2024
Human IPSC-Derived Microglia Sense and Dampen Hyperexcitability of Cortical Neurons Carrying the Epilepsy-Associated SCN2A-L1342P Mutation
Que Z, Olivero-Acosta M, Robinson M, Chen I, Zhang J, Wettschurack K, Wu J, Xiao T, Otterbacher C, Shankar V, Harlow H, Hong S, Zirkle B, Wang M, Cui N, Mandal P, Chen X, Deming B, Halurkar M, Zhao Y, Rochet J, Xu R, Brewster A, Wu L, Yuan C, Skarnes W, Yang Y. Human IPSC-Derived Microglia Sense and Dampen Hyperexcitability of Cortical Neurons Carrying the Epilepsy-Associated SCN2A-L1342P Mutation. Journal Of Neuroscience 2024, 45: e2027232024. PMID: 39557580, PMCID: PMC11735681, DOI: 10.1523/jneurosci.2027-23.2024.Peer-Reviewed Original ResearchNeuronal excitabilityHyperexcitable neuronsHuman microgliaCo-CultureVoltage-gated sodium channel NaV1.2Neuronal activityRepetitive action potential firingRodent models of seizuresBrain-resident immune cellsSodium channel expressionInfluence neuronal excitabilityAction potential firingHyperexcitability of cortical neuronsModulates neuronal excitabilityEpilepsy-causing mutationsSodium channel Nav1.2Resident immune cellsAbnormal neuronal activityPresence of microgliaSuppression of seizuresModulate neuronal activityDensity of sodium channelsModels of seizuresPresence of neuronsAxon initial segment
2021
HMGB1, neuronal excitability and epilepsy
Dai S, Zheng Y, Wang Y, Chen Z. HMGB1, neuronal excitability and epilepsy. Acta Epileptologica 2021, 3: 13. DOI: 10.1186/s42494-021-00048-y.Peer-Reviewed Original ResearchN-methyl-D-aspartateModulation of neuronal excitabilityAnimal models of epilepsyToll-like receptor 4Antiepileptic drug therapyInterleukin (IL)-1bTranslocation of HMGB1Multiple animal modelsDevelopment of epilepsyAnti-epileptic drugsMobility group protein B1HMGB1-related pathwayModels of epilepsyNuclear factor kappa BPotential of HMGB1Advanced glycation end productsFactor kappa BGlycation end productsNeuronal excitabilityBlocking HMGB1Downstream Signaling PathwaysGlutamate receptorsHMGB1 signalingHyperexcitable neuronsDrug therapy
2015
Erratum: Differential responses to lithium in hyperexcitable neurons from patients with bipolar disorder
Mertens J, Wang Q, Kim Y, Yu D, Pham S, Yang B, Zheng Y, Diffenderfer K, Zhang J, Soltani S, Eames T, Schafer S, Boyer L, Marchetto M, Nurnberger J, Calabrese J, Oedegaard K, McCarthy M, Zandi P, Alda M, Nievergelt C, Mi S, Brennand K, Kelsoe J, Gage F, Yao J. Erratum: Differential responses to lithium in hyperexcitable neurons from patients with bipolar disorder. Nature 2015, 530: 242-242. PMID: 26605530, DOI: 10.1038/nature16182.Peer-Reviewed Original ResearchDifferential responses to lithium in hyperexcitable neurons from patients with bipolar disorder
Mertens J, Wang Q, Kim Y, Yu D, Pham S, Yang B, Zheng Y, Diffenderfer K, Zhang J, Soltani S, Eames T, Schafer S, Boyer L, Marchetto M, Nurnberger J, Calabrese J, Oedegaard K, McCarthy M, Zandi P, Alda M, Nievergelt C, Mi S, Brennand K, Kelsoe J, Gage F, Yao J. Differential responses to lithium in hyperexcitable neurons from patients with bipolar disorder. Nature 2015, 527: 95-99. PMID: 26524527, PMCID: PMC4742055, DOI: 10.1038/nature15526.Peer-Reviewed Original Research
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