2025
Hippocampal and amygdala subfield volumes in obsessive–compulsive disorder by medication status
Ntwatwa Z, Lochner C, Roos A, Sevenoaks T, van Honk J, Batistuzzo M, Choi S, Hoexter M, Kim M, Kwon J, Mataix-Cols D, Menchón J, Miguel E, Nakamae T, Soriano-Mas C, Veltman D, Groenewold N, van den Heuvel O, Stein D, Ipser J. Hippocampal and amygdala subfield volumes in obsessive–compulsive disorder by medication status. Journal Of Psychiatry And Neuroscience 2025, 50: e170-e180. PMID: 40398928, PMCID: PMC12114122, DOI: 10.1503/jpn.230119.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderSubfield volumesMedical statusSymptom severityNeuroimaging studies of obsessive-compulsive disorderObsessive-compulsive disorder symptom severityStudies of obsessive-compulsive disorderNeurobiology of obsessive-compulsive disorderHealthy controlsObsessive-compulsive disorder severityBrain volumetric alterationsPsychotropic medication useHippocampal dentate gyrusQuadratic effects of ageAssess between-group differencesComorbid anxietyUnmedicated peopleNeuroimaging studiesPsychotropic medicationsVolumetric findingsBetween-group differencesVolumetric alterationsHippocampal subfieldsAmygdalaBrain volumeSequential decreases in basolateral amygdala response to threat predict failure to recover from PTSD
Roeckner A, Lin E, Hinrichs R, Harnett N, Lebois L, van Rooij S, Ely T, Jovanovic T, Murty V, Bruce S, House S, Beaudoin F, An X, Neylan T, Clifford G, Linnstaedt S, Germine L, Rauch S, Haran J, Storrow A, Lewandowski C, Musey P, Hendry P, Sheikh S, Jones C, Punches B, Swor R, Hudak L, Pascual J, Seamon M, Datner E, Pearson C, Peak D, Merchant R, Domeier R, Rathlev N, O’Neil B, Sergot P, Sanchez L, Joormann J, Sheridan J, Harte S, Koenen K, Kessler R, McLean S, Ressler K, Stevens J. Sequential decreases in basolateral amygdala response to threat predict failure to recover from PTSD. Neuropsychopharmacology 2025, 1-10. PMID: 40319171, DOI: 10.1038/s41386-025-02115-1.Peer-Reviewed Original ResearchBasolateral amygdalaResponses to threatMonths post-traumaPTSD severityTraumatic eventsFunctional connectivityPost-traumaAmygdala responses to threatAssociated with PTSD severityBLA functionIncreased PTSD severityReactivity to threatDorsal attention networkGeneralizability of findingsAmygdala hyperreactivityThreat cuesThreat processingNeurobiological correlatesFear memoryStress disorderAttention networkMultisite studyAmygdalaSample of ED patientsReplicate samplesMEMORY RELATED STRUCTURAL AND FUNCTIONAL NEURAL CHANGES FOLLOWING A SINGLE INFUSION OF KETAMINE IN PTSD
Harpaz-Rotem *, Duek O, Korem N, Krystal J. MEMORY RELATED STRUCTURAL AND FUNCTIONAL NEURAL CHANGES FOLLOWING A SINGLE INFUSION OF KETAMINE IN PTSD. The International Journal Of Neuropsychopharmacology 2025, 28: i38-i38. PMCID: PMC11814760, DOI: 10.1093/ijnp/pyae059.066.Peer-Reviewed Original ResearchPost-retrieval extinctionInfusion of ketamineIntravenous infusion of ketamineTrauma memoriesTraumatic memoriesFear responsesSs' responsesAssociated with decreased connectivityAmygdala-vmPFC connectivityTrauma-focused psychotherapyTreatment of PTSDNMDA receptor antagonistPre-post treatmentAmygdala activationLower amygdalaReconsolidation windowUncinate fasciculusAssessed before treatmentKetamine administrationMemory learningNaturalistic stimuliLabile stateAmygdalaPTSDExtinction process
2024
Magnetic resonance imaging of regional gray matter volume in persons who died by suicide
Deininger-Czermak E, Spencer L, Zoelch N, Sankar A, Gascho D, Guggenberger R, Mathieu S, Thali M, Blumberg H. Magnetic resonance imaging of regional gray matter volume in persons who died by suicide. Molecular Psychiatry 2024, 30: 1029-1033. PMID: 39237718, PMCID: PMC11835744, DOI: 10.1038/s41380-024-02730-2.Peer-Reviewed Original ResearchGray matter volumeMatter volumeBrain regionsIn vivo neuroimaging researchRegional gray matter volumeGray matter volume measurementsBrain voxel-based analysisStudy of suicideEmotion regulationNeuroimaging researchSuicide attemptsSelf-PerceptionSuicideCompare personsMagnetic resonance imagingSuicide deathsPersonsBrainAmygdalaInsulaStriatumNeuroimagingMotivationIndividualsHypothesisAmygdala Cannabinoid 1 Receptor, Pain Response, and Emotional Numbing in Trauma-Exposed Individuals
Korem N, Hillmer A, D’Souza D, Nia A, Levy I, Pietrzak R, Harpaz-Rotem I. Amygdala Cannabinoid 1 Receptor, Pain Response, and Emotional Numbing in Trauma-Exposed Individuals. JAMA Network Open 2024, 7: e2432387. PMID: 39250156, PMCID: PMC11385051, DOI: 10.1001/jamanetworkopen.2024.32387.Peer-Reviewed Original ResearchMaternal Prenatal Social Disadvantage and Neonatal Functional Connectivity: Associations With Psychopathology Symptoms at Age 12 Months
Herzberg M, Nielsen A, Brady R, Kaplan S, Alexopoulos D, Meyer D, Arora J, Miller J, Smyser T, Barch D, Rogers C, Warner B, Smyser C, Luby J. Maternal Prenatal Social Disadvantage and Neonatal Functional Connectivity: Associations With Psychopathology Symptoms at Age 12 Months. Developmental Psychology 2024, 60: 1562-1579. PMID: 38386382, PMCID: PMC11869658, DOI: 10.1037/dev0001708.Peer-Reviewed Original ResearchConceptsFunctional connectivityNeonatal functional connectivityRight amygdalaInfant-Toddler Social and Emotional AssessmentInfant brain functionSocioeconomically diverse sampleMotor-related regionsInfant neurobehavioral outcomesEffect of socioeconomic statusPsychopathological symptomsInfant externalizingInternalizing symptomsExternalizing symptomsNeonatal amygdalaBrain structuresInternalizing behaviorsBrain functionSocial disadvantageDiverse sampleAmygdalaInfant-ToddlerEmotional AssessmentNeurobehavioral developmentNeurobehavioral outcomesMagnetic resonance imagingMedial Amygdalar Tau Is Associated With Mood Symptoms in Preclinical Alzheimer’s Disease
Li J, Tun S, Ficek-Tani B, Xu W, Wang S, Horien C, Toyonaga T, Nuli S, Zeiss C, Powers A, Zhao Y, Mormino E, Fredericks C. Medial Amygdalar Tau Is Associated With Mood Symptoms in Preclinical Alzheimer’s Disease. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2024, 9: 1301-1311. PMID: 39059466, PMCID: PMC11625605, DOI: 10.1016/j.bpsc.2024.07.012.Peer-Reviewed Original ResearchAssociated with mood symptomsMood symptomsAmyloid-positive individualsMedial amygdalaSeed-based functional connectivity analysisAssociated with anxiety symptomsSelf-reported mood symptomsPost hoc correlation analysisAlzheimer's diseaseFunctional connectivity analysisPreclinical Alzheimer's diseaseTau bindingOrbitofrontal cortexTau depositionAmygdalar connectivityEmotional processingAnxiety symptomsRetrosplenial cortexBetween-group differencesAmygdalaFunctional connectivityLateral amygdalaConnectivity analysisDepression scoresNeuropsychiatric symptomsNPY-mediated synaptic plasticity in the extended amygdala prioritizes feeding during starvation
Dodt S, Widdershooven N, Dreisow M, Weiher L, Steuernagel L, Wunderlich F, Brüning J, Fenselau H. NPY-mediated synaptic plasticity in the extended amygdala prioritizes feeding during starvation. Nature Communications 2024, 15: 5439. PMID: 38937485, PMCID: PMC11211344, DOI: 10.1038/s41467-024-49766-0.Peer-Reviewed Original ResearchConceptsBed nucleus of the stria terminalisNPY-deficient miceBed nucleus of the stria terminalis neuronsGABAergic inputsControl of feeding behaviorPromote feedingAgRP neuronsOrexigenic neuropeptide Y (NPYSuppress food intakeNeuropeptide Y (NPYAmygdala circuitsAnxiety signalsExtended amygdalaCentral amygdalaBed nucleusCeA projectionsStria terminalisSynaptic adaptationDecreased anxietyAmygdalaSynaptic plasticityRelevant circuitsDecreased feedingAnxietyHypothalamic neuronsSelective disrupted gray matter volume covariance of amygdala subregions in schizophrenia
Chang Z, Liu L, Lin L, Wang G, Zhang C, Tian H, Liu W, Wang L, Zhang B, Ren J, Zhang Y, Xie Y, Du X, Wei X, Wei L, Luo Y, Dong H, Li X, Zhao Z, Liang M, Zhang C, Wang X, Yu C, Qin W, Liu H. Selective disrupted gray matter volume covariance of amygdala subregions in schizophrenia. Frontiers In Psychiatry 2024, 15: 1349989. PMID: 38742128, PMCID: PMC11090100, DOI: 10.3389/fpsyt.2024.1349989.Peer-Reviewed Original ResearchGray matter volume covarianceGray matter volumeAnterior amygdaloid areaAmygdala subregionsSchizophrenia patientsNegative Symptom ScaleVoxel-wise general linear modelHealthy controlsDuration of illnessOrbitofrontal cortexMatter volumeRight BASchizophreniaAmygdalaSymptom ScaleConnectivity patternsSubregionsSample size of patientsSize of patientsFunctional abnormalitiesCorrelation analysisStriatumGeneralized linear modelPatientsHippocampusEncoding and context-dependent control of reward consumption within the central nucleus of the amygdala
Fraser K, Kim T, Castro M, Drieu C, Padovan-Hernandez Y, Chen B, Pat F, Ottenheimer D, Janak P. Encoding and context-dependent control of reward consumption within the central nucleus of the amygdala. IScience 2024, 27: 109652. PMID: 38650988, PMCID: PMC11033178, DOI: 10.1016/j.isci.2024.109652.Peer-Reviewed Original ResearchCentral amygdalaCentral nucleus of the amygdalaEnhanced alcohol intakeOptogenetic stimulationAlcohol use disorderAmygdala neural activityCentral amygdala neuronsReward consumptionDrinking sucroseReward choicesUse disorderAberrant choiceAmygdala neuronsAmygdala stimulationCentral nucleusNeural activityAmygdalaReward approachRewardMale ratsActivity changesAlcohol intakeAlcoholIdentity optionsRatsNeurogenetic underpinnings of nicotine use severity: Integrating the brain transcriptomes and GWAS variants via network approaches
Yang B, Xiang B, Wang T, Ma S, Li C. Neurogenetic underpinnings of nicotine use severity: Integrating the brain transcriptomes and GWAS variants via network approaches. Psychiatry Research 2024, 334: 115815. PMID: 38422867, PMCID: PMC11017751, DOI: 10.1016/j.psychres.2024.115815.Peer-Reviewed Original ResearchConceptsMediodorsal nucleus of the thalamusMedial prefrontal cortexPrefrontal cortexNeurogenetic underpinningsDorsolateral prefrontal cortexBrain transcriptomeDrug memoryOrbitofrontal cortexInhibitory controlSmoking severityAssociated with CPDHuman brain transcriptomeMediodorsal nucleusWhole-brainNeurogenetic mechanismsPrimary motor cortexMechanisms of individual variationCortexHub proteinsGenetic riskAmygdalaStriatumMotor cortexOPFCHippocampusMethylone is a rapid-acting neuroplastogen with less off-target activity than MDMA
Warner-Schmidt J, Stogniew M, Mandell B, Rowland R, Schmidt E, Kelmendi B. Methylone is a rapid-acting neuroplastogen with less off-target activity than MDMA. Frontiers In Neuroscience 2024, 18: 1353131. PMID: 38389788, PMCID: PMC10882719, DOI: 10.3389/fnins.2024.1353131.Peer-Reviewed Original ResearchPost-traumatic stress disorderTreatment of post-traumatic stress disorderFrontal cortexBrain areasMDMA-Assisted PsychotherapyEffects of methyloneMonoamine uptake inhibitorsNeuroplasticity-related genesMyelin-related genesAntidepressant-likeAnxiolytic effectsBrain substratesStress disorderPsychiatric disordersNeuropsychiatric disordersUptake inhibitorsBrain effectsAvailable pharmacotherapiesMDMAMDDEmotional learningMethyloneAmygdalaGene expression changesDisordersA role for the cerebellum in motor-triggered alleviation of anxiety
Zhang X, Wu W, Shen L, Ji M, Zhao P, Yu L, Yin J, Xie S, Xie Y, Zhang Y, Li H, Zhang Q, Yan C, Wang F, De Zeeuw C, Wang J, Zhu J. A role for the cerebellum in motor-triggered alleviation of anxiety. Neuron 2024, 112: 1165-1181.e8. PMID: 38301648, DOI: 10.1016/j.neuron.2024.01.007.Peer-Reviewed Original ResearchAlleviation of anxietyAnxiolytic effectsDentate neuronsBrain mechanismsOrexinergic projectionsAmygdalar neuronsEmotional systemsCerebellar dentate nucleusAnxietyReduce anxietyPhysical exerciseMotor systemRotarodHypothalamic neuronsDentate nucleusNeuronsAmygdalaSubject animalsDentateCerebellumBrainAnimalsResponding to threat: Associations between neural reactivity to and behavioral avoidance of threat in pediatric anxiety
Kitt E, Zacharek S, Odriozola P, Nardini C, Hommel G, Martino A, Anderson T, Spencer H, Broussard A, Dean J, Marin C, Silverman W, Lebowitz E, Gee D. Responding to threat: Associations between neural reactivity to and behavioral avoidance of threat in pediatric anxiety. Journal Of Affective Disorders 2024, 351: 818-826. PMID: 38290579, PMCID: PMC10981528, DOI: 10.1016/j.jad.2024.01.204.Peer-Reviewed Original ResearchConceptsReactivity to threatMeasures of avoidanceVentral anterior insulaClinician-based measuresNeural reactivityPediatric anxietyAnxiety disordersBehavioral avoidanceFunctional magnetic resonance imaging taskAmygdala functional connectivityVentromedial prefrontal cortexTreatment-seeking sampleAvoidance of threatClinically significant constructsAssociated with tasksGeneralizability of findingsPrefrontal cortexAnterior insulaNeural findingsLaboratory tasksFunctional connectivityAnxietyAmygdalaAvoidanceSignificant constructsNeural Mechanisms of Resting-State Networks and the Amygdala Underlying the Cognitive and Emotional Effects of Psilocybin
Stoliker D, Novelli L, Vollenweider F, Egan G, Preller K, Razi A. Neural Mechanisms of Resting-State Networks and the Amygdala Underlying the Cognitive and Emotional Effects of Psilocybin. Biological Psychiatry 2024, 96: 57-66. PMID: 38185235, DOI: 10.1016/j.biopsych.2024.01.002.Peer-Reviewed Original ResearchCentral executive networkDefault mode networkResting-state networksEffective connectivitySalience networkNeural mechanismsAltered cognitionLarge-scale resting-state networksBasic cognitive functionsCognitive systemBehavioral measuresExecutive networkHierarchical organizationEmotional effectsMode networkCognitive functionSubcortical systemsSubjective experienceCognitionFunctional MRIPsychedelic therapyAmygdalaEmotionsHealthy adultsPsychiatric disorders
2023
Neural Circuit Transitions Supporting Developmentally Specific Social Behavior
Ferrara N, Che A, Briones B, Padilla-Coreano N, Lovett-Barron M, Opendak M. Neural Circuit Transitions Supporting Developmentally Specific Social Behavior. Journal Of Neuroscience 2023, 43: 7456-7462. PMID: 37940586, PMCID: PMC10634550, DOI: 10.1523/jneurosci.1377-23.2023.Peer-Reviewed Original ResearchConceptsSocial behaviorSocial neuroscience researchFlexible social behaviorAppropriate social behaviorPrefrontal cortexNeural mechanismsFlexible behaviorNeuroscience researchSensory cortexIn adulthoodSocial interactionMotor controlCortexAdulthoodBehavioral transitionsUnique demandsAmygdalaHabenulaBehaviorTime pointsThalamusEarly time pointsMemoryBrainEffects of a dissociative drug on fronto-limbic resting-state functional connectivity in individuals with posttraumatic stress disorder: a randomized controlled pilot study
Danböck S, Duek O, Ben-Zion Z, Korem N, Amen S, Kelmendi B, Wilhelm F, Levy I, Harpaz-Rotem I. Effects of a dissociative drug on fronto-limbic resting-state functional connectivity in individuals with posttraumatic stress disorder: a randomized controlled pilot study. Psychopharmacology 2023, 241: 243-252. PMID: 37872291, PMCID: PMC10806226, DOI: 10.1007/s00213-023-06479-4.Peer-Reviewed Original ResearchResting-state functional connectivityPosttraumatic stress disorderFunctional magnetic resonance imagingMedial prefrontal cortexMPFC subregionsAnterior medial PFCFunctional connectivityStress disorderAspartate glutamate receptor antagonistPilot studyNon-competitive N-methylGlutamate receptor antagonistsEffects of ketamineDissociative drugsMagnetic resonance imagingIntravenous drug infusionReceptor antagonistSubanesthetic doseDrug infusionCorrelative findingsKetamineResonance imagingTransient decreaseDrug midazolamAmygdalaSex differences in the effects of trait anxiety and age on resting-state functional connectivities of the amygdala
Chaudhary S, Hu S, Hu K, Dominguez J, Chao H, Li C. Sex differences in the effects of trait anxiety and age on resting-state functional connectivities of the amygdala. Journal Of Affective Disorders Reports 2023, 14: 100646. PMID: 38105798, PMCID: PMC10723810, DOI: 10.1016/j.jadr.2023.100646.Peer-Reviewed Original ResearchResting-state functional connectivityAmygdala resting-state functional connectivityTrait anxietyFunctional connectivitySex differencesInferior temporal gyrusCalcarine cortexTask-based dataNeural basisIndividual differencesEmotional traitsSupramarginal gyrusEmotional disordersTemporal gyrusNeural markersPosterior insulaAnxietyEffect of ageGyrusIndependent samplesMultiple regressionCorrelatesAmygdalaResults AnxietyCortexMultiple Memory Subsystems: Reconsidering Memory in the Mind and Brain
Sherman B, Turk-Browne N, Goldfarb E. Multiple Memory Subsystems: Reconsidering Memory in the Mind and Brain. Perspectives On Psychological Science 2023, 19: 103-125. PMID: 37390333, PMCID: PMC10756937, DOI: 10.1177/17456916231179146.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMemory representationsDistinct brain systemsLong-term memoryBrain structuresCross-species findingsSame brain structuresMemory-related structuresMemory researchBrain systemsMemory typesMemory organizationMemoryFuture researchOrganizational principlesClassic theoryMemory subsystemNovel perspectiveRepresentationAmygdalaResearchRecent workLearningMindTheoryDistinct typesDissociation of vicarious and experienced rewards by coupling frequency within the same neural pathway
Putnam P, Chu C, Fagan N, Dal Monte O, Chang S. Dissociation of vicarious and experienced rewards by coupling frequency within the same neural pathway. Neuron 2023, 111: 2513-2522.e4. PMID: 37348507, PMCID: PMC10527039, DOI: 10.1016/j.neuron.2023.05.020.Peer-Reviewed Original ResearchConceptsExperienced rewardsVicarious rewardBasolateral amygdalaAlpha/beta frequencyLocal field potentialsSame neural pathwaysSelect brain regionsSocial learningNeural systemsSocial interactionDirectional influenceRewardBrain regionsBeta frequenciesNeural pathwaysGamma frequenciesShared experienceDecision makingNeuronal interactionsSocial agencyField potentialsVoluntary choiceSocial choiceGyrusAmygdala
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