK1 signalling via LRP6 promote migration and longevity of neutrophils in the infection site. Frontiers In Immunology 2024, 15: 1473133. PMID: 39502693, PMCID: PMC11534728, DOI: 10.3389/fimmu.2024.1473133.Peer-Reviewed Original ResearchParasite-infected miceBALB/c miceDickkopf-1Infection siteInfected BALB/c micePathogen-associated molecular patternsWild-type BALB/c miceLevels of apoptosisNull mutantsLeishmania infectionDickkopf-1 levelsDraining Lymph NodesNeutrophil-platelet aggregatesLeukocyte-platelet aggregatesInfiltration of neutrophilsReduced neutrophil activationDay 3 PIResponse to infectionSignaling pathwayHost-related factorsMolecular patternsMembrane componentsLRP6Lymph nodesTh2 differentiationA Lymph Node Immune Score (LNIS) Identifies Prognostic Immune Phenotypes Shared across Head and Neck Cancers
Karpinets T, Garden A, Rosenthal D, Fuller C, Frank S, Gunn G, Phan J, Morrison W, Lee A, Moreno A, Song X, Mitani Y, Ferrarotto R, Gross N, Zhang J, Myers J, El-Naggar A, Spiotto M. A Lymph Node Immune Score (LNIS) Identifies Prognostic Immune Phenotypes Shared across Head and Neck Cancers. International Journal Of Radiation Oncology • Biology • Physics 2024, 120: s222-s223. DOI: 10.1016/j.ijrobp.2024.07.2308.Peer-Reviewed Original ResearchHead and neck squamous cell cancerNon-small cell lung cancerLymph node metastasisPrognostic gene signatureRelapse free survivalExtranodal extensionFree survivalGene signatureImmune microenvironmentImmune scoreLymph nodesImmune phenotypeRejection subtypeHPV-positive HNSCCImmune rejectionAbsence of extranodal extensionNon-small cell lung cancer cohortsHPV-negative HNSCC patientsUnivariate Cox proportional hazards modelHead and neck cancerImmunology-related genesMetastatic lymph nodesLymph node microenvironmentSquamous cell cancerCell lung cancerNational Patterns of Hospital Admission Versus Home Recovery Following Mastectomy for Breast Cancer
Kim L, Moore M, Schneider E, Canner J, Ayyala H, Chen J, Anant P, Graetz E, Lynch M, Zanieski G, Gillego A, Valero M, Proussaloglou E, Berger E, Golshan M, Greenup R, Park T. National Patterns of Hospital Admission Versus Home Recovery Following Mastectomy for Breast Cancer. Annals Of Surgical Oncology 2024, 31: 9088-9099. PMID: 39322830, DOI: 10.1245/s10434-024-16107-w.Peer-Reviewed Original ResearchHR patientsLymph nodesRate of neoadjuvant chemotherapyHospital admissionNational patterns of careEmergency departmentDecrease wound complicationsNeoadjuvant chemo-Hospital re-admissionNeoadjuvant chemotherapyIn-hospital admissionRate of reconstructionPerioperative outcomesPostoperative hematomaComplication ratePostoperative complicationsWound complicationsHome recoveryPatterns of careBreast cancerMastectomyEmergency room visitsMultivariate analysisComplicationsPatientsASO Visual Abstract: Clipping the Positive Lymph Node in Patients with Clinically Node-Positive Breast Cancer Treated with Neoadjuvant Chemotherapy: Impact on Axillary Surgery in the ISPY-2 Clinical Trial
Switalla K, Boughey J, Dimitroff K, Yau C, Ladores V, Yu H, Tchou J, Golshan M, Ahrendt G, Postlewait L, Piltin M, Reyna C, Matsen C, Tuttle T, Wallace A, Arciero C, Lee M, Tseng J, Son J, Rao R, Sauder C, Naik A, Howard-McNatt M, Lancaster R, Norwood P, Esserman L, Mukhtar R. ASO Visual Abstract: Clipping the Positive Lymph Node in Patients with Clinically Node-Positive Breast Cancer Treated with Neoadjuvant Chemotherapy: Impact on Axillary Surgery in the ISPY-2 Clinical Trial. Annals Of Surgical Oncology 2024, 31: 7262-7263. DOI: 10.1245/s10434-024-15965-8.Peer-Reviewed Original ResearchEnhanced Intratumoral Delivery of Immunomodulator Monophosphoryl Lipid A through Hyperbranched Polyglycerol–Coated Biodegradable Nanoparticles
Chang J, Shin K, Lewis J, Suh H, Lee J, Damsky W, Xu S, Bosenberg M, Saltzman W, Girardi M. Enhanced Intratumoral Delivery of Immunomodulator Monophosphoryl Lipid A through Hyperbranched Polyglycerol–Coated Biodegradable Nanoparticles. Journal Of Investigative Dermatology 2024, 145: 593-604. PMID: 39122142, DOI: 10.1016/j.jid.2024.07.019.Peer-Reviewed Original ResearchMonophosphoryl lipid ATumor microenvironmentImmunomodulatory agentsStimulation of anti-tumor immune responseEfficacy of monophosphoryl lipid AT-helper (Th)1 responsesAnti-tumor immune responseTumor-draining lymph nodesToxicity associated with systemic administrationImmune responseModel of malignant melanomaAgonist monophosphoryl lipid ABiodegradable nanoparticlesImmunogenic tumor microenvironmentAntitumor immune responseDraining Lymph NodesSystemic side effectsNatural killer cellsGradual drug releaseKiller cellsAntitumor efficacyMalignant melanomaImproved survivalLymph nodesChemotherapeutic agentsMeningeal lymphatic vessel dysfunction driven by CGRP signaling causes migraine-like pain in mice
Thomas J, Schindler E, Gottschalk C. Meningeal lymphatic vessel dysfunction driven by CGRP signaling causes migraine-like pain in mice. Journal Of Clinical Investigation 2024, 134: e182556. PMID: 39087472, PMCID: PMC11290958, DOI: 10.1172/jci182556.Peer-Reviewed Original ResearchConceptsBlocking CGRP signalingCGRP receptor componentsMigraine-like painCervical lymph nodesGap junction proteinPrimary headache disordersLymphatic vessel dysfunctionAcute migrainePharmacological blockadeLymph nodesHeadache disordersNeurological symptomsJunction proteinsCGRPLymphatic vesselsMeningeal lymphatic vesselsInducible knockoutVessel dysfunctionMigraineReceptor componentsHeadachePainPathophysiologyDysfunctionMiceZonation and ligand and dose dependence of sphingosine 1-phosphate receptor-1 signalling in blood and lymphatic vasculature
Del Gaudio I, Nitzsche A, Boyé K, Bonnin P, Poulet M, Nguyen T, Couty L, Ha H, Nguyen D, Cazenave-Gassiot A, Alaya K, Thérond P, Chun J, Wenk M, Proia R, Henrion D, Nguyen L, Eichmann A, Camerer E. Zonation and ligand and dose dependence of sphingosine 1-phosphate receptor-1 signalling in blood and lymphatic vasculature. Cardiovascular Research 2024, 120: 1794-1810. PMID: 39086170, PMCID: PMC11587562, DOI: 10.1093/cvr/cvae168.Peer-Reviewed Original ResearchHigh endothelial venulesS1PR1 signalingEndothelial functionS1P productionDisease states associated with endothelial dysfunctionPlasma S1PDose-dependentlyLymphatic vasculatureEndothelial cellsResistance-sized arteriesLevels of sphingosine 1-phosphateLung capillariesS1P receptor 1Sphingosine 1-phosphateImmunosuppressive therapyLigand-independent mechanismResistance arteriesLymph nodesDeficient miceAlbumin extravasationHematopoietic cellsCirculating LevelsEndothelial dysfunctionS1P releaseCirculating Biomarkers057 Single cell RNA and TCR sequencing reveals hyperexpansion of T cell clones and novel regulatory mechanisms of CD8+ T cells in murine alopcecia areata skin and draining lymph nodes
Wang Y, Yu W, Micevic G, Daccache J, Wang A, Park K, Wang G, Palmatier M, Wheeler J, King B, Damsky W. 057 Single cell RNA and TCR sequencing reveals hyperexpansion of T cell clones and novel regulatory mechanisms of CD8+ T cells in murine alopcecia areata skin and draining lymph nodes. Journal Of Investigative Dermatology 2024, 144: s10. DOI: 10.1016/j.jid.2024.06.073.Peer-Reviewed Original ResearchCauses of death and patterns of metastatic disease at the end of life for patients with advanced melanoma in the immunotherapy era
Lee D, McNamara M, Yang A, Yaskolko M, Kluger H, Tran T, Olino K, Clune J, Sznol M, Ishizuka J. Causes of death and patterns of metastatic disease at the end of life for patients with advanced melanoma in the immunotherapy era. Pigment Cell & Melanoma Research 2024, 37: 847-853. PMID: 39073002, PMCID: PMC11809125, DOI: 10.1111/pcmr.13188.Peer-Reviewed Original ResearchSite of metastasisPattern of metastatic diseaseMelanoma mortalityRetrospective observational cohort studyCause of cancer mortalityDistant lymph nodesObservational cohort studyDiagnosis to deathImmunotherapy eraAdvanced melanomaMetastatic diagnosisMetastatic diseaseMetastatic melanomaImmunotherapy treatmentRespiratory failureCause of deathMedian timeLymph nodesTherapeutic advancesCohort studyMelanomaImmunotherapyMechanism of deathPatientsEnd of lifeUnderuse of Postoperative Radiation After Nipple-Sparing Mastectomy for Standard Radiation Indications
Talcott W, Marta G, Moran M. Underuse of Postoperative Radiation After Nipple-Sparing Mastectomy for Standard Radiation Indications. Advances In Radiation Oncology 2024, 9: 101569. PMID: 39188995, PMCID: PMC11345291, DOI: 10.1016/j.adro.2024.101569.Peer-Reviewed Original ResearchPost-operative radiationNipple-sparing mastectomyRegional nodal irradiationAdverse pathologic featuresOverall survivalPathological featuresEarly-stage breast cancerNational Cancer DatabasePost-operative settingType of surgeryHigh-risk subgroupsNipple preservationNodal irradiationPN+ ratePositive marginsRadiation deliveryInvasive carcinomaSurgical subtypesCancer DatabaseLymph nodesPatient selectionPN+Breast cancerCox regressionMultivariate analysisClipping the Positive Lymph Node in Patients with Clinically Node Positive Breast Cancer Treated with Neoadjuvant Chemotherapy: Impact on Axillary Surgery in the ISPY-2 Clinical Trial
Switalla K, Boughey J, Dimitroff K, Yau C, Ladores V, Yu H, Tchou J, Golshan M, Ahrendt G, Postlewait L, Piltin M, Reyna C, Matsen C, Tuttle T, Wallace A, Arciero C, Lee M, Tseng J, Son J, Rao R, Sauder C, Naik A, Howard-McNatt M, Lancaster R, Norwood P, Esserman L, Mukhtar R. Clipping the Positive Lymph Node in Patients with Clinically Node Positive Breast Cancer Treated with Neoadjuvant Chemotherapy: Impact on Axillary Surgery in the ISPY-2 Clinical Trial. Annals Of Surgical Oncology 2024, 31: 7249-7259. PMID: 38995451, PMCID: PMC11452431, DOI: 10.1245/s10434-024-15792-x.Peer-Reviewed Original ResearchPositive lymph nodesEvent-free survivalNeoadjuvant chemotherapyAxillary surgeryClip placementLymph nodesPN+ diseasePositive nodesNode-positive breast cancer treated with neoadjuvant chemotherapyBreast cancer treated with neoadjuvant chemotherapyOmission of axillary dissectionSentinel lymph node biopsyClinically node-positiveNeoadjuvant chemotherapy trialsPathologically node-positiveLymph node biopsySurgical management strategiesProportion of patientsMultivariate logistic regressionNode-positiveAssociated with higher oddsCN+ patientsPre-NACNode biopsyAxillary dissectionMaturation of germinal center B cells after influenza virus vaccination in humans
McIntire K, Meng H, Lin T, Kim W, Moore N, Han J, McMahon M, Wang M, Malladi S, Mohammed B, Zhou J, Schmitz A, Hoehn K, Carreño J, Yellin T, Suessen T, Middleton W, Teefey S, Presti R, Krammer F, Turner J, Ward A, Wilson I, Kleinstein S, Ellebedy A. Maturation of germinal center B cells after influenza virus vaccination in humans. Journal Of Experimental Medicine 2024, 221: e20240668. PMID: 38935072, PMCID: PMC11211068, DOI: 10.1084/jem.20240668.Peer-Reviewed Original ResearchConceptsB cellsInfluenza vaccineGerminal centersAntigen-specific GC B cellsResponse to seasonal influenza vaccinationLong-lived bone marrow plasma cellsResponse to influenza vaccinationBone marrow plasma cellsGerminal center B cellsGC B cell clonesInfluenza virus vaccineMaturation of B cellsMarrow plasma cellsSeasonal influenza vaccineMemory B cellsHemagglutinin (HAB cell clonesGC B cellsInfluenza hemagglutinin (HAH5 HANeedle aspirationLymphoid structuresLymph nodesPlasma cellsGC reaction
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