6612 Both Overt And Mild Hypercortisolism Accelerate Biological Aging
Yu K, Saini J, Farr J, Vanessa F, Khosla S, Bancos I. 6612 Both Overt And Mild Hypercortisolism Accelerate Biological Aging. Journal Of The Endocrine Society 2024, 8: bvae163.126. PMCID: PMC11454948, DOI: 10.1210/jendso/bvae163.126.Peer-Reviewed Original ResearchMild autonomous cortisol secretionP16<sup>INK4a</sup> expressionAutonomous cortisol secretionCushing's syndromeAdvanced glycation end productsP16<sup>INK4a</sup>Frailty index scoreSex-matched reference subjectsCortisol secretionCell senescenceReference subjectsSingle-center cross-sectional studyCompared to reference subjectsAdvanced glycation end product readerPresence of hypercortisolismOvert Cushing's syndromeIndex scoreHistory of cardiovascular diseaseEvidence of cell senescenceAssociated with history of cardiovascular diseaseAssociated with hypercortisolismRisk of comorbiditiesAssociated with CVDAging-related comorbiditiesAssociated with history
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