2023
Responsive Neurostimulation for People With Drug-Resistant Epilepsy and Autism Spectrum Disorder
Fields M, Marsh C, Eka O, Johnson E, Marcuse L, Kwon C, Young J, LaVega-Talbott M, Kurukumbi M, Von Allmen G, Zempel J, Friedman D, Jette N, Singh A, Yoo J, Blank L, Panov F, Ghatan S. Responsive Neurostimulation for People With Drug-Resistant Epilepsy and Autism Spectrum Disorder. Journal Of Clinical Neurophysiology 2023, 41: 64-71. PMID: 35512185, PMCID: PMC10756699, DOI: 10.1097/wnp.0000000000000939.Peer-Reviewed Original ResearchConceptsDrug-resistant epilepsySuper respondersSeizure reductionPromising surgical optionResponsive neurostimulator systemRNS SystemAutism spectrum disorderSurgical candidatesSurgical evaluationSurgical optionsMulticenter studySpectrum disorderGeneral populationResponsive neurostimulationPatientsResponse rateSmall cohortEpilepsyNeurostimulator systemHigh rateRespondersDescriptive statisticsSystem placementBehavioral outcomesDisordersCan biomarkers identified from the uterine fluid transcriptome be used to establish a noninvasive endometrial receptivity prediction tool? A proof-of-concept study
He A, Wu H, Zou Y, Wan C, Zhao J, Zhang Q, Liu N, Liu D, Li Y, Fu J, Li H, Huang X, Yang T, Hu C, Hou Z, Sun Y, Dong X, Wu J, Lu S, Li Y. Can biomarkers identified from the uterine fluid transcriptome be used to establish a noninvasive endometrial receptivity prediction tool? A proof-of-concept study. Reproductive Biology And Endocrinology 2023, 21: 20. PMID: 36805767, PMCID: PMC9938621, DOI: 10.1186/s12958-023-01070-0.Peer-Reviewed Original ResearchConceptsIn vitro fertilization patientsIn vitro fertilizationEndometrial receptivityFrozen-thawed blastocyst transferCell-cell adherens junctionsTranscriptomic biomarkersSequencing data qualityTranscriptome sequencing dataEndometrial receptivity testIntrauterine pregnancyBlastocyst transferPregnancy outcomesEndometrial biopsyFluid specimensSequence dataER-associatedEmbryo implantationRNA-seqClinical application potentialReceptive endometriumSmall cohortPregnancyAdherens junctionsHub genesPatients
2022
Long-Term Lung Abnormalities Associated with COVID-19 Pneumonia
Kanne J, Little B, Schulte J, Haramati A, Haramati L. Long-Term Lung Abnormalities Associated with COVID-19 Pneumonia. Radiology 2022, 306: e221806. PMID: 36040336, PMCID: PMC9462591, DOI: 10.1148/radiol.221806.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsCOVID-19 pneumoniaSARS-CoV-2 infectionCT 1 yearAcute lung injuryIntensive care therapySARS-CoV-2 pandemicBronchial dilationFrank fibrosisVascular sequelaeVenothromboembolic eventsLung injuryResidual abnormalitiesCare therapyMechanical ventilationParenchymal bandsSevere pneumoniaHistologic abnormalitiesLong-term effectsLung abnormalitiesSmall cohortPneumoniaPatientsAbnormalitiesOne-thirdSequelaeImpact of Circulating Tumor DNA–Based Detection of Molecular Residual Disease on the Conduct and Design of Clinical Trials for Solid Tumors
Kasi PM, Fehringer G, Taniguchi H, Starling N, Nakamura Y, Kotani D, Powles T, Li BT, Pusztai L, Aushev VN, Kalashnikova E, Sharma S, Malhotra M, Demko ZP, Aleshin A, Rodriguez A, Billings PR, Grothey A, Taieb J, Cunningham D, Yoshino T, Kopetz S. Impact of Circulating Tumor DNA–Based Detection of Molecular Residual Disease on the Conduct and Design of Clinical Trials for Solid Tumors. JCO Precision Oncology 2022, 6: e2100181. PMID: 35263168, PMCID: PMC8926064, DOI: 10.1200/po.21.00181.Peer-Reviewed Original ResearchConceptsMolecular residual diseaseSurrogate end pointsCtDNA testingMRD detectionResidual diseaseClinical trialsCancer recurrenceTumor DNAEnd pointMRD-positive patientsUse of ctDNAHigh-risk categoryCtDNA dynamicsTrial enrichmentAccelerated approvalDifferent cancer typesCancer managementClinical utilityHigh riskClinical practiceSmall cohortSolid tumorsRecurrenceTrial durationTreatment assignmentWorsening physical functioning in patients with neuroinflammatory disease during the COVID-19 pandemic
Levit E, Cohen I, Dahl M, Edwards K, Weinstock-Guttman B, Ishikawa T, Kavak K, Leavitt V, Nelson K, Onomichi K, Bar-Or A, Perrone C, Riley C, Venkatesh S, De Jager PL, Xia Z, Longbrake EE, Collaborative M. Worsening physical functioning in patients with neuroinflammatory disease during the COVID-19 pandemic. Multiple Sclerosis And Related Disorders 2022, 58: 103482. PMID: 35016114, PMCID: PMC8742609, DOI: 10.1016/j.msard.2021.103482.Peer-Reviewed Original ResearchConceptsPhysical functionDepression scoresCOVID-19 pandemicPhysical disabilityNeurological inflammatory diseasesMajor academic medical centerAcademic medical centerHigher baseline levelsLack of diseaseDisease durationStudy entryTherapy useNeuroinflammatory diseasesMale genderInflammatory diseasesPhysical functioningMedical CenterMood symptomsDepressive symptomsSmall cohortBaseline levelsSerial surveysSignificant depressionOlder ageWorse depression
2021
Sexual Health Education in Obstetrics and Gynecology (Ob-Gyn) Residencies-A Resident Physician Survey.
Worly B, Manriquez M, Stagg A, Blanchard M, Ogburn T, Carson S, Woodland M. Sexual Health Education in Obstetrics and Gynecology (Ob-Gyn) Residencies-A Resident Physician Survey. The Journal Of Sexual Medicine 2021, 18: 1042-1052. PMID: 37057469, DOI: 10.1016/j.jsxm.2021.03.005.Peer-Reviewed Original ResearchSexual functionResident physiciansSexual healthSexual health curriculumSexual historyResident physician surveysClinical vignettesPrimary outcome measureSexual health trainingHealth curriculumSexual health concernsCross-sectional studySexual health issuesLogistic regression analysisDidactic sessionsSexual health educationHormone therapyCommon medicationsOB-GYN residentsPhysician surveyOutcome measuresCare providersSmall cohortHealth educationPhysician program
2020
Non-invasive venous waveform analysis (NIVA) for volume assessment in patients undergoing hemodialysis: an observational study
Alvis BD, Polcz M, Miles M, Wright D, Shwetar M, Leisy P, Forbes R, Fissell R, Whitfield J, Eagle S, Brophy C, Hocking K. Non-invasive venous waveform analysis (NIVA) for volume assessment in patients undergoing hemodialysis: an observational study. BMC Nephrology 2020, 21: 194. PMID: 32448178, PMCID: PMC7245891, DOI: 10.1186/s12882-020-01845-2.Peer-Reviewed Original ResearchConceptsNon-Invasive Venous waveform AnalysisIntradialytic hypotensionNIVA valueVolume statusPre-dialysis levelsIntravascular volume statusEnd of dialysisInpatient hemodialysisIntradialytic changesMethodsFifty subjectsInadequate dialysisConcept studyVolar aspectBackgroundAccurate assessmentAccess siteObservational studyClinical challengeCardiac rateSmall cohortNon-invasive techniqueWaveform analysisHemodialysisPatientsVolume assessmentDialysisLow toxicity and favorable overall survival in relapsed/refractory B-ALL following CAR T cells and CD34-selected T-cell depleted allogeneic hematopoietic cell transplant
Fabrizio VA, Kernan NA, Boulad F, Cancio M, Allen J, Higman M, Margossian SP, Mauguen A, Prockop S, Scaradavou A, Shah N, Spitzer B, Stieglitz E, Yeager N, O’Reilly R, Brentjens RJ, Jan Boelens J, Curran KJ. Low toxicity and favorable overall survival in relapsed/refractory B-ALL following CAR T cells and CD34-selected T-cell depleted allogeneic hematopoietic cell transplant. Bone Marrow Transplantation 2020, 55: 2160-2169. PMID: 32390002, PMCID: PMC7606268, DOI: 10.1038/s41409-020-0926-1.Peer-Reviewed Original ResearchConceptsCAR T cellsAllo-HSCTT cellsCumulative incidenceCell transplantAllogeneic hematopoietic stem cell transplantAllogeneic hematopoietic cell transplantHematopoietic stem cell transplantCAR T-cell therapyConsolidative allo-HSCTHematopoietic cell transplantYoung adult patientsFavorable overall survivalStem cell transplantT-cell therapyFavorable OSOverall survivalAdult patientsSevere toxicitySmall cohortDisease controlPatientsCD34IncidenceRelapse
2019
Pre- and Postoperative Neratinib for HER2-Positive Breast Cancer Brain Metastases: Translational Breast Cancer Research Consortium 022
Freedman RA, Gelman RS, Agar NYR, Santagata S, Randall EC, Lopez B, Connolly RM, Dunn IF, Van Poznak CH, Anders CK, Melisko ME, Silvestri K, Cotter CM, Componeschi KP, Marte JM, Moy B, Blackwell KL, Puhalla SL, Ibrahim N, Moynihan TJ, Nangia J, Tung N, Burns R, Rimawi MF, Krop IE, Wolff AC, Winer EP, Lin NU, Consortium T. Pre- and Postoperative Neratinib for HER2-Positive Breast Cancer Brain Metastases: Translational Breast Cancer Research Consortium 022. Clinical Breast Cancer 2019, 20: 145-151.e2. PMID: 31558424, PMCID: PMC7035200, DOI: 10.1016/j.clbc.2019.07.011.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, OralAdultAntineoplastic Combined Chemotherapy ProtocolsBrainBrain NeoplasmsBreastBreast NeoplasmsChemotherapy, AdjuvantCraniotomyDrug Administration ScheduleFemaleHumansMiddle AgedNeoadjuvant TherapyPilot ProjectsQuinolinesReceptor, ErbB-2Tissue DistributionTreatment OutcomeConceptsCentral nervous system penetrationCerebrospinal fluidBrain metastasesStudy treatmentDisease progressionHER2-positive breast cancer brain metastasesHER2-positive metastatic breast cancerHER2-positive brain metastasesBreast cancer brain metastasesGrade 3 diarrheaCancer brain metastasesMetastatic breast cancerCentral nervous systemResected tumor tissueBlood-based analysesNeratinib monotherapyPostoperative cyclesParenchymal tumorsStudy protocolBreast cancerTumor histopathologyPatientsNervous systemSmall cohortSurgical tissues
2018
Chapter 16 Reflections on the Present and Future State of Lung Cancer Research and Management
Detterbeck F, Tanoue L. Chapter 16 Reflections on the Present and Future State of Lung Cancer Research and Management. 2018, 243-249. DOI: 10.1016/b978-0-323-48565-4.00016-3.Peer-Reviewed Original ResearchStereotactic body radiotherapyLung cancer researchCancer cell growthNew trial designsSurgical resectionUnresectable tumorsCurative treatmentBody radiotherapyLung cancerTobacco addictionTrial designSmall cohortBiologic driversResearch endpointsMinimal toxicityEarly detectionInvasive surgeryTumor's abilityTreatmentRadiotherapyCancer researchCell growthNew optionsMajor advancesMinor events
2017
The tumor genome in human immunodeficiency virus–related head and neck cancer: Exploitable targets?
Burtness B. The tumor genome in human immunodeficiency virus–related head and neck cancer: Exploitable targets? Cancer 2017, 124: 14-17. PMID: 29053184, DOI: 10.1002/cncr.31059.Peer-Reviewed Original ResearchMulticohort analysis reveals baseline transcriptional predictors of influenza vaccination responses
Avey S, Cheung F, Fermin D, Frelinger J, Gaujoux R, Gottardo R, Khatri P, Kleinstein S, Kotliarov Y, Meng H, Sauteraud R, Shen-Orr S, Tsang J, Vallania F, Anguiano E, Baisch J, Baldwin N, Belshe R, Blevins T, Chaussabel D, Davis M, Fikrig E, Grill D, Hafler D, Henrich E, Joshi S, Kaech S, Kennedy R, Mohanty S, Montgomery R, Oberg A, Obermoser G, Ovsyannikova I, Palucka A, Pascual V, Poland G, Pulendran B, Reinherz E, Shaw A, Siconolfi B, Stuart K, Tsang S, Ueda I, Wilson J, Zapata H. Multicohort analysis reveals baseline transcriptional predictors of influenza vaccination responses. Science Immunology 2017, 2 PMID: 28842433, PMCID: PMC5800877, DOI: 10.1126/sciimmunol.aal4656.Peer-Reviewed Original ResearchAntibody responseInfluenza vaccination responsesVaccination responseHuman Immunology Project ConsortiumInfluenza vaccinationMulticohort analysisOlder individualsLower vaccine responsesSuccessful vaccination responseAnnual influenza vaccinationYoung individualsSubstantial antibody responseInflammatory gene signatureLarge independent studiesIndividuals 6 monthsGood antibody responsePublic health successImmune profiling studiesVaccination cohortVaccine responsesCell subsetsSmall cohortWorse responseVaccinationHealth successOptic Nerve Obscuration in Retinoblastoma: A Risk Factor for Optic Nerve Invasion
Berry JL, Zolfaghari E, Chen A, Murphree AL, Jubran R, Kim JW. Optic Nerve Obscuration in Retinoblastoma: A Risk Factor for Optic Nerve Invasion. Ocular Oncology And Pathology 2017, 3: 283-291. PMID: 29344482, PMCID: PMC5757559, DOI: 10.1159/000464468.Peer-Reviewed Original ResearchOptic nerve invasionNerve invasionAdvanced retinoblastomaOptic nervePostlaminar optic nerve invasionPoor prognostic signPostlaminar invasionSalvage therapySalvage groupPrimary enucleationGlobe salvageRetrospective reviewPrognostic signRisk factorsIntraocular tumorsHistopathologic analysisSmall cohortNervePatientsDiagnosisRetinoblastomaEyesSecond groupInvasionTreatment
2016
In vivo variation in same-day estimates of metabotropic glutamate receptor subtype 5 binding using [11C]ABP688 and [18F]FPEB
DeLorenzo C, Gallezot JD, Gardus J, Yang J, Planeta B, Nabulsi N, Ogden RT, Labaree DC, Huang YH, Mann JJ, Gasparini F, Lin X, Javitch JA, Parsey RV, Carson RE, Esterlis I. In vivo variation in same-day estimates of metabotropic glutamate receptor subtype 5 binding using [11C]ABP688 and [18F]FPEB. Cerebrovascular And Brain Metabolism Reviews 2016, 37: 2716-2727. PMID: 27742888, PMCID: PMC5536783, DOI: 10.1177/0271678x16673646.Peer-Reviewed Original ResearchConceptsMetabotropic glutamate receptor subtype 5Test-retest studySubtype 5Absolute test-retest variabilityBrain glutamatergic systemSame dayPositron emission tomography (PET) tracerTest-retest variabilityEmission tomography tracerGlutamatergic systemLarge cohortSmall cohortStudy designTomography tracerMGluR5ScansCohortVivo variationsDaysReplication studyBinding increasesResidual radioactivitySubjectsBinding differences
2015
Normalization of brain morphology after surgery in sagittal craniosynostosis.
Brooks ED, Yang J, Beckett JS, Lacadie C, Scheinost D, Persing S, Zellner EG, Oosting D, Keifer C, Friedman HE, Wyk BV, Jou RJ, Sun H, Gary C, Duncan CC, Constable RT, Pelphrey KA, Persing JA. Normalization of brain morphology after surgery in sagittal craniosynostosis. Journal Of Neurosurgery Pediatrics 2015, 17: 460-8. PMID: 26684766, PMCID: PMC7182140, DOI: 10.3171/2015.7.peds15221.Peer-Reviewed Original ResearchConceptsBrain growthNonsyndromic craniosynostosisBrain morphological differencesWhole-brain techniqueYears of ageSignificant learning disabilitiesIQ-matched control subjectsUntreated infantsMean ageAdolescent patientsControl subjectsWhole-vault cranioplastyBrain dysmorphologySurgical reconstructionBrain areasTemporooccipital regionsSmall cohortSurgeryCognitive functionBrain morphologyBrain normalizationSagittal craniosynostosisLiberal thresholdSagittal nonsyndromic craniosynostosisFrontoparietal regionsIdentification of neurotoxic cytokines by profiling Alzheimer’s disease tissues and neuron culture viability screening
Wood LB, Winslow AR, Proctor EA, McGuone D, Mordes DA, Frosch MP, Hyman BT, Lauffenburger DA, Haigis KM. Identification of neurotoxic cytokines by profiling Alzheimer’s disease tissues and neuron culture viability screening. Scientific Reports 2015, 5: 16622. PMID: 26564777, PMCID: PMC4643219, DOI: 10.1038/srep16622.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAlzheimer DiseaseAmyloid beta-PeptidesBrainCell SurvivalCells, CulturedCytokinesFemaleGene Expression ProfilingGene Regulatory NetworksHumansInflammation MediatorsInterleukin-5Least-Squares AnalysisMaleMiddle AgedMultivariate AnalysisNeuronsRegression AnalysisTumor Necrosis Factor-alphaVascular Endothelial Growth Factor AConceptsCytokine expressionNeuronal deathNeuron culturesAD-associated cytokinesPathologic disease statesDisease tissuesControl brain tissueAlzheimer's disease tissueDisease therapeuticsAlzheimer's disease therapeuticsNeurotoxic cytokinesPro-death effectAD pathogenesisNeuronal viabilityAD tissueAmyloid betaAmyloid hypothesisMinimal efficacyHuman ADSmall cohortPathological severityCytokinesBrain tissueDisease statesVEGF
2010
Parameters Favorable to Intraprostatic Radiation Dose Escalation in Men With Localized Prostate Cancer
Housri N, Ning H, Ondos J, Choyke P, Camphausen K, Citrin D, Arora B, Shankavaram U, Kaushal A. Parameters Favorable to Intraprostatic Radiation Dose Escalation in Men With Localized Prostate Cancer. International Journal Of Radiation Oncology • Biology • Physics 2010, 80: 614-620. PMID: 20932672, PMCID: PMC3580994, DOI: 10.1016/j.ijrobp.2010.06.050.Peer-Reviewed Original ResearchConceptsSimultaneous integrated boostIntraprostatic lesionIntegrated boostPrescribed doseDose constraintsCurrent phase I trialRadiation Therapy Oncology Group (RTOG) protocolBladder dose constraintsHigh-dose cohortPhase I trialLocalized prostate cancerRadiation dose escalationIntensity-modulated radiotherapy plansHigh-dose radiationDominant intraprostatic lesionCritical normal tissuesDose cohortsDose escalationI trialProstate cancerIndividual patientsCT scanMRI scansCancer lesionsSmall cohort
2004
Automated Quantitative Analysis of Tissue Microarrays Reveals an Association between High Bcl-2 Expression and Improved Outcome in Melanoma
DiVito KA, Berger AJ, Camp RL, Dolled-Filhart M, Rimm DL, Kluger HM. Automated Quantitative Analysis of Tissue Microarrays Reveals an Association between High Bcl-2 Expression and Improved Outcome in Melanoma. Cancer Research 2004, 64: 8773-8777. PMID: 15574790, DOI: 10.1158/0008-5472.can-04-1387.Peer-Reviewed Original ResearchConceptsBcl-2 expressionHigh Bcl-2 expressionTissue microarrayMetastatic specimensResponse rateSmall cohortProgression-free survivalImproved response ratesLarge patient cohortMelanoma patientsClark levelEntire cohortBreslow depthClinical variablesPatient cohortMetastatic melanomaContinuous index scoreBetter outcomesIndex scoreMelanoma specimensCohortMelanomaBcl-2PatientsOutcomes
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