2024
Intracellular endothelial cell metabolism in vascular function and dysfunction
Citrin K, Chaube B, Fernández-Hernando C, Suárez Y. Intracellular endothelial cell metabolism in vascular function and dysfunction. Trends In Endocrinology And Metabolism 2024 PMID: 39672762, PMCID: PMC12159263, DOI: 10.1016/j.tem.2024.11.004.Peer-Reviewed Original ResearchFatty acid oxidationEndothelial cellsIntracellular metabolic pathwaysInner lining of blood vesselsVascular functionCell metabolismMetabolic pathwaysEndothelial cell metabolismLipid handlingDesign new therapiesRegulate vascular toneInfluence disease progressionAcid oxidationMetabolic signaturesVascular toneNew therapiesLining of blood vesselsDisease progressionLeukocyte adhesionMetabolic changesVascular diseaseOxidative stressBlood vesselsIncreased permeabilityWound healingFoxp3+ regulatory T cells reside within the corneal epithelium and co-localize with limbal stem cells
Tahvildari M, Me R, Setia M, Gao N, Suvas P, McClellan S, Suvas S. Foxp3+ regulatory T cells reside within the corneal epithelium and co-localize with limbal stem cells. Experimental Eye Research 2024, 249: 110123. PMID: 39396695, PMCID: PMC11622170, DOI: 10.1016/j.exer.2024.110123.Peer-Reviewed Original ResearchConceptsLimbal stem cellsRegulatory T cellsResident TregsT cellsFoxp3<sup>+</sup> regulatory T cellsLimbal stem cell functionMouse modelCorneal epithelial wound healingModel of mechanical injuryStem cellsDepletion of TregsCell functionEpithelial wound healingEpithelial cell functionWound healingStem cell functionMechanical injuryAnti-CD25Epithelial healingSubconjunctival injectionCorneal epitheliumCorneal stromaTregsCornealCorneaTargeting hypoxia and thrombospondin‐2 in diabetic wound healing
Huang Y, Xing H, Naud S, Kyriakides T. Targeting hypoxia and thrombospondin‐2 in diabetic wound healing. The FASEB Journal 2024, 38: e70091. PMID: 39383062, PMCID: PMC11486302, DOI: 10.1096/fj.202302429rrr.Peer-Reviewed Original ResearchConceptsThrombospondin-2Diabetic miceWound healingHIF-1aMatricellular protein thrombospondin-2Diabetic woundsImpaired wound healingWounds of diabetic miceDimethyloxalylglycine treatmentTargeting hypoxiaSustained hypoxiaDiabetic patientsTSP2 expressionCell dysfunctionIncreased neovascularizationDiabetic wound healingGenetic ablationDiabetic fibroblastsElevated glucoseReduced hypoxiaImprove healingImmunofluorescence analysisHIF-1a activationHypoxiaWestern blottingSelf-Assembled Fibroblast Growth Factor Nanoparticles as a Therapeutic for Oxidant-Induced Neuronal and Skin Cell Injury
Kumar S, Chu A, Theis T, Rastogi S, Costea D, Banerjee R, Das B, Yarmush M, Hsia H, Cohen R, Schachner M, Berthiaume F. Self-Assembled Fibroblast Growth Factor Nanoparticles as a Therapeutic for Oxidant-Induced Neuronal and Skin Cell Injury. ACS Applied Bio Materials 2024, 7: 5158-5170. PMID: 39038169, DOI: 10.1021/acsabm.4c00135.Peer-Reviewed Original ResearchSpinal cord injuryFGF-2Cell injuryTraumatic brain injurySkin wound healingResponses in vivoInflammatory response in vivoWound healingPressure woundsOxidant-mediated injuryFibroblast growth factor-2Growth factor 2Delayed injuryLocal inflammationNanoparticle sizeChronic skin woundsSecondary complicationsCultured neuronal cellsEndothelial cellsGrowth factorPromote neurite outgrowthCord injuryNeurological sensationsRecombinant fusion proteinNanoparticlesWound Healing Society 2023 update on guidelines for arterial ulcers
Federman D, Dardik A, Shapshak D, Ueno C, Masterson L, Hopf H, Abdullah N, Junkins S, Mostow E. Wound Healing Society 2023 update on guidelines for arterial ulcers. Wound Repair And Regeneration 2024, 32: 619-629. PMID: 39021056, DOI: 10.1111/wrr.13204.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsRelevant new findingsLevel of evidenceEmergency medicine physiciansWound bed preparationAdjuvant therapySociety guidelinesWound Healing SocietyMedicine physiciansVascular surgeonsPlastic surgeonsInfection controlLong-term maintenanceBed preparationArterial ulcersUlcer managementWound healingArterial insufficiency ulcersSurgeonsWoundAdvisory PanelUlcersGuidelinesSurgeryHealing SocietyTherapyTANGO1 inhibitors reduce collagen secretion and limit tissue scarring
Raote I, Rosendahl A, Häkkinen H, Vibe C, Küçükaylak I, Sawant M, Keufgens L, Frommelt P, Halwas K, Broadbent K, Cunquero M, Castro G, Villemeur M, Nüchel J, Bornikoel A, Dam B, Zirmire R, Kiran R, Carolis C, Andilla J, Loza-Alvarez P, Ruprecht V, Jamora C, Campelo F, Krüger M, Hammerschmidt M, Eckes B, Neundorf I, Krieg T, Malhotra V. TANGO1 inhibitors reduce collagen secretion and limit tissue scarring. Nature Communications 2024, 15: 3302. PMID: 38658535, PMCID: PMC11043333, DOI: 10.1038/s41467-024-47004-1.Peer-Reviewed Original ResearchConceptsEndoplasmic reticulum exit sitesECM proteinsSecretion of ECM proteinsPeptide inhibitorFibrotic diseasesCollagen exportTANGO1Binding interfaceWound healingZebrafish resultsECM componentsReduced granulation tissue formationGranulation tissue formationEffective therapyCutaneous wound healingInhibitor treatmentFibrotic processUncontrolled secretionWidespread occurrenceProtein levelsExit siteExcessive scarringAmount of collagenTherapeutic modulationTissue scarringCellular therapeutics and immunotherapies in wound healing – on the pulse of time?
Huelsboemer L, Knoedler L, Kochen A, Yu C, Hosseini H, Hollmann K, Choi A, Stögner V, Knoedler S, Hsia H, Pomahac B, Kauke-Navarro M. Cellular therapeutics and immunotherapies in wound healing – on the pulse of time? Military Medical Research 2024, 11: 23. PMID: 38637905, PMCID: PMC11025282, DOI: 10.1186/s40779-024-00528-5.Peer-Reviewed Original ResearchConceptsStandard of careChronic wound healing disordersLocal wound irrigationWound healingChronic inflammatory microenvironmentFree flap techniqueWound healing disordersChronic woundsGenetic risk profilesPhysiological wound healingAdequate blood supplySurgical debridementFlap techniqueCellular therapyCurrent therapiesHealing disordersInflammatory microenvironmentWound irrigationNon-healing woundsCellular therapeuticsGeneral anesthesiaFormation of biofilmsWound debridementSkin graftsImmunotherapyBioengineering approaches for the endometrial research and application
Dai W, Liang J, Guo R, Zhao Z, Na Z, Xu D, Li D. Bioengineering approaches for the endometrial research and application. Materials Today Bio 2024, 26: 101045. PMID: 38600921, PMCID: PMC11004221, DOI: 10.1016/j.mtbio.2024.101045.Peer-Reviewed Original ResearchInvestigation of regulatory factorsDefect in vitroHuman endometriumEndometrial injuryGynecological complicationsOvarian hormonesEndometrial regenerationEndometriumTherapeutic methodsEndometrial researchConstitutive cellsTissue bioengineeringWound healingRegulatory factorsBiomechanical propertiesBioengineering approachesFemale reproductive potentialExtracellular matrixEndoscopic Repair of Partial Gluteus Medius Tear: Staple Configuration With Suture Anchors
Park N, Surucu S, Mahatme R, Kardestuncer K, Patel S, Jimenez A. Endoscopic Repair of Partial Gluteus Medius Tear: Staple Configuration With Suture Anchors. Arthroscopy Techniques 2024, 13: 102929. PMID: 38835474, PMCID: PMC11144733, DOI: 10.1016/j.eats.2024.102929.Peer-Reviewed Original ResearchLateral hip painGluteus medius tearsConventional open proceduresMinimally invasive alternative strategiesReturn to activityExtensive tissue damageHip painSurgical interventionEndoscopic approachOpen procedurePain alleviationPromote wound healingTissue damageFunctional impairmentTechnical Note detailsWound healingPainProtracted recoveryInsertion footprintTearsGluteus mediusFinesse in Gender Affirming Frontal Contouring With Corrugator Resection
Hu K, Ihnat J, Parikh N, Vassallo M, Almeida M, Alper D, Prassinos A, Aral A, Vasquez T, Alperovich M. Finesse in Gender Affirming Frontal Contouring With Corrugator Resection. Aesthetic Surgery Journal Open Forum 2024, 6: ojae108. PMID: 40007598, PMCID: PMC11852261, DOI: 10.1093/asjof/ojae108.Peer-Reviewed Original ResearchSupraorbital nerveBrow contourCorrugator resectionFollow-up visitFacial feminization surgeryYears of ageTransgender female patientsMuscle resectionFemale patientsPost-operativelyBone reductionForehead flapFeminization surgeryRevision surgeryResectionPatientsPatient satisfactionSoft tissueWound healingSurgeryForeheadForehead aestheticsNerveFrequent componentFrontal contour
2023
Regulatory T cells in skin regeneration and wound healing
Knoedler S, Knoedler L, Kauke-Navarro M, Rinkevich Y, Hundeshagen G, Harhaus L, Kneser U, Pomahac B, Orgill D, Panayi A. Regulatory T cells in skin regeneration and wound healing. Military Medical Research 2023, 10: 49. PMID: 37867188, PMCID: PMC10591349, DOI: 10.1186/s40779-023-00484-6.Peer-Reviewed Original ResearchConceptsRegulatory T cellsT cellsRole of TregsIntegumentary systemNew treatment modalitiesTissue-resident cellsSubsequent wound healing processCutaneous wound healingExcessive inflammationImmune homeostasisTreatment modalitiesImmune cellsSkin adnexaWound healing processImmune responseTregsHealing processWound repairWound healingHealingEpidermal integrityCellsCollateral damageAdnexaInflammationFibroblasts – the cellular choreographers of wound healing
Knoedler S, Broichhausen S, Guo R, Dai R, Knoedler L, Kauke-Navarro M, Diatta F, Pomahac B, Machens H, Jiang D, Rinkevich Y. Fibroblasts – the cellular choreographers of wound healing. Frontiers In Immunology 2023, 14: 1233800. PMID: 37646029, PMCID: PMC10461395, DOI: 10.3389/fimmu.2023.1233800.Peer-Reviewed Original ResearchConceptsFibroblast diversityInnate immune cellsNovel treatment modalitiesWound healing functionsFascial connective tissueRole of fibroblastsTreatment modalitiesImmune cellsWound repairScar tissueDiversityFibroblastsConnective tissueHealing processWound healingComprehensive understandingMachineryTissueHealing functionCascade
2022
Reindeer light the way to scarless wound healing
Caves E, Horsley V. Reindeer light the way to scarless wound healing. Cell 2022, 185: 4675-4677. PMID: 36493748, DOI: 10.1016/j.cell.2022.11.013.Peer-Reviewed Original ResearchAdipocyte plasticity in tissue regeneration, repair, and disease
Horsley V. Adipocyte plasticity in tissue regeneration, repair, and disease. Current Opinion In Genetics & Development 2022, 76: 101968. PMID: 35988318, DOI: 10.1016/j.gde.2022.101968.Peer-Reviewed Original ResearchConceptsMammalian tissue repairTissue repairEssential regulatorAdipocyte plasticityFunction of adipocytesCritical regulatorLipid-filled cellsMultiple tissuesTissue functionRegenerative medicineAdipocytesSkeletal muscleBioactive productsRegulatorMammary glandTherapeutic avenuesFibrotic lesionsEndocrine functionTissue regenerationPlasticityWound healingContractile fibroblastsTissueRepairTumorigenesismiRNA‐encapsulated abiotic materials and biovectors for cutaneous and oral wound healing: Biogenesis, mechanisms, and delivery nanocarriers
Dey A, Yousefiasl S, Kumar A, Moghaddam F, Rahimmanesh I, Samandari M, Jamwal S, Maleki A, Mohammadi A, Rabiee N, Paiva‐Santos A, Tamayol A, Sharifi E, Makvandi P. miRNA‐encapsulated abiotic materials and biovectors for cutaneous and oral wound healing: Biogenesis, mechanisms, and delivery nanocarriers. Bioengineering & Translational Medicine 2022, 8: e10343. PMID: 36684081, PMCID: PMC9842058, DOI: 10.1002/btm2.10343.Peer-Reviewed Original ResearchLung Injury Induces Alveolar Type 2 Cell Hypertrophy and Polyploidy with Implications for Repair and Regeneration.
Weng A, Maciel Herrerias M, Watanabe S, Welch LC, Flozak AS, Grant RA, Aillon RP, Dada LA, Han SH, Hinchcliff M, Misharin AV, Budinger GRS, Gottardi CJ. Lung Injury Induces Alveolar Type 2 Cell Hypertrophy and Polyploidy with Implications for Repair and Regeneration. American Journal Of Respiratory Cell And Molecular Biology 2022, 66: 564-576. PMID: 35202558, PMCID: PMC9116356, DOI: 10.1165/rcmb.2021-0356oc.Peer-Reviewed Original ResearchConceptsLung injuryCell hypertrophyAT2 cellsAlveolar epithelial injuryIntegrated stress responseDistal lung epitheliumBleomycin injuryEpithelial injuryLung epitheliumInjuryBarrier restorationHypertrophic growthSmall molecule ISRIBWound healingFacultative progenitorsHypertrophyStress responseAT2BinucleationCellsReinjuryShort termEpitheliumResponseEvolution of Surgical Management of Metastatic Disease of the Pelvis.
Benevenia J, Guinand LA, Ippolito J, Neilson JC, Fabbri N, Lee FY, Yang R, Kurland AM. Evolution of Surgical Management of Metastatic Disease of the Pelvis. Instructional Course Lectures 2022, 71: 185-201. PMID: 35254782.Peer-Reviewed Original ResearchConceptsSurgical managementSignificant pain reliefMetastatic bone diseaseRestoration of ambulationStandardized modalityPain reliefSevere painMetastatic diseasePostoperative periodSurgical treatmentMinimal complicationsSuccessful treatmentSurgical methodsSurgical reconstructionBone diseasePelvic lesionsInterventional methodsPatientsFrail stateMultidisciplinary approachDiseaseWound healingComplicationsLesionsLimited life span
2021
Adipose-Derived Stem Cells Therapy for Radiation-Induced Skin Injury
Huayllani MT, Ruiz-Garcia H, Boczar D, Avila FR, Lu X, Rinker BD, Moran SL, Sarabia-Estrada R, Quiñones-Hinojosa A, Forte AJ. Adipose-Derived Stem Cells Therapy for Radiation-Induced Skin Injury. Annals Of Plastic Surgery 2021, 87: 639-649. PMID: 34724441, DOI: 10.1097/sap.0000000000003039.Peer-Reviewed Original ResearchConceptsRadiation-induced skin injuryAdipose-derived stem cell therapySkin injuryStem cell therapyCell therapyDifferent medical therapiesWound healingAdipose-derived stem cell-based therapyNon-English studiesUse of ADSCsMeta-Analyses (PRISMA) guidelinesPreferred Reporting ItemsStem cell-based therapiesMedical therapyCell-based therapiesEmbase databasesOvid MEDLINEInclusion criteriaAdipose-derived stem cellsReporting ItemsSystematic reviewTherapyInjuryExperimental modelMeSH termsPorcine Xenograft and Epidermal Fully Synthetic Skin Substitutes in the Treatment of Partial-Thickness Burns: A Literature Review
Haller H, Blome-Eberwein S, Branski L, Carson J, Crombie R, Hickerson W, Kamolz L, King B, Nischwitz S, Popp D, Shupp J, Wolf S. Porcine Xenograft and Epidermal Fully Synthetic Skin Substitutes in the Treatment of Partial-Thickness Burns: A Literature Review. Medicina 2021, 57: 432. PMID: 33946298, PMCID: PMC8146423, DOI: 10.3390/medicina57050432.Peer-Reviewed Original ResearchConceptsPorcine xenograftsPartial-thickness burnsPrimary endpointStudy's primary endpointComplete wound healingLow infection rateSynthetic skin substituteLarger TBSASkin graftsXenograft studiesPRISMA guidelinesHealing timeThickness burnsSuprathelInfection rateSystematic reviewXenograftsTreatment ratesPartial thicknessWound healingDonor siteSignificant differencesTreatmentLow necessitySkin substitutesWound formation, wound size, and progression of wound healing after intratumoral treatment of mast cell tumors in dogs with tigilanol tiglate
Reddell P, De Ridder TR, Morton JM, Jones PD, Campbell JE, Brown G, Johannes CM, Schmidt PF, Gordon V. Wound formation, wound size, and progression of wound healing after intratumoral treatment of mast cell tumors in dogs with tigilanol tiglate. Journal Of Veterinary Internal Medicine 2021, 35: 430-441. PMID: 33438258, PMCID: PMC7848365, DOI: 10.1111/jvim.16009.Peer-Reviewed Original ResearchConceptsMast cell tumorsPretreatment tumor volumeIntratumoral treatmentCell tumorsTigilanol tiglateTumor volumeWound areaWound management interventionsComplete tumor resolutionWound healingConsistent clinical patternTT treatmentTumor resolutionClinical patternClinical recordsSecondary intentionComplete resolutionClinical studiesMost dogsNecrotic tumorNovel small moleculesGranulation tissueWound sizeMost woundsTumors
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