2025
Dehydroepiandrosterone Sulfate in Diagnosing Mild Autonomous Cortisol Secretion and Adrenal Insufficiency
Saini J, Salama B, Yu K, Chacko S, Han A, Torres C, Murad M, Bancos I. Dehydroepiandrosterone Sulfate in Diagnosing Mild Autonomous Cortisol Secretion and Adrenal Insufficiency. Journal Of The Endocrine Society 2025, 9: bvaf136. PMID: 40909019, PMCID: PMC12406124, DOI: 10.1210/jendso/bvaf136.Peer-Reviewed Original ResearchMild autonomous cortisol secretionAutonomous cortisol secretionAdrenal insufficiencyRisk of biasDiagnostic accuracyMeta-analysisDehydroepiandrosterone sulfateModerate riskCortisol secretionRandom-effects meta-analysisModerate risk of biasCosyntropin stimulation testMeta-analysis of published studiesEffects meta-analysisBivariate random-effects meta-analysisMeta-analysis of studiesStimulation testSystematic reviewPostdexamethasone cortisolQUADAS-2DHEAHeterogeneous evidenceReference standardInsufficiencyMeasurement of DHEA-S
2024
Cognition in patients with mild autonomous cortisol secretion at baseline and post-adrenalectomy
Saini J, Nathani R, Singh S, Ebbehoj A, Thangamuthu K, Suresh M, Zhang C, Nevin S, Fell V, Atkinson E, Achenbach S, Stricker N, Bancos I. Cognition in patients with mild autonomous cortisol secretion at baseline and post-adrenalectomy. European Journal Of Endocrinology 2024, 191: 636-645. PMID: 39671564, PMCID: PMC11662234, DOI: 10.1093/ejendo/lvae157.Peer-Reviewed Original ResearchConceptsMild autonomous cortisol secretionReference subjectsT-scorePost-adrenalectomyBeck Depression InventoryComposite T-scoreAutonomous cortisol secretionSF-36Urine steroid profileImpact of adrenalectomyFrailty indexCross-sectional studyShort Form-36Longitudinal cohort studyNational Institutes of Health Toolbox Cognition BatteryCohort studyMultivariate analysisSteroid profileLower cognitionCortisol secretionPatientsAssociated with lower cognitionStandardized T scoresAdrenalectomyCognitive battery6612 Both Overt And Mild Hypercortisolism Accelerate Biological Aging
Yu K, Saini J, Farr J, Vanessa F, Khosla S, Bancos I. 6612 Both Overt And Mild Hypercortisolism Accelerate Biological Aging. Journal Of The Endocrine Society 2024, 8: bvae163.126. PMCID: PMC11454948, DOI: 10.1210/jendso/bvae163.126.Peer-Reviewed Original ResearchMild autonomous cortisol secretionP16<sup>INK4a</sup> expressionAutonomous cortisol secretionCushing's syndromeAdvanced glycation end productsP16<sup>INK4a</sup>Frailty index scoreSex-matched reference subjectsCortisol secretionCell senescenceReference subjectsSingle-center cross-sectional studyCompared to reference subjectsAdvanced glycation end product readerPresence of hypercortisolismOvert Cushing's syndromeIndex scoreHistory of cardiovascular diseaseEvidence of cell senescenceAssociated with history of cardiovascular diseaseAssociated with hypercortisolismRisk of comorbiditiesAssociated with CVDAging-related comorbiditiesAssociated with history12444 Steroid Profiling And Circadian Cortisol Secretion In Patients With Mild Autonomous Cortisol Secretion: A Single-Center Cross-Sectional Study
Saini J, Singh S, Ebbehøj A, Zhang C, Nathani R, Fell V, Atkinson E, Achenbach S, Rivard A, Singh R, Grebe S, Bancos I. 12444 Steroid Profiling And Circadian Cortisol Secretion In Patients With Mild Autonomous Cortisol Secretion: A Single-Center Cross-Sectional Study. Journal Of The Endocrine Society 2024, 8: bvae163.295. PMCID: PMC11454430, DOI: 10.1210/jendso/bvae163.295.Peer-Reviewed Original ResearchUrine steroid metabolomeAutonomous cortisol secretionSteroid metabolomeReference subjectsCortisol secretionMild autonomous cortisol secretionSteroid profileSteroid productionSingle-center cross-sectional studyCompared to reference subjectsUrine steroid profileSubgroup of patientsArea under the curveHigh-resolution mass spectrometry assayCross-sectional studyCircadian cortisol secretionMass spectrometry assaySingle-centerAndrogen ratioFree cortisolCircadian secretionPatientsMetabolomicsSteroidsSeparate days12430 Urine Steroid Profiling In Patients With Unilateral And Bilateral Mild Autonomous Cortisol Secretion
Salama B, Saini J, Fell V, Atkinson E, Achenbach S. 12430 Urine Steroid Profiling In Patients With Unilateral And Bilateral Mild Autonomous Cortisol Secretion. Journal Of The Endocrine Society 2024, 8: bvae163.317. PMCID: PMC11454782, DOI: 10.1210/jendso/bvae163.317.Peer-Reviewed Original ResearchMild autonomous cortisol secretionAutonomous cortisol secretionMacronodular adrenal hyperplasiaUrine steroid profileAdrenal hyperplasiaTumor bulkDehydroepiandrosterone sulfateDST cortisolBilateral macronodular adrenal hyperplasiaInterim analysis of patientsSteroid profileCortisol secretionInterim analysisSingle-center cross-sectional studyAdrenal mass sizeUrine steroid metabolomeBilateral adrenal adenomasCompared to patientsAnalysis of patientsPost-DST cortisolProfile of patientsHigh-resolution mass spectrometry assayPrevalence of comorbiditiesSteroid profile analysisPlasma steroid profiles8740 Visceral Adipose Tissue Assessment in Patients With Mild Autonomous Cortisol Secretion Using Dual-Energy X-Ray Absorptiometry: A Cross-Sectional Study
Saini J, Zhang C, Fell V, Atkinson E, Achenbach S, Bancos I. 8740 Visceral Adipose Tissue Assessment in Patients With Mild Autonomous Cortisol Secretion Using Dual-Energy X-Ray Absorptiometry: A Cross-Sectional Study. Journal Of The Endocrine Society 2024, 8: bvae163.321. PMCID: PMC11454869, DOI: 10.1210/jendso/bvae163.321.Peer-Reviewed Original ResearchDual-energy X-ray absorptiometryVisceral adipose tissueAutonomous cortisol secretionX-ray absorptiometryFat massReference subjectsLean massComputed tomographyFull-body DXA scanMild autonomous cortisol secretionVisceral adipose tissue assessmentDual-energy X-ray absorptiometry scanCortisol secretionAssociated with increased visceral adiposityFollow-up of patientsSingle-center cross-sectional studyCompared to reference subjectsDual-energyBMI-adjusted analysisAndroid fat massCross-sectional study of adultsDexamethasone suppression testGynoid fat massPost-DST cortisolBody composition measurements12429 Overnight Metyrapone Therapy In Patients With Mild Autonomous Cortisol Secretion (MACS): An Open Label Phase 2 Interventional Study
Ferreira E, Saini J, Larson J, Atkinson E, Powell C, Nevin S, Fell V, Bancos I. 12429 Overnight Metyrapone Therapy In Patients With Mild Autonomous Cortisol Secretion (MACS): An Open Label Phase 2 Interventional Study. Journal Of The Endocrine Society 2024, 8: bvae163.251. PMCID: PMC11453951, DOI: 10.1210/jendso/bvae163.251.Peer-Reviewed Original ResearchMild autonomous cortisol secretionAutonomous cortisol secretionMacronodular adrenal hyperplasiaOvernight metyraponeManagement of patientsAdrenal adenomaMetyrapone therapyAdrenal hyperplasiaCortisol secretionAdverse eventsDehydroepiandrosterone-sulfateIncidence of treatment related adverse eventsSeverity scoreTreatment-related adverse eventsTreatment related adverse eventsIncidence of cardiovascular morbidityPatients discontinued therapyBilateral adrenal adenomasClinical severity scoreSenescence biomarkersSingle-center studyEffective medical therapyAssociated with increased prevalenceRelated adverse eventsPost-dexamethasone cortisol6425 Impact Of Adrenalectomy On Mood, Sleep, And Quality Of Life In Patients With Mild Autonomous Cortisol Secretion: A Prospective Longitudinal Study
Saini J, Fell V, Atkinson B, Achenbach S, Bancos I. 6425 Impact Of Adrenalectomy On Mood, Sleep, And Quality Of Life In Patients With Mild Autonomous Cortisol Secretion: A Prospective Longitudinal Study. Journal Of The Endocrine Society 2024, 8: bvae163.212. PMCID: PMC11453505, DOI: 10.1210/jendso/bvae163.212.Peer-Reviewed Original ResearchPittsburgh Sleep Quality IndexQuality of lifeImpact of adrenalectomyBeck Depression InventoryAutonomous cortisol secretionReference subjectsProspective longitudinal studyAdrenal adenomaMental component of quality of lifeComponent scoresSF-36 mental component scoreComponents of quality of lifeRole-physical limitationMild autonomous cortisol secretionSF36 physical component scoreCortisol secretionMental component scorePhysical component scorePittsburgh Sleep Quality Index scoreSingle-center prospective longitudinal studyShort Form-36Beck Depression Inventory questionnaireNonfunctioning adrenal adenomasLongitudinal studySleep Quality Index7829 Hydrocortisone Vs Prednisone During Recovery Following Surgical Cure For Endogenous Hypercortisolism: A Longitudinal Observational Study
Sandooja R, Saini J, Garcia R, Zhang C, Achenbach S, Atkinson E, Van Gompel J, Young W, Bancos I. 7829 Hydrocortisone Vs Prednisone During Recovery Following Surgical Cure For Endogenous Hypercortisolism: A Longitudinal Observational Study. Journal Of The Endocrine Society 2024, 8: bvae163.206. PMCID: PMC11454907, DOI: 10.1210/jendso/bvae163.206.Peer-Reviewed Original ResearchGlucocorticoid withdrawal syndromeMild autonomous cortisol secretionSeverity of hypercortisolismTreated with hydrocortisoneEndogenous hypercortisolismSurgical cureCushing's syndromeSF-36Clinical severityPost-surgeryFemale sexPatients treated with prednisoneSeverity scorePatients treated with hydrocortisoneSF-36 mental component scoreQuality of lifeSF-36 physical component scoreEtiology of hypercortisolismAutonomous cortisol secretionClinical severity scoreBaseline clinical severityConstellation of symptomsWeeks post-surgeryPhysical component scoreGlucocorticoid replacement6427 Impact of Adrenalectomy On Frailty And Muscle Function In Patients With Mild Autonomous Cortisol Secretion: A Prospective Longitudinal Study
Saini J, Fell V, Atkinson B, Achenbach S, Bancos I. 6427 Impact of Adrenalectomy On Frailty And Muscle Function In Patients With Mild Autonomous Cortisol Secretion: A Prospective Longitudinal Study. Journal Of The Endocrine Society 2024, 8: bvae163.211. PMCID: PMC11454285, DOI: 10.1210/jendso/bvae163.211.Peer-Reviewed Original ResearchTimed Up and Go testUp-and-go testParameters of muscle strengthAutonomous cortisol secretionImpact of adrenalectomyMuscle strengthReference subjectsGait speedAdrenal adenomaAdrenal disordersProspective longitudinal studyWalk testMild autonomous cortisol secretionCortisol secretionHand grip muscle strengthSingle-center prospective longitudinal studyNonfunctioning adrenal adenomasGrip muscle strengthReference groupReduced muscle strengthDexamethasone suppression testDaily living activitiesFollow-up visitPrevalence of frailtyLongitudinal study12426 Performance Of Dehydroepiandrosterone-Sulphate In Diagnosing Mild Autonomous Cortisol Secretion: A Systematic Review And Meta-Analysis
Saini J, Salama B, Chacko S, Yu K, Bancos I. 12426 Performance Of Dehydroepiandrosterone-Sulphate In Diagnosing Mild Autonomous Cortisol Secretion: A Systematic Review And Meta-Analysis. Journal Of The Endocrine Society 2024, 8: bvae163.256. PMCID: PMC11454422, DOI: 10.1210/jendso/bvae163.256.Peer-Reviewed Original ResearchMild autonomous cortisol secretionRisk of biasMeta-analysisAutonomous cortisol secretionSystematic reviewDehydroepiandrosterone sulfateReference groupRandom-effects meta-analysisEffects meta-analysisOvid Cochrane Central Register of Controlled TrialsNon-Indexed CitationsCochrane Central Register of Controlled TrialsCentral Register of Controlled TrialsMeta-analysis of published literatureRegister of Controlled TrialsDiagnostic accuracy studiesMeta-analysis of studiesDiagnostic accuracy estimatesMeasurement of dehydroepiandrosterone sulfateDatabase inceptionCortisol secretionBaseline dehydroepiandrosterone sulfateMeasured dehydroepiandrosterone sulfateOvid MEDLINEReference standardEnhanced Chronic Inflammation and Increased Branched-Chain Amino Acids in Adrenal Disorders: A Cross-Sectional Study
Kittithaworn A, Dogra P, Saini J, Gruppen E, Atkinson E, Achenbach S, Yu K, Thangamuthu K, Connelly M, Dullaart R, Bancos I. Enhanced Chronic Inflammation and Increased Branched-Chain Amino Acids in Adrenal Disorders: A Cross-Sectional Study. The Journal Of Clinical Endocrinology & Metabolism 2024, 110: e330-e338. PMID: 38546526, PMCID: PMC11747673, DOI: 10.1210/clinem/dgae204.Peer-Reviewed Original ResearchMild autonomous cortisol secretionBranched-chain amino acidsMalignant adrenal massesNonfunctioning adenomasCushing's syndromeAdrenocortical carcinomaAdrenal massPrimary aldosteronismAdrenal disordersIncreasing TMAONon-functioning adrenal massesIncreased branched-chain amino acidsIncreased BCAACross-sectional study of patientsReference subjectsSingle-center cross-sectional studyAutonomous cortisol secretionTrimethylamine N-oxideKetone bodiesAdrenal hormone excessSimilar to patientsMultivariate logistic analysisIncreased cardiovascular riskMetabolite trimethylamine N-oxideStudy of patients
2023
Kidney Function in Patients With Adrenal Adenomas: A Single-Center Retrospective Cohort Study
Rahimi L, Kittithaworn A, Garcia R, Saini J, Dogra P, Atkinson E, Achenbach S, Kattah A, Bancos I. Kidney Function in Patients With Adrenal Adenomas: A Single-Center Retrospective Cohort Study. The Journal Of Clinical Endocrinology & Metabolism 2023, 109: e1750-e1758. PMID: 38157409, PMCID: PMC11318994, DOI: 10.1210/clinem/dgad765.Peer-Reviewed Original ResearchMild autonomous cortisol secretionNonfunctioning adrenal adenomasFactors associated with chronic kidney diseaseChronic kidney diseaseTime of diagnosisAdrenal adenomaKidney functionSingle-center retrospective cohort studyMultivariate analysisSingle-center cohort study of patientsSingle-center cohort studyIncreased risk of chronic kidney diseaseCohort study of patientsRisk of chronic kidney diseaseAngiotensin II receptor blockersAutonomous cortisol secretionAngiotensin-converting enzyme inhibitorsTreated with adrenalectomyImpact of adrenalectomyIndependent risk factorRetrospective cohort studyII receptor blockersFollow-up periodStudy of patientsConverting Enzyme InhibitorsTHU605 Impact Of Abnormal Circadian Cortisol Secretion On Bone Metabolism In Patients With Mild Autonomous Cortisol Secretion
Saini J, Nathani R, Singh S, Fell V, Atkinson E, Achenbach S, Khosla S, Bancos I. THU605 Impact Of Abnormal Circadian Cortisol Secretion On Bone Metabolism In Patients With Mild Autonomous Cortisol Secretion. Journal Of The Endocrine Society 2023, 7: bvad114.135. PMCID: PMC10554199, DOI: 10.1210/jendso/bvad114.135.Peer-Reviewed Original ResearchArea under the curveAutonomous cortisol secretionParathyroid hormoneBone metabolism biomarkersCortisol secretionFree cortisolType 1 collagenBone metabolismReference subjectsCircadian cortisol secretionCarboxy-terminal telopeptide of type 1 collagenMetabolic biomarkersMild autonomous cortisol secretionIncreased risk of fractureCross-sectional study of patientsCortisol productionParathyroid hormone productionDexamethasone suppression testRisk of fractureCarboxy-terminal telopeptideImpaired bone metabolismStudy of patientsCircadian secretory patternClinical research unitIncreased cortisol productionTHU606 Cognitive Impairment In Patients With Mild Autonomous Cortisol Secretion: A Cross-sectional Study
Saini J, Nathani R, Singh S, Thangamuthu K, Suresh M, Zhang C, Ebbehøj A, Thomas M, Fell V, Atkinson E, Achenbach S, Stricker N, Bancos I. THU606 Cognitive Impairment In Patients With Mild Autonomous Cortisol Secretion: A Cross-sectional Study. Journal Of The Endocrine Society 2023, 7: bvad114.136. PMCID: PMC10553766, DOI: 10.1210/jendso/bvad114.136.Peer-Reviewed Original ResearchComposite T-scoreDexamethasone suppression testPost-DST cortisolFluid cognitionCrystallized cognitionCognitive performanceCognitive impairmentNIH Toolbox Cognition BatteryPattern of cognitive impairmentCrystallized composite scoresComposite scoreReference subjectsT-scoreCognitive batterySubgroup analysisCognitive agingComposite cognitionMild autonomous cortisol secretionCognitive domainsNIH ToolboxSubgroup analysis of patientsImpaired cognitionCognitive functionSingle-center cross-sectional studyCompared to reference subjectsFRI185 Post-adrenalectomy Improvement Of Kidney Function In Patients With Mild Autonomous Cortisol Secretion And Nonfunctioning Adrenal Adenoma
Rahimi L, Kittithaworn A, Garcia R, Saini J, Dogra P, Atkinson E, Achenbach S, Kattah A, Bancos I. FRI185 Post-adrenalectomy Improvement Of Kidney Function In Patients With Mild Autonomous Cortisol Secretion And Nonfunctioning Adrenal Adenoma. Journal Of The Endocrine Society 2023, 7: bvad114.180. PMCID: PMC10553513, DOI: 10.1210/jendso/bvad114.180.Peer-Reviewed Original ResearchNonfunctioning adrenal adenomasImprovement of eGFRAutonomous cortisol secretionImprovement of kidney functionPost-adrenalectomyChronic kidney diseaseKidney functionAdrenal adenomaMild autonomous cortisol secretionMultivariate analysisRetrospective single-center studyCortisol secretionPrevalence of chronic kidney diseaseDecline of eGFRYounger ageSingle-center studyEffects of hypercortisolismPrevalence of hypertensionFactors associated andPrevalence of diabetesProportion of womenDelta eGFRAntihypertensive therapyAssociated with improvementsAdult patientsFRI184 Impact Of Adrenalectomy On Cognition In Patients With Mild Autonomous Cortisol Secretion
Saini J, Nathani R, Zhang C, Suresh M, Thangamuthu K, Singh S, Fell V, Atkinson E, Achenbach S, Stricker N, Bancos I. FRI184 Impact Of Adrenalectomy On Cognition In Patients With Mild Autonomous Cortisol Secretion. Journal Of The Endocrine Society 2023, 7: bvad114.179. PMCID: PMC10555084, DOI: 10.1210/jendso/bvad114.179.Peer-Reviewed Original ResearchComposite T-scoreDexamethasone suppression testImpact of adrenalectomyCognitive functionNational Institutes of Health (NIH) Toolbox Cognition BatteryCognitive evaluationT-scoreCortisol secretionLongitudinal study of adultsPost-DST cortisolProspective longitudinal study of adultsAutonomous cortisol secretionFluid cognitionCognitive batteryCrystallized cognitionImpaired cognitionTotal cognitionAssociated with improvementsCognitionStudy of adultsSuppression testAdrenal adenomaFollow-upScore changesMild autonomous cortisol secretionDeterminants of muscle function and health-related quality of life in patients with endogenous hypercortisolism: a cross-sectional study
Li D, Zhang C, Saini J, Singh S, Nathani R, Thangamuthu K, Suresh M, Atkinson E, Achenbach S, Van Gompel J, Young W, Bancos I. Determinants of muscle function and health-related quality of life in patients with endogenous hypercortisolism: a cross-sectional study. European Journal Of Endocrinology 2023, 189: 40-49. PMID: 37327378, PMCID: PMC10376436, DOI: 10.1093/ejendo/lvad069.Peer-Reviewed Original ResearchConceptsMild autonomous cortisol secretionQuality of lifeReduced muscle strengthCushing's syndromeMuscle strengthEndogenous hypercortisolismComponent scoresPhysical component of SF36Sit-to-stand test performanceHealth-related quality of lifeSF36 mental component scoreMuscle functionSeverity scoreReference subjectsMental component scorePhysical component scoreHealth-related qualityAutonomous cortisol secretionClinical severity scoreMuscle strength impairmentCross-sectional studyDeterminants of muscle functionStrength impairmentsAdrenal CSEctopic CS
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