2021
Immunomodulatory nanosystems for treating inflammatory diseases
Ahamad N, Kar A, Mehta S, Dewani M, Ravichandran V, Bhardwaj P, Sharma S, Banerjee R. Immunomodulatory nanosystems for treating inflammatory diseases. Biomaterials 2021, 274: 120875. PMID: 34010755, DOI: 10.1016/j.biomaterials.2021.120875.Peer-Reviewed Original ResearchConceptsHyperactive immune cellsInflammatory diseasesImmune cellsInflammatory bowel diseaseShort-term reliefMechanism of actionCytokine neutralizationStandard therapyT-regsBowel diseaseImmunosuppressive agentsChronic inflammationCytokine productionImmunomodulatory actionsMyocardial infarctionPulmonary disordersMacrophage polarizationInflamed sitesTherapeutic advantageCellular infiltrationLymphatic drainageImmune systemCentral manifestationsSevere burdenDisease
2015
Inflammatory Cell Migration in Rheumatoid Arthritis: A Comprehensive Review
Nevius E, Gomes AC, Pereira JP. Inflammatory Cell Migration in Rheumatoid Arthritis: A Comprehensive Review. Clinical Reviews In Allergy & Immunology 2015, 51: 59-78. PMID: 26511861, PMCID: PMC5785098, DOI: 10.1007/s12016-015-8520-9.Peer-Reviewed Original ResearchConceptsRheumatoid arthritisOsteoclast differentiationInflammatory cytokinesT lymphocytesOsteoclast precursorsChronic inflammatory autoimmune diseaseMultiple myeloid cellsInflammatory autoimmune diseaseChronic inflammatory diseaseInflammatory cellular infiltrationAdaptive immune responsesKey inflammatory cytokinesInflammatory cell migrationBone-resorbing osteoclastsIL-17Bone erosionAutoimmune diseasesAntibody responseBone resorptionInflammatory diseasesInnate signalsIL-1Immune responseArticular sitesCellular infiltrationThe Impact of Chemotherapy and Radiation Therapy on the Remodeling of Acellular Dermal Matrices in Staged, Prosthetic Breast Reconstruction
Myckatyn TM, Cavallo JA, Sharma K, Gangopadhyay N, Dudas JR, Roma AA, Baalman S, Tenenbaum MM, Matthews BD, Deeken CR. The Impact of Chemotherapy and Radiation Therapy on the Remodeling of Acellular Dermal Matrices in Staged, Prosthetic Breast Reconstruction. Plastic & Reconstructive Surgery 2015, 135: 43e-57e. PMID: 25539350, PMCID: PMC4515029, DOI: 10.1097/prs.0000000000000807.Peer-Reviewed Original ResearchConceptsExtracellular matrix depositionAcellular dermal matrixNeoadjuvant chemotherapyBiopsy specimensCellular infiltrationDermal matrixCLINICAL QUESTION/LEVELType IMatrix depositionDermal matrix remodelingImpact of chemotherapyProsthetic breast reconstructionMultiple biopsy specimensMastectomy skin flapsAdjuvant therapyBreast reconstructionFibrous encapsulationRadiation therapySkin flapsChemotherapyTreatment groupsTissue expanderBreast implantsBiopsy locationAcellular dermis
2014
The Receptor for Advanced Glycation End Products (RAGE) Affects T Cell Differentiation in OVA Induced Asthma
Akirav EM, Henegariu O, Preston-Hurlburt P, Schmidt AM, Clynes R, Herold KC. The Receptor for Advanced Glycation End Products (RAGE) Affects T Cell Differentiation in OVA Induced Asthma. PLOS ONE 2014, 9: e95678. PMID: 24759895, PMCID: PMC3997417, DOI: 10.1371/journal.pone.0095678.Peer-Reviewed Original ResearchConceptsAdaptive immune responsesT cell responsesEffects of RAGEGlycation end productsT cell activationT cellsImmune responseWT miceCellular infiltrationCell activationCell responsesBronchial alveolar lavage fluidAdvanced glycation end productsMediastinal lymph nodesT cell infiltrationIL-5 productionOT-II miceRAGE-deficient miceT cell subsetsAlveolar lavage fluidMultiplex bead analysisRole of RAGET cell proliferationDeficient T cellsT cell differentiation
2012
Impaired NLRP3 inflammasome activity in elderly hosts contributes to the prevalence of primary and secondary Streptococcus pneumoniae infection. (114.4)
Stout-Delgado H, Shirali A, Jaramillo R, Harrod K. Impaired NLRP3 inflammasome activity in elderly hosts contributes to the prevalence of primary and secondary Streptococcus pneumoniae infection. (114.4). The Journal Of Immunology 2012, 188: 114.4-114.4. DOI: 10.4049/jimmunol.188.supp.114.4.Peer-Reviewed Original ResearchSecondary bacterial infectionSecondary S. pneumoniae infectionS. pneumoniae infectionElderly miceNLRP3 inflammasome activityPneumoniae infectionInfluenza infectionBacterial infectionsIL-1βInflammasome activitySecondary Streptococcus pneumoniae infectionStreptococcus pneumoniae infectionInfluenza viral infectionWhole lung tissueExpression of ASCHigher bacterial titersCapase-1Elderly hostsIL-18NLRP3 inflammasomeLung tissueYoung miceCellular infiltrationElderly populationLethal pneumonia
2003
Molecular profiles of invasive mucinous and ductal carcinomas of the breast a molecular case study
Pusztai L, Sotiriou C, Buchholz TA, Meric F, Symmans WF, Esteva FJ, Sahin A, Liu ET, Hortobagi GN. Molecular profiles of invasive mucinous and ductal carcinomas of the breast a molecular case study. Cancer Genetics 2003, 141: 148-153. PMID: 12606133, DOI: 10.1016/s0165-4608(02)00737-9.Peer-Reviewed Original ResearchConceptsExpression profilingComprehensive genetic analysisExpression of enzymesCDNA microarrayGenetic analysisMolecular case studyExpression profilesInhibitory genesNovel pathwayTumor phenotypeMolecular profileTherapeutic targetPhenotypeTarget therapeuticsBilateral cancerHistologic subclassificationDuctal carcinomaDifferent histologyProfilingHuman backgroundInvasive tumorsMucin productionCellular infiltrationMucinous phenotypeMolecular classification
2001
The Increased Expression of Gelatinolytic Proteases Due to Gigarette Smoking Exposure in the Lung of Guinea Pig
Kang M, Lee J, Yoo C, Lee G, Chung H, Seo J, Kim Y, Han S, Shim Y. The Increased Expression of Gelatinolytic Proteases Due to Gigarette Smoking Exposure in the Lung of Guinea Pig. Tuberculosis And Respiratory Diseases 2001, 50: 426-436. DOI: 10.4046/trd.2001.50.4.426.Peer-Reviewed Original ResearchPathogenesis of COPDInflammatory cellular infiltrationIntraalveolar cellsCS exposureGuinea pigsCellular infiltrationLung parenchymeHistologic changesAlveolar wallsGelatinolytic enzymesAlveolar inflammatory cellsBAL fluid cellsDuration of CSDays/weekHours/daySmoking exposureBAL fluidInflammatory cellsLung parenchymaWeek groupMMP expressionGelatin zymographyControl groupAdult populationDestructive changes
1999
A Novel Mouse with B Cells but Lacking Serum Antibody Reveals an Antibody-independent Role for B Cells in Murine Lupus
Chan O, Hannum L, Haberman A, Madaio M, Shlomchik M. A Novel Mouse with B Cells but Lacking Serum Antibody Reveals an Antibody-independent Role for B Cells in Murine Lupus. Journal Of Experimental Medicine 1999, 189: 1639-1648. PMID: 10330443, PMCID: PMC2193634, DOI: 10.1084/jem.189.10.1639.Peer-Reviewed Original ResearchConceptsB cellsAutoantibody productionMRL/MpJ-Faslpr miceAutoreactive T cellsAntigen-presenting cellsAntibody-independent roleB cell functionFunctional B cellsExpression of diseaseSerum autoantibodiesMurine lupusLocal inflammationSystemic autoimmunitySerum antibodiesPathogenic roleAntigen presentationT cellsCellular infiltrationSurface immunoglobulinPathologic phenotypeDisease expressionCell functionMiceNovel mousePrecise roleRole of the C-C chemokine, TCA3, in the protective anticryptococcal cell-mediated immune response.
Doyle H, Murphy J. Role of the C-C chemokine, TCA3, in the protective anticryptococcal cell-mediated immune response. The Journal Of Immunology 1999, 162: 4824-33. PMID: 10202026, DOI: 10.4049/jimmunol.162.8.4824.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, FungalAntigens, FungalCell MovementChemokine CCL1Chemokine CCL3Chemokine CCL4Chemokines, CCCryptococcosisCryptococcus neoformansCytokinesFemaleGelatin Sponge, AbsorbableHypersensitivity, DelayedImmunity, CellularKineticsLeukocytesMacrophage Inflammatory ProteinsMiceMice, Inbred CBANeutrophilsReceptors, CCR8Recombinant ProteinsConceptsDelayed-type hypersensitivityMIP-1alphaC chemokinesAnticryptococcal cell-mediated immune responseCell-mediated immune responsesCell-mediated immune reactionsMacrophage inflammatory protein-1alphaMonocyte chemotactic protein-1DTH reaction sitesNumber of neutrophilsActivated T lymphocytesGelatin sponge modelCMI responsesNaive miceDTH reactionInfected miceCMI reactionsT cellsT lymphocytesImmune responseImmune reactionsCellular infiltrationLymphocytesChemokinesNeutrophils
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply