2025
Health Status Improvement After Peripheral Vascular Intervention: Insights From the LIBERTY 360 Study
Mosarla R, Chowdhury M, Smolderen K, Mena-Hurtado C, Spertus J, Yeh R, Secemsky E. Health Status Improvement After Peripheral Vascular Intervention: Insights From the LIBERTY 360 Study. The American Journal Of Cardiology 2025, 243: 22-31. PMID: 39894333, DOI: 10.1016/j.amjcard.2025.01.017.Peer-Reviewed Original ResearchPredictor of health statusHealth statusEQ-VASAssociated with health statusHealth status measuresTarget vessel/lesion revascularizationTotal scoreBaseline health statusAll-cause deathImprove health statusPeripheral endovascular interventionsHealth status improvementChronic limb-threatening ischemiaRepeated measures modelPeripheral arterial disease severitySymptomatic peripheral arterial diseaseStatus measuresPeripheral arterial diseaseLimb-threatening ischemiaLong-term improvementPeripheral vascular interventionsStatus improvementHealthMultivariate regressionClaudication
2024
Twelve-month health status response after peripheral vascular intervention for femoropopliteal lesions using Zilver PTX databases focusing on the role of preprocedural health status, comorbid risks, and global setting
Smolderen K, Romain G, Cleman J, Callegari S, Peri-Okonny P, Mena-Hurtado C. Twelve-month health status response after peripheral vascular intervention for femoropopliteal lesions using Zilver PTX databases focusing on the role of preprocedural health status, comorbid risks, and global setting. Journal Of Vascular Surgery 2024, 81: 210-220.e7. PMID: 39214426, DOI: 10.1016/j.jvs.2024.08.035.Peer-Reviewed Original ResearchMinimal Clinically Important DifferenceEQ-5D indexHealth statusPeripheral vascular interventionsPeripheral arterial diseaseEQ-5DNon-respondersValue-based careEuroQol-5D-3LClinically Important DifferenceSecondary data analysisFemoropopliteal peripheral vascular interventionsStable health statusLogistic regression modelsArtery diseaseSymptomatic peripheral arterial diseaseStatus responseTailored resourcesVascular interventionsSingle-arm studyImportant differenceCarotid artery diseaseComorbidity riskEnrolling centersPatient characteristicsImpact of early intervention on health status outcomes in peripheral artery disease patients with chronic total occlusion lesions using the PORTRAIT registry
Cerrud-Rodriguez R, Romain G, Hussain Y, Cleman J, Callegari S, Scierka L, Smolderen K, Mena-Hurtado C. Impact of early intervention on health status outcomes in peripheral artery disease patients with chronic total occlusion lesions using the PORTRAIT registry. Journal Of Vascular Surgery 2024, 80: 780-790.e10. PMID: 38735596, DOI: 10.1016/j.jvs.2024.04.061.Peer-Reviewed Original ResearchPeripheral Artery QuestionnairePeripheral arterial diseaseHealth statusChronic total occlusionChronic total occlusion lesionsPAD-specific health statusEarly invasive treatmentMultilevel generalized linear regression modelsPeripheral arterial disease symptomsLower extremity peripheral arterial diseaseBaseline health statusHealth status outcomesInvasive treatmentHealth status trajectoriesNon-invasive treatmentPatients' health statusImpact of early interventionHigh health statusFollow-upPeripheral arterial disease patientsSymptomatic peripheral arterial diseaseMonths of follow-upPresence of chronic total occlusionNon-invasive treatment strategyStatus outcomesASSOCIATION BETWEEN DEPRESSIVE SYMPTOMS AND HEALTH STATUS OUTCOMES IN PATIENTS WITH SYMPTOMATIC PERIPHERAL ARTERY DISEASE
Jacque F, Romain G, Peri-Okonny P, Sinusas A, Callegari S, Cleman J, Scierka L, Mares A, Hurtado C, Smolderen K. ASSOCIATION BETWEEN DEPRESSIVE SYMPTOMS AND HEALTH STATUS OUTCOMES IN PATIENTS WITH SYMPTOMATIC PERIPHERAL ARTERY DISEASE. Journal Of The American College Of Cardiology 2024, 83: 2308. DOI: 10.1016/s0735-1097(24)04298-0.Peer-Reviewed Original ResearchHealth status outcomesSymptomatic peripheral arterial diseaseStatus outcomesPeripheral arterial diseaseDepressive symptomsArtery diseaseHealthPsychosocial and socioeconomic factors are most predictive of health status in patients with claudication
Scierka L, Peri-Okonny P, Romain G, Cleman J, Spertus J, Fitridge R, Secemsky E, Patel M, Gosch K, Mena-Hurtado C, Smolderen K. Psychosocial and socioeconomic factors are most predictive of health status in patients with claudication. Journal Of Vascular Surgery 2024, 79: 1473-1482.e5. PMID: 38266885, PMCID: PMC11180544, DOI: 10.1016/j.jvs.2024.01.021.Peer-Reviewed Original ResearchPeripheral Artery QuestionnairePeripheral Artery Questionnaire summary scoresPeripheral arterial diseaseHealth statusSummary scoreSymptomatic peripheral arterial diseaseSocial supportInsurance statusPAD-specific health statusHierarchical multivariable linear regression modelSocioeconomic patient characteristicsLow social supportPeripheral artery disease cohortPeripheral artery questionnaire scoresImprove health statusComparative effectiveness researchDiagnosis of depressionPatient characteristicsMultivariate linear regression modelPrediction of health statusDepression scoresLinear regression modelsAge of patientsDuration of symptomsAnxiety scores
2021
Variability in utilization of diagnostic imaging tests in patients with symptomatic peripheral artery disease
Derbas LA, Patel KK, Muskula PR, Wang J, Gosch K, Fitridge R, Spertus JA, Smolderen KG. Variability in utilization of diagnostic imaging tests in patients with symptomatic peripheral artery disease. International Journal Of Cardiology 2021, 330: 200-206. PMID: 33581177, DOI: 10.1016/j.ijcard.2021.02.014.Peer-Reviewed Original ResearchConceptsPeripheral arterial diseaseMedian odds ratioImaging testsSymptomatic peripheral artery diseaseSymptomatic peripheral arterial diseaseInvasive imaging testsPAQ summary scoreVascular specialty clinicsPatient-level factorsPeripheral artery diseaseDiagnostic imaging testsHierarchical logistic regression modelsLogistic regression modelsMean ABIPAD diagnosisNew onsetPAD symptomsPatient demographicsArtery diseasePatient characteristicsVascular clinicArterial diseaseDisease characteristicsRecent exacerbationReferral rates
2018
A prospective, multi‐center study of the chocolate balloon in femoropopliteal peripheral artery disease: The Chocolate BAR registry
Mustapha JA, Lansky A, Shishehbor M, McClure J, Johnson S, Davis T, Makam P, Crowder W, Konstantino E, Attaran RR, Investigators T. A prospective, multi‐center study of the chocolate balloon in femoropopliteal peripheral artery disease: The Chocolate BAR registry. Catheterization And Cardiovascular Interventions 2018, 91: 1144-1148. PMID: 29513389, DOI: 10.1002/ccd.27565.Peer-Reviewed Original ResearchMeSH KeywordsAgedAngioplasty, BalloonEquipment DesignFemaleFemoral ArteryHumansMaleMiddle AgedPeripheral Arterial DiseasePopliteal ArteryProduct Surveillance, PostmarketingProspective StudiesRegistriesRisk FactorsStentsTime FactorsTreatment OutcomeUnited StatesVascular Access DevicesVascular PatencyConceptsTarget lesion revascularizationPrimary endpointFemoropopliteal peripheral artery diseaseSymptomatic peripheral arterial diseaseExcellent procedural outcomesLower dissection ratePeripheral arterial diseasePeripheral artery diseaseAcute procedural successLong-term outcomesPost-market registryMulti-center studyAngioplasty balloon catheterPercutaneous transluminal angioplasty balloon catheterRutherford classCause mortalityLesion revascularizationMajor amputationArtery diseaseArterial diseaseProcedural successUnplanned amputationBalloon catheterProcedural outcomesProcedure success
2017
TCT-762 The BioMimics 3DTM Stent System in the Femoropopliteal Arteries of Patients with Symptomatic Peripheral Arterial Disease: Clinical and Angiographic Performance in the MIMICS-2 Study
Bouras G, Sullivan T, Zeller T, Nakamura M, Cristea E, Xin Z, Lansky A. TCT-762 The BioMimics 3DTM Stent System in the Femoropopliteal Arteries of Patients with Symptomatic Peripheral Arterial Disease: Clinical and Angiographic Performance in the MIMICS-2 Study. Journal Of The American College Of Cardiology 2017, 70: b322. DOI: 10.1016/j.jacc.2017.09.1001.Peer-Reviewed Original ResearchSymptomatic peripheral arterial diseasePeripheral arterial diseaseAngiographic performanceArterial diseaseFemoropopliteal arteriesStent systemPatientsArteryDisease
2016
SEX DIFFERENCES IN DISEASE SPECIFIC HEALTH STATUS MEASURES IN PATIENTS WITH SYMPTOMATIC PERIPHERAL ARTERIAL DISEASE
Roumia M, Aronow H, Soukas P, Gosch K, Smolderen K, Spertus J, Abbott J. SEX DIFFERENCES IN DISEASE SPECIFIC HEALTH STATUS MEASURES IN PATIENTS WITH SYMPTOMATIC PERIPHERAL ARTERIAL DISEASE. Journal Of The American College Of Cardiology 2016, 67: 2276. DOI: 10.1016/s0735-1097(16)32277-x.Peer-Reviewed Original ResearchSymptomatic peripheral arterial diseasePeripheral arterial diseaseHealth status measuresArterial diseaseStatus measuresSex differencesDiseasePatients
2015
Contemporary Outcomes for Open Infrainguinal Bypass in the Endovascular Era
Reifsnyder T, Arhuidese I, Hicks C, Obeid T, Massada K, Khaled A, Qazi U, Malas M. Contemporary Outcomes for Open Infrainguinal Bypass in the Endovascular Era. Annals Of Vascular Surgery 2015, 30: 52-58. PMID: 26549809, DOI: 10.1016/j.avsg.2015.10.003.Peer-Reviewed Original ResearchConceptsPeripheral arterial diseaseInfrainguinal bypassLimb salvage rateCritical limb ischemiaGraft failureVein conduitSociety for Vascular Surgery standardsSalvage ratePredictors of graft failureLimb ischemiaAutogenous vein conduitPrimary-assisted patencySymptomatic peripheral arterial diseaseCohort of patientsMonitoring of high-risk groupsCox regression analysisLong-term outcomesSixty-five casesHigh-risk groupManagement of comorbiditiesLower-extremity revascularizationPrimary patencySecondary patencyRedo bypassAutogenous vein grafts
2014
Critical evaluation of stents in the peripheral arterial disease of the superficial femoral artery – focus on the paclitaxel eluting stent
Litsky J, Chanda A, Stilp E, Lansky A, Mena C. Critical evaluation of stents in the peripheral arterial disease of the superficial femoral artery – focus on the paclitaxel eluting stent. Medical Devices Evidence And Research 2014, 7: 149-156. PMID: 24920940, PMCID: PMC4045256, DOI: 10.2147/mder.s45472.Peer-Reviewed Original ResearchSuperficial femoral arteryPeripheral arterial diseaseArterial diseaseSymptomatic peripheral arterial diseasePercutaneous transluminal balloon angioplastyPreferred initial therapyTransluminal balloon angioplastySelf-expanding nitinol stentsInitial therapyObstructive lesionsSFA diseaseEndovascular managementObstructive diseaseEndovascular treatmentAdequate therapyBalloon angioplastySFA stenosisFemoral arteryDurable resultsClinical practiceLong occlusionsDiseaseNitinol stentsStentsBiomechanical forces
2013
Comparison of surgical bypass with angioplasty and stenting of superficial femoral artery disease
Malas M, Enwerem N, Qazi U, Brown B, Schneider E, Reifsnyder T, Freischlag J, Perler B. Comparison of surgical bypass with angioplasty and stenting of superficial femoral artery disease. Journal Of Vascular Surgery 2013, 59: 129-135. PMID: 23891488, DOI: 10.1016/j.jvs.2013.05.100.Peer-Reviewed Original ResearchMeSH KeywordsAgedAngioplasty, BalloonBaltimoreBlood Vessel Prosthesis ImplantationChi-Square DistributionFemaleFemoral ArteryHumansKaplan-Meier EstimateMaleMiddle AgedMultivariate AnalysisPeripheral Arterial DiseasePostoperative ComplicationsProportional Hazards ModelsRegistriesRisk FactorsStentsTime FactorsTreatment OutcomeVascular GraftingVascular PatencyVeinsConceptsPeripheral arterial diseaseFemoral-popliteal bypassPercutaneous transluminal angioplasty/stentingJohns Hopkins Bayview Medical CenterAngioplasty/stentingSuperficial femoral arteryReintervention rateTASC CSymptomatic patientsD lesionsMedical managementB lesionsFemoral arteryMedical CenterSuperficial femoral artery diseaseSymptomatic peripheral arterial diseaseFemoral artery diseaseTASC II ARate of reinterventionHigher reintervention rateBest treatment optionSimilar risk factorsProportional hazards modelTerms of patencyFisher's exact test
2010
Younger women with symptomatic peripheral arterial disease are at increased risk of depressive symptoms
Smolderen KG, Spertus JA, Vriens PW, Kranendonk S, Nooren M, Denollet J. Younger women with symptomatic peripheral arterial disease are at increased risk of depressive symptoms. Journal Of Vascular Surgery 2010, 52: 637-644. PMID: 20576397, DOI: 10.1016/j.jvs.2010.04.025.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsAgedAged, 80 and overAnkle Brachial IndexDepressionFemaleHealth Status DisparitiesHumansIncidenceLogistic ModelsMaleMiddle AgedNetherlandsOdds RatioPeripheral Vascular DiseasesProspective StudiesPsychiatric Status Rating ScalesRegistriesRisk AssessmentRisk FactorsSex FactorsTime FactorsConceptsPeripheral arterial diseaseSignificant depressive symptomsDepressive symptomsGender-age groupsYoung womenArterial diseaseSymptomatic peripheral arterial diseaseEpidemiological Studies Depression ScaleFourfold greater oddsVascular outpatient clinicAnkle-brachial indexPatients' depressive symptomsTime of diagnosisLogistic regression modelsImportant comorbidityPAD diagnosisPAD patientsClinical factorsDepression screeningOutpatient clinicCardiovascular diseaseDepression riskDepression ScaleAdditional adjustmentGreater odds
2009
Type D Personality and Mortality in Peripheral Arterial Disease: A Pilot Study
Aquarius AE, Smolderen KG, Hamming JF, De Vries J, Vriens PW, Denollet J. Type D Personality and Mortality in Peripheral Arterial Disease: A Pilot Study. JAMA Surgery 2009, 144: 728-733. PMID: 19687376, DOI: 10.1001/archsurg.2009.75.Peer-Reviewed Original ResearchConceptsPeripheral arterial diseaseType D personalityCause mortalityD personalityIndependent predictorsRenal diseaseArterial diseaseSymptomatic peripheral arterial diseasePilot studyAnkle-brachial indexHigh-risk patientsTraditional risk factorsPatients' medical filesMultivariable logistic regressionRisk of deathVascular surgery departmentType D ScaleClinical predictorsDiabetes mellitusPulmonary diseasePilot followMedical filesSurgery departmentRisk factorsTeaching hospital
2008
Clinical validity of a disease-specific health status questionnaire: The Peripheral Artery Questionnaire
Hoeks SE, Smolderen KG, Reimer W, Verhagen HJ, Spertus JA, Poldermans D. Clinical validity of a disease-specific health status questionnaire: The Peripheral Artery Questionnaire. Journal Of Vascular Surgery 2008, 49: 371-377. PMID: 19028064, DOI: 10.1016/j.jvs.2008.08.089.Peer-Reviewed Original ResearchMeSH KeywordsAgedDisability EvaluationFactor Analysis, StatisticalFemaleHealth Status IndicatorsHumansIntermittent ClaudicationMaleNetherlandsPain MeasurementPatient SatisfactionPeripheral Arterial DiseasePredictive Value of TestsPsychometricsRecovery of FunctionReproducibility of ResultsRetrospective StudiesSensitivity and SpecificitySeverity of Illness IndexSurveys and QuestionnairesTreatment OutcomeVascular Surgical ProceduresWalkingConceptsPeripheral Artery QuestionnairePeripheral arterial diseaseDisease-specific Peripheral Artery QuestionnaireClear dose-response relationPAQ summary scoreDose-response relationClinical indicesClinical validitySummary scoresPAD patientsEQ-VASEQ-5DHealth statusLee Cardiac Risk IndexSymptomatic peripheral arterial diseaseEuroQol visual analogue scaleBaseline clinical indicesConsecutive PAD patientsGeneric EQ-5DSeverity of claudicationCardiac Risk IndexDisease-specific health status questionnaireEQ-5D indexHealth Status QuestionnairePatient-centered outcomes
2004
Impact of Symptomatic Peripheral Arterial Disease on 1-Year Mortality in Patients Undergoing Percutaneous Coronary Interventions
Nikolsky E, Mehran R, Mintz GS, Dangas GD, Lansky AJ, Aymong ED, Negoita M, Fahy M, Moussa I, Roubin GS, Moses JW, Stone GW, Leon MB. Impact of Symptomatic Peripheral Arterial Disease on 1-Year Mortality in Patients Undergoing Percutaneous Coronary Interventions. Journal Of Endovascular Therapy 2004, 11: 60-70. PMID: 14748627, DOI: 10.1177/152660280401100108.Peer-Reviewed Original ResearchConceptsSymptomatic peripheral arterial diseasePeripheral arterial diseasePercutaneous coronary interventionCoronary interventionArterial diseaseProcedural successTarget lesionsPresence of PADUrgent coronary artery bypassSmaller body surface areaMore target lesionsAtherosclerotic risk factorsChronic renal insufficiencyCoronary artery bypassFifth of patientsTransient ischemic attackHigh rateBody surface areaHigh mortality rateLower ratesFemoral hematomaHospital complicationsIschemic attackRe-PCIArtery bypassImpact of Symptomatic Peripheral Arterial Disease on 1-Year Mortality in Patients Undergoing Percutaneous Coronary Interventions
Nikolsky E, Mehran R, Mintz G, Dangas G, Lansky A, Aymong E, Negoita M, Fahy M, Moussa I, Roubin G, Moses J, Stone G, Leon M. Impact of Symptomatic Peripheral Arterial Disease on 1-Year Mortality in Patients Undergoing Percutaneous Coronary Interventions. Journal Of Endovascular Therapy 2004, 11: 60-70. DOI: 10.1583/1545-1550(2004)011<0060:iospad>2.0.co;2.Peer-Reviewed Original ResearchSymptomatic peripheral arterial diseasePeripheral arterial diseasePercutaneous coronary interventionCoronary interventionArterial diseaseProcedural successTarget lesionsPresence of PADUrgent coronary artery bypassSmaller body surface areaMore target lesionsAtherosclerotic risk factorsChronic renal insufficiencyCoronary artery bypassFifth of patientsTransient ischemic attackHigh rateBody surface areaHigh mortality rateLower ratesFemoral hematomaHospital complicationsIschemic attackRe-PCIArtery bypass
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