2025
Brief exposure to oral antibiotics has age-dependent effects on morphine reward and gene expression in the medial prefrontal cortex of adolescent and adult mice
Hofford R, Sens J, Shipman A, Kimble V, Coric C, Meckel K, Kiraly D. Brief exposure to oral antibiotics has age-dependent effects on morphine reward and gene expression in the medial prefrontal cortex of adolescent and adult mice. Brain Behavior And Immunity 2025 PMID: 40645237, DOI: 10.1016/j.bbi.2025.07.005.Peer-Reviewed Original ResearchMedial prefrontal cortexPrefrontal cortexMorphine rewardDrug reward behaviorsMorphine place preferenceSubstance use disordersResponse to morphineCortical gene expressionOral antibioticsDrug rewardPlace preferenceOpioid rewardAdolescent miceReward behaviorAge-dependent effectsBrain regionsAdult miceHeightened vulnerabilityEffects of oral antibioticsRewardOpioid sensitivityCortexDrug useRodent modelsAdolescentsThe interoceptive origin of reinforcement learning
Weber L, Yee D, Small D, Petzschner F. The interoceptive origin of reinforcement learning. Trends In Cognitive Sciences 2025 PMID: 40500611, DOI: 10.1016/j.tics.2025.05.008.Peer-Reviewed Original ResearchPolygenic risks for depression and neural responses to reward and punishment in young adults
Chen Y, Li H, Luo X, Li G, Ide J, Li C. Polygenic risks for depression and neural responses to reward and punishment in young adults. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2025 PMID: 40412620, DOI: 10.1016/j.bpsc.2025.05.008.Peer-Reviewed Original ResearchPolygenic risk scoresPunishment processingNeural responsesAchenbach Adult Self-ReportInfluence of genetic riskCortical activityAdult Self-ReportYoung adultsGenetic riskRisk of depressionGambling TaskAberrant rewardDrinking severityHuman Connectome ProjectDepression severityPublished routinesBrain responsesPolygenic riskDepression scoresSelf-ReportDepressionConnectome ProjectRewardBrain imagingPunishmentExpert of Experts Verification and Alignment (EVAL) Framework for Large Language Models Safety in Gastroenterology
Giuffrè M, You K, Pang Z, Kresevic S, Chung S, Chen R, Ko Y, Chan C, Saarinen T, Ajcevic M, Crocè L, Garcia-Tsao G, Gralnek I, Sung J, Barkun A, Laine L, Sekhon J, Stadie B, Shung D. Expert of Experts Verification and Alignment (EVAL) Framework for Large Language Models Safety in Gastroenterology. Npj Digital Medicine 2025, 8: 242. PMID: 40319106, PMCID: PMC12049514, DOI: 10.1038/s41746-025-01589-z.Peer-Reviewed Original ResearchReward modelSimilarity-based rankingZero-shot baselineSupervised fine-tuningRejection samplingLanguage modelSimilarity metricModel safetyHuman performanceFine-tuningHuman gradingExpert verificationTime-consumingDecision-makingMedical decision-makingMedical questionsEVALAccuracyLanguageDatasetMetricsAssess accuracyRewardVerificationSets602. Transdiagnostic Neural Signature of Reward Processing, and Its Relevance for Substance Use Abstinence
Cheng A, Silwal S, Day M, Lichenstein S, Grilo C, Potenza M, Yip S. 602. Transdiagnostic Neural Signature of Reward Processing, and Its Relevance for Substance Use Abstinence. Biological Psychiatry 2025, 97: s346-s347. DOI: 10.1016/j.biopsych.2025.02.841.Peer-Reviewed Original ResearchRewards Transiently and Automatically Enhance Sustained Attention
Trach J, deBettencourt M, Radulescu A, McDougle S. Rewards Transiently and Automatically Enhance Sustained Attention. Journal Of Experimental Psychology General 2025, 154: 1063-1079. PMID: 39836118, DOI: 10.1037/xge0001727.Peer-Reviewed Original ResearchSustained attentionAttentional vigilanceAttentional lapsesRewarding effectsAttentional performanceReward feedbackArousal accountModulate vigilanceAttentional stateImproved vigilanceRewardTransient boostRL tasksArousalVigilanceMotivationTaskPerformance-based rewardsDaily lifeReinforcement learningLapseAttentionCore componentsReinforcementRL rewardInformation-driven attentional capture
Doyle A, Volkova K, Crotty N, Massa N, Grubb M. Information-driven attentional capture. Attention, Perception, & Psychophysics 2025, 87: 721-727. PMID: 39971884, PMCID: PMC11965227, DOI: 10.3758/s13414-024-03008-z.Peer-Reviewed Original ResearchExperience-driven attentionTask-irrelevantAttentional captureReward prediction error hypothesisAbsence of monetary rewardReward prediction errorNon-salient stimuliAllocation of attentionReward associationsNeural signaturesAttentional differencesPre-cueMonetary rewardsBehavioral costsVisual attentionDistractorsEye movementsExperimental manipulationInternational goalsError hypothesisSensory informationEmpirical workResponse timeHypothesisRewardUnderstanding the development of a functional brain circuit: reward processing as an illustration
Opendak M, Meyer H, Callaghan B, Abramson L, John S, Bath K, Lee F, Tottenham N, Sullivan R. Understanding the development of a functional brain circuit: reward processing as an illustration. Translational Psychiatry 2025, 15: 53. PMID: 39962048, PMCID: PMC11832941, DOI: 10.1038/s41398-025-03280-z.Peer-Reviewed Original ResearchConceptsReward processingReward systemAberrant reward processingNeural reward circuitsAdult circuit functionEnvironmental demands changePromote adaptive behaviorFunctional brain circuitsBrain network functionDevelopmental research questionsReward circuitReward behaviorPsychiatric disordersBrain circuitsAdaptive behaviorRewardCircuit functionDevelopmental transitionsImpact infantsDevelopmental processesDisordersStimuliBrainBehaviorChildhoodRole of Altered Neural Circuits of Stress and Reward Regulation in Alcohol Use Disorder and Treatment-Related Recovery
Seo D, Choi J, Sinha R, De Aquiar R. Role of Altered Neural Circuits of Stress and Reward Regulation in Alcohol Use Disorder and Treatment-Related Recovery. Drug And Alcohol Dependence 2025, 267: 112197. DOI: 10.1016/j.drugalcdep.2024.112197.Peer-Reviewed Original ResearchA randomized controlled trial to assess whether a telehealth-based contingency management intervention reduces alcohol use for individuals with alcohol use disorder
Jett J, Tyutyunnyk D, Beck R, Palmer K, Ryan D, Sanchez J, Weeks D, McPherson S, Chaytor N, Kiluk B, Javors M, Ginsburg B, Murphy S, Hill-Kapturczak N, McDonell M. A randomized controlled trial to assess whether a telehealth-based contingency management intervention reduces alcohol use for individuals with alcohol use disorder. Contemporary Clinical Trials 2025, 150: 107807. PMID: 39824379, DOI: 10.1016/j.cct.2025.107807.Peer-Reviewed Original ResearchConceptsAlcohol use disorderContingency managementAlcohol useUse disorderPredictors of intervention outcomeOnline cognitive behavioral therapyCognitive behavioral therapyContingency management interventionAlcohol-related outcomesDecreased alcohol useReducing alcohol useReward contingenciesBehavioral therapyImpact of CMConfirm abstinencePEth resultsCM interventionIntervention outcomesExcessive drinkingCBT4CBTAbstinenceIn-personRewardFollow-upAlcoholBrain Development and the Risk for Substance Use, Misuse, and Substance Use Disorders
Ruiz S, Casey B, Baskin-Sommers A. Brain Development and the Risk for Substance Use, Misuse, and Substance Use Disorders. 2025, 675-684. DOI: 10.1093/med/9780197640654.003.0049.Peer-Reviewed Original ResearchSubstance use disordersSubstance useMaintenance of substance use disordersFamily history of substance use disorderHistory of substance use disorderRegulation of rewardStress-related circuitryEarly life adversityAdolescent substance useCognitive controlPersonality traitsSensation seekingLife adversityNeurodevelopmental changesUse disorderAbstract AdolescentsIntervention scienceInfluence of peersSubstance exposureBrain developmentAdolescentsDisordersRewardMisuseCircuitry
2024
Representation of Anticipated Rewards and Punishments in the Human Brain
Ben-Zion Z, Levy I. Representation of Anticipated Rewards and Punishments in the Human Brain. Annual Review Of Psychology 2024, 76: 197-226. PMID: 39418537, PMCID: PMC11930275, DOI: 10.1146/annurev-psych-022324-042614.Peer-Reviewed Original ResearchNeural representationReward valuePunishment valueRepresentation of reward valueValue-based decision-makingStress-related psychopathologySubjective reward valueCross-species studiesPunishment processingAnticipated rewardsReward typeBrain regionsSubjective valueMental illnessNeural encodingAnimal researchHuman brainRewardHuman studiesBrainPunishmentMethodological challengesPsychopathologyDecision-makingNeuroeconomicsReprint of: Sex differences in appeal, reward, and sensory experience of E-cigarette flavors among adults who smoke cigarettes
Davis D, Buta E, Green B, Krishnan-Sarin S. Reprint of: Sex differences in appeal, reward, and sensory experience of E-cigarette flavors among adults who smoke cigarettes. Preventive Medicine 2024, 188: 108114. PMID: 39232940, DOI: 10.1016/j.ypmed.2024.108114.Peer-Reviewed Original ResearchDrug Effects QuestionnaireE-cigarette appealLabeled Hedonic ScaleGeneral Labeled Magnitude ScaleSensory experienceEffects of sexSex differencesRewardEffective questionnairesExploratory analysisE-cigarette flavorsNicotine concentrationsE-cigarettesSmoking cigarettesE-cigarette experienceLinear mixed modelsEffects of e-cigarettesIntensity of flavorMenthol flavorsAdultsSexScaleCuesCigaretteHedonic scaleNovel multi-modal methodology to investigate placebo response in major depressive disorder
Cusin C, Dillon D, Belleau E, Normandin M, Petibon Y, El-Fakri G, Dhaynaut M, Hooker J, Kaptchuk T, McKee M, Hayden E, Meyer A, Jahan A, Origlio J, Ang Y, Brunner D, Kang M, Long Y, Fava M, Pizzagalli D. Novel multi-modal methodology to investigate placebo response in major depressive disorder. Journal Of Affective Disorders 2024, 368: 1-7. PMID: 39233242, DOI: 10.1016/j.jad.2024.08.226.Peer-Reviewed Original ResearchPlacebo responseDepressive disorderRates of placebo responseMesocorticolimbic dopaminergic pathwayExpectation of rewardAntidepressant responseMesolimbic systemReward circuitryNeurobiological underpinningsNeurobiological mechanismsDopaminergic activityDopaminergic systemPlacebo respondersSymptom reductionDopaminergic pathwaysMulti-modal methodologyPlacebo phenomenonPsychological constructsTreatment developmentMDDPlacebo-ControlledClinical trialsDouble-blindRewardDesigning Clinical TrialsAn affordable and open-source tool for mouse behavioral studiespyControl in an undergraduate research setting
Coller A, Alpern E, Clinton K, Estrada M, Emmons E. An affordable and open-source tool for mouse behavioral studiespyControl in an undergraduate research setting. BIOS 2024, 95: 176-182. DOI: 10.1893/bios-d-23-00018.Peer-Reviewed Original ResearchEnvironmental Support Moderates the association of Socioeconomic Distress and Delay Discounting across Adolescence
Felton J, Rabinowitz J, Sadler R, Hampton T, Sosnowski D, Lejuez C, Yi R. Environmental Support Moderates the association of Socioeconomic Distress and Delay Discounting across Adolescence. Journal Of Youth And Adolescence 2024, 53: 2695-2705. PMID: 39023841, DOI: 10.1007/s10964-024-02051-1.Peer-Reviewed Original ResearchEnvironmental supportSocioeconomic distressDiscount delayed rewardsRates of delayPerceived environmental supportSample of participantsPositive youth outcomesDelay discountingRate of unemploymentLone parenthoodAdolescent periodIntervention effortsYouth outcomesDistressed areasEducational attainmentDistress indexDistressRewardEarly exposureAdolescentsYouthEnvironmental disadvantagesHome addressSupportBaselineFunctional Networks of Reward and Punishment Processing and Their Molecular Profiles Predicting the Severity of Young Adult Drinking
Li Y, Yang L, Hao D, Chen Y, Ye-Lin Y, Li C, Li G. Functional Networks of Reward and Punishment Processing and Their Molecular Profiles Predicting the Severity of Young Adult Drinking. Brain Sciences 2024, 14: 610. PMID: 38928610, PMCID: PMC11201596, DOI: 10.3390/brainsci14060610.Peer-Reviewed Original ResearchConnectome-based predictive modelingAlcohol use severityReward processingPunishment processingFunctional connectivityAssociated with alcohol use severityAlcohol misusePatterns of network connectivitySemi-Structured AssessmentYoung adult drinkersYoung adultsGenetics of AlcoholismYoung adult drinkingHuman Connectome Project dataNetwork connectivity featuresFronto-parietalAdult drinkersJuSpace toolboxAdult drinkingNeural fingerprintsMolecular profilingGABAA signalingRewardFunctional networksConnectivity featuresLesions to the mediodorsal thalamus, but not orbitofrontal cortex, enhance volatility beliefs linked to paranoia
Suthaharan P, Thompson S, Rossi-Goldthorpe R, Rudebeck P, Walton M, Chakraborty S, Noonan M, Costa V, Murray E, Mathys C, Groman S, Mitchell A, Taylor J, Corlett P, Chang S. Lesions to the mediodorsal thalamus, but not orbitofrontal cortex, enhance volatility beliefs linked to paranoia. Cell Reports 2024, 43: 114355. PMID: 38870010, PMCID: PMC11231991, DOI: 10.1016/j.celrep.2024.114355.Peer-Reviewed Original ResearchOrbitofrontal cortexMediodorsal thalamusReward learning rateAssociated with paranoiaExcitotoxic lesionsBrain regionsUnoperated monkeysAction selectionAdaptive behaviorParanoiaBelief updatingMDmcMeaningful changeCortexThalamusBeliefsLearning rateRobust to variabilityCompare performanceRewardBehaviorBrainMonkeysAction policiesPerceptionTask–Rest Reconfiguration Efficiency of the Reward Network Across Adolescence and Its Association With Early Life Stress and Depressive Symptoms
Lee Y, Yuan J, Winkler A, Kircanski K, Pine D, Gotlib I. Task–Rest Reconfiguration Efficiency of the Reward Network Across Adolescence and Its Association With Early Life Stress and Depressive Symptoms. Journal Of The American Academy Of Child & Adolescent Psychiatry 2024, 64: 290-300. PMID: 38878818, PMCID: PMC11638404, DOI: 10.1016/j.jaac.2024.04.018.Peer-Reviewed Original ResearchEarly life stressReward networkDepressive symptomsLife stressReconfiguration efficiencyFunctional connectivityExperiences of early life stressExposure to early life stressEffects of early life stressTask-based fMRI scansHigher levels of depressive symptomsLevels of depressive symptomsSevere early life stressReward processingAge-related associationsFMRI scanningAdolescent depressionCommunity sampleTask demandsResting-stateAsymptomatic youthOlder adolescentsEffects of ageRewardBrain statesSex differences in appeal, reward, and sensory experience of E-cigarette flavors among adults who smoke cigarettes
Davis D, Buta E, Green B, Krishnan-Sarin S. Sex differences in appeal, reward, and sensory experience of E-cigarette flavors among adults who smoke cigarettes. Preventive Medicine 2024, 185: 108040. PMID: 38866212, PMCID: PMC11323236, DOI: 10.1016/j.ypmed.2024.108040.Peer-Reviewed Original ResearchDrug Effects QuestionnaireE-cigarette appealLabeled Hedonic ScaleGeneral Labeled Magnitude ScaleSensory experienceEffects of sexSex differencesRewardEffective questionnairesExploratory analysisE-cigarette flavorsNicotine concentrationsE-cigarettesSmoking cigarettesE-cigarette experienceIntensity of flavorLinear mixed modelsMenthol flavorsEffects of e-cigarettesAdultsSexScaleHedonic scaleCigaretteCues
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