2024
Selenomethionine supplementation mitigates fluoride-induced liver apoptosis and inflammatory reactions by blocking Parkin-mediated mitophagy in mice
Wang T, Li H, Li Y, Li M, Zhao H, Zhang W, Zhao T, Wang Y, Wang J, Wang J. Selenomethionine supplementation mitigates fluoride-induced liver apoptosis and inflammatory reactions by blocking Parkin-mediated mitophagy in mice. The Science Of The Total Environment 2024, 951: 175458. PMID: 39142410, DOI: 10.1016/j.scitotenv.2024.175458.Peer-Reviewed Original ResearchParkin-mediated mitophagyCysteinyl aspartate specific proteinase 3Protein expression levelsLight chain 3Expression levelsInterleukin-6Wild-typeLiver damageContents of proinflammatory factorsTumor necrosis factor-aNuclear factor kappa BLevels of liver functionMitochondrial fusionFactor kappa BParkin-/-Inflammatory signaling pathwaysMicrotubule-associated protein light chain 3MitophagyInterferon-gMitochondrial alterationsProtein light chain 3Gene knockoutIFN-gFluorosis miceLiver functionInflammasomes in chronic liver disease: Hepatic injury, fibrosis progression and systemic inflammation
Taru V, Szabo G, Mehal W, Reiberger T. Inflammasomes in chronic liver disease: Hepatic injury, fibrosis progression and systemic inflammation. Journal Of Hepatology 2024, 81: 895-910. PMID: 38908436, PMCID: PMC11881887, DOI: 10.1016/j.jhep.2024.06.016.Peer-Reviewed Original ResearchAcute-on-chronic liver failureChronic liver diseaseLiver disease progressionToll-like receptorsLiver diseasePortal hypertensionLiver failureDisease progressionLiver injuryImmune systemEnd-stage liver diseaseRelease of pro-inflammatory cytokinesInnate immune cellsFlares of inflammationDysfunctional immune systemInflammasome activationPro-inflammatory stateNuclear factor kappa BPro-inflammatory cytokinesAdaptive immune systemFactor kappa BSystemic inflammationLiver parenchymal cellsWhite adipose tissueImmune cells
2022
The Role of PARP‐1 and NF‐κB in Bile‐Induced DNA Damage and Oncogenic Profile in Hypopharyngeal Cells
Doukas PG, Vageli DP, Judson BL. The Role of PARP‐1 and NF‐κB in Bile‐Induced DNA Damage and Oncogenic Profile in Hypopharyngeal Cells. The Laryngoscope 2022, 133: 1146-1155. PMID: 35791892, DOI: 10.1002/lary.30284.Peer-Reviewed Original ResearchConceptsHypopharyngeal cellsAcidic bileNF-κBNF-κB activationGamma-H2A histone family member XHypopharyngeal squamous cell carcinomaOncogenic profileNuclear factor kappa BPARP-1Squamous cell carcinomaB-cell lymphoma 2 expressionNF-κB transcriptional activityFactor kappa BDNA damageEnzyme-linked immunosorbent assayH2A histone family member XCell survivalDNA/RNA damageHypopharyngeal carcinogenesisReflux contentsAnti-apoptotic phenotypeCell carcinomaWidespread DNA damageBAY 11PARP-1 overexpression
2021
14-3-3 epsilon is an intracellular component of TNFbib2 receptor complex and its activation protects against osteoarthritis
Fu W, Hettinghouse A, Chen Y, Hu W, Ding X, Chen M, Ding Y, Mundra J, Song W, Liu R, Yi Y, Attur M, Samuels J, Strauss E, Leucht P, Schwarzkopf R, Liu C. 14-3-3 epsilon is an intracellular component of TNFbib2 receptor complex and its activation protects against osteoarthritis. Annals Of The Rheumatic Diseases 2021, 80: 1615-1627. PMID: 34226187, PMCID: PMC8595573, DOI: 10.1136/annrheumdis-2021-220000.Peer-Reviewed Original ResearchConceptsPathogenesis of osteoarthritisTNFR2 complexTherapeutic effectSingle-cell RNA-seqIntracellular componentsReceptor complexExtracellular signal-regulated kinaseNuclear factor kappa BSignal-regulated kinaseCommon joint diseaseFactor kappa BChondrocyte-specific deletionProteomic screenElk-1RNA-seqTranscription factorsCell-based assaysTNF signalingTNFR2 pathwayInducible componentJoint diseaseActivity screenTherapeutic targetKappa BOsteoarthritisHMGB1, neuronal excitability and epilepsy
Dai S, Zheng Y, Wang Y, Chen Z. HMGB1, neuronal excitability and epilepsy. Acta Epileptologica 2021, 3: 13. DOI: 10.1186/s42494-021-00048-y.Peer-Reviewed Original ResearchN-methyl-D-aspartateModulation of neuronal excitabilityAnimal models of epilepsyToll-like receptor 4Antiepileptic drug therapyInterleukin (IL)-1bTranslocation of HMGB1Multiple animal modelsDevelopment of epilepsyAnti-epileptic drugsMobility group protein B1HMGB1-related pathwayModels of epilepsyNuclear factor kappa BPotential of HMGB1Advanced glycation end productsFactor kappa BGlycation end productsNeuronal excitabilityBlocking HMGB1Downstream Signaling PathwaysGlutamate receptorsHMGB1 signalingHyperexcitable neuronsDrug therapyEndothelial p300 Promotes Portal Hypertension and Hepatic Fibrosis Through C‐C Motif Chemokine Ligand 2–Mediated Angiocrine Signaling
Gao J, Wei B, Liu M, Hirsova P, Sehrawat T, Cao S, Hu X, Xue F, Yaqoob U, Kang N, Cui H, Pomerantz W, Kostallari E, Shah V. Endothelial p300 Promotes Portal Hypertension and Hepatic Fibrosis Through C‐C Motif Chemokine Ligand 2–Mediated Angiocrine Signaling. Hepatology 2021, 73: 2468-2483. PMID: 33159815, PMCID: PMC8102654, DOI: 10.1002/hep.31617.Peer-Reviewed Original ResearchConceptsLiver sinusoidal endothelial cellsPartial inferior vena cava ligationPortal hypertensionLiver fibrosisLiver injuryMacrophage accumulationCCL2 transcriptionKnockout miceC motif chemokine ligand 2Inferior vena cava ligationP50 knockout miceNuclear factor kappa BVena cava ligationChemokine ligand 2Accumulation of macrophagesPathological inflammatory responsesWild-type miceFactor kappa BSinusoidal endothelial cellsInhibition of p300CCL2 deficiencyPortal pressureLiver diseaseInflammatory cellsCCL2 expressionChapter 12 Innate immunity in SLE pathogenesis
Kang I. Chapter 12 Innate immunity in SLE pathogenesis. 2021, 181-188. DOI: 10.1016/b978-0-12-820583-9.00025-7.Peer-Reviewed Original ResearchDanger-associated molecular patternsSystemic lupus erythematosusInnate immune cellsToll-like receptorsPattern recognition receptorsDendritic cellsSelf-nucleic acidsImmune cellsGermline-encoded pattern recognition receptorsMultiple inflammatory pathwaysMolecular patternsNuclear factor kappa BAntigen-presenting cellsArray of cytokinesFactor kappa BPathogen-associated molecular patternsCell-intrinsic alterationsLupus erythematosusSLE pathogenesisInflammatory pathwaysInflammatory eventsInterferon regulatory factorIntrinsic alterationsKappa BInnate immunity
2018
Tumor necrosis factor alfa and interleukin 1 alfa induced phosphorylation and degradation of inhibitory kappa B alpha are regulated by estradiol in endometrial cells
Arlıer S, Kayışlı Ü, Arıcı A. Tumor necrosis factor alfa and interleukin 1 alfa induced phosphorylation and degradation of inhibitory kappa B alpha are regulated by estradiol in endometrial cells. Journal Of Turkish Society Of Obstetric And Gynecology 2018, 15: 50-59. PMID: 29662717, PMCID: PMC5894537, DOI: 10.4274/tjod.47700.Peer-Reviewed Original ResearchEndometrial cellsNormal endometriumEctopic endometriumInhibitory kappa B-alphaTranscription factor nuclear factor kappa BInhibitory kappa B (IκBα) proteinMonocyte chemoattractant protein-1Ectopic endometrial cellsHomologous eutopic endometriumNuclear factor kappa BCultured endometrial cellsEffects of estradiolNecrosis factor alfaChemoattractant protein-1Human endometrial cellsRegulation of chemokinesTumor necrosis factorFactor kappa BKappa B alphaUterine endometrial cellsEutopic endometriumInflammatory responseNecrosis factorEndometriumKappa B
2017
Extracellular vesicles released by hepatocytes from gastric infusion model of alcoholic liver disease contain a MicroRNA barcode that can be detected in blood
Eguchi A, Lazaro R, Wang J, Kim J, Povero D, Willliams B, Ho S, Stärkel P, Schnabl B, Ohno‐Machado L, Tsukamoto H, Feldstein A. Extracellular vesicles released by hepatocytes from gastric infusion model of alcoholic liver disease contain a MicroRNA barcode that can be detected in blood. Hepatology 2017, 65: 475-490. PMID: 27639178, PMCID: PMC5407075, DOI: 10.1002/hep.28838.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAnalysis of VarianceAnimalsBiopsy, NeedleCells, CulturedDisease Models, AnimalExtracellular VesiclesFatty Liver, AlcoholicHepatocytesHumansImmunoblottingImmunohistochemistryMiceMicroRNAsMiddle AgedRandom AllocationReal-Time Polymerase Chain ReactionSampling StudiesSeverity of Illness IndexStatistics, NonparametricYoung AdultConceptsBlood extracellular vesiclesLiver injuryExtracellular vesiclesNuclear factor kappa BAlcoholic liver diseaseChronic liver injuryWeeks of infusionBile duct ligationB-cell lymphoma 2Levels of EVsFactor kappa BSteatohepatitis developmentNonalcoholic steatohepatitisLiver diseaseObese miceHepatic macrophagesDuct ligationKappa BMiR-340Cell originLymphoma 2Intragastric infusionMiceMiRNA signatureTime points
2016
Hypothalamic TLR2 triggers sickness behavior via a microglia-neuronal axis
Jin S, Kim JG, Park JW, Koch M, Horvath TL, Lee BJ. Hypothalamic TLR2 triggers sickness behavior via a microglia-neuronal axis. Scientific Reports 2016, 6: 29424. PMID: 27405276, PMCID: PMC4942617, DOI: 10.1038/srep29424.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnorexiaArcuate Nucleus of HypothalamusCyclooxygenase InhibitorsEnergy MetabolismFeverInflammationLipopeptidesMaleMiceMice, KnockoutMicrogliaMyeloid Differentiation Factor 88NF-kappa BPro-OpiomelanocortinRatsReceptor, Melanocortin, Type 3Receptor, Melanocortin, Type 4Toll-Like Receptor 2Weight LossConceptsSickness behaviorHypothalamic inflammationToll-like receptor 2 (TLR2) activationSickness behavior symptomsNuclear factor kappa BBody weight lossReceptor 2 activationFactor kappa BNeuronal circuit functionHypothalamic microgliaProopiomelanocortin neuronsInflammatory mechanismsIntracerebroventricular injectionPathophysiologic mechanismsTLR2 activationInflammatory processCyclooxygenase pathwayNeuronal activationKappa BBehavior symptomsWeight lossInput organizationMicrogliaTLR2InflammationComplement C5 Inhibition Reduces T Cell–Mediated Allograft Vasculopathy Caused by Both Alloantibody and Ischemia Reperfusion Injury in Humanized Mice
Qin L, Li G, Kirkiles-Smith N, Clark P, Fang C, Wang Y, Yu Z, Devore D, Tellides G, Pober J, Jane-Wit D. Complement C5 Inhibition Reduces T Cell–Mediated Allograft Vasculopathy Caused by Both Alloantibody and Ischemia Reperfusion Injury in Humanized Mice. American Journal Of Transplantation 2016, 16: 2865-2876. PMID: 27104811, PMCID: PMC5075274, DOI: 10.1111/ajt.13834.Peer-Reviewed Original ResearchConceptsIschemia-reperfusion injuryAllograft vasculopathyEndothelial cell activationReperfusion injuryCell activationComplement C5 inhibitionNuclear factor kappa BSolid organ transplantsT cell infiltrationTerminal complement activationVCAM-1 expressionComplement C5 activationFactor kappa BNeutrophil infiltrationHumanized miceDiffuse stenosisIntraluminal thrombosisArterial graftsC5 inhibitionCell infiltrationHumanized modelNeointimal hyperplasiaOrgan transplantsAlloantibodiesNF-kB
2015
St. John's Wort Attenuates Colorectal Carcinogenesis in Mice through Suppression of Inflammatory Signaling
Manna SK, Golla S, Golla JP, Tanaka N, Cai Y, Takahashi S, Krausz KW, Matsubara T, Korboukh I, Gonzalez FJ. St. John's Wort Attenuates Colorectal Carcinogenesis in Mice through Suppression of Inflammatory Signaling. Cancer Prevention Research 2015, 8: 786-795. PMID: 26069204, PMCID: PMC4584416, DOI: 10.1158/1940-6207.capr-14-0113.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnticarcinogenic AgentsAzoxymethaneCarcinogenesisCell Transformation, NeoplasticColonColorectal NeoplasmsDietDietary SupplementsDisease Models, AnimalExtracellular Signal-Regulated MAP KinasesHypericumInflammationMaleMiceNF-kappa BOligonucleotide Array Sequence AnalysisOligonucleotidesPlant ExtractsSignal TransductionConceptsDiet-fed miceSJW extractColorectal carcinogenesisAzoxymethane-induced colorectal carcinogenesisAIN-93G dietLong-term treatment regimensAzoxymethane-treated miceEffect of SJWNuclear factor kappa BBody weight lossWort extractTotal tumor volumeFactor kappa BSt. John's wort extractDose-dependent mannerAzoxymethane treatmentSJW administrationRectal bleedingOverall survivalTreatment regimensColorectal cancerProinflammatory processesTumor multiplicityLarge tumorsCholesterol levels
2012
A novel mechanism of control of NFκB activation and inflammation involving A2B adenosine receptors
Sun Y, Duan Y, Eisenstein A, Hu W, Quintana A, Lam W, Wang Y, Wu Z, Ravid K, Huang P. A novel mechanism of control of NFκB activation and inflammation involving A2B adenosine receptors. Journal Of Cell Science 2012, 125: 4507-4517. PMID: 22767505, PMCID: PMC3500865, DOI: 10.1242/jcs.105023.Peer-Reviewed Original ResearchConceptsExpression of anti-NFkB activationC-terminusEctopic expressionP105 proteinsAdenosine receptorsTranscription factor NFKB1A(2B) adenosine receptorsInhibited NFkB activationPolyubiquitylationSpecific sitesA2B adenosine receptorsLigand activationNFkB pathwayP105Interleukin (IL)-10Nuclear factor kappa BProtein levelsTumor necrosis factorPro-inflammatory cytokinesFactor kappa BRegulationIL-12PathwayTNF-a
2008
Cross-talk between the Akt and NF-κB Signaling Pathways Inhibits MEHP-Induced Germ Cell Apoptosis
Rogers R, Ouellet G, Brown C, Moyer B, Rasoulpour T, Hixon M. Cross-talk between the Akt and NF-κB Signaling Pathways Inhibits MEHP-Induced Germ Cell Apoptosis. Toxicological Sciences 2008, 106: 497-508. PMID: 18755736, PMCID: PMC2581679, DOI: 10.1093/toxsci/kfn186.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosis Regulatory ProteinsBase Sequencebcl-X ProteinBlotting, WesternCarrier ProteinsDiethylhexyl PhthalateDNA PrimersMaleMiceMitochondrial ProteinsNF-kappa BPhosphorylationProto-Oncogene Proteins c-aktReverse Transcriptase Polymerase Chain ReactionSignal TransductionSpermatozoaSuperoxidesTestisConceptsGerm cell apoptosisMono-(2-ethylhexyl) phthalatePI3K/AktCell apoptosisI kappaB alpha proteinNF-kappaBNuclear factor kappa BWild-type miceFactor kappa BNF-kappaB subunitsTwofold increaseGerm cell survivalWild-type testesTesticular injuryLoss of Akt1MEHP exposureP50 mRNAKappa BP65 subunitPostnatal developmentOxidative stressPremature onsetAktMitochondrial target genesTestis
1996
Rhinovirus stimulation of interleukin-6 in vivo and in vitro. Evidence for nuclear factor kappa B-dependent transcriptional activation.
Zhu Z, Tang W, Ray A, Wu Y, Einarsson O, Landry ML, Gwaltney J, Elias JA. Rhinovirus stimulation of interleukin-6 in vivo and in vitro. Evidence for nuclear factor kappa B-dependent transcriptional activation. Journal Of Clinical Investigation 1996, 97: 421-430. PMID: 8567963, PMCID: PMC507033, DOI: 10.1172/jci118431.Peer-Reviewed Original ResearchConceptsIL-6 productionIL-6RV infectionPotent stimulatorIL-6 protein productionIL-6 siteSymptomatic RV infectionsNuclear factor kappa BFactor kappa BIL-6 mRNA accumulationNF-kappa B activationNF-kappa B DNA binding activityPromoter-driven luciferase activityRhinovirus stimulationRV challengeNF-kappa BNF-kappa B siteInterleukin-6Nasal washingsKappa BSymptomatic volunteersRhinovirusStimulation pathwayNuclear factorB activation
1993
Endothelial activation by hydrogen peroxide. Selective increases of intercellular adhesion molecule-1 and major histocompatibility complex class I.
Bradley JR, Johnson DR, Pober JS. Endothelial activation by hydrogen peroxide. Selective increases of intercellular adhesion molecule-1 and major histocompatibility complex class I. American Journal Of Pathology 1993, 142: 1598-609. PMID: 8098585, PMCID: PMC1886909.Peer-Reviewed Original ResearchConceptsIntercellular adhesion molecule-1Tumor necrosis factorAdhesion molecule-1Major histocompatibility complex class I.Major histocompatibility complex class IHistocompatibility complex class IMolecule-1Complex class IInterleukin-1Intercellular adhesion molecule-1 surface expressionMumol/L hydrogen peroxideVascular cell adhesion molecule-1Transcription factor nuclear factor kappa BEndothelial leukocyte adhesion molecule-1Class ICell adhesion molecule-1Leukocyte-derived cytokinesNuclear factor kappa BVascular endothelial cell functionLeukocyte adhesion molecule-1Surface expressionClass I.Factor kappa BEC surface receptorsEndothelial cell function
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply