2024
Medial Amygdalar Tau Is Associated With Mood Symptoms in Preclinical Alzheimer’s Disease
Li J, Tun S, Ficek-Tani B, Xu W, Wang S, Horien C, Toyonaga T, Nuli S, Zeiss C, Powers A, Zhao Y, Mormino E, Fredericks C. Medial Amygdalar Tau Is Associated With Mood Symptoms in Preclinical Alzheimer’s Disease. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2024, 9: 1301-1311. PMID: 39059466, PMCID: PMC11625605, DOI: 10.1016/j.bpsc.2024.07.012.Peer-Reviewed Original ResearchAssociated with mood symptomsMood symptomsAmyloid-positive individualsMedial amygdalaSeed-based functional connectivity analysisAssociated with anxiety symptomsSelf-reported mood symptomsPost hoc correlation analysisAlzheimer's diseaseFunctional connectivity analysisPreclinical Alzheimer's diseaseTau bindingOrbitofrontal cortexTau depositionAmygdalar connectivityEmotional processingAnxiety symptomsRetrosplenial cortexBetween-group differencesAmygdalaFunctional connectivityLateral amygdalaConnectivity analysisDepression scoresNeuropsychiatric symptoms
2022
Examining the effects of age and sex on tau PET binding in the absence of beta‐amyloid pathology
Gordon B, Flores S, Dincer A, Keefe S, McKay N, Hobbs D, Wisch J, Hornbeck R, Franklin E, Jack C, Koeppe R, Xiong C, McDade E, van Dyck C, Klein G, Pariente J, Bateman R, Morris J, Perrin R, Benzinger T. Examining the effects of age and sex on tau PET binding in the absence of beta‐amyloid pathology. Alzheimer's & Dementia 2022, 18 DOI: 10.1002/alz.063285.Peer-Reviewed Original ResearchPrimary age-related tauopathyTau-PET bindingTau-PETTemporal gyrusPET bindingBeta-amyloid pathologyAge-related tauopathyRostral middle frontal gyrusSubthreshold levelsElevated tracer uptakeTau PET imagingTau bindingInferior temporal gyrusInferior temporal cortexMiddle frontal gyrusSuperior temporal gyrusEffect of ageAlzheimer pathologyAmyloid pathologySignificant positive associationLateral parietalTemporal cortexTracer uptakeAlzheimer's diseaseSecondary analysisExamining the effects of sex and age on tau PET binding in the absence of beta‐amyloid pathology
Gordon B, Flores S, Dincer A, Keefe S, McKay N, Hobbs D, Wisch J, Hornbeck R, Franklin E, Jack C, Koeppe R, Xiong C, van Dyck C, McDade E, Klein G, Pariente J, Bateman R, Morris J, Ances B, Benzinger T, Perrin R. Examining the effects of sex and age on tau PET binding in the absence of beta‐amyloid pathology. Alzheimer's & Dementia 2022, 18 DOI: 10.1002/alz.061090.Peer-Reviewed Original ResearchPrimary age-related tauopathyTau-PET bindingTau-PETTemporal gyrusPET bindingBeta-amyloid pathologyAge-related tauopathyRostral middle frontal gyrusElevated tracer uptakeSub-threshold levelsTau PET imagingTau bindingInferior temporal gyrusInferior temporal cortexMiddle frontal gyrusSuperior temporal gyrusAlzheimer pathologyAmyloid pathologySignificant positive association
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